公开(公告)号：WO2013164829A1

公开(公告)日：2013-11-07

申请号：PCT/IL2013/050375

申请日：2013-05-02

Applicant: ENOPACE BIOMEDICAL LTD. ,  ELAZAR, Moshe ,  DAGAN, Amir ,  BERNSHTEIN, Vadim ,  GROSS, Yossi ,  GOLAN, Saar ,  HANANI, Nitai ,  GINDIN, Igor ,  ARMONY, Nir

Inventor： ELAZAR, Moshe ,  DAGAN, Amir ,  BERNSHTEIN, Vadim ,  GROSS, Yossi ,  GOLAN, Saar ,  HANANI, Nitai ,  GINDIN, Igor ,  ARMONY, Nir

IPC: A61F2/82

CPC classification number: A61N1/05 ,  A61F2/856 ,  A61F2/88 ,  A61F2/915 ,  A61F2002/8483 ,  A61F2002/91558 ,  A61F2002/9505 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2230/0013 ,  A61F2230/0054 ,  A61F2250/0001 ,  A61N1/37205

Abstract: Apparatus and methods are provided including a stent (20) configured to be placed in a blood vessel. The stent includes first (214) and second (216) strut portions at first and second ends of the stent, and a flexible central portion (210) of the stent. In the absence of any force being applied to the stent, the length of the central portion is more than 50 percent of a total length of the stent. At any given longitudinal location along the central portion, the central portion defines no struts around a continuous angular region of more than 180 degrees around a longitudinal axis of the stent. A control capsule (30), coupled to the second strut portion, drives a current into the blood vessel via an electrode (22), which is coupled to the stent. An antenna (28), coupled to the first strut portion, receives power and powers the control capsule.

Abstract translation: 提供了包括构造成放置在血管中的支架（20）的装置和方法。 支架在支架的第一端和第二端处以及支架的柔性中心部分（210）包括第一（214）和第二（216）支柱部分。 在没有施加任何力的支架上，中心部分的长度大于支架总长度的50％。 在沿着中心部分的任何给定的纵向位置处，中心部分围绕围绕支架的纵向轴线的大于180度的连续角度区域不限定支柱。 耦合到第二支柱部分的控制盒（30）经由与支架相连的电极（22）将电流驱动到血管中。 耦合到第一支柱部分的天线（28）接收功率并为控制盒提供电力。

公开(公告)号：WO2013035092A2

公开(公告)日：2013-03-14

申请号：PCT/IL2012/000336

申请日：2012-09-09

Applicant: ENOPACE BIOMEDICAL LTD. ,  DAGAN, Amir ,  ELAZAR, Moshe ,  HANANI, Nitai ,  ARIAV, Gal ,  MEIRI, Oded ,  GINDIN, Igor ,  BERNSHTEIN, Vadim ,  ARMONY, Nir ,  GROSS, Yossi ,  REISNER, Yotam ,  GLASBERG, Offer

Inventor： DAGAN, Amir ,  ELAZAR, Moshe ,  HANANI, Nitai ,  ARIAV, Gal ,  MEIRI, Oded ,  GINDIN, Igor ,  BERNSHTEIN, Vadim ,  ARMONY, Nir ,  GROSS, Yossi ,  REISNER, Yotam ,  GLASBERG, Offer

CPC classification number: A61N1/40 ,  A61B5/0215 ,  A61B5/04 ,  A61B5/0402 ,  A61B5/0816 ,  A61F2/82 ,  A61F2/915 ,  A61F2002/8483 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0002 ,  A61F2250/0018 ,  A61N1/05 ,  A61N1/0514 ,  A61N1/0558 ,  A61N1/056 ,  A61N1/057 ,  A61N1/36053 ,  A61N1/3756 ,  A61N2001/0585

Abstract: Apparatus and methods are provided for use with a blood vessel of a subject, including a stent (20) configured to be placed in the blood vessel. The stent includes at least first (32), second (34), and third (36) strut portions disposed along the stent. The first and second strut portions are coupled to one another at a first junction (37A) that facilitates bending of the first and second strut portions with respect to one another. The second and third strut portions are coupled to one another at a second junction (37B) that facilitates bending of the second and third strut portions with respect to one another. At least one electrode (22) is disposed on at least an outer surface of the stent. Other applications are also described.

