公开(公告)号：WO2012125245A1

公开(公告)日：2012-09-20

申请号：PCT/US2012/024799

申请日：2012-02-13

Applicant: R.J. REYNOLDS TOBACCO COMPANY ,  CHEN, Gong ,  DUBE, Michael, Francis ,  CANTRELL, Daniel, Verdin ,  MARSHALL, Jerry, Wayne ,  ST. CHARLES, Frank, Kelley ,  GAN, Huamin ,  SCOTT, Cheryl, Cooper ,  FAGG, Barry, Smith

Inventor： CHEN, Gong ,  DUBE, Michael, Francis ,  CANTRELL, Daniel, Verdin ,  MARSHALL, Jerry, Wayne ,  ST. CHARLES, Frank, Kelley ,  GAN, Huamin ,  SCOTT, Cheryl, Cooper ,  FAGG, Barry, Smith

IPC: A24B3/12

CPC classification number: A24B3/12 ,  A24B3/00 ,  A24B15/183 ,  A24B15/22

Abstract: A method is provided for curing tobacco. The method includes steps of wilting, bruising, aerating, and drying tobacco, where each of the steps is measured in hours or days rather than months. In some aspects, aeration may take two to twelve hours or less. In some aspects, the entire curing method may be completed in 24 hours or less.

Abstract translation: 提供了一种固化烟草的方法。 该方法包括荨麻疹，瘀伤，充气和干燥烟草的步骤，其中每个步骤以数小时或数天而不是几个月测量。 在某些方面，曝气可能需要2至12小时或更短时间。 在一些方面，整个固化方法可以在24小时或更短时间内完成。

公开(公告)号：WO2012061390A2

公开(公告)日：2012-05-10

申请号：PCT/US2011/058791

申请日：2011-11-01

Applicant: THE PENN STATE RESEARCH FOUNDATION ,  CHEN, Gong ,  WANG, Yanming ,  LI, Pingxin ,  HU, Jing ,  WANG, Shu ,  WANG, Yuji

Inventor： CHEN, Gong ,  WANG, Yanming ,  LI, Pingxin ,  HU, Jing ,  WANG, Shu ,  WANG, Yuji

IPC: A61K31/496 ,  A61K31/551 ,  A61K31/437 ,  A61K31/4188 ,  A61P35/00

CPC classification number: A61K31/165 ,  A61K31/166 ,  A61K31/167 ,  A61K31/18 ,  A61K31/33 ,  A61K31/395 ,  A61K31/4188 ,  A61K31/47 ,  A61K31/472 ,  A61K31/496 ,  A61K31/4965 ,  A61K31/4985 ,  A61K31/551 ,  A61K31/5513 ,  A61K45/06 ,  C07C257/14 ,  C07D215/48 ,  C07D215/52 ,  C07D217/26 ,  C07D241/08 ,  C07D243/14 ,  C07D245/02 ,  C07D487/04 ,  C07D495/04 ,  C12Q1/34

Abstract: PAD4 inhibitory compositions and methods for their use in treatment of cancer and autoimmune disease are provided according to embodiments of the present invention.

Abstract translation: 根据本发明的实施方案提供了PAD4抑制组合物及其用于治疗癌症和自身免疫性疾病的方法。

公开(公告)号：WO2012021683A2

公开(公告)日：2012-02-16

申请号：PCT/US2011/047385

申请日：2011-08-11

Applicant: R. J. REYNOLDS TOBACCO COMPANY ,  CHEN, Gong ,  GERARDI, Anthony Richard ,  MUA, John-Paul ,  HOLTON, JR., Darrell Eugene ,  CANTRELL, Daniel Verdin ,  ST. CHARLES, Frank Kelley ,  MOLDOVEANU, Serban C. ,  BRINKLEY, Paul Andrew

Inventor： CHEN, Gong ,  GERARDI, Anthony Richard ,  MUA, John-Paul ,  HOLTON, JR., Darrell Eugene ,  CANTRELL, Daniel Verdin ,  ST. CHARLES, Frank Kelley ,  MOLDOVEANU, Serban C. ,  BRINKLEY, Paul Andrew

IPC: A24B3/18 ,  A24C5/00 ,  A24D3/00

CPC classification number: A24B15/18 ,  A24B3/12 ,  A24B13/00 ,  A24B15/20 ,  A24B15/30 ,  A24B15/306 ,  A24B15/307 ,  A24C5/00 ,  A24D3/00

Abstract: A method of preparing a tobacco material for use in a smoking article is provided, including (i) mixing a tobacco material, water, and an additive selected from the group consisting of lysine, glycine, histidine, alanine, methionine, glutamic acid, aspartic acid, proline, phenylalanine, valine, arginine, di- and trivalent cations, asparaginase, saccharides, phenolic compounds, reducing agents, compounds having a free thiol group, oxidizing agents, oxidation catalysts, plant extracts, and combinations thereof; (ii) heating the mixture; and (iii) incorporating the heat-treated mixture into a smoking article as a smokable material. A smoking article in the form of a cigarette is also provided that includes a tobacco material pre-treated to inhibit reaction of asparagine to form acrylamide in mainstream smoke. Upon smoking, the smoking article is characterized by an acrylamide content of mainstream smoke that is reduced relative to an untreated control smoking article.

