公开(公告)号：WO2013035092A2

公开(公告)日：2013-03-14

申请号：PCT/IL2012/000336

申请日：2012-09-09

Applicant: ENOPACE BIOMEDICAL LTD. ,  DAGAN, Amir ,  ELAZAR, Moshe ,  HANANI, Nitai ,  ARIAV, Gal ,  MEIRI, Oded ,  GINDIN, Igor ,  BERNSHTEIN, Vadim ,  ARMONY, Nir ,  GROSS, Yossi ,  REISNER, Yotam ,  GLASBERG, Offer

Inventor： DAGAN, Amir ,  ELAZAR, Moshe ,  HANANI, Nitai ,  ARIAV, Gal ,  MEIRI, Oded ,  GINDIN, Igor ,  BERNSHTEIN, Vadim ,  ARMONY, Nir ,  GROSS, Yossi ,  REISNER, Yotam ,  GLASBERG, Offer

CPC classification number: A61N1/40 ,  A61B5/0215 ,  A61B5/04 ,  A61B5/0402 ,  A61B5/0816 ,  A61F2/82 ,  A61F2/915 ,  A61F2002/8483 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0002 ,  A61F2250/0018 ,  A61N1/05 ,  A61N1/0514 ,  A61N1/0558 ,  A61N1/056 ,  A61N1/057 ,  A61N1/36053 ,  A61N1/3756 ,  A61N2001/0585

Abstract: Apparatus and methods are provided for use with a blood vessel of a subject, including a stent (20) configured to be placed in the blood vessel. The stent includes at least first (32), second (34), and third (36) strut portions disposed along the stent. The first and second strut portions are coupled to one another at a first junction (37A) that facilitates bending of the first and second strut portions with respect to one another. The second and third strut portions are coupled to one another at a second junction (37B) that facilitates bending of the second and third strut portions with respect to one another. At least one electrode (22) is disposed on at least an outer surface of the stent. Other applications are also described.

Abstract translation: 提供了与被检体的血管一起使用的装置和方法，包括构造成放置在血管中的支架（20）。 所述支架包括沿支架设置的至少第一（32），第二（34）和第三（36）支柱部分。 第一和第二支柱部分在促进第一和第二支柱部分相对于彼此的弯曲的第一接合部（37A）处彼此联接。 第二和第三支柱部分在促进第二和第三支柱部分相对于彼此的弯曲的第二接合部（37B）处彼此联接。 至少一个电极（22）设置在支架的至少外表面上。 还描述了其它应用。

公开(公告)号：WO2012073239A3

公开(公告)日：2012-06-07

申请号：PCT/IL2011/000916

申请日：2011-12-01

Applicant: GROSS, Yossi ,  GELBER, Moshe ,  AMIT, Noah ,  ALON, Ruth

Inventor： GROSS, Yossi ,  GELBER, Moshe ,  AMIT, Noah ,  ALON, Ruth

IPC: A61M99/00

Abstract: Apparatus and methods are described for generating a hole in a subject's nail. A nail penetration device (20) has a nail-contacting surface (26), a first electrode (29) being disposed on the surface. A skin-contact sensor unit (27) detects contact between the surface and the nail bed, the sensor unit including a pair of second electrodes (31) disposable on the subject's skin. A control unit (33) generates a hole in the subject's nail by moving the surface, while the surface is in contact with the nail. The control unit drives current having a given set of parameters via the first electrode, and detects a voltage between the second electrodes. The control unit does not move the surface, in response to detecting a change in the voltage between the second electrodes that is indicative of the current having travelled to the pair of second electrodes.

公开(公告)号：WO2011141918A3

公开(公告)日：2012-01-19

申请号：PCT/IL2011000382

申请日：2011-05-12

Applicant: TSOREF LIAT ,  GROSS YOSSI ,  KARDOSH MICHAEL

Inventor： TSOREF LIAT ,  GROSS YOSSI ,  KARDOSH MICHAEL

IPC: A61B18/04

CPC classification number: A61B34/20 ,  A61B8/0841 ,  A61B8/0883 ,  A61B8/12 ,  A61B8/445 ,  A61B8/481 ,  A61B8/5223 ,  A61B17/320016 ,  A61B17/320092 ,  A61B19/5244 ,  A61B2017/00026 ,  A61B2017/00084 ,  A61B2017/00106 ,  A61B2017/00243 ,  A61B2017/320052 ,  A61B2018/00285 ,  A61B2034/2063 ,  A61B2090/3784 ,  A61N7/022 ,  A61N2007/0052 ,  A61N2007/0056 ,  A61N2007/0069 ,  A61N2007/0091

Abstract: Apparatus comprising an ultrasound ablation system (10), which comprises a reflection-facilitation element (12), configured to be placed at an extramyocardial site of a subject, and to provide an extramyocardial reflective region; and an ultrasound tool (20), which comprises at least one ultrasound transducer (40) configured to be positioned within a heart chamber of the subject. The ultrasound transducer (40) is configured to ablate myocardial tissue by applying ultrasound energy to the myocardial tissue such that at least a portion of the transmitted energy is reflected by the reflective region onto the myocardial tissue. Other embodiments are also described.