Abstract translation: 提供了与被检体的血管一起使用的装置和方法，包括构造成放置在血管中的支架（20）。 所述支架包括沿支架设置的至少第一（32），第二（34）和第三（36）支柱部分。 第一和第二支柱部分在促进第一和第二支柱部分相对于彼此的弯曲的第一接合部（37A）处彼此联接。 第二和第三支柱部分在促进第二和第三支柱部分相对于彼此的弯曲的第二接合部（37B）处彼此联接。 至少一个电极（22）设置在支架的至少外表面上。 还描述了其它应用。

公开(公告)号：WO2013035092A3

公开(公告)日：2015-04-16

申请号：PCT/IL2012000336

申请日：2012-09-09

Applicant: ENOPACE BIOMEDICAL LTD ,  DAGAN AMIR ,  ELAZAR MOSHE ,  HANANI NITAI ,  ARIAV GAL ,  MEIRI ODED ,  GINDIN IGOR ,  BERNSHTEIN VADIM ,  ARMONY NIR ,  GROSS YOSSI ,  REISNER YOTAM ,  GLASBERG OFFER

Inventor： DAGAN AMIR ,  ELAZAR MOSHE ,  HANANI NITAI ,  ARIAV GAL ,  MEIRI ODED ,  GINDIN IGOR ,  BERNSHTEIN VADIM ,  ARMONY NIR ,  GROSS YOSSI ,  REISNER YOTAM ,  GLASBERG OFFER

IPC: A61F2/06

CPC classification number: A61N1/40 ,  A61B5/0215 ,  A61B5/04 ,  A61B5/0402 ,  A61B5/0816 ,  A61F2/82 ,  A61F2/915 ,  A61F2002/8483 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0002 ,  A61F2250/0018 ,  A61N1/05 ,  A61N1/0514 ,  A61N1/0558 ,  A61N1/056 ,  A61N1/057 ,  A61N1/36053 ,  A61N1/3756 ,  A61N2001/0585

Abstract: Apparatus and methods are provided for use with a blood vessel of a subject, including a stent (20) configured to be placed in the blood vessel. The stent includes at least first (32), second (34), and third (36) strut portions disposed along the stent. The first and second strut portions are coupled to one another at a first junction (37A) that facilitates bending of the first and second strut portions with respect to one another. The second and third strut portions are coupled to one another at a second junction (37B) that facilitates bending of the second and third strut portions with respect to one another. At least one electrode (22) is disposed on at least an outer surface of the stent. Other applications are also described.

Abstract translation: 提供了与被检体的血管一起使用的装置和方法，包括构造成放置在血管中的支架（20）。 所述支架包括沿支架设置的至少第一（32），第二（34）和第三（36）支柱部分。 第一和第二支柱部分在促进第一和第二支柱部分相对于彼此的弯曲的第一接合部（37A）处彼此联接。 第二和第三支柱部分在促进第二和第三支柱部分相对于彼此弯曲的第二接合部（37B）处彼此联接。 至少一个电极（22）设置在支架的至少外表面上。 还描述了其它应用。

公开(公告)号：WO2013069020A1

公开(公告)日：2013-05-16

申请号：PCT/IL2012/050452

申请日：2012-11-08

Applicant: ENOPACE BIOMEDICAL LTD. ,  DAGAN, Amir ,  GLASBERG, Offer ,  REISNER, Yotam ,  ARIAV, Gal ,  HANANI, Nitai

Inventor： DAGAN, Amir ,  GLASBERG, Offer ,  REISNER, Yotam ,  ARIAV, Gal ,  HANANI, Nitai

IPC: A61N1/05

CPC classification number: A61N1/05 ,  A61N1/0558 ,  A61N1/36017 ,  A61N1/36114

Abstract: Apparatus and methods are described including an electrode device (30) that is configured to assume a coiled configuration when the device is in an unconstrained state, the electrode device being shaped to define a lumen (40). At least one electrode (21) is disposed on the electrode device. At least one electrical wire (32) is coupled to the electrode. A flexible lead (34) defines a lumen (42) therethrough, the electrical wire being housed inside the lead. A stylet (36) constrains the electrode device into a straightened configuration by being inserted into the lumen defined by the electrode device. The stylet additionally stiffens the flexible lead by being inserted into the lumen defined by the flexible lead. Other applications are also described.

