Abstract:
An analyte detection system (1709) for analysis of a body fluid is provided, comprising an analysis portion and a sample collection portion which is configured to be removably coupled to the analysis portion. The analysis portion comprises a detector (250) configured to detect electromagnetic radiation and a source of electromagnetic radiation (220). The source is positioned with respect to the detector such that electromagnetic radiation emitted by the source is received by the detector. The sample collection portion comprises a housing, a lance (1704) and a sample chamber (1734). The lance is mounted within and moveable with respect to the housing. The sample chamber is configured to be positionable, upon coupling of the sample collection portion to the analysis portion, with respect to the source and detector such that at least a portion of any electromagnetic radiation emitted by the source passes through the sample chamber prior to being received by the detector.
Abstract:
An analyte detection system (10) is configured to measure concentrations of at least first and second analytes in a single material sample supported by a sample element (120, 302, 402, 602). The measurement of a second analyte can be conditioned on a quantitative or qualitative result of the first measurement. In one embodiment, the first analyte is glucose and the second analyte is a ketone. According to such an embodiment the ketone is measured if the result of the glucose measurement exceeds a previously-specified value or falls outside of a previously-specified range.
Abstract:
An analyte detection system (1709) for analysis of a body fluid is provided, comprising an analysis portion and a sample collection portion which is configured to be removably coupled to the analysis portion. The analysis portion comprises a detector (250) configured to detect electromagnetic radiation and a source of electromagnetic radiation (220). The source is positioned with respect to the detector such that electromagnetic radiation emitted by the source is received by the detector. The sample collection portion comprises a housing, a lance (1741) and a sample chamber (1734). The lance is mounted within and moveable with respect to the housing. The sample chamber is configured to be positionable, upon coupling of the sample collection portion to the analysis portion, with respect to the source and detector such that at least a portion of any electromagnetic radiation emitted by the source passes through the sample chamber prior to being received by the detector.
Abstract:
A device and method are provided for use with a noninvasive optical measurement system, such as a thermal gradient spectrometer, for improved determination of analyte concentrations within living tissue. In one embodiment, a wearable window (100) is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The wearable window (100) effectively replaces a window of the spectrometer, and thus forms an interface between the patient's skin and a thermal mass window of the spectrometer. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the wearable window (100) is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the wearable window (100) will again form an interface between the spectrometer and the same location of skin as before.
Abstract:
A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.
Abstract:
An analyte detection system includes a first wearable module, a detector, and a processor. The first wearable module has an optical input through which electromagnetic radiation may enter said first wearable module. The first wearable module is configured to be worn on and engage a living wearer’s body such that electromagnetic radiation omitted by the body of the wearer can enter the first wearable module via the optical input. The detector is in optical communication with the optical input. The processor is in communication with the detector. The processor is configured to estimate the concentration of an analyte in the wearer’s tissue based on the emitted electromagnetic radiation.
Abstract:
A method determines an analyte concentration in a sample including the analyte and a substance. The method (100) includes providing an absorption spectrum of the sample (200). The absorption spectrum has an absorption baseline. The method further includes shifting the absorption spectrum (300) so that the absorption baseline equals a selected absorption value in a selected wavelength range. The method further includes subtracting a substance contribution (400) from the absorption spectrum. Thus, the method provides a corrected absorption spectrum substantially free of a contribution from the substance.
Abstract:
Herein is described a system that includes a processing circuit for identifying possible zone D errors among estimated blood glucose concentration values. The system converts estimated blood glucose concentration values which are identified as possible zone D errors into adjusted blood glucose concentration values which are lower in blood glucose concentration magnitude than their corresponding estimated blood glucose concentration values, thereby decreasing the occurrence of zone D errors. Herein is also disclosed a method for improving the clinical accuracy of an analyte concentration measurement. One method includes a first act of computing an estimated analyte concentration having an associated first error that is clinically significant and a second act of processing the estimated analyte concentration to generate an adjusted analyte concentration having a second error that is clinically insignificant.
Abstract:
In accordance with one embodiment there is provided a method of providing a known spectrum to a noninvasive optical detection system of the type having a window for receiving infrared energy. The method comprises affixing a standard to the window. The standard comprises a body formed from a material having known and stable spectral properties. The method further comprises placing at least a portion of the body directly against the window, and operating the optical detection system to detect an emission spectrum of the body. In accordance with another embodiment an infrared spectrometer comprises a window for receiving infrared energy. The window has an exposed surface. The infrared spectrometer further comprises a standard comprising a body formed of a material having known and stable spectral properties. At least part of the body is removably disposed directly against the exposed surface of the window.
Abstract:
A system and method are provided for determining a concentration of an analyte in a material sample. The method includes providing a sample element with a sample chamber at least partially defined by at least one window formed from a material having greater than about 1% wavelength-domain variation in absorbtivity of electromagnetic radiation incident thereon. The methot further includes employing the sample element with an analyte detection system which determines the concentration of the analyte with clinically acceptable accuracy.