公开(公告)号：WO2012153325A3

公开(公告)日：2014-03-06

申请号：PCT/IL2012000186

申请日：2012-05-09

Applicant: NANO RETINA INC ,  GEFEN RA ANAN ,  GROSS YOSSI ,  LIRAN TUVIA ,  VAINGAST SHAI

Inventor： GEFEN RA ANAN ,  GROSS YOSSI ,  LIRAN TUVIA ,  VAINGAST SHAI

IPC: A61N1/36

CPC classification number: A61N1/36046 ,  A61F2/16 ,  A61F2250/0001 ,  A61N1/0543 ,  A61N1/3787

Abstract: Apparatus for use with an external non-visible light source (24) is provided. The apparatus includes an intraocular device (60) configured for implantation in a human eye, and including an energy receiver (32). The energy receiver (32) is configured to receive light emitted from the external non-visible light source (24), and extract energy from the emitted light for powering the intraocular device (60). The intraocular device (60) is configured to regulate a parameter of operation of the intraocular device (60) based on a modulation of the light emitted by the external non-visible light source (24) and received by the energy receiver (32). Other embodiments are also described.

Abstract translation: 提供了用于与外部不可见光源（24）一起使用的装置。 该装置包括配置用于植入人眼中并包括能量接收器（32）的眼内装置（60）。 能量接收器（32）被配置为接收从外部不可见光源（24）发射的光，并且从所发射的光中提取能量来为眼内装置（60）供电。 眼内装置（60）被配置为基于由外部不可见光源（24）发射并由能量接收器（32）接收的光的调制来调节眼内装置（60）的操作参数。 还描述了其它实施例。

公开(公告)号：WO2012114327A3

公开(公告)日：2015-06-18

申请号：PCT/IL2012000057

申请日：2012-02-02

Applicant: NANO RETINA INC ,  LIRAN TUVIA ,  GEFEN RA ANAN

Inventor： LIRAN TUVIA ,  GEFEN RA ANAN

IPC: A61N1/04 ,  A61F9/08

CPC classification number: A61F2/14 ,  A61N1/36046

Abstract: A medical device includes an array of electrodes (26), configured for implantation in contact with tissue in an eye (22) of a living subject. Driver circuitry (46) is configured to drive the electrodes (26) in an alternating pattern, such that different groups of the electrodes are driven to stimulate the tissue during different, predetermined respective time periods. A power sensor (132), may be coupled to deactivate a first group of the electrodes when the available electrical power drops below a predetermined threshold, while a second group of the electrodes remains active. Other embodiments are also described.

Abstract translation: 医疗装置包括电极阵列（26），其构造成用于植入与活体的眼睛（22）中的组织接触。 驱动器电路（46）被配置为以交替模式驱动电极（26），使得不同组的电极被驱动以在不同的预定相应时间段期间刺激组织。 功率传感器（132）可以被耦合以当可用电功率降低到预定阈值以下时停用第一组电极，而第二组电极保持活动。 还描述了其它实施例。

公开(公告)号：WO2011086545A2

公开(公告)日：2011-07-21

申请号：PCT/IL2011000022

申请日：2011-01-10

Applicant: NANO RETINA INC ,  GEFEN RA ANAN ,  SAINI RAHUL

Inventor： GEFEN RA ANAN ,  SAINI RAHUL

IPC: A61N1/05

CPC classification number: A61N1/0543

Abstract: Apparatus configured for implantation in a body of a subject is provided. The apparatus includes a support substrate (62), and at least 500 electrodes (64) protruding at least 50 um from the support substrate (62), each electrode (64) having (a) a distal tip (72), (b) an electrically-exposed tip portion (70), and (c) a cross-section of 50-1500 um2, 20 um from the distal tip (72). Other embodiments are also described.

Abstract translation: 提供了构造成用于植入物体的体内的装置。 该设备包括支撑基板（62）和至少500个从支撑基板（62）突出至少50μm的电极（64），每个电极（64）具有（a）远端尖端（72），（b） 电暴露的尖端部分（70），和（c）距离远端尖端（72）的50-1500μm，20μm的横截面。 还描述了其它实施例。

公开(公告)号：WO2010089739A3

公开(公告)日：2010-10-07

申请号：PCT/IL2010000097

申请日：2010-02-03

Applicant: NANO RETINA INC ,  GROSS YOSSI ,  VAINGAST SHAI ,  GEFEN RA ANAN

Inventor： GROSS YOSSI ,  VAINGAST SHAI ,  GEFEN RA ANAN

IPC: A61N1/00

CPC classification number: A61N1/36046 ,  A61N1/0543 ,  A61N1/37217 ,  A61N1/3787 ,  H01L27/14621 ,  H01L27/14627 ,  H01L31/145

Abstract: An external device (20) includes a mount (22), which is placed in front of a subject's eye. A laser (24) is coupled to the mount (22) and emits radiation (26) that is outside of 380-750 nm. A partially-transparent mirror (23) is coupled to the mount (22). An intraocular device (30) is implanted entirely in the subject's eye, and includes a plurality of stimulating electrodes (38), and an energy receiver (32), which receives the radiation (26) from the laser (24) and generates a voltage drop. A plurality of photosensors (34) detect photons (33) and generate a signal. Driving circuitry (36) is coupled to the energy receiver (32) and to the photosensors (34), and receives the signals from the photosensors (34) and utilizes the voltage drop to drive the electrodes (38) to apply currents to the retina in response to the signals from the photosensors (34). Other embodiments are also described.

