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公开(公告)号：WO2001066183A1
公开(公告)日：2001-09-13
申请号：PCT/IL2000/000566
申请日：2000-09-13
Applicant: IMPULSE DYNAMICS (ISRAEL), LTD. , DARVISH, Nissim , HAREL, Tami , FELSEN, Bella , GLASBERG, Offer
Inventor： DARVISH, Nissim , HAREL, Tami , FELSEN, Bella , GLASBERG, Offer
IPC: A61N1/36
CPC classification number: A61N1/36007
Abstract: A pancreatic controller (102), comprising: at least one electrode (110, 112) adapted for electrifying at least a portion of a pancreas (100); and a controller (106) programmed to electrify said electrode so as to positively control at least the effect of at least two members of a group consisting of blood glucose level, blood insulin level and blood level of another pancreatic hormone. In one example, the controller (106) controls insulin, glucagon and/or glucose blood levels.
Abstract translation: 一种胰脏控制器（102），包括：至少一个电极（110,112），适于使至少一部分胰腺（100）通电; 以及控制器（106），其被编程为使所述电极通电，以便至少主动地控制由血糖水平，血液胰岛素水平和另一胰腺激素的血液水平组成的组中的至少两个成员的影响。 在一个示例中，控制器（106）控制胰岛素，胰高血糖素和/或葡萄糖血液水平。
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公开(公告)号：WO2009149462A8
公开(公告)日：2011-01-27
申请号：PCT/US2009046646
申请日：2009-06-08
Applicant: EDWARDS LIFESCIENCES CORP , HARITON ILIA , BENICHOU NETANEL , NITZAN YAACOV , FELSEN BELLA , NGUYEN-THIEN-NH DIANA , KHANNA RAJESH , NGUYEN SON , LEVI TAMIR , PELLED ITAI
Inventor： HARITON ILIA , BENICHOU NETANEL , NITZAN YAACOV , FELSEN BELLA , NGUYEN-THIEN-NH DIANA , KHANNA RAJESH , NGUYEN SON , LEVI TAMIR , PELLED ITAI
IPC: A61F2/24
CPC classification number: A61F2/2418 , A61F2/2412 , A61F2/2433 , A61F2/2475 , A61F2002/9522 , A61F2220/0033 , A61F2220/005 , A61F2220/0075 , A61F2230/0054 , Y10T29/49863
Abstract: An implantable prosthetic valve (10), according to one embodiment, comprises a frame (12), a leaflet structure (14), and a skirt member (16). The frame can have a plurality of axial struts (20) interconnected by a plurality of circumferential struts (22, 24). The leaflet structure comprises a plurality of leaflets (e.g., three leaflets arrange to form a tricuspid valve). The leaflet structure has a scalloped lower edge portion secured to the frame. The skirt member can be disposed between the leaflet structure and the frame.
Abstract translation: 根据一个实施例的可植入人造瓣膜（10）包括框架（12），小叶结构（14）和裙部构件（16）。 框架可以具有通过多个圆周支柱（22,24）互连的多个轴向支柱（20）。 小叶结构包括多个传单（例如，安排形成三尖瓣的三个小叶）。 小叶结构具有固定到框架的扇形下边缘部分。 裙部构件可以设置在小叶结构和框架之间。
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公开(公告)号：WO0004947A2
公开(公告)日：2000-02-03
申请号：PCT/IL9900392
申请日：1999-07-18
Applicant: IMPULSE DYNAMICS NV , DARVISH NISSIM , FELSEN BELLA , SHEMER ITZIK , KORNFELD JUDITH
Inventor： DARVISH NISSIM , FELSEN BELLA , SHEMER ITZIK , KORNFELD JUDITH
CPC classification number: A61N1/362 , A61N1/3627
Abstract: Apparatus (170) for heart pacing with hemodynamic improvement, including one or more electrodes (36), which convey electrical signals to respective cardiac muscle segments. Signal generation circuitry (50) applies an extended pacing signal (60, 61), having an overall duration greater than three times a chronaxie time, to the one or more electrodes so as to pace the heart. The signal preferably includes a train of a plurality of biphasic pulses, and has an amplitude at least three times as great as a threshold for pacing the heart, but not sufficient for cardioversion.
