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    NOISE REDUCTION FOR ANALYTE DETECTION SYSTEM
    1.
    发明申请
    NOISE REDUCTION FOR ANALYTE DETECTION SYSTEM 审中-公开
    用于分析仪检测系统的噪声减少

    公开(公告)号：WO2007120745A2

    公开(公告)日：2007-10-25

    申请号：PCT/US2007008997

    申请日：2007-04-11

    Applicant: OPTISCAN BIOMEDICAL CORP ,  HEPPELL KEVIN ,  BRAIG JAMES R

    Inventor： HEPPELL KEVIN ,  BRAIG JAMES R

    CPC classification number: A61B5/14532 ,  A61B5/1459 ,  G01N21/07 ,  G01N21/274 ,  G01N21/35

    Abstract: Methods and apparatus are provided for determining the concentration of an analyte in a sample, such as an analyte in a sample of bodily fluid. Some embodiments use a synchronous demodulator and digital filter to reduce microphonic signal content. Some embodiments monitor the microphonic signal content and "hold off" on making a measurement until vibrations subside. Monitoring can be performed using an accelerometer or other vibration sensor. An algorithm can be used to examine the detector output signal and detect excessive microphonic components, making an accelerometer unnecessary.

    Abstract translation: 提供了用于确定样品（例如体液样品中的分析物）中的分析物的浓度的方法和装置。 一些实施例使用同步解调器和数字滤波器来减少麦克风信号内容。 一些实施例监视麦克风信号内容并在进行测量时“保持”直到振动消退。 可以使用加速度计或其他振动传感器进行监视。 可以使用一种算法来检测检测器输出信号并检测过多的麦克风分量，使加速度计不必要。

    ANALYTE DETECTION SYSTEM AND METHOD WITH PERIODIC SAMPLE DRAW AND BODY FLUID ANALYZER
    2.
    发明申请
    ANALYTE DETECTION SYSTEM AND METHOD WITH PERIODIC SAMPLE DRAW AND BODY FLUID ANALYZER 审中-公开
    分析仪检测系统和方法与定期抽样和体液分析仪

    公开(公告)号：WO2007073392A1

    公开(公告)日：2007-06-28

    申请号：PCT/US2006/005113

    申请日：2006-02-13

    Applicant: OPTISCAN BIOMEDICAL CORPORATION ,  BRAIG, James, R. ,  RULE, Peter

    Inventor： BRAIG, James, R. ,  RULE, Peter

    IPC: A61B5/15 ,  A61M5/172

    CPC classification number: A61B5/1486 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/14557 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/4839 ,  A61B2562/0295 ,  A61M5/14232 ,  A61M2005/1726 ,  A61M2230/201 ,  G01N27/3271 ,  G01N33/49

    Abstract: Described is a system for analyzing a body fluid of a patient comprises a fluid transport network having a patient end configured to provide fluid communication with the body fluid in the patient and a fluid delivery point spaced from the patient end. A pump system (203) is coupled to the fluid transport network. The pump system has an infusion mode in which the pump system is operable to pump an infusion fluid toward the patient end of the fluid transport network and a draw mode in which the pump system is operable to draw the body fluid from the patient into the fluid transport network through the patient end. At least one electrochemical test element is located near the fluid delivery point of the fluid transport network. The electrochemical test element (9520) is positioned to receive a portion of the body fluid delivered to the delivery point by the fluid transport network. An analyte detection system (334) is configured to receive the test element and to measure at least one analyte in the portion of the body fluid.

    Abstract translation: 描述了一种用于分析患者的体液的系统，包括流体输送网络，其具有构造成提供与患者体液的流体连通的患者端和与患者端间隔开的流体输送点。 泵系统（203）联接到流体输送网络。 泵系统具有输液模式，其中泵系统可操作以将输液流体朝向流体输送网络的患者端泵送，并且抽吸模式，其中泵系统可操作以将体液从患者吸入流体 运输网络通过患者终点。 至少一个电化学测试元件位于流体输送网络的流体输送点附近。 电化学测试元件（9520）定位成接收由流体输送网络输送到输送点的体液的一部分。 分析物检测系统（334）被配置为接收测试元件并且测量体液部分中的至少一种分析物。

    APPARATUS AND METHODS FOR ANALYZING BODY FLUID SAMPLES
    4.
    发明申请
    APPARATUS AND METHODS FOR ANALYZING BODY FLUID SAMPLES 审中-公开
    用于分析身体液体样品的装置和方法

    公开(公告)号：WO2006088771A2

    公开(公告)日：2006-08-24

    申请号：PCT/US2006004928

    申请日：2006-02-13

    Applicant: OPTISCAN BIOMEDICAL CORP ,  HALL W DALE ,  CALLICOAT DAVID N ,  GABLE JENNIFER H ,  BRAIG JAMES R ,  WITTE KENNETH G ,  WESCHLER MARK ,  RULE PETER ,  KEENAN RICHARD

