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    CONSTANT TEMPERATURE AGITATING DEVICE AND AGITATING METHOD USING THE SAME
    1.
    发明申请
    CONSTANT TEMPERATURE AGITATING DEVICE AND AGITATING METHOD USING THE SAME 审中-公开
    恒温恒温装置及其使用方法

    公开(公告)号：WO2010123205A2

    公开(公告)日：2010-10-28

    申请号：PCT/KR2010001792

    申请日：2010-03-24

    Applicant: COLLEGE MEDICINE POCHON CHA UNIV IND ACAD COOP FOUND ,  CHUNG KWANG HOE ,  LEE KWANG-HYOUNG ,  CHOI HAENG-SUK ,  KO JUNG-JAE

    Inventor： CHUNG KWANG HOE ,  LEE KWANG-HYOUNG ,  CHOI HAENG-SUK ,  KO JUNG-JAE

    IPC: B01F11/00 ,  B01F15/06

    CPC classification number: B01F11/0008 ,  B01F11/0014 ,  B01F15/065 ,  B01F2015/062 ,  B01L7/00 ,  B01L9/06 ,  B01L9/52 ,  B01L2300/1827

    Abstract: A constant temperature agitating device for agitating substances received in a container comprises a base, a container receiving body part and a shaking motion part. The container receiving body part is positioned at an upper part of the base, and includes upper and lower body parts for covering the upper and lower parts of the container so as to receive the container, wherein the inner surfaces of the upper and lower body parts which contact with the container form a container receiving part corresponding to the outer surface of the container. The shaking motion part shakes the container receiving body part against the base. The container receives heat via the inner surface contacting with the container receiving part.

    Abstract translation: 用于搅拌容纳在容器中的物质的恒温搅拌装置包括基座，容器容纳体部和摇动部分。 容器容纳体部分位于基部的上部，并且包括用于覆盖容器的上部和下部以容纳容器的上部和下部主体部分，其中上部和下部主体部分的内表面 其与容器接触形成与容器的外表面相对应的容器接收部分。 摇动运动部件将容器接收体部分摇动到底座上。 容器通过与容器接收部分接触的内表面接收热量。

    PRODUCTION METHOD FOR A NANOPATTERNED EPOXY SUBSTRATE
    2.
    发明申请
    PRODUCTION METHOD FOR A NANOPATTERNED EPOXY SUBSTRATE 审中-公开
    纳米级环氧树脂基材的生产方法

    公开(公告)号：WO2009157646A9

    公开(公告)日：2010-03-04

    申请号：PCT/KR2009001916

    申请日：2009-04-14

    Applicant: BIOBUD CO LTD ,  CHUNG KWANG HOE ,  HONG SUNG YU ,  DOH HYUN JU ,  CHOI JIN SUB ,  LIM JAE HOON ,  KIM SUNG JOONG

    Inventor： CHUNG KWANG HOE ,  HONG SUNG YU ,  DOH HYUN JU ,  CHOI JIN SUB ,  LIM JAE HOON ,  KIM SUNG JOONG

    IPC: B82B3/00

    CPC classification number: G01N33/4905

    Abstract: The present invention relates to a production method for an epoxy substrate exhibiting a nanopattern, comprising the stages of: (a) forming a titanium oxide film by anodization of a titanium substrate; (b) obtaining a titanium substrate having a concave shape formed on its surface by removing the titanium oxide film from the titanium substrate on which the titanium oxide film has been formed; (c) coating an epoxy resin onto the titanium substrate on which the concave shape has been formed; and (d) obtaining an epoxy substrate formed with a nanopattern of convex surfaces by removing the titanium substrate. In the production method of the present invention, an epoxy substrate formed with a nanopattern of convex surfaces is produced after anodizing titanium, coating an epoxy resin onto a nanopattern formed with a concave shape on the titanium surface, and removing the titanium substrate. This straightforward process makes it possible to efficiently produce an epoxy resin exhibiting a nanopattern for the measurement of blood coagulation formed with a fine pattern which is uniform and on the nano scale. Further, the epoxy substrate produced by means of the present invention makes it possible to efficiently use an electrochemical technique to ascertain whether or not blood coagulation is present in a blood sample.