Abstract translation: 用于具有血液动力学改善的心脏起搏的装置（170），包括一个或多个电极（36），其将电信号传送到相应的心肌段。 信号生成电路（50）将延长的起搏信号（60,61）应用于一个或多个电极，以将心脏起搏，所述延长的起搏信号具有大于三倍时间的总持续时间。 该信号优选地包括一系列多个双相脉冲，并且具有至少三倍于用于起搏心脏的阈值的幅度，但是不足以用于心脏复律。
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公开(公告)号：WO2013012801A3
公开(公告)日：2013-01-24
申请号：PCT/US2012/046916
申请日：2012-07-16
Applicant: EDWARDS LIFESCIENCES CORPORATION , YOHANAN, Ziv , GUROVICH, Nik , FELSEN, Bella , PELLED, Itai , MEIRI, Oded
Inventor： YOHANAN, Ziv , GUROVICH, Nik , FELSEN, Bella , PELLED, Itai , MEIRI, Oded
Abstract: The present disclosure is directed to embodiments of catheter-based prosthetic heart valves, and in particular, prosthetic heart valves having sealing devices configured to seal the interface between the prosthetic valve and the surrounding tissue of the native annulus in which the prosthetic valve is implanted. In one embodiment, a prosthetic heart valve includes an annular sealing member that can be placed in a delivery orientation extending axially away from one end of the valve when the valve is in a radially compressed state. When the valve is expanded, the expansion of the frame causes the sealing member to be pulled to an operative orientation covering a portion of the frame. The present disclosure also discloses new mechanisms and techniques for mounting valve leaflets to a frame of a prosthetic heart valve.
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Patent Agency Ranking
公开(公告)号：WO2012048035A2
公开(公告)日：2012-04-12
申请号：PCT/US2011/054973
申请日：2011-10-05
Applicant: EDWARDS LIFESCIENCES CORPORATION , LEVI, Tamir , NGUYEN, Son, V. , BENICHOU, Netanel , MAIMON, David , YOHANAN, Ziv , GUROVICH, Nik , FELSEN, Bella , DADONKIN, Larisa
Inventor： LEVI, Tamir , NGUYEN, Son, V. , BENICHOU, Netanel , MAIMON, David , YOHANAN, Ziv , GUROVICH, Nik , FELSEN, Bella , DADONKIN, Larisa
CPC classification number: A61F2/2418 , A61F2/2412 , A61F2/2433 , A61F2220/0075 , A61F2230/0054 , A61F2250/0036 , A61F2250/0097
Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.
Abstract translation: 公开了径向可折叠和可扩张的假体心脏瓣膜的实施例。 当安装在输送轴上时，阀架可以具有锥形轮廓，流入端部的直径小于流出端部分的直径。 阀可以包括大致V形的小叶，在框架的流入端内还原材料。 外裙可以固定到框架的流入端部分的外部，当阀门膨胀时，外裙部具有纵向松弛，并且当阀门折叠时，外裙部平放在框架上。 对角编织的内裙可以与框架轴向伸长。 相邻小叶的侧翼可以延伸穿过并固定到框架的窗框部分以形成连合。 当阀被压接到输送轴上时，窗框部分可以相对于周围的框架部分径向向内按压。
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公开(公告)号：WO2013012801A2
公开(公告)日：2013-01-24
申请号：PCT/US2012046916
申请日：2012-07-16
Applicant: EDWARDS LIFESCIENCES CORP , YOHANAN ZIV , GUROVICH NIK , FELSEN BELLA , PELLED ITAI , MEIRI ODED
Inventor： YOHANAN ZIV , GUROVICH NIK , FELSEN BELLA , PELLED ITAI , MEIRI ODED
CPC classification number: A61F2/2418 , A61F2/2436 , A61F2220/0075 , A61F2230/0054 , A61F2250/0065 , A61F2250/0069
Abstract: The present disclosure is directed to embodiments of catheter-based prosthetic heart valves, and in particular, prosthetic heart valves having sealing devices configured to seal the interface between the prosthetic valve and the surrounding tissue of the native annulus in which the prosthetic valve is implanted. In one embodiment, a prosthetic heart valve includes an annular sealing member that can be placed in a delivery orientation extending axially away from one end of the valve when the valve is in a radially compressed state. When the valve is expanded, the expansion of the frame causes the sealing member to be pulled to an operative orientation covering a portion of the frame. The present disclosure also discloses new mechanisms and techniques for mounting valve leaflets to a frame of a prosthetic heart valve.