    Inventor： HALL W DALE ,  CALLICOAT DAVID N ,  GABLE JENNIFER H ,  BRAIG JAMES R ,  WITTE KENNETH G ,  WESCHLER MARK ,  RULE PETER ,  KEENAN RICHARD

    IPC: A61B5/15 ,  A61B5/00 ,  A61M5/172 ,  G01N33/487

    CPC classification number: A61B5/14546 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61M5/14212 ,  A61M2230/20

    Abstract: An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient. The apparatus comprises an infusion line and a catheter configured for insertion into a blood vessel of the patient, and a reversible infusion pump connected between a source of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The sample cell is substantially transmissive to light comprising a wavelength ?. The apparatus further comprises a controller that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The body fluid sample drawn from the patient is disposed such that a first portion of the body fluid sample is in sensing contact with the first sensor of the body fluid sensor assembly, and a second portion of the body fluid sample is disposed within the sample cell of the body fluid sensor assembly. The controller further is configured to monitor the signal provided by the first sensor of the body fluid sensor assembly and to detect a change in the signal indicative of the arrival of the body fluid sample at the first sensor. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction. The signal produced by the first sensor provides an indication of a predetermined parameter of the patient's body fluid when the body fluid sample is in sensing contact with the first sensor.

    Abstract translation: 提供了一种用于在将输注液注入患者体内时监测患者体液的预定参数的装置。 该装置包括输注管线和构造成用于插入患者血管的导管以及连接在输注液源和输注管线和导管之间的可逆输液泵。 该装置还包括体液传感器组件，其安装成与输注管线流体连通并且包括第一传感器和样品池。 第一传感器提供指示输注管线中存在的任何流体的预定参数的信号。 样品池对于包含波长λ的光是基本上透射的。 所述装置还包括控制器，所述控制器被配置为沿向前方向操作所述输注泵，以便将所述输注流体泵送通过所述输注管线和导管以输注到所述患者体内。 控制器被配置为间歇地中断其在向前方向上的输液泵的操作，以在向后的方向上操作输注泵，以便通过导管和输注管线从患者抽取体液样品。 从患者抽出的体液样品被设置成使得体液样品的第一部分与体液传感器组件的第一传感器感测接触，并且体液样品的第二部分设置在样品池内 的体液传感器组件。 控制器还被配置为监测由体液传感器组件的第一传感器提供的信号，并且检测指示体液样品到达第一传感器的信号的变化。 响应于检测体液样品到达第一传感器，控制器被配置为在向后的方向停止输注泵的操作。 当体液样品与第一传感器感测接触时，由第一传感器产生的信号提供患者体液的预定参数的指示。

    CARTRIDGE LANCE
    5.
    发明申请
    CARTRIDGE LANCE 审中-公开

    公开(公告)号：WO2004062500A8

    公开(公告)日：2004-12-23

    申请号：PCT/US0341610

    申请日：2003-12-30

    Applicant: OPTISCAN BIOMEDICAL CORP ,  RULE PETER ,  BRAIG JAMES R ,  HARTSTEIN PHILIP C

    Inventor： RULE PETER ,  BRAIG JAMES R ,  HARTSTEIN PHILIP C

    IPC: A61B5/00 ,  A61B5/15 ,  G01N21/71

    CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150442 ,  A61B5/150503 ,  A61B5/15087 ,  A61B5/15142 ,  A61B5/1519 ,  A61B5/157 ,  G01N21/71

    Abstract: An analyte detection system (1709) for analysis of a body fluid is provided, comprising an analysis portion and a sample collection portion which is configured to be removably coupled to the analysis portion. The analysis portion comprises a detector (250) configured to detect electromagnetic radiation and a source of electromagnetic radiation (220). The source is positioned with respect to the detector such that electromagnetic radiation emitted by the source is received by the detector. The sample collection portion comprises a housing, a lance (1704) and a sample chamber (1734). The lance is mounted within and moveable with respect to the housing. The sample chamber is configured to be positionable, upon coupling of the sample collection portion to the analysis portion, with respect to the source and detector such that at least a portion of any electromagnetic radiation emitted by the source passes through the sample chamber prior to being received by the detector.