    Abstract translation: 本发明涉及一种表现出纳米图案的环氧树脂基板的制造方法，其特征在于，包括：（a）通过钛基板的阳极氧化而形成氧化钛膜; （b）从形成有氧化钛膜的钛基板上除去氧化钛膜，得到表面形成有凹形状的钛基板; （c）将环氧树脂涂布到已经形成凹形的钛基板上; 和（d）通过除去钛基材得到形成有凸面的纳米图案的环氧树脂基材。 在本发明的制造方法中，在阳极氧化钛之后，在钛表面上涂布环氧树脂到形成为凹形的纳米图案上，并除去钛基板，制作形成有凸面的纳米图案的环氧树脂基板。 这种直接的方法使得可以有效地制备出显示用于测量均匀且纳米尺度的精细图案形成的凝血的纳米图案的环氧树脂。 此外，通过本发明制造的环氧树脂基板使得可以有效地使用电化学技术来确定血液样品中是否存在凝血。

    MUTATED NUCLEOTIDE SEQUENCES OF BATROXOBIN, MUTATED ALPHA FACTOR SECRETION SIGNAL SEQUENCE AND PROCESSES FOR PREPARING BATROXOBIN USING THE SAME
    3.
    发明申请
    MUTATED NUCLEOTIDE SEQUENCES OF BATROXOBIN, MUTATED ALPHA FACTOR SECRETION SIGNAL SEQUENCE AND PROCESSES FOR PREPARING BATROXOBIN USING THE SAME 审中-公开
    巴克洛新突变的核苷酸序列，突变的α因子分泌信号序列以及使用相同的方法制备巴比妥脂的方法

    公开(公告)号：WO2009084841A3

    公开(公告)日：2009-09-17

    申请号：PCT/KR2008007605

    申请日：2008-12-23

    Applicant: BIOBUD CO LTD ,  SOHN YOUNG-DOUG ,  KIM BUM JOON ,  KIM OK HWAN ,  KIM KYOUNG JUN ,  SHIN JI HUN ,  HONG SUNG YU ,  HWANG JAE HOON ,  CHUNG KWANG HOE

    Inventor： SOHN YOUNG-DOUG ,  KIM BUM JOON ,  KIM OK HWAN ,  KIM KYOUNG JUN ,  SHIN JI HUN ,  HONG SUNG YU ,  HWANG JAE HOON ,  CHUNG KWANG HOE

    IPC: C12N9/64

    CPC classification number: C12N9/6418 ,  C07K2319/02

    Abstract: The present invention relates to a batroxobin-encoding nucleotide sequence and/or a mutated a-factor secretion signal sequence, and a vector and a transformant using the same. The batroxobin-encoding nucleotide sequence of this invention exhibits an excellent expression efficiency in yeast, particular Pichia pastoris and the recombinant batroxobin is obtained at 4-13 fold higher yield than natural-occurring batroxobin-encoding sequences. The protein expression system which uses the batroxobin-encoding nucleotide sequence as well as mutated a-factor secretion signal peptide sequence of this invention obtains the recombinant batroxobin at about 20-fold higher yield than natural-occurring batroxobin-encoding sequences. In addition, the recombinant batroxobin prepared using the sequence of this invention has a significantly plausible activity and stability compared with natural-occuring batroxobin.

    Abstract translation: 本发明涉及编码巴曲酶的核苷酸序列和/或突变的α-因子分泌信号序列，以及使用其的载体和转化体。 本发明的巴曲酶编码核苷酸序列在酵母，特别是巴斯德毕赤酵母中表现出优异的表达效率，并且以比天然存在的巴曲酶编码序列高4-13倍的产率获得重组巴曲酶。 使用本发明的巴曲酶编码核苷酸序列以及突变的α-因子分泌信号肽序列的蛋白质表达系统以比天然存在的巴曲酶编码序列高约20倍的产量获得重组巴曲酶。 此外，与天然存在的巴曲酶相比，使用本发明的序列制备的重组巴曲酶具有显着合理的活性和稳定性。

    MULTI-CORE-SHELL NANOPARTICLES
    6.
    发明申请
    MULTI-CORE-SHELL NANOPARTICLES 审中-公开
    多核壳纳米粒子

