公开(公告)号：WO2003039362A1

公开(公告)日：2003-05-15

申请号：PCT/US2002/035707

申请日：2002-11-06

Applicant: OPTISCAN BIOMEDICAL CORPORATION ,  STERLING, Bernhard, B. ,  HARTSTEIN, Philip, C. ,  LI, Kenneth, I. ,  AGOSTINO, Mark, D. ,  KLONOFF, David, C. ,  GAFFNEY, Robert, D. ,  ZHENG, Peng ,  GABLE, Jennifer, H. ,  WITTE, Kenneth, G. ,  SMITH, Heidi, M. ,  SHEILL, Jane, J. ,  MUNROW, Mike, A. ,  HALL, W., Dale ,  GOLDBERGER, Daniel, S. ,  FENNELL, Martin, J. ,  CORTELLA, Julian, M. ,  BRAIG, James, R. ,  RULE, Peter

Inventor： STERLING, Bernhard, B. ,  HARTSTEIN, Philip, C. ,  LI, Kenneth, I. ,  AGOSTINO, Mark, D. ,  KLONOFF, David, C. ,  GAFFNEY, Robert, D. ,  ZHENG, Peng ,  GABLE, Jennifer, H. ,  WITTE, Kenneth, G. ,  SMITH, Heidi, M. ,  SHEILL, Jane, J. ,  MUNROW, Mike, A. ,  HALL, W., Dale ,  GOLDBERGER, Daniel, S. ,  FENNELL, Martin, J. ,  CORTELLA, Julian, M. ,  BRAIG, James, R. ,  RULE, Peter

IPC: A61B5/00

CPC classification number: A61B5/1455 ,  A61B5/01 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150061 ,  A61B5/150213 ,  A61B5/150274 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150755 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/157 ,  A61B5/6826 ,  A61B5/6838 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/35

Abstract: A reagentless whole-blood analyte detection system (200, 400, 450, 1000, 1100) that is capable of being deployed near a patient has a source (220) capable of emitting a beam of radiation that includes a spectral band. The whole-blood system (200, 400, 450, 1000, 1100) also has at least one detector (250, 1152, 1154) in an optical path of the beam. The whole-blood system (200, 400, 450, 1000, 1100) also has a housing (402, 452) that is configured to house the source (220) and the detector(s) (250, 1152, 1154). The whole-blood system (200, 400, 450, 1000, 1100) also has a sample element (240, 305, 605, 805, 885, 905, 1040, 1205, 1305, 1355, 1405) that is situated in the optical path of the beam. The sample element (240, 305, 605, 805, 885, 905, 1040, 1205, 1305, 1355, 1405) has a sample cell (242, 310, 610, 810) and a sample cell wall (244, 330, 335) that does not eliminate transmittance of the beam of radiation in the spectral band.

Abstract translation: 能够在患者附近部署的无试剂全血分析物检测系统（200,400,450,1000,1100）具有能够发射包括光谱带的辐射束的源（220）。 全血系统（200,400,450,1000,1100）还具有在光束的光路中的至少一个检测器（250,1152,1154）。 全血系统（200,400,450,1000,1100）还具有构造成容纳源（220）和检测器（250,1152,1154）的壳体（402,452）。 全血系统（200,400,450,1000,1100）还具有位于光学系统中的样品元件（240,305,605,805,885,905,1040,1205,1305,135,1405） 梁的路径。 样品元件（240,305,605,805,885,905,1040,1205,1305,135,1405）具有样品池（242,310,610,810）和样品池壁（244,330,335） ），其不消除光谱带中的辐射束的透射率。

公开(公告)号：WO03013345A2

公开(公告)日：2003-02-20

申请号：PCT/US0225366

申请日：2002-08-08

Applicant: OPTISCAN BIOMEDICAL CORP ,  RULE PETER ,  BRAIG JAMES R ,  GOLDBERGER DANIEL S ,  CORTELLA JULIAN M ,  SMITH HEIDI M ,  HERRERA ROGER O ,  WITTE KENNETH G ,  HARTSTEIN PHILIP C ,  AGOSTINO MARK D