Abstract translation: 提供了一种制备供在吸烟制品中使用的烟草材料的方法，其包括（i）将烟草材料，水和选自赖氨酸，甘氨酸，组氨酸， 丙氨酸，甲硫氨酸，谷氨酸，天冬氨酸，脯氨酸，苯丙氨酸，缬氨酸，精氨酸，二价和三价阳离子，天冬酰胺酶，糖类，酚类化合物，还原剂，具有游离巯基的化合物，氧化剂，氧化催化剂，植物提取物， 及其组合; （ii）加热混合物; 和（iii）将热处理过的混合物作为可吸材料装入吸烟制品中。 还提供了香烟形式的吸烟制品，其包括预处理的烟草材料以抑制天冬酰胺在主流烟雾中形成丙烯酰胺的反应。 吸烟时，吸烟制品的特征在于相对于未经处理的对照吸烟制品，主流烟雾中的丙烯酰胺含量降低。

公开(公告)号：WO2012061390A3

公开(公告)日：2012-06-28

申请号：PCT/US2011058791

申请日：2011-11-01

Applicant: PENN STATE RES FOUND ,  CHEN GONG ,  WANG YANMING ,  LI PINGXIN ,  HU JING ,  WANG SHU ,  WANG YUJI

Inventor： CHEN GONG ,  WANG YANMING ,  LI PINGXIN ,  HU JING ,  WANG SHU ,  WANG YUJI

IPC: A61K31/496 ,  A61K31/4188 ,  A61K31/437 ,  A61K31/551 ,  A61P35/00

CPC classification number: A61K31/165 ,  A61K31/166 ,  A61K31/167 ,  A61K31/18 ,  A61K31/33 ,  A61K31/395 ,  A61K31/4188 ,  A61K31/47 ,  A61K31/472 ,  A61K31/496 ,  A61K31/4965 ,  A61K31/4985 ,  A61K31/551 ,  A61K31/5513 ,  A61K45/06 ,  C07C257/14 ,  C07D215/48 ,  C07D215/52 ,  C07D217/26 ,  C07D241/08 ,  C07D243/14 ,  C07D245/02 ,  C07D487/04 ,  C07D495/04 ,  C12Q1/34

Abstract: PAD4 inhibitory compositions and methods for their use in treatment of cancer and autoimmune disease are provided according to embodiments of the present invention.

Abstract translation: 根据本发明的实施方式提供PAD4抑制组合物和用于治疗癌症和自身免疫疾病的方法。

公开(公告)号：WO2012021683A3

公开(公告)日：2012-05-31

申请号：PCT/US2011047385

申请日：2011-08-11

Applicant: REYNOLDS TOBACCO CO R ,  CHEN GONG ,  GERARDI ANTHONY RICHARD ,  MUA JOHN-PAUL ,  HOLTON JR DARRELL EUGENE ,  CANTRELL DANIEL VERDIN ,  ST CHARLES FRANK KELLEY ,  MOLDOVEANU SERBAN C ,  BRINKLEY PAUL ANDREW

Inventor： CHEN GONG ,  GERARDI ANTHONY RICHARD ,  MUA JOHN-PAUL ,  HOLTON JR DARRELL EUGENE ,  CANTRELL DANIEL VERDIN ,  ST CHARLES FRANK KELLEY ,  MOLDOVEANU SERBAN C ,  BRINKLEY PAUL ANDREW

IPC: A24B15/20 ,  A24B15/30

CPC classification number: A24B15/18 ,  A24B3/12 ,  A24B13/00 ,  A24B15/20 ,  A24B15/30 ,  A24B15/306 ,  A24B15/307 ,  A24C5/00 ,  A24D3/00

Abstract: A method of preparing a tobacco material for use in a smoking article is provided, including (i) mixing a tobacco material, water, and an additive selected from the group consisting of lysine, glycine, histidine, alanine, methionine, glutamic acid, aspartic acid, proline, phenylalanine, valine, arginine, di- and trivalent cations, asparaginase, saccharides, phenolic compounds, reducing agents, compounds having a free thiol group, oxidizing agents, oxidation catalysts, plant extracts, and combinations thereof; (ii) heating the mixture; and (iii) incorporating the heat-treated mixture into a smoking article as a smokable material. A smoking article in the form of a cigarette is also provided that includes a tobacco material pre-treated to inhibit reaction of asparagine to form acrylamide in mainstream smoke. Upon smoking, the smoking article is characterized by an acrylamide content of mainstream smoke that is reduced relative to an untreated control smoking article.