    公开(公告)号：WO2011136500A3

    公开(公告)日：2012-04-05

    申请号：PCT/KR2011002870

    申请日：2011-04-21

    Applicant: CHABIOMED CO LTD ,  YOON TAE JONG ,  CHUNG KWANG-HOE ,  KO JUNG-JAE

    Inventor： YOON TAE JONG ,  CHUNG KWANG-HOE ,  KO JUNG-JAE

    IPC: B82B3/00 ,  A61K49/06 ,  B82B1/00

    CPC classification number: A61K49/1848

    Abstract: The present invention relates to core-shell nanoparticles comprising: a manganese-containing magnetic nanoparticle (Mn-MNP) multi-core; and a silica shell coating the multi-core. Since the core-shell nanoparticles used in the present invention have high saturation magnetization (Ms) value and transverse relaxivity (R2), a sensor of the present invention using the same can detect analytes with remarkably improved sensitivity. It is possible to detect a trace amount of analytes, for example, a protein or a nucleic acid molecule as an anti-cancer marker in the blood, a chemical material, and the like with the improved sensitivity. Therefore, the core-shell nanoparticles of the present invention can be useful in an effective and practical magnetic nanoparticle system and a magnetic sensing method or a contrast medium using the same due to excellent magnetic characteristics, in vivo non-toxicity, high solubility and easy surface modification.

    Abstract translation: 本发明涉及核 - 壳纳米颗粒，其包含：含锰磁性纳米颗粒（Mn-MNP）多核; 和涂覆多芯的二氧化硅壳。 由于本发明中使用的核 - 壳纳米粒子具有高的饱和磁化强度（Ms）值和横向弛豫度（R2），所以使用该传感器的本发明的传感器可以以显着提高的灵敏度检测分析物。 可以检测痕量的分析物，例如蛋白质或核酸分子，作为血液中的抗癌标志物，具有改善的敏感性的化学物质等。 因此，本发明的核 - 壳纳米颗粒可用于有效和实用的磁性纳米颗粒系统和磁感应方法或使用其的造影剂，由于其优异的磁特性，体内无毒性，高溶解性和易于使用 表面改性。

    MUTATED NUCLEOTIDE SEQUENCES OF BATROXOBIN, MUTATED ALPHA FACTOR SECRETION SIGNAL SEQUENCE AND PROCESSES FOR PREPARING BATROXOBIN USING THE SAME
    7.
    发明申请
    MUTATED NUCLEOTIDE SEQUENCES OF BATROXOBIN, MUTATED ALPHA FACTOR SECRETION SIGNAL SEQUENCE AND PROCESSES FOR PREPARING BATROXOBIN USING THE SAME 审中-公开
    巴豆红素的突变核苷酸序列，突变的ALPHA因子分泌信号序列和使用其制备巴豆红素的方法

    公开(公告)号：WO2009084841A2

    公开(公告)日：2009-07-09

    申请号：PCT/KR2008/007605

    申请日：2008-12-23

    Applicant: BIOBUD CO., LTD. ,  SOHN, Young-Doug ,  KIM, Bum Joon ,  KIM, Ok Hwan ,  KIM, Kyoung Jun ,  SHIN, Ji Hun ,  HONG, Sung Yu ,  HWANG, Jae Hoon ,  CHUNG, Kwang Hoe

    Inventor： SOHN, Young-Doug ,  KIM, Bum Joon ,  KIM, Ok Hwan ,  KIM, Kyoung Jun ,  SHIN, Ji Hun ,  HONG, Sung Yu ,  HWANG, Jae Hoon ,  CHUNG, Kwang Hoe

    IPC: C12N9/64

    CPC classification number: C12N9/6418 ,  C07K2319/02

    Abstract: The present invention relates to a batroxobin-encoding nucleotide sequence and/or a mutated α-factor secretion signal sequence, and a vector and a transformant using the same. The batroxobin-encoding nucleotide sequence of this invention exhibits an excellent expression efficiency in yeast, particular Pichia pastoris and the recombinant batroxobin is obtained at 4-13 fold higher yield than natural-occurring batroxobin-encoding sequences. The protein expression system which uses the batroxobin-encoding nucleotide sequence as well as mutated α-factor secretion signal peptide sequence of this invention obtains the recombinant batroxobin at about 20-fold higher yield than natural-occurring batroxobin-encoding sequences. In addition, the recombinant batroxobin prepared using the sequence of this invention has a significantly plausible activity and stability compared with natural-occuring batroxobin.

