公开(公告)号：WO03069308A2

公开(公告)日：2003-08-21

申请号：PCT/US0304548

申请日：2003-02-12

Applicant: OPTISCAN BIOMEDICAL CORP ,  STERLING BERNHARD B ,  BRAIG JAMES R ,  GOLDBERGER DANIEL S ,  HARTSTEIN PHILIP C ,  GAFFNEY ROBERT D

Inventor： STERLING BERNHARD B ,  BRAIG JAMES R ,  GOLDBERGER DANIEL S ,  HARTSTEIN PHILIP C ,  GAFFNEY ROBERT D

IPC: G01N33/483 ,  A61B5/00 ,  G01N21/27 ,  G01N21/31 ,  G01N21/35 ,  G01N33/487 ,  G01N33/66 ,  G01N

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B2562/0295 ,  G01N21/274 ,  G01N21/314 ,  G01N21/35 ,  G01N27/3271

Abstract: A method determines an analyte concentration in a sample including the analyte and a substance. The method includes providing an absorption spectrum of the sample. The absorption spectrum has an absorption baseline. The method further includes shifting the absorption spectrum so that the absorption baseline approximately equals a selected absorption value in a selected absorption wavelength range. The method further includes subtracting a substance contribution from the absorption spectrum. Thus, the method provides a corrected absorption spectrum substantially free of a contribution from the substance.

Abstract translation: 一种方法确定包含分析物和物质的样品中的分析物浓度。 该方法包括提供样品的吸收光谱。 吸收光谱具有吸收基线。 该方法还包括移动吸收光谱，使得吸收基线大约等于所选吸收波长范围内的选定吸收值。 该方法还包括从吸收光谱中减去物质贡献。 因此，该方法提供基本上不含该物质的贡献的校正吸收光谱。

公开(公告)号：WO2003039362A1

公开(公告)日：2003-05-15

申请号：PCT/US2002/035707

申请日：2002-11-06

Applicant: OPTISCAN BIOMEDICAL CORPORATION ,  STERLING, Bernhard, B. ,  HARTSTEIN, Philip, C. ,  LI, Kenneth, I. ,  AGOSTINO, Mark, D. ,  KLONOFF, David, C. ,  GAFFNEY, Robert, D. ,  ZHENG, Peng ,  GABLE, Jennifer, H. ,  WITTE, Kenneth, G. ,  SMITH, Heidi, M. ,  SHEILL, Jane, J. ,  MUNROW, Mike, A. ,  HALL, W., Dale ,  GOLDBERGER, Daniel, S. ,  FENNELL, Martin, J. ,  CORTELLA, Julian, M. ,  BRAIG, James, R. ,  RULE, Peter

Inventor： STERLING, Bernhard, B. ,  HARTSTEIN, Philip, C. ,  LI, Kenneth, I. ,  AGOSTINO, Mark, D. ,  KLONOFF, David, C. ,  GAFFNEY, Robert, D. ,  ZHENG, Peng ,  GABLE, Jennifer, H. ,  WITTE, Kenneth, G. ,  SMITH, Heidi, M. ,  SHEILL, Jane, J. ,  MUNROW, Mike, A. ,  HALL, W., Dale ,  GOLDBERGER, Daniel, S. ,  FENNELL, Martin, J. ,  CORTELLA, Julian, M. ,  BRAIG, James, R. ,  RULE, Peter

IPC: A61B5/00

CPC classification number: A61B5/1455 ,  A61B5/01 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150061 ,  A61B5/150213 ,  A61B5/150274 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150755 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/157 ,  A61B5/6826 ,  A61B5/6838 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/35

Abstract: A reagentless whole-blood analyte detection system (200, 400, 450, 1000, 1100) that is capable of being deployed near a patient has a source (220) capable of emitting a beam of radiation that includes a spectral band. The whole-blood system (200, 400, 450, 1000, 1100) also has at least one detector (250, 1152, 1154) in an optical path of the beam. The whole-blood system (200, 400, 450, 1000, 1100) also has a housing (402, 452) that is configured to house the source (220) and the detector(s) (250, 1152, 1154). The whole-blood system (200, 400, 450, 1000, 1100) also has a sample element (240, 305, 605, 805, 885, 905, 1040, 1205, 1305, 1355, 1405) that is situated in the optical path of the beam. The sample element (240, 305, 605, 805, 885, 905, 1040, 1205, 1305, 1355, 1405) has a sample cell (242, 310, 610, 810) and a sample cell wall (244, 330, 335) that does not eliminate transmittance of the beam of radiation in the spectral band.

Abstract translation: 能够在患者附近部署的无试剂全血分析物检测系统（200,400,450,1000,1100）具有能够发射包括光谱带的辐射束的源（220）。 全血系统（200,400,450,1000,1100）还具有在光束的光路中的至少一个检测器（250,1152,1154）。 全血系统（200,400,450,1000,1100）还具有构造成容纳源（220）和检测器（250,1152,1154）的壳体（402,452）。 全血系统（200,400,450,1000,1100）还具有位于光学系统中的样品元件（240,305,605,805,885,905,1040,1205,1305,135,1405） 梁的路径。 样品元件（240,305,605,805,885,905,1040,1205,1305,135,1405）具有样品池（242,310,610,810）和样品池壁（244,330,335） ），其不消除光谱带中的辐射束的透射率。

公开(公告)号：WO2003069308A3

公开(公告)日：2003-08-21

申请号：PCT/US2003/004548

申请日：2003-02-12

Applicant: OPTISCAN BIOMEDICAL CORPORATION ,  STERLING, Bernhard, B. ,  BRAIG, James, R. ,  GOLDBERGER, Daniel, S. ,  HARTSTEIN, Philip, C. ,  GAFFNEY, Robert, D.

Inventor： STERLING, Bernhard, B. ,  BRAIG, James, R. ,  GOLDBERGER, Daniel, S. ,  HARTSTEIN, Philip, C. ,  GAFFNEY, Robert, D.

IPC: G01N33/49

Abstract: A method determines an analyte concentration in a sample including the analyte and a substance. The method (100) includes providing an absorption spectrum of the sample (200). The absorption spectrum has an absorption baseline. The method further includes shifting the absorption spectrum (300) so that the absorption baseline equals a selected absorption value in a selected wavelength range. The method further includes subtracting a substance contribution (400) from the absorption spectrum. Thus, the method provides a corrected absorption spectrum substantially free of a contribution from the substance.