公开(公告)号：WO2008036642A3

公开(公告)日：2008-08-07

申请号：PCT/US2007078745

申请日：2007-09-18

Applicant: INCYTE CORP ,  COMBS ANDREW P ,  GLASS BRIAN M ,  SPARKS RICHARD B ,  YUE EDDY WAI

Inventor： COMBS ANDREW P ,  GLASS BRIAN M ,  SPARKS RICHARD B ,  YUE EDDY WAI

IPC: C07D413/04 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/416 ,  A61K31/426 ,  A61P11/06 ,  A61P25/00 ,  A61P31/18 ,  A61P35/00 ,  A61P37/00 ,  C07D261/18 ,  C07D261/20 ,  C07D277/56 ,  C07D417/04

CPC classification number: C07D413/04 ,  C07D261/18 ,  C07D261/20 ,  C07D277/56 ,  C07D417/04

Abstract: The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.

Abstract translation: 本发明涉及作为吲哚胺2,3-双加氧酶（IDO）调节剂的N-羟基脒基化合物，以及其组合物和药物方法。

公开(公告)号：WO2008036653A3

公开(公告)日：2008-03-27

申请号：PCT/US2007/078759

申请日：2007-09-18

Applicant: INCYTE CORPORATION ,  COMBS, Andrew P. ,  GLASS, Brian M. ,  SPARKS, Richard B. ,  YUE, Eddy Wai

Inventor： COMBS, Andrew P. ,  GLASS, Brian M. ,  SPARKS, Richard B. ,  YUE, Eddy Wai

IPC: C07D261/18 ,  C07D261/20 ,  C07D333/70 ,  C07D307/68 ,  A61K31/415 ,  A61K31/34 ,  A61K31/381 ,  A61P35/00 ,  A61P29/00 ,  A61P25/00 ,  A61P31/12

Abstract: The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.

公开(公告)号：WO2008036653A2

公开(公告)日：2008-03-27

申请号：PCT/US2007078759

申请日：2007-09-18

Applicant: INCYTE CORP ,  COMBS ANDREW P ,  GLASS BRIAN M ,  SPARKS RICHARD B ,  YUE EDDY WAI

Inventor： COMBS ANDREW P ,  GLASS BRIAN M ,  SPARKS RICHARD B ,  YUE EDDY WAI

IPC: C07D261/18 ,  A61K31/34 ,  A61K31/381 ,  A61K31/415 ,  A61P25/00 ,  A61P29/00 ,  A61P31/12 ,  A61P35/00 ,  C07D261/20 ,  C07D307/68 ,  C07D333/70

CPC classification number: C07D261/18 ,  C07D261/20 ,  C07D307/68 ,  C07D333/70

Abstract: The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.

Abstract translation: 本发明涉及作为吲哚胺2,3-双加氧酶（IDO）的调节剂的N-羟基脒基化合物及其组合物和药物方法。

公开(公告)号：WO2008036642A2

公开(公告)日：2008-03-27

申请号：PCT/US2007/078745

申请日：2007-09-18

Applicant: INCYTE CORPORATION ,  COMBS, Andrew, P. ,  GLASS, Brian, M. ,  SPARKS, Richard, B. ,  YUE, Eddy Wai

Inventor： COMBS, Andrew, P. ,  GLASS, Brian, M. ,  SPARKS, Richard, B. ,  YUE, Eddy Wai

IPC: C07D413/04 ,  C07D261/20 ,  C07D261/18 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/416 ,  A61K31/426 ,  A61P11/06 ,  A61P25/00 ,  A61P37/00 ,  A61P31/18 ,  A61P35/00 ,  C07D417/04 ,  C07D277/56

CPC classification number: C07D413/04 ,  C07D261/18 ,  C07D261/20 ,  C07D277/56 ,  C07D417/04

Abstract: The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.

Abstract translation: 本发明涉及作为吲哚胺2,3-双加氧酶（IDO）调节剂的N-羟基脒基化合物，以及其组合物和药物方法。

公开(公告)号：WO2007095050A2

公开(公告)日：2007-08-23

申请号：PCT/US2007003364

申请日：2007-02-08

Applicant: INCYTE CORP ,  COMBS ANDREW P ,  GLASS BRIAN M

Inventor： COMBS ANDREW P ,  GLASS BRIAN M

CPC classification number: C07C279/18 ,  C07D213/38 ,  C07D213/64 ,  C07D213/74 ,  C07D231/12 ,  C07D231/38 ,  C07D231/40 ,  C07D263/32 ,  C07D277/28 ,  C07D285/06 ,  C07D295/13 ,  C07D295/215

Abstract: The present invention is directed to modulators of indoleamine 2,3-dioxygenase (IDO), as well as pharmaceutical compositions containing the same and methods for the treatment of IDO-associated diseases.

Abstract translation: 本发明涉及吲哚胺2,3-双加氧酶（IDO）的调节剂，以及含有其的药物组合物和治疗IDO相关疾病的方法。

公开(公告)号：WO2007095050A3

公开(公告)日：2007-08-23

申请号：PCT/US2007/003364

申请日：2007-02-08

Applicant: INCYTE CORPORATION ,  COMBS, Andrew, P. ,  GLASS, Brian, M.

Inventor： COMBS, Andrew, P. ,  GLASS, Brian, M.

IPC: C07C279/18 ,  A61K31/155 ,  C07D213/75 ,  C07D231/40 ,  C07D263/32 ,  C07D285/06

Abstract: The present invention is directed to modulators of indoleamine 2,3-dioxygenase (IDO), as well as pharmaceutical compositions containing the same and methods for the treatment of IDO-associated diseases.