公开(公告)号：WO2021208008A1

公开(公告)日：2021-10-21

申请号：PCT/CN2020/085097

申请日：2020-04-16

Applicant: THE PROCTER & GAMBLE COMPANY ,  LIU, Xiaoxin ,  TANG, Li ,  SUN, Kun ,  WANG, Fancheng ,  CHEN, Meng

Inventor： LIU, Xiaoxin ,  TANG, Li ,  SUN, Kun ,  WANG, Fancheng ,  CHEN, Meng

IPC: D04H1/425 ,  D04H1/4258 ,  D04H1/4266 ,  D04H1/4374 ,  A61F13/511 ,  A61F13/512 ,  A61F13/514 ,  A61F13/515

Abstract: The present invention relates to apertured nonwovens (30) comprising a first nonwoven layer comprising cellulose-based fibers and a plurality of apertures (302), wherein the plurality apertures (302) have a minimum aperture distance between two adjacent apertures which has a relative standard deviation no greater than about 40%, as measured according to the Aperture Quality Test, and either the apertures (302) has an aperture size no greater than about 2.2mm 2 and have an occlusion no greater than about 9%, as measured according to the Aperture Quality Test, or wherein the apertures (302) have an aspect ratio no greater than about 2.5 as measured according to the Aspect Ratio Test. The present invention also relates to an apertured nonwoven (30) comprising a first nonwoven layer comprising cellulose-based fibers and a plurality of apertures (302), the apertures (302) formed by pin-hole aperturing, wherein the plurality apertures (302) have a minimum aperture distance between two adjacent apertures which have a relative standard deviation no greater than about 40%, as measured according to the Aperture Quality Test.

公开(公告)号：WO2021163869A1

公开(公告)日：2021-08-26

申请号：PCT/CN2020/075657

申请日：2020-02-18

Applicant: THE PROCTER & GAMBLE COMPANY ,  MORIMOTO, Koichi ,  ERDEM, Gueltekin ,  CHEN, Meng ,  LIU, Li ,  YUAN, Yi ,  ZHANG, Jing

Inventor： MORIMOTO, Koichi ,  ERDEM, Gueltekin ,  CHEN, Meng ,  LIU, Li ,  YUAN, Yi ,  ZHANG, Jing

IPC: A61F13/512 ,  A61F13/15

Abstract: A three-dimensional substrate comprises a pattern comprising a repeat unit, wherein the repeat unit comprises a non-apertured area and a plurality of apertures defining the non-apertured area, wherein the non-apertured area comprises a protrusion, the non-apertured area having an area no less than 100mm 2 as measured according to Area of Non-apertured Area; a three-dimensional substrate comprising a pattern comprising a repeat unit, wherein the repeat unit comprises at least one three-dimensional element such as protrusion and at least one land, wherein the three-dimensional element comprises at least one concave portion; and an absorbent article comprises the three-dimensional substrate disclosed herein.

公开(公告)号：WO2021163867A1

公开(公告)日：2021-08-26

申请号：PCT/CN2020/075655

申请日：2020-02-18

Applicant: THE PROCTER & GAMBLE COMPANY ,  YUAN, Yi ,  CHEN, Meng ,  LIU, Hui ,  MORIMOTO, Koichi ,  ERDEM, Gueltekin ,  LIU, Li

Inventor： YUAN, Yi ,  CHEN, Meng ,  LIU, Hui ,  MORIMOTO, Koichi ,  ERDEM, Gueltekin ,  LIU, Li

IPC: A61F13/514

Abstract: An absorbent article is provided, comprising a liquid pervious topsheet (24), a backsheet (26) an absorbent core (28) disposed between the topsheet (24) and the backsheet (26), and an outer cover forming at least part of a garment-facing surface of the absorbent article, the outer cover comprising a three-dimensional substrate, wherein the three-dimensional substrate comprises a first layer (1) and a second layer (2), and a plurality of protrusions (9) where the first layer (1) is unbonded to the second layer (2), and wherein the absorbent article has a Qmax-wet of 1300W/m2or less as measured according to Qmax Test described herein.

公开(公告)号：WO2016127692A1

公开(公告)日：2016-08-18

申请号：PCT/CN2015/096390

申请日：2015-12-04

Applicant: THE PROCTER & GAMBLE COMPANY ,  CHEN, Meng ,  TANG, Ming ,  SI, Gang ,  ZHANG, Yang ,  ZHANG, Qi ,  FLORES-FIGUEROA, Aaron

Inventor： CHEN, Meng ,  TANG, Ming ,  SI, Gang ,  ZHANG, Yang ,  ZHANG, Qi ,  FLORES-FIGUEROA, Aaron

IPC: C11D1/12 ,  C11D1/40

CPC classification number: C11D3/3776 ,  C11D1/146 ,  C11D1/22 ,  C11D1/37 ,  C11D1/72 ,  C11D1/83 ,  C11D3/0026 ,  C11D3/3769 ,  C11D3/3773

Abstract: A cleaning composition contains one or more linear or branched C 6 -C 18 alkyl sulphate surfactants with a specific chain length distribution in combination with a cationic polymer containing one or more cationic structural unit with a cationic charge density ranging from 0.05 to 10 milliequivalents/g. Such cleaning compositions exhibit surprising and unexpected improvement in the sudsing profiles and are particularly suitable for use in hand-washing fabrics.