Inventor： RULE PETER ,  BRAIG JAMES R ,  GOLDBERGER DANIEL S ,  CORTELLA JULIAN M ,  SMITH HEIDI M ,  HERRERA ROGER O ,  WITTE KENNETH G ,  HARTSTEIN PHILIP C ,  AGOSTINO MARK D

IPC: A61B5/00 ,  G01N21/01 ,  G01N21/03 ,  G01N21/35 ,  A61B

CPC classification number: A61B5/01 ,  A61B5/061 ,  A61B5/14532 ,  A61B5/6824 ,  G01J3/0286 ,  G01J3/0291 ,  G01N21/01 ,  G01N21/35 ,  G01N2021/0389 ,  G01N2201/021 ,  G01N2201/0245

Abstract: A device and method are provided for use with a noninvasive optical measurement system, such as a thermal gradient spectrometer, for improved determination of analyte concentrations within living tissue. In one embodiment, a wearable window is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The wearable window effectively replaces a window of the spectrometer, and thus forms an interface between the patient's skin and a thermal mass window of the spectrometer. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the wearable window is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the wearable window will again form an interface between the spectrometer and the same location of skin as before.

Abstract translation: 提供了一种用于非侵入性光学测量系统（例如热梯度光谱仪）的装置和方法，用于改善活体组织内分析物浓度的测定。 在一个实施例中，可佩戴的窗户被固定到患者的前臂，从而隔离患者皮肤上的测量部位以确定血糖水平。 穿戴式窗户有效地代替了光谱仪的窗口，从而形成了患者皮肤与光谱仪的热质量窗口之间的界面。 当光谱仪必须临时从患者皮肤上移除时，例如允许患者移动，则将可佩戴的窗口固定在前臂上，以便在皮肤上保持一致的测量部位。 当光谱仪后来重新连接到患者身上时，穿戴式窗户将再次形成光谱仪与以前相同的皮肤位置之间的界面。

公开(公告)号：WO2003003915A2

公开(公告)日：2003-01-16

申请号：PCT/US2002/021416

申请日：2002-07-03

Applicant: OPTISCAN BIOMEDICAL ,  RULE, Peter ,  BRAIG, James, R. ,  GOLDBERGER, Daniel, S. ,  CORTELLA, Julian, M. ,  SMITH, Heidi, M. ,  HERRERA, Roger, O. ,  WITTE, Kenneth, G. ,  HARTSTEIN, Philip, C. ,  AGOSTINO, Mark, D.

Inventor： RULE, Peter ,  BRAIG, James, R. ,  GOLDBERGER, Daniel, S. ,  CORTELLA, Julian, M. ,  SMITH, Heidi, M. ,  HERRERA, Roger, O. ,  WITTE, Kenneth, G. ,  HARTSTEIN, Philip, C. ,  AGOSTINO, Mark, D.

IPC: A61B5/00

CPC classification number: A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/1491 ,  A61B5/6824 ,  A61B5/6826 ,  A61B5/6838

Abstract: A device and method for selecting and stabilizing proper sites for the measurement of the concentration of an analyte, for example glucose, within the tissue of a subject or patient are disclosed. One embodiment of the device immobilizes the subject's forearm and finger, thereby stabilizing measurement sites thereon for exposure to a noninvasive monitor which captures analyte concentration data within the subject's skin. The method involves the choice of a location on the subject's body at which to take the analyte measurement, preferably based on the amount of time that has elapsed since the last time the subject ate.

Abstract translation: 公开了用于选择和稳定用于测量受试者或患者的组织内的分析物（例如葡萄糖）的浓度的适当位点的装置和方法。 该装置的一个实施例使受试者的前臂和手指固定，由此稳定其上的测量位置以暴露于非侵入性监测器，其捕获受试者皮肤内的分析物浓度数据。 该方法包括在受试者的身体上选择要进行分析物测量的位置，优选地基于自上次被摄体以来经过的时间量。

公开(公告)号：WO2011072238A2

公开(公告)日：2011-06-16

申请号：PCT/US2010/059916

申请日：2010-12-10

Applicant: SOUND SURGICAL TECHNOLOGIES, LLC ,  SIEBRECHT, Wayne, A. ,  WESLEY, David, J. ,  MOGILL, David, B. ,  GOLDBERGER, Daniel, S.

