公开(公告)号：WO2016123532A1

公开(公告)日：2016-08-04

申请号：PCT/US2016/015738

申请日：2016-01-29

Applicant: MEDTRONIC, INC. ,  STADLER, Robert W. ,  STEGEMANN, Berthold ,  CORNELUSSEN, Richard ,  GHOSH, Subham ,  CHO, Yong K. ,  GILLBERG, Jeffrey M. ,  WHITMAN, Teresa A.

IPC: A61B5/11 ,  A61B5/0472 ,  A61B5/00 ,  A61B5/0428 ,  A61N7/00 ,  A61N1/368

CPC classification number: A61N7/00 ,  A61B5/0053 ,  A61B5/04085 ,  A61B5/04286 ,  A61B5/0472 ,  A61B5/1107 ,  A61B5/4848 ,  A61B5/743 ,  A61B2505/05 ,  A61N1/362 ,  A61N1/3627 ,  A61N7/02 ,  A61N2007/0004 ,  A61N2007/0026 ,  A61N2007/0056

Abstract: Systems, methods, and interfaces are described herein for noninvasively determining whether a patient can benefit from cardiac resynchronization therapy. One exemplary method involves delivering ultrasonic energy to cardiac tissue. In response to delivering ultrasonic energy to the cardiac tissue, receiving, with a processing unit, a torso-surface potential signal from each of a plurality of electrodes distributed on a torso of a patient. For at least a subset of the plurality of electrodes, calculating, with the processing unit, a torso-surface activation time based on the signal sensed from the electrode. Presenting, by the processing unit, to a user, an indication of a degree of dyssynchrony of the torso-surface activation times via a display.

Abstract translation: 本文描述了系统，方法和界面，用于非侵入性地确定患者是否可以从心脏再同步治疗中受益。 一种示例性方法涉及将超声能量递送到心脏组织。 响应于向心脏组织递送超声能量，用处理单元接收分布在患者躯干上的多个电极中的每一个的躯干表面电位信号。 对于多个电极的至少一个子集，基于从电极感测的信号，利用处理单元计算躯干表面激活时间。 由处理单元向用户呈现经由显示器的躯干表面激活时间的不同步程度的指示。

公开(公告)号：WO2012154489A1

公开(公告)日：2012-11-15

申请号：PCT/US2012/036285

申请日：2012-05-03

Applicant: MEDTRONIC, INC. ,  GHOSH, Subham ,  GILLBERG, Jeffrey M.

Inventor： GHOSH, Subham ,  GILLBERG, Jeffrey M.

IPC: A61B5/04 ,  A61B5/0452 ,  A61N1/362

CPC classification number: A61B5/686 ,  A61B5/04012 ,  A61B5/0452 ,  A61N1/3621

Abstract: A medical device, comprising: a memory; and a processing module configured to retrieve electrogram (EGM) data for N cardiac cycles from the memory, wherein N is an integer greater than 1, categorize each of the N cardiac cycles into one of a plurality of categories based on a morphology of the N cardiac cycles, perform comparisons be¬ tween pairs of the N cardiac cycles, each of the comparisons between two cardiac cycles comprising: detecting a mismatch between the two cardiac cycles when the two cardiac cycles are in different categories; and detecting a match between the two cardiac cycles when the two cardiac cycles are in the same category, wherein the processing module is further configured to classify the rhythm of the N cardiac cycles based on a number of detected matches and detected mismatches.

Abstract translation: 一种医疗装置，包括：存储器; 以及处理模块，被配置为从存储器中检索N个心动周期的电描记图（EGM）数据，其中N是大于1的整数，基于N的形态将N个心动周期中的每一个分类为多个类别 心动周期，执行N个心动周期对之间的比较，两个心动周期之间的每个比较包括：当两个心动周期处于不同类别时，检测两个心动周期之间的失配; 以及当所述两个心动周期处于相同类别时，检测所述两个心动周期之间的匹配，其中所述处理模块还被配置为基于检测到的匹配的数量和检测到的错配来对所述N个心动周期的节律进行分类。

公开(公告)号：WO2012151364A1

公开(公告)日：2012-11-08

申请号：PCT/US2012/036262

申请日：2012-05-03

Applicant: MEDTRONIC, INC. ,  GHOSH, Subham ,  GILLBERG, Jeffrey M. ,  STADLER, Robert W.

Inventor： GHOSH, Subham ,  GILLBERG, Jeffrey M. ,  STADLER, Robert W.

IPC: A61B5/0402 ,  A61B5/0408 ,  A61N1/362 ,  A61N1/368

CPC classification number: A61B5/04012 ,  A61B5/02 ,  A61B5/0402 ,  A61B5/04085 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/05 ,  A61B5/742 ,  A61N1/0476 ,  A61N1/0484 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

Abstract: Techniques for evaluating cardiac electrical dyssynchrony are described. In some examples, an activation time is determined for each of a plurality of torso-surface potential signals. The dispersion or sequence of these activation times may be analyzed or presented to provide variety of indications of the electrical dyssynchrony of the heart of the patient. In some examples, the locations of the electrodes of the set of electrodes, and thus the locations at which the torso-surface potential signals were sensed, may be projected on the surface of a model torso that includes a model heart. The inverse problem of electrocardiography may be solved to determine electrical activation times for regions of the model heart based on the torso-surface potential signals sensed from the patient.

Abstract translation: 描述了评估心脏电气不同步的技术。 在一些示例中，为多个躯干表面电位信号中的每一个确定激活时间。 可以分析或呈现这些激活时间的分散或序列以提供患者心脏的电不同步的各种指示。 在一些示例中，电极组的电极的位置以及因此感测躯干表面电位信号的位置可以投影在包括模型心脏的模型躯干的表面上。 可以解决心电图的逆问题，以基于从患者感测的躯干表面电位信号来确定模型心脏区域的电激活时间。

公开(公告)号：WO2012151389A1

公开(公告)日：2012-11-08

申请号：PCT/US2012/036302

申请日：2012-05-03

Applicant: MEDTRONIC, INC. ,  GHOSH, Subham ,  GILLBERG, Jeffrey M ,  STADLER, Robert W.

Inventor： GHOSH, Subham ,  GILLBERG, Jeffrey M ,  STADLER, Robert W.

IPC: A61B5/0402 ,  A61B5/0408 ,  A61N1/362 ,  A61N1/368

CPC classification number: A61B5/04012 ,  A61B5/02 ,  A61B5/0402 ,  A61B5/04085 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/05 ,  A61B5/742 ,  A61N1/0476 ,  A61N1/0484 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

Abstract: Techniques for evaluating cardiac electrical dyssynchrony are described. In some examples, an activation time is determined for each of a plurality of torso-surface potential signals. The dispersion or sequence of these activation times may be analyzed or presented to provide variety of indications of the electrical dyssynchrony of the heart of the patient. In some examples, the locations of the electrodes of the set of electrodes, and thus the locations at which the torso-surface potential signals were sensed, may be projected on the surface of a model torso that includes a model heart. The inverse problem of electrocardiography may be solved to determine electrical activation times for regions of the model heart based on the torso-surface potential signals sensed from the patient.

Abstract translation: 描述了评估心脏电气不同步的技术。 在一些示例中，为多个躯干表面电位信号中的每一个确定激活时间。 可以分析或呈现这些激活时间的分散或序列以提供患者心脏的电不同步的各种指征。 在一些示例中，电极组的电极的位置以及因此感测躯干表面电位信号的位置可以投影在包括模型心脏的模型躯干的表面上。 可以基于从患者感测到的躯干表面电位信号来解决心电图的逆问题，以确定模型心脏区域的电激活时间。