Abstract translation: 外部装置（20）包括安装件（22），其安置在被检眼的前方。 激光器（24）耦合到安装件（22）并且发射在380-750nm之外的辐射（26）。 部分透明的反射镜（23）联接到安装件（22）。 将眼内装置（30）完全注入被检者的眼睛，并且包括多个刺激电极（38）和能量接收器（32），其从激光器（24）接收辐射（26）并产生电压 下降。 多个光电传感器（34）检测光子（33）并产生信号。 驱动电路（36）耦合到能量接收器（32）和光电传感器（34），并且接收来自光电传感器（34）的信号并利用电压降来驱动电极（38）以向视网膜施加电流 响应于来自光电传感器（34）的信号。 还描述了其它实施例。

公开(公告)号：WO2014141089A3

公开(公告)日：2015-02-19

申请号：PCT/IB2014059672

申请日：2014-03-12

Applicant: NANO RETINA INC ,  GEFEN RA ANAN

Inventor： GEFEN RA ANAN

IPC: A61N1/36 ,  A61N1/05

CPC classification number: A61F2/1624 ,  A61N1/0543 ,  A61N1/36046

Abstract: An apparatus is provided having an intraocular device (20) for implantation entirely in a subject's eye, the intraocular device (20) including: a photosensor array (22) having a plurality of photosensors (24), each photosensor (24) detecting ambient photons and generating a signal in response thereto. A spatial density of the photosensors (24) in a central portion (26) of the array (22) is greater than a spatial density of the photosensors (24) in an outer portion (28) of the array (22). The intraocular device (20) additionally includes a plurality of stimulating electrodes (30) and driving circuitry (32) coupled to the photosensors (24), and configured to drive the electrodes (30) to apply electrical pulses to a retina of the eye in response to the signals from the photosensors (24). Other applications are also described.

Abstract translation: 提供一种装置，其具有用于完全植入受试者眼睛的眼内装置（20），所述眼内装置（20）包括：具有多个光电传感器（24）的光电传感器阵列（22），每个光电传感器（24）检测环境光子 并响应于此产生信号。 阵列（22）的中心部分（26）中的光电传感器（24）的空间密度大于阵列（22）的外部部分（28）中的光电传感器（24）的空间密度。 眼内装置（20）还包括耦合到光电传感器（24）的多个刺激电极（30）和驱动电路（32），并被配置为驱动电极（30）将电脉冲施加到眼睛的视网膜 响应于来自光电传感器的信号（24）。 还描述了其它应用。

公开(公告)号：WO2004073484A3

公开(公告)日：2004-12-09

申请号：PCT/IL2004000183

申请日：2004-02-24

Applicant: GROSS YOSSI ,  GEFEN RA ANAN

Inventor： GROSS YOSSI ,  GEFEN RA ANAN

IPC: A61B20060101 ,  A61M1/10 ,  A61M1/12 ,  A61N1/362

CPC classification number: A61M1/1055 ,  A61M1/1008 ,  A61M1/1037 ,  A61M1/1051 ,  A61M1/107 ,  A61M1/1086 ,  A61M1/122 ,  A61M1/127 ,  A61M2205/33 ,  A61M2205/3303 ,  A61M2205/8243

Abstract: Apparatus (20) is provided including an inflatable bladder (40), adapted to be coupled to a blood vessel (22) of a subject (18) carrying oxygenated blood, such that an interior of the bladder (40) is in fluid communication with the blood. The apparatus also includes a piston (48) in mechanical communication with the bladder (40); a motor (60), adapted to synchronize contraction and expansion of the bladder (40) with a cardiac cycle of the subject (18) by applying a motor force to the piston (48); and a spring (54), adapted to apply a spring force to the piston (48).

Abstract translation: 提供了装置（20），其包括可膨胀囊（40），其适于联接到携带有氧血液的受试者（18）的血管（22），使得囊（40）的内部与 血液。 该装置还包括与气囊（40）机械连通的活塞（48）; 电机（60），其适于通过向所述活塞（48）施加电动力来使所述气囊（40）的收缩和膨胀与所述对象（18）的心动周期同步; 以及适于向活塞（48）施加弹簧力的弹簧（54）。