Inventor： SIEBRECHT, Wayne, A. ,  WESLEY, David, J. ,  MOGILL, David, B. ,  GOLDBERGER, Daniel, S.

IPC: A61N7/00 ,  A61B18/00

CPC classification number: A61B17/320068 ,  A61B2018/0091

Abstract: Described are embodiments including methods and devices for venting a handpiece of a medical device. These embodiments provide a vent for the handpiece. A porous membrane is positioned over an opening of the vent to allow gas, including steam, to enter and escape from the handpiece and prevent liquids from entering the handpiece. Other embodiments include methods and devices for holding an ultrasonic driver assembly within a handpiece and preventing the ultrasonic driver assembly from rotating within the handpiece. These embodiments include positioning the ultrasonic driver assembly such that the ultrasonic driver assembly is held in place at a node of the ultrasonic driver assembly and an anti-rotation mechanism is also located at the node.

Abstract translation: 描述了包括用于排出医疗装置的手持件的方法和装置的实施例。 这些实施例为手持件提供通风口。 多孔膜定位在通气口的开口上方，以允许气体（包括蒸汽）进入手持件并从手持件中脱离并防止液体进入手持件。 其他实施例包括用于将超声波驱动器组件保持在手持件内并防止超声波驱动器组件在手持件内旋转的方法和装置。 这些实施例包括定位超声驱动器组件，使得超声驱动器组件在超声驱动器组件的节点处保持就位，并且防旋转机构也位于节点处。

公开(公告)号：WO2003069308A3

公开(公告)日：2003-08-21

申请号：PCT/US2003/004548

申请日：2003-02-12

Applicant: OPTISCAN BIOMEDICAL CORPORATION ,  STERLING, Bernhard, B. ,  BRAIG, James, R. ,  GOLDBERGER, Daniel, S. ,  HARTSTEIN, Philip, C. ,  GAFFNEY, Robert, D.

Inventor： STERLING, Bernhard, B. ,  BRAIG, James, R. ,  GOLDBERGER, Daniel, S. ,  HARTSTEIN, Philip, C. ,  GAFFNEY, Robert, D.

IPC: G01N33/49

Abstract: A method determines an analyte concentration in a sample including the analyte and a substance. The method (100) includes providing an absorption spectrum of the sample (200). The absorption spectrum has an absorption baseline. The method further includes shifting the absorption spectrum (300) so that the absorption baseline equals a selected absorption value in a selected wavelength range. The method further includes subtracting a substance contribution (400) from the absorption spectrum. Thus, the method provides a corrected absorption spectrum substantially free of a contribution from the substance.

公开(公告)号：WO1994016614A1

公开(公告)日：1994-08-04

申请号：PCT/US1994000489

申请日：1994-01-21

Applicant: BRAIG, James, R. ,  GOLDBERGER, Daniel, S.

IPC: A61B05/00

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  G01N21/35 ,  G01N21/3581

Abstract: A method and apparatus for monitoring glucose, ethyl alcohol and other blood constituents in a noninvasive manner. The measurements are made by monitoring infrared absorption of the desired blood constituent in the long infrared wavelength range. The long wavelength infrared energy generated by source (400) is passed through a finger (406). To prevent the high energy source from burning or causing patient discomfort, shutter (404) and bandpass filters (410) cause only short bursts of energy to be sent through the finger with a very low duty cycle and low optical bandwidth. The bursts are further synchronized by shutter (404) with systole and diastole of the cardiac cycle so that only two pulses are sent per heart beat, one during diastole and one during systole. The detection signals measured at detectors (412) during application of these bursts of energy are used to calculate the concentration of blood constituents in accordance with a polynomial equation.