Abstract translation: 本公开涉及基于导管的假体心脏瓣膜的具体实施方式，特别地，具有密封装置的假体心脏瓣膜被配置为密封假体瓣膜和植入人造瓣膜的天然环带的周围组织之间的界面。 在一个实施例中，假体心脏瓣膜包括环形密封构件，当阀处于径向压缩状态时，环形密封构件能够沿轴向远离阀的一端延伸的排放方向放置。 当阀膨胀时，框架的膨胀使得密封构件被拉动到覆盖框架的一部分的操作取向。 本公开还公开了将瓣膜瓣安装到假体心脏瓣膜的框架的新机构和技术。
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公开(公告)号：WO2012048035A3
公开(公告)日：2012-07-19
申请号：PCT/US2011054973
申请日：2011-10-05
Applicant: EDWARDS LIFESCIENCES CORP , LEVI TAMIR , NGUYEN SON V , BENICHOU NETANEL , MAIMON DAVID , YOHANAN ZIV , GUROVICH NIK , FELSEN BELLA , DADONKIN LARISA
Inventor： LEVI TAMIR , NGUYEN SON V , BENICHOU NETANEL , MAIMON DAVID , YOHANAN ZIV , GUROVICH NIK , FELSEN BELLA , DADONKIN LARISA
CPC classification number: A61F2/2418 , A61F2/2412 , A61F2/2433 , A61F2220/0075 , A61F2230/0054 , A61F2250/0036 , A61F2250/0097
Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.
Abstract translation: 公开了径向可折叠和可扩张假体心脏瓣膜的实施例。 阀框架在安装在输送轴上时可具有锥形轮廓，其中流入端部的直径小于流出端部的直径。 瓣膜可以包括大致V形小叶，从而减少了在框架流入端内的物质。 外裙部可以固定到框架的流入端部的外侧，当瓣膜膨胀时，外裙部具有纵向松弛并且当瓣膜塌陷时平躺在框架上。 对角编织的内裙部可以与框架轴向延伸。 相邻小叶的侧翼可延伸穿过并固定到框架的窗框部分以形成连合。 当阀压接到输送轴上时，窗框部分可相对于周围框架部分径向向内凹陷。
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公开(公告)号：WO0166183A9
公开(公告)日：2002-11-07
申请号：PCT/IL0000566
申请日：2000-09-13
Applicant: IMPULSE DYNAMICS LTD , DARVISH NISSIM , HAREL TAMI , FELSEN BELLA , GLASBERG OFFER
Inventor： DARVISH NISSIM , HAREL TAMI , FELSEN BELLA , GLASBERG OFFER
IPC: A61N1/36
CPC classification number: A61N1/36007
Abstract: A pancreatic controller (102), comprising: at least one electrode (110, 112) adapted for electrifying at least a portion of a pancreas (100); and a controller (106) programmed to electrify said electrode so as to positively control at least the effect of at least two members of a group consisting of blood glucose level, blood insulin level and blood level of another pancreatic hormone. In one example, the controller (106) controls insulin, glucagon and/or glucose blood levels.
Abstract translation: 一种胰脏控制器（102），包括：至少一个电极（110,112），适于使至少一部分胰腺（100）通电; 以及控制器（106），其被编程为使所述电极通电，以便至少主动地控制由血糖水平，血液胰岛素水平和另一胰腺激素的血液水平组成的组中的至少两个成员的影响。 在一个示例中，控制器（106）控制胰岛素，胰高血糖素和/或葡萄糖血液水平。
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公开(公告)号：WO0110375A2
公开(公告)日：2001-02-15
申请号：PCT/IL0000467
申请日：2000-08-03
Applicant: IMPULSE DYNAMICS NV , FELSEN BELLA , DARVISH NISSIM , GOLDENHOLZ DANIEL
Inventor： FELSEN BELLA , DARVISH NISSIM , GOLDENHOLZ DANIEL
CPC classification number: A61N1/36071 , A61N1/36003 , A61N1/36007 , A61N1/3601
Abstract: Apparatus (20) for modifying the electrical behavior of nervous tissue (30) in a human subject is provided. At least one inhibiting electrode (22) is placed in a vicinity of the subject's nervous tissue, and a control unit (40) drives the at least one inhibiting electrode to apply electrical energy to the nervous tissue to inhibit propagation therein of an action potential. Preferably, application of the electrical energy substantially does not cause generation of an action potential in at least a portion of the nervous tissue.
Abstract translation: 提供了用于修改人类对象中的神经组织（30）的电行为的装置（20）。 至少一个抑制电极（22）放置在对象的神经组织附近，并且控制单元（40）驱动至少一个抑制电极以向神经组织施加电能以抑制其中的动作电位的传播。 优选地，电能的施加基本上不会导致在神经组织的至少一部分中产生动作电位。
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