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    ADZYMES AND USES THEREOF
    2.
    发明申请
    ADZYMES AND USES THEREOF 审中-公开
    ADZYMES及其用途

    公开(公告)号：WO2004019878A2

    公开(公告)日：2004-03-11

    申请号：PCT/US2003/026937

    申请日：2003-08-27

    Applicant: COMPOUND THERAPEUTICS, INC. ,  AFEYAN, Noubar, B. ,  BAYNES, Brian ,  DASGUPTA, Ruchira ,  LEE, Frank, D. ,  WONG, Gordon, G.

    Inventor： AFEYAN, Noubar, B. ,  BAYNES, Brian ,  DASGUPTA, Ruchira ,  LEE, Frank, D. ,  WONG, Gordon, G.

    IPC: A61K

    CPC classification number: C12N15/62 ,  A61K47/6425 ,  A61K47/6839 ,  A61K47/6843 ,  A61K47/6849 ,  C07K2319/00 ,  C07K2319/01 ,  C12N9/00 ,  C12N9/50

    Abstract: Disclosed is a family of novel protein constructs, useful as drugs and for other purposes, termed "adzymes," comprising an address moiety and a catalytic domain. In some types of disclosed adzymes, the address binds with a binding site on or in functional proximity to a targeted biomolecule, e.g., an extracellular targeted biomolecule, and is disposed adjacent the catalytic domain so that its affinity serves to confer anew specificity to the catalytic domain by increasing the effective local concentration of the target in the vicinity of the catalytic domain. The present invention also provides pharmaceutical compositions comprising these adzymes, methods of making adzymes, DNA's encoding adzymes or parts thereof, and methods of using adzymes, such as for treating human subjects suffering from a disease, such as a disease associated with a soluble or membrane bound molecule, e.g., an allergic or inflammatory disease.

    Abstract translation: 公开了一种新型蛋白质构建体家族，其用作药物和用于其它目的，称为“腺苷”，包括地址部分和催化结构域。 在一些类型的所公开的腺病毒中，该地址与靶向生物分子例如细胞外靶向生物分子或功能接近的结合位点结合，并且设置在催化结构域附近，使得其亲和力用于赋予催化剂新的特异性 通过增加靶在催化结构域附近的有效局部浓度。 本发明还提供药物组合物，其包含这些腺病，制造腺体的方法，编码DNA的DNA或其部分，以及使用腺病的方法，例如用于治疗患有疾病例如与可溶性或膜相关的疾病的人类受试者 结合分子，例如过敏性或炎性疾病。

    SERUM ALBUMIN SCAFFOLD-BASED PROTEINS AND USES THEREOF
    8.
    发明申请
    SERUM ALBUMIN SCAFFOLD-BASED PROTEINS AND USES THEREOF 审中-公开
    基于血清白蛋白基于蛋白质的蛋白质及其用途

    公开(公告)号：WO2004101620A2

    公开(公告)日：2004-11-25

    申请号：PCT/US2004/013726

    申请日：2004-05-03

    Applicant: COMPOUND THERAPEUTICS, INC. ,  LIPOVSEK, Dasa ,  SUN, Lin ,  KOVTUN, Alexander, V.

    Inventor： LIPOVSEK, Dasa ,  SUN, Lin ,  KOVTUN, Alexander, V.

    IPC: C07K14/76

    CPC classification number: C07K14/765

    Abstract: Disclosed herein are libraries of candidate binding proteins derived from a serum albumin scaffold, from which useful binding proteins may be selected that are specific for known and unknown targets. Also disclosed herein are methods for selection of serum albumin scaffold-based candidate binding proteins which possess such desired binding characteristics.