    Abstract translation: 提供了一种用于分析体液的分析物检测系统（1709），其包括分析部分和被配置为可移除地耦合到分析部分的样本收集部分。 分析部分包括被配置为检测电磁辐射和电磁辐射源（220）的检测器（250）。 源相对于检测器定位，使得由源发射的电磁辐射由检测器接收。 样品收集部分包括壳体，喷枪（1704）和样品室（1734）。 喷枪相对于壳体安装并可移动。 样品室被配置为在样品收集部分与分析部分相对于源和检测器耦合时可定位，使得由源发射的任何电磁辐射的至少一部分在被存在之前通过样品室 由检测器接收。

    DUAL MEASUREMENT ANALYTE DETECTION SYSTEM
    6.
    发明申请
    DUAL MEASUREMENT ANALYTE DETECTION SYSTEM 审中-公开
    双测量分析仪检测系统

    公开(公告)号：WO2004091387A2

    公开(公告)日：2004-10-28

    申请号：PCT/US2004/011432

    申请日：2004-04-14

    Applicant: OPTISCAN BIOMEDICAL CORPORATION ,  BRAIG, James, R. ,  RULE, Peter ,  WITTE, Kenneth, G. ,  HARTSTEIN, Philip, C. ,  STERLING, Bernhard, B.

    Inventor： BRAIG, James, R. ,  RULE, Peter ,  WITTE, Kenneth, G. ,  HARTSTEIN, Philip, C. ,  STERLING, Bernhard, B.

    IPC: A61B5/00

    CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14546

    Abstract: An analyte detection system (10) is configured to measure concentrations of at least first and second analytes in a single material sample supported by a sample element (120, 302, 402, 602). The measurement of a second analyte can be conditioned on a quantitative or qualitative result of the first measurement. In one embodiment, the first analyte is glucose and the second analyte is a ketone. According to such an embodiment the ketone is measured if the result of the glucose measurement exceeds a previously-specified value or falls outside of a previously-specified range.

    Abstract translation: 分析物检测系统（10）被配置为测量由样品元件（120,302,402,602）支撑的单个材料样品中的至少第一和第二分析物的浓度。 第二分析物的测量可以对第一次测量的定量或定性结果进行调节。 在一个实施方案中，第一分析物是葡萄糖，第二分析物是酮。 根据这样的实施方案，如果葡萄糖测量结果超过预先规定的值或者超出预先规定的范围，则测量酮。

    CARTRIDGE LANCE
    7.
    发明申请
    CARTRIDGE LANCE 审中-公开

    公开(公告)号：WO2004062500A1

    公开(公告)日：2004-07-29

    申请号：PCT/US2003/041610

    申请日：2003-12-30

    Applicant: OPTISCAN BIOMEDICAL CORPORATION ,  RULE, Peter ,  BRAIG, James, R. ,  HARTSTEIN, Philip, C.

    Inventor： RULE, Peter ,  BRAIG, James, R. ,  HARTSTEIN, Philip, C.

    IPC: A61B5/15

    CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150442 ,  A61B5/150503 ,  A61B5/15087 ,  A61B5/15142 ,  A61B5/1519 ,  A61B5/157 ,  G01N21/71

    Abstract: An analyte detection system (1709) for analysis of a body fluid is provided, comprising an analysis portion and a sample collection portion which is configured to be removably coupled to the analysis portion. The analysis portion comprises a detector (250) configured to detect electromagnetic radiation and a source of electromagnetic radiation (220). The source is positioned with respect to the detector such that electromagnetic radiation emitted by the source is received by the detector. The sample collection portion comprises a housing, a lance (1741) and a sample chamber (1734). The lance is mounted within and moveable with respect to the housing. The sample chamber is configured to be positionable, upon coupling of the sample collection portion to the analysis portion, with respect to the source and detector such that at least a portion of any electromagnetic radiation emitted by the source passes through the sample chamber prior to being received by the detector.

    Abstract translation: 提供了一种用于分析体液的分析物检测系统（1709），包括分析部分和样品收集部分，其被配置为可移除地耦合到分析部分。 分析部分包括被配置为检测电磁辐射和电磁辐射源（220）的检测器（250）。 源相对于检测器定位，使得由源发射的电磁辐射由检测器接收。 样品收集部分包括壳体，喷枪（1741）和样品室（1734）。 喷枪相对于壳体安装并可移动。 样品室被配置为在样品收集部分与分析部分相对于源和检测器耦合时可定位，使得由源发射的任何电磁辐射的至少一部分在被存在之前通过样品室 由检测器接收。

    METHOD FOR TRANSFORMING PHASE SPECTRA OBTAINED BY THERMAL GRADIENT SPECTROMETRY TO ABSORPTION SPECTRA
    8.
    发明申请
    METHOD FOR TRANSFORMING PHASE SPECTRA OBTAINED BY THERMAL GRADIENT SPECTROMETRY TO ABSORPTION SPECTRA 审中-公开
    通过热梯度光谱法测定吸收光谱的相位谱的方法

