中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

13 records (took 0.011 seconds)

    AMINO NICOTINIC AND ISONICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS
    8.
    发明申请
    AMINO NICOTINIC AND ISONICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS 审中-公开
    氨基酸和异柠檬酸衍生物作为DHODH抑制剂

    公开(公告)号：WO2008077639A1

    公开(公告)日：2008-07-03

    申请号：PCT/EP2007/011401

    申请日：2007-12-21

    Applicant: LABORATORIOS ALMIRALL, S.A. ,  CASTRO PALOMINO LARIA, Julio Cesar ,  ERRA SOLA, Montserrat ,  LOZOYA TORIBIO, Maria Estrella ,  NAVARRO ROMERO, Eloisa

    Inventor： CASTRO PALOMINO LARIA, Julio Cesar ,  ERRA SOLA, Montserrat ,  LOZOYA TORIBIO, Maria Estrella ,  NAVARRO ROMERO, Eloisa

    IPC: C07D213/79 ,  C07D213/80 ,  A61K31/465 ,  A61P35/00

    CPC classification number: C07D213/79 ,  C07D213/80

    Abstract: A compound of formula (I) wherein : - one of the groups G 1 represents a nitrogen atom or a group CR c and the other represents a group CR c ; - G 2 represents a nitrogen atom or a group CR d ; - R 1 represents a group selected from hydrogen atoms, halogen atoms, C 1-4 alkyl groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, and C 3-8 cycloalkyl groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups; - R 2 represents a group selected from hydrogen atoms, halogen atoms, hydroxyl groups, C 1-4 alkyl groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, C 1-4 alkoxy groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, and C 3-8 cycloalkyl groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups; - R a , R b and R c independently represent groups selected from hydrogen atoms, halogen atoms, C 1-4 alkyl groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, and C 1-4 alkoxy groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups; - R d represents a group selected from hydrogen atoms, halogen atoms, hydroxyl groups, C 1-4 alkyl groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, and C 1-4 alkoxy groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, and C 3-8 cycloalkoxy groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups; - one of the groups G 3 and G 4 is a nitrogen atom and the other is a CH group; - M is a hydrogen atom or an pharmaceutically acceptable cation with the proviso that, when at least one of the groups R a and R b represent a hydrogen atom and G 2 is a group CR d , then Rd represents a groups selected from C 1-4 alkoxy groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, C 3-8 cycloalkoxy groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups; and the pharmaceutically acceptable salts and N-oxides thereof.

    Abstract translation: 式（I）的化合物，其中：基团G 1中的一个表示氮原子或基团CR c，另一个表示基团CR ; G 2表示氮原子或基团CR 11; R 1表示选自氢原子，卤素原子，C 1-4烷基的基团，其可任选被1,2或3个选自卤素原子的取代基取代 和羟基，以及可以被1,2或3个选自卤素原子和羟基的取代基任选取代的C 3-8环烷基; R 2表示选自氢原子，卤素原子，羟基，C 1-4烷基的基团，其可任选被1,2或3个选自以下的取代基取代 可以任选被1,2或3个选自卤素原子和羟基的取代基取代的C 1-4烷氧基和C 3-8烷基， 可以任选地被1,2或3个选自卤素原子和羟基的取代基取代的环烷基; R a，R b和R c独立地表示选自氢原子，卤素原子，C 1-4烷基的基团， 可以任选被1,2或3个选自卤素原子和羟基的取代基取代的亚烷基，和可以被1,2或3个取代基任意取代的C 1-4烷氧基 选自卤素原子和羟基; -R d表示选自氢原子，卤素原子，羟基，C 1-4烷基的基团，其可任选被1,2或3个选自下列的取代基取代： 可以任选地被1,2或3个选自卤素原子和羟基的取代基取代的C 1-4烷氧基和C 3-8烷氧基， 其可任选被1,2或3个选自卤素原子和羟基的取代基取代; G 3和G 4之一是氮原子，另一个是CH基团; - M是氢原子或药学上可接受的阳离子，条件是当基团R a和R b中的至少一个表示氢原子时，G 2 是基团CR d，则Rd表示选自C 1-4烷氧基的基团，其可任选被1,2或3个取代基 选自卤素原子和羟基的取代基，可以任选被1,2或3个选自卤素原子和羟基的取代基取代的C 3-8环烷氧基; 及其药学上可接受的盐和N-氧化物。

Patent Agency Ranking