Abstract translation: 一种以非侵入性方式监测葡萄糖，乙醇和其他血液成分的方法和装置。 通过在长红外波长范围内监测所需血液成分的红外吸收来进行测量。 由源（400）产生的长波长红外能量通过手指（406）。 为了防止高能源燃烧或引起患者不适，快门（404）和带通滤波器（410）只能以非常低的占空比和低的光学带宽通过手指发送短的能量脉冲。 通过快门（404）与心动周期的心律和舒张进一步同步脉冲串，使得每个心跳只发送两个脉冲，一个在舒张期期间发送，一个在心脏收缩期间发送。 在应用这些脉冲能量的情况下在检测器（412）处测量的检测信号用于根据多项式方程计算血液成分的浓度。

公开(公告)号：WO1994008506A1

公开(公告)日：1994-04-28

申请号：PCT/US1992008644

申请日：1992-10-12

Applicant: YELDERMAN, Mark, L. ,  GOLDBERGER, Daniel, S. ,  BRAIG, James, R.

IPC: A61B05/00

CPC classification number: G01J5/04 ,  A61B1/227 ,  G01J5/02 ,  G01J5/028 ,  G01J5/045 ,  G01J5/049 ,  G01J5/08 ,  G01J5/0812 ,  G01J5/0862 ,  G01J5/14 ,  G01J2005/066 ,  G01J2005/068

Abstract: A noncontact infrared tympanic thermometer which does not require environmental stabilization or waveguide temperature control because it utilizes an optically stabilized infrared detector for detecting the infrared energy emitted by the tympanic membrane. This stability is accomplished by locating a neutral density filter (164) over half of the optical aperture (162) of the detector package (16) such that the neutral density filter (164) ''shadows'' only one of two thermopile channels (163) for detecting the infrared energy emitted by the tympanic membrane. The two thermopile channels (163) are connected in series opposition such that any optical signal equally present in both channels will yield a zero net output. Since the infrared energy emitted by the walls (161) of the detector package (16) reach each detector (163) equally, the effects of these emissions on the temperature measurement are eliminated.

Abstract translation: 一种非接触红外鼓膜温度计，其不需要环境稳定或波导温度控制，因为它使用光学稳定的红外检测器来检测由鼓膜发射的红外能量。 这种稳定性是通过将中性密度滤光器（164）定位在检测器封装（16）的光学孔（162）的一半上而实现的，使得中性密度滤光片（164）仅“阴影”两个热电堆通道中的一个 163），用于检测由鼓膜发射的红外能量。 两个热电堆通道（163）串联连接，使得两个通道中同样存在的任何光信号将产生零净输出。 由于检测器封装（16）的壁（161）发射的红外能量同样到达每个检测器（163），消除了这些排放对温度测量的影响。

公开(公告)号：WO2003013345A3

公开(公告)日：2003-02-20

申请号：PCT/US2002/025366

申请日：2002-08-08

Applicant: OPTISCAN BIOMEDICAL CORPORATION ,  RULE, Peter ,  BRAIG, James, R. ,  GOLDBERGER, Daniel, S. ,  CORTELLA, Julian, M. ,  SMITH, Heidi, M. ,  HERRERA, Roger, O. ,  WITTE, Kenneth, G. ,  HARTSTEIN, Philip, C. ,  AGOSTINO, Mark, D.

Inventor： RULE, Peter ,  BRAIG, James, R. ,  GOLDBERGER, Daniel, S. ,  CORTELLA, Julian, M. ,  SMITH, Heidi, M. ,  HERRERA, Roger, O. ,  WITTE, Kenneth, G. ,  HARTSTEIN, Philip, C. ,  AGOSTINO, Mark, D.

IPC: A61B6/00

Abstract: A device and method are provided for use with a noninvasive optical measurement system, such as a thermal gradient spectrometer, for improved determination of analyte concentrations within living tissue. In one embodiment, a wearable window (100) is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The wearable window (100) effectively replaces a window of the spectrometer, and thus forms an interface between the patient's skin and a thermal mass window of the spectrometer. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the wearable window (100) is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the wearable window (100) will again form an interface between the spectrometer and the same location of skin as before.