Abstract translation: 提供一种制备用于吸烟制品的烟草材料的方法，包括（i）将烟草材料，水和选自赖氨酸，甘氨酸，组氨酸，丙氨酸，甲硫氨酸，谷氨酸，天冬氨酸的添加剂混合 酸，脯氨酸，苯丙氨酸，缬氨酸，精氨酸，二价和三价阳离子，天冬酰胺酶，糖类，酚类化合物，还原剂，具有游离巯基的化合物，氧化剂，氧化催化剂，植物提取物及其组合; （ii）加热混合物; 和（iii）将热处理的混合物并入作为吸烟材料的吸烟制品中。 还提供了一种卷烟形式的吸烟制品，其包括预处理以抑制天冬酰胺在主流烟气中形成丙烯酰胺的反应的烟草材料。 吸烟时，吸烟制品的特征在于主流烟雾的丙烯酰胺含量相对于未处理的对照吸烟制品而减少。

公开(公告)号：WO2007120614A3

公开(公告)日：2008-08-21

申请号：PCT/US2007008764

申请日：2007-04-11

Applicant: SLOAN KETTERING INST CANCER ,  DANISHEFSKY SAMUEL J ,  WARREN J DAVID ,  CHEN JIEHAO ,  WU BIN ,  CHEN GONG ,  WAN QIAN ,  TAN ZHONGPING ,  KAN CINDY ,  YUAN YU ,  HUA ZIHAO ,  RANGANATHAN KRISHNAKUMAR ,  TRZUPEK JOHN D

Inventor： DANISHEFSKY SAMUEL J ,  WARREN J DAVID ,  CHEN JIEHAO ,  WU BIN ,  CHEN GONG ,  WAN QIAN ,  TAN ZHONGPING ,  KAN CINDY ,  YUAN YU ,  HUA ZIHAO ,  RANGANATHAN KRISHNAKUMAR ,  TRZUPEK JOHN D

IPC: C07K14/00 ,  A61K38/00 ,  A61K38/16

CPC classification number: C07K14/505 ,  C07K9/00 ,  C12P21/005

Abstract: The present invention provides isolated homogeneous polyfunctionalized proteins (e.g., erythropoietin), isolated glycopeptides, and a method for preparing polyfunctionalized peptides and/or proteins via cysteine-free native chemical ligation. In certain embodiments, the invention provides an isolated homogeneous polyfunctionalized protein having the structure (I). In certain other embodiments, the invention provides an isolated glycopeptide having Formula (II). In certain other embodiments, the inventive method is a method for preparing a polyfunctionalized peptide comprising a peptidic backbone made up of four or more amino acids, wherein two or more non-adjacent amino acids are independently substituted with a moiety having the structure (III) -LH. wherein A and L1 are as defined herein.

Abstract translation: 本发明提供了分离的均相多官能化蛋白质（例如红细胞生成素），分离的糖肽，以及通过不含半胱氨酸的天然化学连接制备多官能化肽和/或蛋白质的方法。 在某些实施方案中，本发明提供具有结构（I）的分离的均相多官能化蛋白质。 在某些其它实施方案中，本发明提供了具有式（II）的分离的糖肽。 在某些其他实施方案中，本发明的方法是制备多功能化肽的方法，其包含由四个或更多个氨基酸组成的肽主链，其中两个或多个不相邻氨基酸独立地被具有结构（III）的部分取代， -LH。 其中A和L1如本文所定义。

公开(公告)号：WO2007120614A2

公开(公告)日：2007-10-25

申请号：PCT/US2007/008764

申请日：2007-04-11

Applicant: SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH ,  DANISHEFSKY, Samuel, J. ,  WARREN, J., David ,  CHEN, Jiehao ,  WU, Bin ,  CHEN, Gong ,  WAN, Qian ,  TAN, Zhongping ,  KAN, Cindy ,  YUAN, Yu ,  HUA, Zihao ,  RANGANATHAN, Krishnakumar ,  TRZUPEK, John, D.

Inventor： DANISHEFSKY, Samuel, J. ,  WARREN, J., David ,  CHEN, Jiehao ,  WU, Bin ,  CHEN, Gong ,  WAN, Qian ,  TAN, Zhongping ,  KAN, Cindy ,  YUAN, Yu ,  HUA, Zihao ,  RANGANATHAN, Krishnakumar ,  TRZUPEK, John, D.

