公开(公告)号：WO2013148865A1

公开(公告)日：2013-10-03

申请号：PCT/US2013/034145

申请日：2013-03-27

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  CHIOU, Pei-Yu ,  HUANG, Kuo-Wei ,  FAN, Yu-Jui ,  KUNG, Yu-Chun

发明人： CHIOU, Pei-Yu ,  HUANG, Kuo-Wei ,  FAN, Yu-Jui ,  KUNG, Yu-Chun

IPC分类号： B01D57/02 ,  G01N27/447 ,  G01N1/10 ,  G01N35/08

CPC分类号： B03C5/005 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0424 ,  B01L2400/0655 ,  B03C5/026 ,  B03C2201/26 ,  G01N15/0656 ,  G01N27/44778 ,  G01N2015/0065 ,  G01N2015/1081

摘要： A 3-dimensional PDMS cell sorter having multiple passages in a PDMS layer that follow the same path in a DEP separation region and that are in fluid communication with each other within that region. The passages may differ in width transverse to the flow direction within the passages. Flat plates may sandwich the PDMS layer; each plate may have a planar electrode used to generate a DEP field within a sample fluid flowed within the passages. The DEP field may concentrate target cells or particulates within one of the passages within the DEP separation region. The passages may diverge after the DEP-separation region, leaving one passage with a high concentration of target cells or particulates. Techniques for manufacturing such structures, as well as other micro-fluidic structures, are also provided.

摘要翻译： 三维PDMS细胞分选器在PDMS层中具有沿DEP分离区域中相同路径并且在该区域内彼此流体连通的多个通道。 这些通道在通道内横向于流动方向的宽度可能不同。 平板可夹住PDMS层; 每个板可以具有用于在通道内流动的样品流体内产生DEP场的平面电极。 DEP场可以将目标细胞或微粒集中在DEP分离区域内的通道之一内。 通道在DEP分离区域之后可能发生分离，留下一个具有高浓度靶细胞或微粒的通道。 还提供了用于制造这种结构以及其它微流体结构的技术。

公开(公告)号：WO2019006292A1

公开(公告)日：2019-01-03

申请号：PCT/US2018/040276

申请日：2018-06-29

申请人： BRISTOL-MYERS SQUIBB COMPANY ,  DELMONTE, Albert, J. ,  COHEN, Benjamin, M. ,  FRAUNHOFFER, Kenneth, Joseph ,  KOLOTUCHIN, Sergei ,  GONZALEZ-BOBES, Francisco ,  BEUTNER, Gregory, Louis ,  FREITAG, Adam, Joseph ,  BULTMAN, Michael, Scott ,  FAN, Yu ,  MAITY, Prantik ,  YOUNG, Ian, Scott ,  BECK, Hilary, Plake ,  OSPOV, Maksim ,  POWERS, Jay, Patrick ,  REILLY, Maureen, Kay ,  SHUNATONA, Hunter, Paul ,  WALKER, James, Ross ,  ZIBINSKY, Mikhail

发明人： DELMONTE, Albert, J. ,  COHEN, Benjamin, M. ,  FRAUNHOFFER, Kenneth, Joseph ,  KOLOTUCHIN, Sergei ,  GONZALEZ-BOBES, Francisco ,  BEUTNER, Gregory, Louis ,  FREITAG, Adam, Joseph ,  BULTMAN, Michael, Scott ,  FAN, Yu ,  MAITY, Prantik ,  YOUNG, Ian, Scott ,  BECK, Hilary, Plake ,  OSPOV, Maksim ,  POWERS, Jay, Patrick ,  REILLY, Maureen, Kay ,  SHUNATONA, Hunter, Paul ,  WALKER, James, Ross ,  ZIBINSKY, Mikhail

IPC分类号： A61K31/5365 ,  C07D498/04

摘要： The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

公开(公告)号：WO2012050764A1

公开(公告)日：2012-04-19

申请号：PCT/US2011/052459

申请日：2011-09-21

申请人： BRISTOL-MYERS SQUIBB COMPANY ,  LEAHY, David K. ,  FAN, Yu ,  CHAN, Collin ,  DESAI, Lopa V. ,  PATEL, Sunil S. ,  SUGIYAMA, Masano

发明人： LEAHY, David K. ,  FAN, Yu ,  CHAN, Collin ,  DESAI, Lopa V. ,  PATEL, Sunil S. ,  SUGIYAMA, Masano

IPC分类号： C07D221/04 ,  C07D471/04

CPC分类号： C07F7/1856 ,  C07D221/04 ,  C07D471/04 ,  C07F7/1844 ,  C07F7/1868

摘要： The disclosure generally relates to a process for the preparation of compounds of formula (I), including synthetic intermediates which are useful in the process.

摘要翻译： 本公开一般涉及制备式（I）化合物的方法，包括在该方法中有用的合成中间体。

公开(公告)号：WO2006039639A1

公开(公告)日：2006-04-13

申请号：PCT/US2005/035467

申请日：2005-09-30

申请人： BRISTOL-MYERS SQUIBB COMPANY ,  DELMONTE, Albert, J. ,  DHAR, T., G. Murali ,  FAN, Yu ,  GOUGOUTAS, Jack, Z. ,  MALLEY, Mary, F. ,  MCLEOD, Douglas, D. ,  WALTERMIRE, Robert ,  WEI, Chenkou

发明人： DELMONTE, Albert, J. ,  DHAR, T., G. Murali ,  FAN, Yu ,  GOUGOUTAS, Jack, Z. ,  MALLEY, Mary, F. ,  MCLEOD, Douglas, D. ,  WALTERMIRE, Robert ,  WEI, Chenkou

IPC分类号： C07D487/10 ,  A61K31/4188 ,  A61P29/00

CPC分类号： C07D487/10

摘要： A process is provided for preparing spiro-hydantoin compounds of the formula (II), wherein Z is N or CR 4b ; K and L are independently O or S; Ar is an optionally substituted aryl or heteroaryl; A 2 is a linker, G' is a linker; Q is a linker; and R 2 , R 4a , R 4c , and R h are defined in the specification. The process optionally includes the enantiomeric separation of intermediates to allow preparation of enantiomers of the spiro-hydantoin compounds of formula II. Substituted spiro-hydantoin compounds may be prepared from the spiro-hydantoin compounds of formula (II). The spiro-hydantoin compound of formula (II) and the substituted spiro-hydantoin compounds are useful in the treatment of immune or inflammatory diseases. Also, provided are products made by the instant inventive process and crystalline forms (prepared by any process) of the substituted spiro-hydantoin compound, 5-[(5 S , 9 R )-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-ylmethyl]-thiophene-3- carboxylic acid, including solvates and salts thereof, as well as methods of use thereof. Crystalline forms of certain intermediates are provided.

摘要翻译： 提供了制备式（II）的螺 - 乙内酰脲化合物的方法，其中Z为N或CR