公开(公告)号：WO2011072238A3

公开(公告)日：2011-10-20

申请号：PCT/US2010059916

申请日：2010-12-10

Applicant: SOUND SURGICAL TECHNOLOGIES LLC ,  SIEBRECHT WAYNE A ,  WESLEY DAVID J ,  MOGILL DAVID B ,  GOLDBERGER DANIEL S

Inventor： SIEBRECHT WAYNE A ,  WESLEY DAVID J ,  MOGILL DAVID B ,  GOLDBERGER DANIEL S

IPC: A61N7/00 ,  A61B18/00

CPC classification number: A61B17/320068 ,  A61B2018/0091

Abstract: Described are embodiments including methods and devices for venting a handpiece of a medical device. These embodiments provide a vent for the handpiece. A porous membrane is positioned over an opening of the vent to allow gas, including steam, to enter and escape from the handpiece and prevent liquids from entering the handpiece. Other embodiments include methods and devices for holding an ultrasonic driver assembly within a handpiece and preventing the ultrasonic driver assembly from rotating within the handpiece. These embodiments include positioning the ultrasonic driver assembly such that the ultrasonic driver assembly is held in place at a node of the ultrasonic driver assembly and an anti-rotation mechanism is also located at the node.

Abstract translation: 描述了包括用于排放医疗装置的手持件的方法和装置的实施例。 这些实施例提供了用于手持件的通气口。 多孔膜定位在通气口的开口上方，以允许包括蒸汽在内的气体进入并从机头逸出并防止液体进入机头。 其他实施例包括用于将超声波驱动器组件保持在手持件内并防止超声波驱动器组件在机头内旋转的方法和装置。 这些实施例包括定位超声波驱动器组件，使得超声波驱动器组件保持在超声波驱动器组件的节点处的适当位置，并且抗旋转机构也位于节点处。

公开(公告)号：WO2004043250A9

公开(公告)日：2004-07-08

申请号：PCT/US0335200

申请日：2003-11-04

Applicant: OPTISCAN BIOMEDICAL CORP ,  BRAIG JAMES R ,  HEWETT GARY E ,  MUNROW MICHAEL E ,  CORTELLA JULIAN M ,  AZIZI KAMRAZA ,  GOLDBERGER DANIEL S

Inventor： BRAIG JAMES R ,  HEWETT GARY E ,  MUNROW MICHAEL E ,  CORTELLA JULIAN M ,  AZIZI KAMRAZA ,  GOLDBERGER DANIEL S

IPC: A61B5/00 ,  G06F19/00

CPC classification number: A61B5/1495 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/1455 ,  A61B2560/0271 ,  A61B2562/0295 ,  G06F19/3418 ,  G16H40/40 ,  G16H40/63 ,  Y10S707/99945

Abstract: An analyte concentration monitoring system having network-based communication features (600) which provide a link between an analyte detection system (602) and a centralized computer (604). The analyte detection system has a processor (610) that calculates analyte concentration in accordance with software (612) executable by the processor. Under certain conditions, the software (612) needs to be updated. Accordingly, when the analyte detection system is connected to the centralized computer, the centralized computer determines whether a software update (614) is needed. If a software update is needed, then the centralized computer conveniently provides the software update to the analyte detection system without intervention from a user.

Abstract translation: 具有基于网络的通信特征（600）的分析物浓度监测系统（600）提供分析物检测系统（602）和集中式计算机（604）之间的链接。 分析物检测系统具有根据处理器可执行的软件（612）计算分析物浓度的处理器（610）。 在某些情况下，软件（612）需要更新。 因此，当分析物检测系统连接到集中式计算机时，集中式计算机确定是否需要软件更新（614）。 如果需要软件更新，那么集中式计算机可方便地将软件更新提供给分析物检测系统，而无需用户介入。