Abstract translation: 描述了包括电极装置（30）的装置和方法，所述电极装置被构造为当所述装置处于非约束状态时呈现线圈构造，所述电极装置被成形为限定内腔（40）。 至少一个电极（21）设置在电极装置上。 至少一根电线（32）与电极连接。 柔性引线（34）限定穿过其中的内腔（42），电线被容纳在引线内。 探针（36）通过插入到由电极装置限定的内腔中将电极装置约束成直线构型。 探针通过插入到由柔性引线限定的内腔中来另外加强柔性引线。 还描述了其它应用。

公开(公告)号：WO2012085907A3

公开(公告)日：2012-06-28

申请号：PCT/IL2011/000952

申请日：2011-12-20

Applicant: RAINBOW MEDICAL LTD. ,  GROSS, Yossi ,  DAGAN, Amir ,  REISNER, Yotam ,  GLASBERG, Offer ,  HANANI, Nitai ,  ARIAV, Gal

Inventor： GROSS, Yossi ,  DAGAN, Amir ,  REISNER, Yotam ,  GLASBERG, Offer ,  HANANI, Nitai ,  ARIAV, Gal

IPC: A61N1/365 ,  A61N1/362

Abstract: Apparatus and methods are provided for use with a heart of a subject, including a set of one or more electrodes (28). A control unit (16) paces the heart by driving a first electric current via the electrode set into tissue of the subject, in accordance with a first set of parameters. The control unit stimulates nitric oxide production by a portion of the heart by driving a second electric current via the electrode set into the portion of the heart, in accordance with a second set of parameters. Other embodiments are also described.

公开(公告)号：WO2012085907A2

公开(公告)日：2012-06-28

申请号：PCT/IL2011000952

申请日：2011-12-20

Applicant: RAINBOW MEDICAL LTD ,  GROSS YOSSI ,  DAGAN AMIR ,  REISNER YOTAM ,  GLASBERG OFFER ,  HANANI NITAI ,  ARIAV GAL

Inventor： GROSS YOSSI ,  DAGAN AMIR ,  REISNER YOTAM ,  GLASBERG OFFER ,  HANANI NITAI ,  ARIAV GAL

IPC: A61N1/365 ,  A61N1/362

CPC classification number: A61N1/3627 ,  A61N1/36542 ,  A61N1/368

Abstract: Apparatus and methods are provided for use with a heart of a subject, including a set of one or more electrodes (28). A control unit (16) paces the heart by driving a first electric current via the electrode set into tissue of the subject, in accordance with a first set of parameters. The control unit stimulates nitric oxide production by a portion of the heart by driving a second electric current via the electrode set into the portion of the heart, in accordance with a second set of parameters. Other embodiments are also described.

Abstract translation: 提供了与受试者的心脏一起使用的装置和方法，包括一组一个或多个电极（28）。 根据第一组参数，控制单元（16）通过将经由电极组的第一电流驱动到对象的组织中而使心脏跳动。 根据第二组参数，控制单元通过经由电极组的第二电流驱动心脏的一部分来刺激一部分心脏的一氧化氮产生。 还描述了其它实施例。

公开(公告)号：WO2012017437A1

公开(公告)日：2012-02-09

申请号：PCT/IL2011/000636

申请日：2011-08-04

Applicant: RAINBOW MEDICAL LTD. ,  GROSS, Yossi ,  DAGAN, Amir ,  REISNER, Yotam ,  HANANI, Nitai ,  ARIAV, Gal

Inventor： GROSS, Yossi ,  DAGAN, Amir ,  REISNER, Yotam ,  HANANI, Nitai ,  ARIAV, Gal

IPC: A61N1/05

CPC classification number: A61N1/05 ,  A61F2/82 ,  A61N1/0514 ,  A61N1/0521 ,  A61N1/056 ,  A61N1/36 ,  A61N1/36564

Abstract: Apparatus and methods are described including a mechanical support element (28) that is placed inside a first vein of a subject. At least one electrode (26) disposed on the mechanical support element is placed inside the first vein, in a vicinity of a site upstream of a bifurcation with a second vein of the subject. A control unit (30) enhances downstream blood flow from the first vein by driving the at least one electrode to divert blood downstream into the second vein by constricting the first vein at the upstream site, by driving the at least one electrode to apply a current to the vicinity of the site. The mechanical support element prevents the first vein from collapsing by providing mechanical support to the vein. Other embodiments are also described.

Abstract translation: 描述的装置和方法包括放置在受试者的第一静脉内部的机械支撑元件（28）。 设置在机械支撑元件上的至少一个电极（26）被放置在第一静脉的内部，在与受试者的第二静脉分叉的上游位置附近。 控制单元（30）通过驱动至少一个电极来增强来自第一静脉的下游血液流动，通过在至少一个电极上驱动至少一个电极来施加电流，从而通过收缩上游部位的第一静脉来将血液下游转移到第二静脉 到现场附近。 机械支撑元件通过向静脉提供机械支撑来防止第一静脉塌陷。 还描述了其它实施例。