公开(公告)号：WO2012071102A3

公开(公告)日：2012-05-31

申请号：PCT/US2011/051296

申请日：2011-09-13

申请人： SACHEM, INC. ,  HAYMORE, Barry L.

发明人： HAYMORE, Barry L.

IPC分类号： C07F9/38 ,  C07F9/40 ,  C07D295/088 ,  C07C211/62 ,  C07C211/63 ,  C07C215/14 ,  C07C215/18 ,  C07C217/28 ,  C07C217/42 ,  C07C233/48 ,  C07C237/06 ,  C07C279/12 ,  C07C309/14

摘要： A method of buffering a chemical or biological composition, comprising adding to the composition an effective buffering amount of at least one protonated or un-protonated amine-quaternary ammonium compound having a general formula(CI) d wherein the variables R, G, n and k are as defined herein.

公开(公告)号：WO2012071102A2

公开(公告)日：2012-05-31

申请号：PCT/US2011051296

申请日：2011-09-13

申请人： SACHEM INC ,  HAYMORE BARRY L

发明人： HAYMORE BARRY L

IPC分类号： C07F9/38 ,  C07C211/63 ,  C07C215/14 ,  C07C215/18 ,  C07C217/28 ,  C07C217/42 ,  C07C233/48 ,  C07C237/06 ,  C07C279/12 ,  C07C309/14 ,  C07D295/088 ,  C07F9/40

CPC分类号： C07D295/088 ,  C07F9/3808 ,  C07F9/4006

摘要： A method of buffering a chemical or biological composition, comprising adding to the composition an effective buffering amount of at least one protonated or un-protonated amine-quaternary ammonium compound having a general formula(CI)d wherein the variables R, G, n and k are as defined herein.

摘要翻译： 一种缓冲化学或生物组合物的方法，包括向组合物中加入有效缓冲量的至少一种具有通式（C1）d的质子化或未质子化的胺 - 季铵化合物，其中变量R，G，n和 k如本文所定义。

公开(公告)号：WO2007064809A2

公开(公告)日：2007-06-07

申请号：PCT/US2006045872

申请日：2006-11-30

申请人： SACHEM INC ,  LITTLE CHARLES J ,  HAYMORE BARRY L

发明人： LITTLE CHARLES J ,  HAYMORE BARRY L

IPC分类号： B01D15/42 ,  C07C309/32 ,  C07C309/34 ,  C07C309/38

CPC分类号： B01D15/422 ,  B01D15/363 ,  C07C309/11 ,  C07C309/32 ,  C07C309/39 ,  C07C309/42 ,  C07C309/58 ,  C07C309/60 ,  C07C2603/26 ,  C07D251/70 ,  C07D263/57

摘要： A displacement chromatography process, including: loading onto a stationary phase comprising an anion-exchange material a mixture comprising one or more component to be separated; displacing at least one of the one or more component from the stationary phase by applying to the stationary phase a mixture comprising an polyaromatic polyanionic displacer compound having a general formula Cen (Ar)w, in which Cen is a central bond or group, Ar is an aromatic nucleus, w = 2 to the maximum number of sites one Cen, and Ar is substituted with a plurality of An - , in which each An - is independently defined as sulfonate, carboxylate, phosphonate, phosphate, sulfate; and Ar is further substituted with a plurality of G, in which G is defined as independently H, C1-C6 alkyl, halogen, nitro, hydroxy, C1-C6 alkoxy In addition, a group of polyaromatic polyanionic displacer compounds useful in the process is disclosed.

摘要翻译： 一种置换色谱方法，包括：将包含一种或多种待分离组分的混合物的包含阴离子交换材料的固定相载入; 通过向固定相施加包含具有通式Cen（Ar）w的多芳族聚阴离子置换剂化合物的混合物，其中Cen是中心键或基团，Ar是从固定相中取代一种或多种组分中的至少一种 一个芳香核，w = 2到最大数目的一个Cen，Ar被多个An取代，其中每个An -O - 独立地被定义为 磺酸盐，羧酸盐，膦酸盐，磷酸盐，硫酸盐; 并且Ar进一步被多个G取代，其中G独立地定义为H，C 1 -C 6烷基，卤素，硝基，羟基，C 1 -C 6烷氧基。另外，用于该方法的一组多芳族聚阴离子置换剂化合物是 披露。

公开(公告)号：WO2007064809A3

公开(公告)日：2007-06-07

申请号：PCT/US2006/045872

申请日：2006-11-30

申请人： SACHEM, INC. ,  LITTLE, Charles, J. ,  HAYMORE, Barry, L.

发明人： LITTLE, Charles, J. ,  HAYMORE, Barry, L.

IPC分类号： B01D15/42 ,  C07C309/32 ,  C07C309/34 ,  C07C309/38 ,  C07C303/06 ,  C07D251/70

摘要： A displacement chromatography process, including: loading onto a stationary phase comprising an anion-exchange material a mixture comprising one or more component to be separated; displacing at least one of the one or more component from the stationary phase by applying to the stationary phase a mixture comprising an polyaromatic polyanionic displacer compound having a general formula Cen (Ar)w, in which Cen is a central bond or group, Ar is an aromatic nucleus, w = 2 to the maximum number of sites one Cen, and Ar is substituted with a plurality of An - , in which each An - is independently defined as sulfonate, carboxylate, phosphonate, phosphate, sulfate; and Ar is further substituted with a plurality of G, in which G is defined as independently H, C1-C6 alkyl, halogen, nitro, hydroxy, C1-C6 alkoxy In addition, a group of polyaromatic polyanionic displacer compounds useful in the process is disclosed.