    Abstract translation: 本发明涉及一种编码巴曲酶的核苷酸序列和/或突变的a因子分泌信号序列，以及使用该序列的载体和转化体。 本发明的巴曲酶编码核苷酸序列在酵母，特别是巴斯德毕赤酵母中表现出优异的表达效率，并且以比天然存在的巴曲酶编码序列高出4-13倍的产量获得重组巴曲酶。 使用巴曲酶编码核苷酸序列以及本发明的突变型a因子分泌信号肽序列的蛋白质表达系统获得比天然存在的巴曲酶编码序列高约20倍的重组巴曲酶。 此外，使用本发明的顺序制备的重组巴曲酶与天然发生的巴曲酶相比具有显着似乎合理的活性和稳定性。

    THROMBIN-LIKE RECOMBINANT BATROXOBIN EXPRESSED BY PICHIA SP.AND PRODUCTION METHOD THEREOF
    9.
    发明申请
    THROMBIN-LIKE RECOMBINANT BATROXOBIN EXPRESSED BY PICHIA SP.AND PRODUCTION METHOD THEREOF 审中-公开
    通过PICHIA SP表示的类似THROMBIN的重组巴豆红素及其生产方法

    公开(公告)号：WO2005045022A1

    公开(公告)日：2005-05-19

    申请号：PCT/KR2003/002318

    申请日：2003-10-31

    Applicant: BIOBUD CO., LTD. ,  YOU, Weon-Kyoo ,  CHOI, Won-Seok ,  KOH, You-Seok ,  KANG, Seung-Woo ,  CHUNG, Kwang-Hoe

    Inventor： YOU, Weon-Kyoo ,  CHOI, Won-Seok ,  KOH, You-Seok ,  KANG, Seung-Woo ,  CHUNG, Kwang-Hoe

    IPC: C12N9/74

    CPC classification number: C12N9/6429 ,  C12Y304/21005

    Abstract: A recombinant thrombin-like enzyme batroxobin expressed by yeast, a production method thereof, and use of the batroxobin as a hemostatic agent or antithrombotic agent is disclosed. In order to express recombinant thrombin-like enzyme, an expression vector is prepared by inserting cDNA encoding the enzyme, the transformed cell is prepared by introducing the expression vector into the cell, the transformed cell then is incubated and the recombinant thrombin-like enzyme is obtained from the cell. The recombinant thrombin-like enzyme may be usefully used as a hemostatic agent because the enzyme effectively decrease bleeding time and blood coagulation time and does not affect various blood coagulation factors. The recombinant thrombin-like enzyme is also useful for a hemostatic agent or antithrombotic agent comprising the recombinant thrombin-like enzyme as an active component.

    Abstract translation: 公开了由酵母表达的重组凝血酶样酶巴曲酶，其制备方法，以及巴曲酶作为止血剂或抗血栓剂的用途。 为了表达重组凝血酶样酶，通过插入编码该酶的cDNA来制备表达载体，通过将表达载体导入细胞来制备转化细胞，然后将转化的细胞孵育，重组凝血酶样酶为 从细胞获得。 重组凝血酶样酶可有效地用作止血剂，因为该酶有效地减少了出血时间和凝血时间，并且不影响各种凝血因子。 重组凝血酶样酶也可用于包含重组凝血酶样酶作为活性成分的止血剂或抗血栓形成剂。

    NOVEL ANTIBIOTIC PEPTIDES
    10.
    发明申请
    NOVEL ANTIBIOTIC PEPTIDES 审中-公开
    新型抗生素PEPTIDES

    公开(公告)号：WO1997002286A1

    公开(公告)日：1997-01-23

    申请号：PCT/KR1996000034

    申请日：1996-03-11

    Applicant: MOGAM BIOTECHNOLOGY RESEARCH INSTITUTE ,  LEE, Keun-Hyeung ,  HONG, Sung-Yu ,  CHO, Hyun-Sook ,  LEE, Bok-Leul ,  CHUNG, Kwang-Hoe ,  YOON, Jeong-Hyeok ,  OH, Jong-Eun ,  MOON, Hong-Mo

    Inventor： MOGAM BIOTECHNOLOGY RESEARCH INSTITUTE

    IPC: C07K07/04

    CPC classification number: C07K14/43563 ,  A61K38/00

    Abstract: The present invention relates to novel antibiotic peptides which possess antibacterial and/or antifungal activities causing no cytotoxicity, and to antibacterial and/or antifungal agents containing said peptides as active ingredients. In accordance with the present invention, it has been discovered that: a number of chemically-synthesized peptides which are derived from Tenecin, show superior antibacterial and/or antifungal activities, while causing no untoward effects, and they can be applied for the development of antibacterial and/or antifungal agents.

    Abstract translation: 本发明涉及具有不引起细胞毒性的抗细菌和/或抗真菌活性的新型抗生素肽以及含有所述肽作为活性成分的抗菌剂和/或抗真菌剂。 根据本发明，已经发现：从Tenecin衍生的许多化学合成的肽显示出优异的抗菌和/或抗真菌活性，同时不会产生不利影响，并且它们可用于开发 抗菌和/或抗真菌剂。

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