Abstract translation: 清洁组合物含有一种或多种具有特定链长度分布的直链或支链C 6 -C 18烷基硫酸盐表面活性剂与含有一个或多个阳离子结构单元的阳离子聚合物组合，其阳离子电荷密度范围为0.05至10毫当量/克。 这种清洁组合物在起泡型材中表现出令人惊奇和意想不到的改进，并且特别适合用于手洗织物。

公开(公告)号：WO2006107858A3

公开(公告)日：2006-10-12

申请号：PCT/US2006/012282

申请日：2006-04-04

Applicant: SPIRENT COMMUNICATIONS OF ROCKVILLE, INC. ,  CHEN, Meng ,  BAILEY, George

Inventor： CHEN, Meng ,  BAILEY, George

IPC: G06K9/03 ,  G06K9/00 ,  G06K9/46

Abstract: A method and system of communicating visual communication quality information, includes extracting reduced-reference (RR) feature data from visual content, embedding the RR feature data in the visual content; and transmitting the visual content with the embedded RR feature data. Visual communication quality is assessed by receiving visual content which includes visual content data and a first set of embedded RR feature data, retrieving the first set of RR feature data from the visual content data, and generating a second set of RR feature data from the visual content data. The second set of RR feature data corresponds to substantially identical features of the visual content data as that used to generate the first set of RR feature data. The first set of RR feature data is compared to the second first set of RR feature data to determine a quality of the visual content based upon the comparison.

公开(公告)号：WO2005026128A1

公开(公告)日：2005-03-24

申请号：PCT/US2004/028266

申请日：2004-08-31

Applicant: MERCK & CO., INC. ,  CHEN, Meng, Hsin ,  DOHERTY, James, B. ,  LIU, Luping ,  NATARAJAN, Swaminathan ,  TYNEBOR, Robert, M.

Inventor： CHEN, Meng, Hsin ,  DOHERTY, James, B. ,  LIU, Luping ,  NATARAJAN, Swaminathan ,  TYNEBOR, Robert, M.

IPC: C07D231/56

CPC classification number: C07D401/06 ,  C07F9/65038 ,  C07F9/65583

Abstract: This invention relates to potent potassium channel blocker compounds of Formula (I) or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans, or a pharmaceutically acceptable salt, in vivo hydrolysable ester, enantiomer, diastereomer or mixture thereof: formula (II) represents C 6-10 aryl or C 3-10 heterocyclyl, said aryl or heterocyclyl optionally substituted with 1-3 groups selected from R a ; Z represents (CH 2 ) n PO(OR)(OR*).

Abstract translation: 本发明涉及式（I）的有效钾通道阻断剂化合物或其制剂用于治疗青光眼和导致患者眼睛中眼内压升高的其它病症。 本发明还涉及这样的化合物在哺乳动物物种，特别是人类或其药学上可接受的盐体内可水解的酯，对映异构体，非对映异构体或其混合物中对眼睛的神经保护作用的用途：式（II）代表C6- 10芳基或C 3-10杂环基，所述芳基或杂环基任选被1-3个选自R a; Z表示（CH 2）n PO（OR）（OR *）。

公开(公告)号：WO2005025568A1

公开(公告)日：2005-03-24

申请号：PCT/US2004/028351

申请日：2004-08-31

Applicant: MERCK & CO., INC. ,  CHEN, Meng, Hsin ,  DOHERTY, James, B. ,  LIU, Luping ,  NATARAJAN, Swaminathan ,  TYNEBOR, Robert, M.

Inventor： CHEN, Meng, Hsin ,  DOHERTY, James, B. ,  LIU, Luping ,  NATARAJAN, Swaminathan ,  TYNEBOR, Robert, M.