IPC: C07K14/505

CPC classification number: C07K14/505 ,  C07K9/00 ,  C12P21/005

Abstract: The present invention provides isolated homogeneous polyfunctionalized proteins (e.g., erythropoietin), isolated glycopeptides, and a method for preparing polyfunctionalized peptides and/or proteins via cysteine-free native chemical ligation. In certain embodiments, the invention provides an isolated homogeneous polyfunctionalized protein having the structure (I). In certain other embodiments, the invention provides an isolated glycopeptide having Formula (II). In certain other embodiments, the inventive method is a method for preparing a polyfunctionalized peptide comprising a peptidic backbone made up of four or more amino acids, wherein two or more non-adjacent amino acids are independently substituted with a moiety having the structure (III) -LH. wherein A and L1 are as defined herein.

Abstract translation: 本发明提供了分离的均相多官能化蛋白（例如促红细胞生成素），分离的糖肽，以及通过不含半胱氨酸的天然化学连接制备多官能化肽和/或蛋白质的方法。 在某些实施方案中，本发明提供具有结构（I）的分离的均相多官能化蛋白质。 在某些其他实施方案中，本发明提供了具有式（II）的分离的糖肽。 在某些其他实施方案中，本发明的方法是制备包含由四个或更多个氨基酸组成的肽主链的多官能化肽的方法，其中两个或更多个不相邻氨基酸独立地被具有结构（III）的部分取代， -LH。 其中A和L1如本文所定义。

公开(公告)号：WO2003010265A1

公开(公告)日：2003-02-06

申请号：PCT/US2000/014253

申请日：2000-05-24

Applicant: THE PROCTER & GAMBLE COMPANY ,  MIRASOL, Maria, Amelita, Gonzales ,  TEE, Johannson, Jimmy ,  CHEN, Gong-Xiang ,  FORD, Francis, Cornelio ,  LIU, Yi-Lun

Inventor： MIRASOL, Maria, Amelita, Gonzales ,  TEE, Johannson, Jimmy ,  CHEN, Gong-Xiang ,  FORD, Francis, Cornelio ,  LIU, Yi-Lun

IPC: C11D3/00

CPC classification number: C11D3/48 ,  C11D1/62 ,  C11D1/645 ,  C11D3/0015

Abstract: A fabric softening composition including from about 1% to about 90% by weight of fabric softening acitve, from about 2% to about 15% by weight of a principal solvent having a ClogP of less than about 3, from about 0.05% to about 15% by weight of a malodor controlling agent is selected from the group consisting of a quaternary ammonium antimicrobial agent or mixtures of this ingredients. The present invention also relates to a method for reducing malodor by applying such a composition to a fabric article, and drying the fabric article.

Abstract translation: 一种织物柔软组合物，其包含约1％至约90％重量的织物柔软度，约2％至约15％重量的ClogP小于约3的主要溶剂，约0.05％至约15％ 恶臭控制剂的重量％选自季铵抗微生物剂或该成分的混合物。 本发明还涉及通过将这种组合物施用于织物制品并干燥织物制品来减少恶臭的方法。

公开(公告)号：WO2021076983A1

公开(公告)日：2021-04-22

申请号：PCT/US2020/056108

申请日：2020-10-16

Applicant: THE PENN STATE RESEARCH FOUNDATION ,  CHEN, Gong

Inventor： CHEN, Gong

IPC: A61P25/00 ,  C07K14/47 ,  C12N15/85

Abstract: This document provides methods and materials involved in treating mammals having a spinal cord injury (SCI). For example, methods and materials for administering a composition containing exogenous nucleic acid encoding a NeuroD1polypeptide (or a biologically active fragment thereof) alone or in combination with a Dlx2 polypeptide (or a biologically active fragment thereof) to a mammal having SCI are provided. This document also provides methods and materials involved in treating mammals having amyotrophic lateral sclerosis (ALS). For example, methods and materials for administering a composition containing exogenous nucleic acid encoding a NeuroD1 polypeptide (or a biologically active fragment thereof) alone or in combination with an Isl1 polypeptide (or a biologically active fragment thereof) to a mammal having ALS are provided.

公开(公告)号：WO2019152857A1

公开(公告)日：2019-08-08

申请号：PCT/US2019/016378

申请日：2019-02-01

Applicant: CHEN, Gong ,  ZHANG, Lei ,  GUO, Ziyuan ,  PEI, Zifei

Inventor： CHEN, Gong ,  ZHANG, Lei ,  GUO, Ziyuan ,  PEI, Zifei

IPC: A61K38/17 ,  A61K48/00 ,  C12N15/86

Abstract: This document provides methods and materials for treating brain injuries. For example, methods and materials for using nucleic acid encoding a NeuroD1 polypeptide to convert reactive astrocytes within a brain ( e.g. , cerebral cortex) into functional neurons ( e.g. , neurons that can be functionally integrated into the brain of a living mammal ( e.g. , a human)) are provided.