Abstract translation: 包括超声消融系统（10）的装置，其包括被配置为放置在受试者的心肌外部位置处的反射促进元件（12），并且提供心外膜反射区域; 和超声波工具（20），其包括构造成定位在受试者的心室内的至少一个超声换能器（40）。 超声换能器（40）被配置为通过向心肌组织施加超声能量来消融心肌组织，使得至少一部分透射能量被反射区域反射到心肌组织上。 还描述了其它实施例。

公开(公告)号：WO2011083456A1

公开(公告)日：2011-07-14

申请号：PCT/IL2010/000975

申请日：2010-11-22

Applicant: RAINBOW MEDICAL LTD. ,  BETTER, Hadar ,  FOSTICK, Gideon ,  GROSS, Yossi

Inventor： BETTER, Hadar ,  FOSTICK, Gideon ,  GROSS, Yossi

IPC: A61B17/32

CPC classification number: A61C8/0006 ,  A61B17/24 ,  A61B17/32 ,  A61B17/3209 ,  A61B18/14 ,  A61B18/20 ,  A61B2017/0647 ,  A61B2017/0648 ,  A61B2017/3225 ,  A61B2018/144 ,  A61B2018/1467 ,  A61N7/02

Abstract: Apparatus is provided for use with a gingival periosteum (230) lining a bone. The apparatus comprises a periosteal mesher (200), which comprises a mesher surface (210), and a plurality of cutting elements (212) distributed over the mesher surface (210), which are configured to cut the gingival periosteum (230) to increase flexibility thereof. Other embodiments are also described.

Abstract translation: 设置用于与骨衬里的牙龈骨膜（230）一起使用。 该装置包括骨膜网（200），其包括网状物表面（210）和分布在所述网状物表面（210）上的多个切割元件（212），其被配置为切割牙龈骨（230）以增加 灵活性。 还描述了其它实施例。

公开(公告)号：WO2010128503A2

公开(公告)日：2010-11-11

申请号：PCT/IL2010/000358

申请日：2010-05-04

Applicant: VALTECH CARDIO, LTD. ,  ZIPORY, Yuval ,  CABIRI, Oz ,  GROSS, Yossi ,  HAMMER, Tal ,  GROSS, Amir ,  MAISANO, Francesco ,  MILLER, Eran ,  WEITZMAN, Yoseph ,  AYVAZIAN, Aram

Inventor： ZIPORY, Yuval ,  CABIRI, Oz ,  GROSS, Yossi ,  HAMMER, Tal ,  GROSS, Amir ,  MAISANO, Francesco ,  MILLER, Eran ,  WEITZMAN, Yoseph ,  AYVAZIAN, Aram

IPC: A61F2/24

CPC classification number: A61F2/2436 ,  A61B17/00234 ,  A61B17/0401 ,  A61B17/064 ,  A61B17/068 ,  A61B17/072 ,  A61B2017/00243 ,  A61B2017/0409 ,  A61B2017/0414 ,  A61B2017/0441 ,  A61B2017/0443 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/0647 ,  A61B2017/0648 ,  A61B2017/0649 ,  A61B2017/12095 ,  A61B2017/2923 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2445 ,  A61F2/2451 ,  A61F2/2457 ,  A61F2/2466 ,  A61F2002/30537 ,  A61F2220/0016 ,  A61F2250/0004

Abstract: Apparatus is provided including an implant structure (22, 500), which includes a contracting mechanism (40), which comprises a rotatable structure (46, 810, 936), arranged such that rotation of the rotatable structure (46, 810, 936) contracts the implant structure (22, 500). A longitudinal member (86) is coupled to the contracting mechanism (40). A tool (80) for rotating the rotatable structure (46, 810, 936) is configured to be guided along the longitudinal member (86), to engage the rotatable structure (46, 810, 936), and to rotate the rotatable structure (46, 810, 936) in response to a rotational force applied to the tool (80). Other applications are also described.