IPC: A61K31/44

CPC classification number: C07D401/06

Abstract: This invention relates to potent potassium channel blocker compounds of structural Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

Abstract translation: 本发明涉及结构式I的有效钾通道阻断剂化合物或其制剂用于治疗青光眼和导致患者眼睛中眼内压升高的其它病症。 本发明还涉及这些化合物对哺乳动物物种尤其是人的眼睛的神经保护作用的用途。

公开(公告)号：WO2005002520A2

公开(公告)日：2005-01-13

申请号：PCT/US2004/020752

申请日：2004-06-25

Applicant: MERCK & CO., INC. ,  CHEN, Meng Hsin ,  DOHERTY, James, B. ,  LIU, Luping ,  NATARAJAN, Swaminathan, R. ,  SHEN, Dong-Ming ,  SHU, Min

Inventor： CHEN, Meng Hsin ,  DOHERTY, James, B. ,  LIU, Luping ,  NATARAJAN, Swaminathan, R. ,  SHEN, Dong-Ming ,  SHU, Min

IPC: A61K

CPC classification number: C07D235/12 ,  C07D235/08 ,  C07D235/16 ,  C07D405/04 ,  C07D471/04

Abstract: This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

Abstract translation: 本发明涉及有效的钾通道阻滞剂或其制剂在治疗青光眼和导致患者眼睛中眼内压升高的其它病症中的用途。 本发明还涉及这些化合物对哺乳动物物种尤其是人的眼睛的神经保护作用的用途。

公开(公告)号：WO2003027152A1

公开(公告)日：2003-04-03

申请号：PCT/US2002/031252

申请日：2002-09-30

Applicant: BIOSURFACE ENGINEERING TECHNOLOGIES, INC. ,  ZAMORA, Paul, O. ,  CHEN, Meng ,  OSAKI, Shigemasa ,  HSIEH, Ting-Ting ,  TSANG, Ray

Inventor： ZAMORA, Paul, O. ,  CHEN, Meng ,  OSAKI, Shigemasa ,  HSIEH, Ting-Ting ,  TSANG, Ray

IPC: C08F2/46

CPC classification number: C09D4/00 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  A61L33/0029 ,  A61L33/0088 ,  A61L33/0094 ,  A61L2400/10 ,  B05D1/62 ,  Y10T428/31511 ,  Y10T428/31529 ,  Y10T428/31663 ,  Y10T428/31678 ,  Y10T428/31938 ,  C08F230/08 ,  C08F226/02

Abstract: A method for making a hydrophilic and lubricious coating, the coating so made and a medical device including such coating, wherein the coating includes a hydrophilic polymeric unit layer cross- linked with a plasma deposited double bond monomer, The hydrophilic polymeric unit can include ethylene oxide with one or more primary or secondary alcohol groups or glycosaminoglycans such as hyaluronic acid, and the double bond monomer includes monomers containing at least one double bond, preferably a C=C, C=N or C=O bond, including N-trimethylsilyl-allylamine, ethylene, propylene and allyl alcohol, The invention also provides products containing such coatings and their uses in medical, pharmaceutical and cosmetic applications.

Abstract translation: 一种制备亲水和光滑涂层的方法，如此制成的涂层和包括这种涂层的医疗装置，其中涂层包括与等离子体沉积的双键单体交联的亲水聚合单元层。亲水性聚合单元可包括环氧乙烷 与一个或多个伯醇或仲醇基或糖胺聚糖如透明质酸，双键单体包括含有至少一个双键，优选C = C，C = N或C = O键的单体，包括N-三甲基甲硅烷基 - 烯丙胺，乙烯，丙烯和烯丙醇，本发明还提供含有这些涂料及其在医药，制药和化妆品应用中的用途的产品。

公开(公告)号：WO1997036873A1

公开(公告)日：1997-10-09

申请号：PCT/US1997005378

申请日：1997-03-31

Applicant: MERCK & CO., INC. ,  CHAKRAVARTY, Prasun, K. ,  CHEN, Meng, H. ,  NARGUND, Ravi ,  PATCHETT, Arthur, A. ,  TATA, James, R. ,  WU, Mu, Tsu ,  YANG, Lihu

Inventor： MERCK & CO., INC.

IPC: C07D221/20

CPC classification number: C07K5/021 ,  A61K38/00 ,  C07K5/0202 ,  C07K5/0802

Abstract: The present invention is directed to certain piperidines, pyrrolidines, and hexahydro-1H-azepines of general structural formula (I), wherein B is selected from (a) and (b), and R , R , R , R , R , R , R , R , R , R , D, X, Y, n, x and y are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.

Abstract translation: 本发明涉及一般结构式（I）的某些哌啶，吡咯烷和六氢-1H-吖庚因，其中B选自（a）和（b），R 1，R 1a，R R 2a，R 4a，R 4b，R 4c，R 5，D，X，Y，n，x和y 如本文所定义。 这些化合物促进人和动物中生长激素的释放。 这种性质可以用于促进食用动物的生长，使食用肉制品的生产更有效，并且在人类中，用于治疗特征为生长激素分泌不足的生理或医学状况，例如生长激素缺乏的身材矮小 儿童，并且治疗通过生长激素的合成代谢作用改善的医疗状况。 还公开了含有这些化合物作为其活性成分的生长激素释放组合物。