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    OXIDATIVE PROTECTION OF LIPID LAYER BIOSENSORS
    3.
    发明申请
    OXIDATIVE PROTECTION OF LIPID LAYER BIOSENSORS 审中-公开
    润滑层生物传感器的氧化保护

    公开(公告)号：WO2007112273A2

    公开(公告)日：2007-10-04

    申请号：PCT/US2007/064680

    申请日：2007-03-22

    Applicant: MCAULIFFE, Joseph C. ,  GEBERT, Mark S. ,  CASCAO-PEREIRA, Luis G.

    Inventor： MCAULIFFE, Joseph C. ,  GEBERT, Mark S. ,  CASCAO-PEREIRA, Luis G.

    IPC: G01N33/53 ,  C12M1/34

    CPC classification number: G01N33/54393 ,  G01N2405/00

    Abstract: The present invention provides methods and composition related to lipid layers with increased stability to oxidative degradation. In one embodiment, the invention provides lipid layers comprising antioxidant inclusion molecules that permit biosensors with increased performance and functional lifetime due to increased oxidative protection. In addition to these lipid-layer compositions, the present invention provides methods for further protection of lipid layers from oxidation. These methods include application of solutions and coatings comprising barrier compounds (e.g., trehalose), storage under anaerobic conditions (e.g., with inert gases), storage with oxidant scavengers (e.g., dessicants and catalysts), and packaging with barrier materials (e.g., mylar, polyethylene) that prevent oxidant exposure.

    Abstract translation: 本发明提供了与氧化降解的稳定性增加的与脂质层相关的方法和组合。 在一个实施方案中，本发明提供包含抗氧化剂包含分子的脂质层，其允许生物传感器由于增加的氧化保护而具有增加的性能和功能寿命。 除了这些脂质层组合物之外，本发明还提供进一步保护脂质层免于氧化的方法。 这些方法包括应用包含阻挡化合物（例如海藻糖）的溶液和涂层，在厌氧条件下（例如，用惰性气体）储存，与氧化剂清除剂（例如，干燥剂和催化剂）的储存以及与阻隔材料（例如聚酯薄片）的包装 ，聚乙烯），防止氧化剂暴露。

    SILICA DERIVED SOL-GELS SENSITIVE TO WATER CONTENT CHANGE
    4.
    发明申请
    SILICA DERIVED SOL-GELS SENSITIVE TO WATER CONTENT CHANGE 审中-公开
    二氧化硅衍生的溶胶对水含量变化敏感

    公开(公告)号：WO2005028604A1

    公开(公告)日：2005-03-31

    申请号：PCT/US2004/030990

    申请日：2004-09-17

    Applicant: GENENCOR INTERNATIONAL, INC. ,  SOUTHERN ILLINOIS UNIVERSITY ,  BECKER, Nathaniel, Todd ,  BAKUL, Dave, C. ,  DESHPANDE, Kiranmayi ,  GEBERT, Mark, S. ,  MCAULIFFE, Joseph, C. ,  SMITH, Wyatt, Charles

    Inventor： BECKER, Nathaniel, Todd ,  BAKUL, Dave, C. ,  DESHPANDE, Kiranmayi ,  GEBERT, Mark, S. ,  MCAULIFFE, Joseph, C. ,  SMITH, Wyatt, Charles

    IPC: C11D3/20

    CPC classification number: B01J13/0056 ,  C11D3/162 ,  C11D3/386 ,  C11D17/003

    Abstract: The present invention provides an enzyme-containing sol-gel composition wherein one or more enzymes are stably entrapped within the gels and are released from the gels in responsive to an increase in environmental water percentage (by weight). The enzyme-containing sol-gels are prepared from starting materials comprising one or more aminoalkylsilane precursors such as bis(trialkoxyalkylsilane)amine, bis(trialkoxyalkylsilane)alkylenediamine, bis(dialkyldialkoxysilane)amine, and aminoalkyltrialkoxysilane, and one or more alkoxysilane precursors such as dialkyldialkoxysilane and alkyltrialkoxysilane. The present invention further provides a liquid detergent, a liquid soap or a shampoo formulation comprising an enzyme-entrapped sol-gel system, wherein the enzymes are released upon dilution of the formulation in water. The silica gel matrices not only improve the thermal stability of enzymes but also prevent the enzyme denaturation due to proteolysis/autolysis or interference from other components of the formulation.

    Abstract translation: 本发明提供了一种含酶溶胶凝胶组合物，其中一种或多种酶稳定地包埋在凝胶内并且响应于环境水百分数（重量）的增加而从凝胶中释放出来。 由含有一种或多种氨基烷基硅烷前体的起始材料制备含酶溶胶凝胶，例如双（三烷氧基烷基硅烷）胺，双（三烷氧基烷基硅烷）亚烷基二胺，双（二烷基二烷氧基硅烷）胺和氨基烷基三烷氧基硅烷，以及一种或多种烷氧基硅烷前体如二烷基二烷氧基硅烷 和烷基三烷氧基硅烷。 本发明还提供了一种液体洗涤剂，液体皂或包含酶包被溶胶 - 凝胶系统的洗发剂制剂，其中在将制剂稀释在水中时释放酶。 硅胶基质不仅提高了酶的热稳定性，而且防止了由于蛋白水解/自溶或制剂中其他组分的干扰引起的酶变性。

    OXIDATIVE PROTECTION OF LIPID LAYER BIOSENSORS
    7.
    发明申请
    OXIDATIVE PROTECTION OF LIPID LAYER BIOSENSORS 审中-公开
    润滑层生物传感器的氧化保护

    公开(公告)号：WO2007112273A3

    公开(公告)日：2008-07-03

    申请号：PCT/US2007064680

    申请日：2007-03-22

    Applicant: MCAULIFFE JOSEPH C ,  GEBERT MARK S ,  CASCAO-PEREIRA LUIS G

    Inventor： MCAULIFFE JOSEPH C ,  GEBERT MARK S ,  CASCAO-PEREIRA LUIS G

    IPC: G01N33/53 ,  C12M1/34 ,  G01N1/28

    CPC classification number: G01N33/54393 ,  G01N2405/00

    Abstract: The present invention provides methods and composition related to lipid layers with increased stability to oxidative degradation. In one embodiment, the invention provides lipid layers comprising antioxidant inclusion molecules that permit biosensors with increased performance and functional lifetime due to increased oxidative protection. In addition to these lipid-layer compositions, the present invention provides methods for further protection of lipid layers from oxidation. These methods include application of solutions and coatings comprising barrier compounds (e.g., trehalose), storage under anaerobic conditions (e.g., with inert gases), storage with oxidant scavengers (e.g., dessicants and catalysts), and packaging with barrier materials (e.g., mylar, polyethylene) that prevent oxidant exposure.

    Abstract translation: 本发明提供了与氧化降解的稳定性增加的与脂质层相关的方法和组合。 在一个实施方案中，本发明提供包含抗氧化剂包含分子的脂质层，其允许生物传感器由于增加的氧化保护而具有增加的性能和功能寿命。 除了这些脂质层组合物之外，本发明还提供进一步保护脂质层免于氧化的方法。 这些方法包括应用包含阻挡化合物（例如海藻糖）的溶液和涂层，在厌氧条件下（例如，用惰性气体）储存，与氧化剂清除剂（例如，干燥剂和催化剂）的储存以及与阻隔材料（例如聚酯薄片）的包装 ，聚乙烯），防止氧化剂暴露。

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