利索-全球专利检索

  1. Login
  2. Sign Up

Search Results

62 records (took 0.028 seconds)

    SALTS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF
    2.
    发明申请
    SALTS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF 审中-公开
    钾ATP通道开口的盐及其用途

    公开(公告)号：WO2013130411A1

    公开(公告)日：2013-09-06

    申请号：PCT/US2013/027676

    申请日：2013-02-25

    Applicant: ESSENTIALIS, INC.

    Inventor： COWEN, Neil, M. ,  PASTERNARK, Richard, C.

    IPC: A61K31/549 ,  A61K31/38 ,  A61P3/00 ,  A61P9/00

    CPC classification number: C07D285/24 ,  A61K31/14 ,  A61K31/192 ,  A61K31/202 ,  A61K31/44 ,  A61K31/549 ,  A61K31/655 ,  A61K45/06 ,  A61K2300/00

    Abstract: Provided are immediate or prolonged administration of certain salts of KATP channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of the salts that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are method of co-administering the salts with other drugs to treat diseases of humans and animals.

    Abstract translation: 提供对受试者立即或长期给予KATP通道开放剂如二氮嗪的某些盐，以在治疗涉及KATP通道的疾病或病症中获得新颖的药效学，药代动力学，治疗学，生理学，代谢和组合结果。 还提供了实现这些结果的药物制剂，施用方法和给药盐，并减少治疗个体的不良反应的发生率。 进一步提供了与其它药物共同施用盐以治疗人和动物疾病的方法。

    SALTS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF
    6.
    发明申请
    SALTS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF 审中-公开
    钾ATP通道开口的盐及其用途

    公开(公告)号：WO2007081521A2

    公开(公告)日：2007-07-19

    申请号：PCT/US2006/048711

    申请日：2006-12-20

    Applicant: ESSENTIALIS, INC. ,  COWEN, Neil, M. ,  KASHKIN, Kenneth, B. ,  YAMOUT, Khaled, A.

    Inventor： COWEN, Neil, M. ,  KASHKIN, Kenneth, B. ,  YAMOUT, Khaled, A.

    IPC: A61K31/549

    CPC classification number: A61K31/549 ,  A61K9/2086 ,  A61K31/54 ,  A61K38/27 ,  A61K45/06 ,  C07C209/68 ,  C07C213/08 ,  C07D285/24

    Abstract: Provided are immediate or prolonged administration of certain salts of K ATP channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving K ATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of the salts that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are method of co-administering the salts with other drugs to treat diseases of humans and animals.

    Abstract translation: 提供对受试者立即或长期施用某些K ATP通道开放剂如二氮嗪的盐，以在治疗涉及的疾病或病症中获得新颖的药效学，药代动力学，治疗学，生理学，代谢和组合结果 ATP通道。 还提供了实现这些结果的药物制剂，施用方法和给药盐，并减少治疗个体的不良反应的发生率。 进一步提供了与其它药物共同施用盐以治疗人和动物疾病的方法。

    BENZOTHIADIAZINE DERIVATIVE
    10.
    发明申请
    BENZOTHIADIAZINE DERIVATIVE 审中-公开
    苯并噻嗪衍生物

    公开(公告)号：WO1992020666A1

    公开(公告)日：1992-11-26

    申请号：PCT/JP1992000672

    申请日：1992-05-22

    Applicant: TAIHO PHARMACEUTICAL COMPANY, LIMITED ,  OHNO, Tomoyasu ,  YANO, Shingo ,  FUJIWARA, Kosuke ,  AJIOKA, Hirofusa ,  YAMAMOTO, Noriyuki ,  YAMADA, Shozo ,  KAJITANI, Makoto

    Inventor： TAIHO PHARMACEUTICAL COMPANY, LIMITED

    IPC: C07D285/24

    CPC classification number: C07D417/12 ,  C07D285/24

    Abstract: A benzothiadiazine derivative represented by general formula (I), a hydrate and acid addition salt thereof, and a remedy for peptic ulcer containing said derivative, said hydrate or said salt as an active ingredient. In formula (I) X represents methylene or a lower alkyl-substituted nitrogen atom; Y and Z represent each methylene or carbonyl; A represents phenylene which may be substituted by methoxycarbonyl; B represents lower alkylene or lower alkenylene; R1 represents hydrogen, acetoxyacetyl, cyclohexylmethyl, or benzyl wherein the benzene ring may be substituted by lower alkoxy, halogen, nitro, lower alkyl, methylenedioxy or hydroxyl; R2 represents lower alkyl or phenyl; and R3 represents hydrogen, halogen or lower alkoxy, provided that the case where X, Y and Z represent each methylene, A represents unsubstituted phenylene, B represents lower alkylene, and R1 represents hydrogen is excluded.

    Abstract translation: 由通式（I）表示的苯并噻二嗪衍生物，其水合物和酸加成盐，以及含有所述衍生物，所述水合物或所述盐作为活性成分的消化性溃疡的药物。 在式（I）中，X表示亚甲基或低级烷基取代的氮原子; Y和Z代表每个亚甲基或羰基; A表示可被甲氧基羰基取代的亚苯基; B表示低级亚烷基或低级亚烯基; 卤素，硝基，低级烷基，亚甲基二氧基或羟基取代的苯环，其中R 1表示氢，乙酰氧基乙酰基，环己基甲基或苄基，其中苯环可被低级烷氧基， R2代表低级烷基或苯基; 并且R 3表示氢，卤素或低级烷氧基，条件是X，Y和Z表示各亚甲基的情况，A表示未取代的亚苯基，B表示低级亚烷基，R 1表示氢。

Patent Agency Ranking