    Abstract translation: 本文公开了源自血清白蛋白支架的候选结合蛋白的文库，可从其中选择对已知和未知靶特异的有用结合蛋白。 本文还公开了用于选择具有所需结合特征的基于血清白蛋白支架的候选结合蛋白的方法。

    SERUM ALBUMIN SCAFFOLD-BASED PROTEINS AND USES THEREOF
    9.
    发明申请
    SERUM ALBUMIN SCAFFOLD-BASED PROTEINS AND USES THEREOF 审中-公开
    基于血清白蛋白基于蛋白质的蛋白质及其用途

    公开(公告)号：WO2004101620A3

    公开(公告)日：2005-03-31

    申请号：PCT/US2004013726

    申请日：2004-05-03

    Applicant: COMPOUND THERAPEUTICS INC ,  LIPOVSEK DASA ,  SUN LIN ,  KOVTUN ALEXANDER V

    Inventor： LIPOVSEK DASA ,  SUN LIN ,  KOVTUN ALEXANDER V

    IPC: C07K14/765 ,  C12N15/10

    CPC classification number: C07K14/765

    Abstract: Disclosed herein are libraries of candidate binding proteins derived from a serum albumin scaffold, from which useful binding proteins may be selected that are specific for known and unknown targets. Also disclosed herein are methods for selection of serum albumin scaffold-based candidate binding proteins which possess such desired binding characteristics.

    Abstract translation: 本文公开了源自血清白蛋白支架的候选结合蛋白的文库，可以从其中选择对已知和未知靶特异的有用的结合蛋白。 本文还公开了用于选择具有所需结合特征的基于血清白蛋白支架的候选结合蛋白的方法。

    ADZYMES AND USES THEREOF
    10.
    发明申请
    ADZYMES AND USES THEREOF 审中-公开
    ADZYMES及其用途

    公开(公告)号：WO2004019878A3

    公开(公告)日：2004-07-15

    申请号：PCT/US0326937

    申请日：2003-08-27

    Applicant: COMPOUND THERAPEUTICS INC ,  AFEYAN NOUBAR B ,  BAYNES BRIAN ,  DASGUPTA RUCHIRA ,  LEE FRANK D ,  WONG GORDON G

    Inventor： AFEYAN NOUBAR B ,  BAYNES BRIAN ,  DASGUPTA RUCHIRA ,  LEE FRANK D ,  WONG GORDON G

    IPC: C12N15/09 ,  A61K38/43 ,  A61K38/46 ,  A61K47/48 ,  A61P29/00 ,  A61P37/08 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/50 ,  C12N15/62 ,  C12P21/04 ,  A61K38/00 ,  C07H21/04 ,  C07K1/00 ,  C12P21/06

    CPC classification number: C12N15/62 ,  A61K47/6425 ,  A61K47/6839 ,  A61K47/6843 ,  A61K47/6849 ,  C07K2319/00 ,  C07K2319/01 ,  C12N9/00 ,  C12N9/50

    Abstract: Disclosed is a family of novel protein constructs, useful as drugs and for other purposes, termed "adzymes," comprising an address moiety and a catalytic domain. In some types of disclosed adzymes, the address binds with a binding site on or in functional proximity to a targeted biomolecule, e.g., an extracellular targeted biomolecule, and is disposed adjacent the catalytic domain so that its affinity serves to confer anew specificity to the catalytic domain by increasing the effective local concentration of the target in the vicinity of the catalytic domain. The present invention also provides pharmaceutical compositions comprising these adzymes, methods of making adzymes, DNA's encoding adzymes or parts thereof, and methods of using adzymes, such as for treating human subjects suffering from a disease, such as a disease associated with a soluble or membrane bound molecule, e.g., an allergic or inflammatory disease.

    Abstract translation: 公开了一类新型蛋白质构建体，其可用作药物并用于其他目的，称为“酶”，其包含地址部分和催化结构域。 在某些类型的公开的辅酶中，地址与靶向生物分子（例如细胞外靶向生物分子）上或与其功能性接近的结合位点结合，并且邻近催化结构域设置，使得其亲和性用于赋予催化剂新的特异性 通过增加催化结构域附近靶标的有效局部浓度来实现。 本发明还提供了包含这些酶的药物组合物，制备酶的方法，编码DNA的酶或其部分的DNA，以及使用辅酶的方法，例如用于治疗患有疾病的人类受试者，例如与可溶性或膜相关的疾病 结合的分子，例如变应性或炎性疾病。

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