Abstract translation: 提供了包括植入结构（22,500）的设备，其包括收缩机构（40），该收缩机构包括可旋转结构（46,810,936），其可旋转结构（46,810,936） 收缩植入物结构（22,500）。 纵向构件（86）联接到收缩机构（40）。 用于旋转可旋转结构（46,810,936）的工具（80）被构造成沿着纵向构件（86）被引导以接合可旋转结构（46,810,936），并且使可旋转结构（ 46,810,936）响应于施加到工具（80）的旋转力。 还描述了其它应用。

公开(公告)号：WO2010029556A1

公开(公告)日：2010-03-18

申请号：PCT/IL2009/000894

申请日：2009-09-13

Applicant: SLENDER MEDICAL, LTD. ,  AZHARI, Haim ,  TSOREF, Liat ,  GROSS, Yossi ,  BENARIE, Jacob

Inventor： AZHARI, Haim ,  TSOREF, Liat ,  GROSS, Yossi ,  BENARIE, Jacob

IPC: A61B8/00 ,  A61H1/00

CPC classification number: A61B8/08 ,  A61B8/0825 ,  A61B18/18 ,  A61B18/20 ,  A61B2017/00084 ,  A61B2017/00106 ,  A61B2018/00011 ,  A61B2018/00642 ,  A61B2090/378 ,  A61H23/0245 ,  A61N7/02 ,  A61N2007/0008 ,  A61N2007/0039 ,  A61N2007/0056 ,  A61N2007/0065 ,  A61N2007/0078 ,  A61N2007/027

Abstract: Apparatus is provided, including first and second support structures (30, 32) for placement on skin of a subject. At least one of the first and second structures (30, 32) is moveable with respect to the other so as to draw a portion (122) of the skin and underlying tissue of the subject between respective lateral surfaces (51, 53) of the support structures (30, 32). At least one ultrasound transducer (40) is moveably coupled to the first support structure (30) along an axis of the structure (30) that is not parallel to the lateral surface (51) of the structure (30). The ultrasound transducer (40) is configured to transmit toward the portion (122) of skin and underlying tissue one or more forms of acoustic radiation energy, including treatment energy. At least one acoustic element (42) is coupled to the second support structure (32). Other applications are also described.

Abstract translation: 提供了包括用于放置在受试者皮肤上的第一和第二支撑结构（30,32）的装置。 所述第一和第二结构（30,32）中的至少一个可相对于另一个结构（30,32）移动，以便在所述第一和第二结构（30,32）的相应的侧表面（51,53）之间绘制所述皮肤的部分（122）和所述对象的下方组织 支撑结构（30,32）。 至少一个超声换能器（40）沿着不平行于结构（30）的侧表面（51）的结构（30）的轴线可移动地联接到第一支撑结构（30）。 超声换能器（40）被配置为向皮肤部分（122）和下面的组织传递一种或多种形式的声辐射能量，包括治疗能量。 至少一个声学元件（42）联接到第二支撑结构（32）。 还描述了其它应用。

公开(公告)号：WO2009095918A3

公开(公告)日：2010-03-11

申请号：PCT/IL2009000115

申请日：2009-01-29

Applicant: RAINBOW MEDICAL LTD ,  GROSS YOSSI

Inventor： GROSS YOSSI

IPC: A61F5/00

CPC classification number: A61F2/26 ,  A61N1/0408 ,  A61N1/0476 ,  A61N1/0492 ,  A61N1/05 ,  A61N1/321 ,  A61N1/36007

Abstract: In some embodiments of the present invention, apparatus is provided for treating erectile dysfunction of a subject. The apparatus includes one or more electrodes (22) configured to be coupled to a vicinity of a blood vessel (50) that carries blood into or out of a penis (52) of the subject, and a control unit (24) configured to facilitate erection of the penis by peristaltically pumping blood in the blood vessel by stimulating nitric oxide (NO) production in the vicinity, by driving the electrodes to drive a current into the vicinity. Additional embodiments are also described.

Abstract translation: 在本发明的一些实施方案中，提供了用于治疗受试者勃起功能障碍的装置。 该装置包括一个或多个电极（22），其被配置为耦合到携带血液进入或离开受试者的阴茎（52）的血管（50）附近;以及控制单元（24），其被配置为便于 通过驱动电极驱动电流进入附近，通过刺激附近的一氧化氮（NO）生成，通过蠕动地抽血血液来竖立阴茎。 还描述了另外的实施例。