    公开(公告)号：WO03040696A3

    公开(公告)日：2003-07-10

    申请号：PCT/US0236363

    申请日：2002-11-12

    Applicant: OPTISCAN BIOMEDICAL CORP ,  BRAIG JAMES R ,  HALL W DALE ,  BARNES CASPER W ,  GABLE JENNIFER H

    Inventor： BRAIG JAMES R ,  HALL W DALE ,  BARNES CASPER W ,  GABLE JENNIFER H

    IPC: A61B5/00 ,  G01N21/17 ,  G01N21/35 ,  G01N21/71

    CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1491 ,  G01N21/1717 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/71

    Abstract: A device and method for determining analyte concentrations within a material sample are provided. A modulating temperature gradient is induced in the sample and resultant, emitted infrared radiation is measured at selected analyte absorbance peaks (K) and reference wavelengths(J, L). The modulating temperature gradient is controlled by a surface temperature modulation. One embodiment provides a transfer function relating the surface temperature modulation to a modulation of the measured infrared radiation. Phase and magnitude differences in the transfer function are detected in the presence of the sought-after analyte. These phase and magnitude differences, having a relationship to analyte concentration, are measured, correlated and processed to determine analyte concentration in the material sample. Another embodiment provides a method for transforming thermal phase spectra to absorption spectra for consistent determination of analyte concentration within the sample.

    Abstract translation: 提供了用于确定材料样品中的分析物浓度的装置和方法。 在样品中诱导调制温度梯度，并在所选的分析物吸收峰（K）和参考波长（J，L）上测量发射的红外辐射。 调制温度梯度由表面温度调制控制。 一个实施例提供了将表面温度调制与测量的红外辐射的调制相关联的传递函数。 在所寻求的分析物的存在下检测传递函数的相位和幅度差异。 测量，相关和处理与分析物浓度有关的这些相位和幅度差异，以确定材料样品中的分析物浓度。 另一个实施方案提供了一种用于将热相谱转化为吸收光谱的方法，用于一致地测定样品中的分析物浓度。

    ANALYTE DETECTION SYSTEM WITH USER INTERFACE
    10.
    发明申请
    ANALYTE DETECTION SYSTEM WITH USER INTERFACE 审中-公开
    具有用户界面的分析检测系统

    公开(公告)号：WO2008022001A3

    公开(公告)日：2008-06-05

    申请号：PCT/US2007075647

    申请日：2007-08-09

    Applicant: OPTISCAN BIOMEDICAL CORP ,  KEENAN RICHARD ,  KING RICHARD A ,  WISOR HEATHER T ,  BRAIG JAMES R ,  WITTE KENNETH G

    Inventor： KEENAN RICHARD ,  KING RICHARD A ,  WISOR HEATHER T ,  BRAIG JAMES R ,  WITTE KENNETH G

    IPC: G06F19/00 ,  A61B5/155 ,  A61M5/142 ,  G01N21/27

    CPC classification number: G01N21/274 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14557 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150854 ,  A61B5/153 ,  A61B5/157 ,  A61B5/7475 ,  A61M5/142 ,  A61M5/172 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/18 ,  A61M2205/505 ,  A61M2205/60 ,  G01N21/35 ,  G01N2021/3133 ,  G06F19/3468

    Abstract: An embodiment of an analyte detection system includes a fluid transport network having a patient end configured to provide fluid communication with a body fluid in a patient. The system includes a body fluid analyzer, accessible via the fluid transport network, configured to measure a level of an analyte of interest in the body fluid. A pump unit having a sample input mode and an infusion mode may be coupled to the fluid transport network. The system also includes a user interface for communication with the body fluid analyzer. The user interface may include an input element (4946) configured to accept user input corresponding to a patient health event. In some embodiments, the patient health event includes a patient health action or information relevant to clinical interpretation of data pertaining to measured analyte levels. The user interface may include a trend display portion (4922) that includes a trend indicator,, which depicts a trend in determined levels of the analyte of interest. The trend display portion may also include at least one of a high-level indicator (4936) corresponding to a relatively high level of the analyte and a low-level indicator (4938) corresponding to a relatively low level of the analyte.

    Abstract translation: 分析物检测系统的一个实施例包括流体输送网络，其具有被配置为提供与患者体液的流体连通的患者端。 该系统包括体液分析器，可通过流体输送网络接近，其被配置成测量体液中感兴趣的分析物的水平。 具有样品输入模式和输注模式的泵单元可以联接到流体输送网络。 该系统还包括用于与体液分析仪通信的用户界面。 用户界面可以包括被配置为接受对应于患者健康事件的用户输入的输入元件（4946）。 在一些实施方案中，患者健康事件包括与测量的分析物水平有关的数据的临床解释相关的患者健康作用或信息。 用户界面可以包括趋势显示部分（4922），其包括趋势指标，其描绘所确定的感兴趣分析物水平的趋势。 趋势显示部分还可以包括对应于相对较高水平的分析物的高级指示器（4936）和对应于相对较低水平的分析物的低级指示器（4938）中的至少一个。

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