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    TREATMENT OF ENDOMETRIOSIS AND NICLOSAMIDE DERIVATIVES
    4.
    发明申请
    TREATMENT OF ENDOMETRIOSIS AND NICLOSAMIDE DERIVATIVES 审中-公开
    子宫内膜异位症和NICLOSAMIDE衍生物的治疗

    公开(公告)号：WO2017210117A1

    公开(公告)日：2017-12-07

    申请号：PCT/US2017/034730

    申请日：2017-05-26

    申请人： BOARD OF TRUSTEES, SOUTHERN ILLINOIS UNIVERSITY ,  HAYASHI, Kanako ,  MACLEAN, James II ,  KING, Mandy

    发明人： HAYASHI, Kanako ,  MACLEAN, James II ,  KING, Mandy

    IPC分类号： A61K31/166 ,  A61K31/473 ,  C07C235/64

    CPC分类号： C07C235/64 ,  A61K31/609 ,  C07C217/22 ,  C07C309/11 ,  C07F9/3808

    摘要： Niclosamide is an effective therapeutic medicament for the treatment of endometriosis. Niclosamide treatment can reduce the size of endometrioid lesions and reduce cell proliferation in the lesions. Niclosamide treatment can result in the inhibition of proteins and genes associated with inflammatory signaling, including those associated with NFKB and STATS activation, but without altering the expression of steroid hormone receptors. Niclosamide can be effective in reducing the growth of endometrioid lesions in female mice without impairing their ability to become pregnant and without negative effect on gestation and offspring. The invention herein is useful in treating symptoms associated with endometriosis, such as reducing the growth of lesions of the endometrium, without disrupting normal reproductive function in females. The invention also relates to derivatives of niclosamide having improved solubility and enhanced efficacy.

    摘要翻译： 氯硝柳胺是用于治疗子宫内膜异位症的有效治疗药物。 氯硝柳胺治疗可以减少子宫内膜样病变的大小并减少病变中的细胞增殖。 氯硝柳胺治疗可导致抑制蛋白和与炎症信号相关的基因，包括与NFκB和STATS活化相关的那些，但不改变类固醇激素受体的表达。 氯硝柳胺可有效减少雌性小鼠子宫内膜样病变的生长，而不会损害其怀孕能力，并且对妊娠和后代没有负面影响。 本发明可用于治疗与子宫内膜异位症有关的症状，例如减少子宫内膜病变的生长，而不会中断女性的正常生殖功能。 本发明还涉及氯硝柳胺衍生物，其具有改善的溶解度和增强的功效。

    塩素濃度測定などに用いられるのに好適な新規化合物
    6.
    发明申请
    塩素濃度測定などに用いられるのに好適な新規化合物 审中-公开
    适用于氯离子浓度测量或类似方法的新型化合物

    公开(公告)号：WO2004083168A1

    公开(公告)日：2004-09-30

    申请号：PCT/JP2004/001634

    申请日：2004-02-16

    申请人： 株式会社同仁化学研究所 ,  坂本 亮 ,  堀口 大吉

    发明人： 坂本 亮 ,  堀口 大吉

    IPC分类号： C07C309/46

    CPC分类号： C07C309/46 ,  C02F2209/29 ,  C07C309/11 ,  G01N31/22 ,  G01N31/224

    摘要： A compound which has excellent solution stability and is suitable for use as, e.g., a reagent for measurement of the concentration of residual chlorine in water. This compound is represented by the following formula (II) or (III), wherein X is a group represented by the left side in the formula (I), in which the right side is X-. In the formula (I), R , R , R , and R each independently is selected among hydrogen, methyl, and methoxy; R and R each independently is selected among hydrogen and lower alkyls; and R , R , R , R , and R each independently is selected among hydrogen, sulfo, and sulfoalkoxy, provided that the alkyl chain of the sulfoalkoxy may have hydroxy added thereto.