公开(公告)号：WO2009050719A3

公开(公告)日：2010-03-11

申请号：PCT/IL2008001390

申请日：2008-10-22

Applicant: SLENDER MEDICAL LTD ,  AZHARI HAIM ,  TSOREF LIAT ,  GROSS YOSSI ,  BENARIE JACOB

Inventor： AZHARI HAIM ,  TSOREF LIAT ,  GROSS YOSSI ,  BENARIE JACOB

IPC: A61B17/20

CPC classification number: A61N7/02 ,  A61B2017/22008 ,  A61B2017/22024 ,  A61B2017/308 ,  A61B2090/378 ,  A61N2007/0008 ,  A61N2007/0078

Abstract: A housing (50) is placed on skin of a subject, and draws at least a portion of the skin within at least a part of the housing. The housing includes at least first and second support structures (34), placed in contact with a surface of skin surrounding the portion of the skin, the first support structure having a first concave surface (153) and the second support structure having a second concave surface (153) that faces the first concave surface. The apparatus includes one or more first ultrasound transducers (160) coupled to the first support structure and one or more second ultrasound transducers coupled to the second support structure. The apparatus also includes a control unit which drives the first and second ultrasound transducers to induce an implosion wave in a target region of the skin. Other embodiments are also described.

Abstract translation: 将壳体（50）放置在受试者的皮肤上，并且在壳体的至少一部分内吸取皮肤的至少一部分。 壳体包括至少第一和第二支撑结构（34），放置成与围绕皮肤部分的皮肤表面接触，第一支撑结构具有第一凹面（153），第二支撑结构具有第二凹面 面（153）面向第一凹面。 该装置包括耦合到第一支撑结构的一个或多个第一超声换能器（160）和耦合到第二支撑结构的一个或多个第二超声换能器。 该装置还包括控制单元，其驱动第一和第二超声换能器以在皮肤的目标区域中引起内爆波。 还描述了其它实施例。

公开(公告)号：WO2009095918A2

公开(公告)日：2009-08-06

申请号：PCT/IL2009/000115

申请日：2009-01-29

Applicant: RAINBOW MEDICAL LTD. ,  GROSS, Yossi

Inventor： GROSS, Yossi

IPC: A61F5/00

CPC classification number: A61F2/26 ,  A61N1/0408 ,  A61N1/0476 ,  A61N1/0492 ,  A61N1/05 ,  A61N1/321 ,  A61N1/36007

Abstract: In some embodiments of the present invention, apparatus is provided for treating erectile dysfunction of a subject. The apparatus includes one or more electrodes (22) configured to be coupled to a vicinity of a blood vessel (50) that carries blood into or out of a penis (52) of the subject, and a control unit (24) configured to facilitate erection of the penis by peristaltically pumping blood in the blood vessel by stimulating nitric oxide (NO) production in the vicinity, by driving the electrodes to drive a current into the vicinity. Additional embodiments are also described.

Abstract translation: 在本发明的一些实施方案中，提供了用于治疗受试者勃起功能障碍的装置。 该装置包括一个或多个电极（22），其被配置为耦合到携带血液进入或离开受试者的阴茎（52）的血管（50）附近;以及控制单元（24），其被配置为便于 通过驱动电极驱动电流进入附近，通过刺激附近的一氧化氮（NO）生成，通过蠕动地抽血血液来竖立阴茎。 还描述了另外的实施例。

公开(公告)号：WO2007110867A8

公开(公告)日：2009-07-23

申请号：PCT/IL2007000399

申请日：2007-03-28

Applicant: GLUSENSE LTD ,  GROSS YOSSI ,  HYMAN TEHILA

Inventor： GROSS YOSSI ,  HYMAN TEHILA

IPC: A61K49/00 ,  A01N1/00 ,  A01N63/00 ,  A61B5/00 ,  A61F13/00 ,  C12N5/00

CPC classification number: A61B5/14532 ,  A61B5/14556 ,  A61B5/1459 ,  C07K14/43595 ,  C07K2319/60

Abstract: Apparatus is provided for detecting a concentration of an analyte in a subject. The apparatus includes a housing (20) adapted to be implanted in the subject. The housing (20) comprising an optical detector (30) adapted to detect a level of fluorescence resonance energy transfer (FRET). The apparatus also comprises live cells (26) genetically engineered to produce, in a patient's body, a sensor protein comprising a fluorescent protein donor, a fluorescent protein acceptor, and a binding protein for the analyte. Other embodiments are also described. 2

Abstract translation: 提供了用于检测受试者中分析物浓度的装置。 该装置包括适于植入受试者的壳体（20）。 壳体（20）包括适于检测荧光共振能量转移（FRET）的水平的光学检测器（30）。 该装置还包括基因工程改造以在患者体内产生包含荧光蛋白供体，荧光蛋白受体和用于分析物的结合蛋白的传感器蛋白的活细胞（26）。 还描述了其它实施例。 2