    摘要翻译： 具有优异的溶液稳定性并适用于例如用于测量水中残余氯浓度的试剂的化合物。 该化合物由下式（II）或（III）表示，其中X为式（I）中左侧所示的基团，右侧为X-。 在式（I）中，R 1，R 2，R 3和R 4各自独立地选自氢，甲基和甲氧基; R 5和R 6各自独立地选自氢和低级烷基; R 7，R 8，R 9，R 10和R 11各自独立地选自氢，磺基和磺基烷氧基，条件是磺基烷氧基的烷基链可具有羟基， 于此。

    SELF-DOPED CONDUCTIVE POLYANILINES AND METHOD OF PREPARATION
    7.
    发明申请
    SELF-DOPED CONDUCTIVE POLYANILINES AND METHOD OF PREPARATION 审中-公开
    自导电导体聚苯胺及其制备方法

    公开(公告)号：WO1992019666A1

    公开(公告)日：1992-11-12

    申请号：PCT/FR1992000411

    申请日：1992-05-06

    申请人： ALCATEL N.V. ,  GALAJ, Stanislas ,  LE MEHAUTE, Alain

    发明人： ALCATEL N.V.

    IPC分类号： C08G73/02

    CPC分类号： C08G73/0266 ,  C07C303/32 ,  H01B1/128 ,  C07C309/10 ,  C07C309/11

    摘要： The invention discloses self-doped conductive polyanilines and a method for preparing them. The benzene and/or quinone rings of these polyanilines bear functionalized grafts, or substituants, corresponding to the formula: -A-Z where A is a hydrocarbon radical having 2 to 8 atoms interrupted by at least one hetero-atom, Z is a strong acid function or one of its salts.

    摘要翻译： 本发明公开了自掺杂导电聚苯胺及其制备方法。 这些聚苯胺的苯和/或醌环具有对应于下式的官能化接枝或取代基：-AZ其中A是具有至少一个杂原子间隔的2至8个原子的烃基，Z是强酸功能 或其盐之一。

    NOVEL SULFONIC ACID-CONTAINING THYROMIMETICS, AND METHODS FOR THEIR USE
    8.
    发明申请
    NOVEL SULFONIC ACID-CONTAINING THYROMIMETICS, AND METHODS FOR THEIR USE 审中-公开
    新型含硫酸的THYROMIMETICS及其使用方法

    公开(公告)号：WO2010093601A1

    公开(公告)日：2010-08-19

    申请号：PCT/US2010/023560

    申请日：2010-02-09

    申请人： METABASIS THERAPEUTICS, INC. ,  BOYER, Serge, H. ,  HECKER, Scott, J. ,  MALI, Venkat Reddy

    发明人： BOYER, Serge, H. ,  HECKER, Scott, J. ,  MALI, Venkat Reddy

    IPC分类号： C07C309/11 ,  C07C309/24 ,  C07C309/42 ,  A61K31/185 ,  A61P3/04 ,  A61P9/04

    CPC分类号： C07C309/24 ,  C07C309/11 ,  C07C309/42

    摘要： The present invention relates to sulfonic acid containing compounds of formula IB, in which G, R 1 , R 3 and T are as defined in the claims, that bind to thyroid receptors in the liver. Activation of these receptors results in modulation of gene expression of genes regulated by thyroid hormones. The compounds can be used to treat diseases and disorders including metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndrome X and diabetes.

    摘要翻译： 本发明涉及含有磺酸的式IB化合物，其中G，R 1，R 3和T如权利要求中所定义，其结合肝脏中的甲状腺受体。 这些受体的活化导致调节由甲状腺激素调节的基因的基因表达。 该化合物可用于治疗疾病和病症，包括代谢疾病如肥胖症，NASH，高胆固醇血症和高脂血症，以及相关病症如动脉粥样硬化，冠心病，葡萄糖耐量异常，代谢综合征X和糖尿病。

    ANION-EXCHANGE DISPLACEMENT CHROMATOGRAPHY PROCESS AND ANIONIC ORGANIC COMPOUNDS FOR USE AS DISPLACER COMPOUNDS IN ANION-EXCHANGE DISPLACEMENT CHROMATOGRAPHY PROCESS
    10.
    发明申请
    ANION-EXCHANGE DISPLACEMENT CHROMATOGRAPHY PROCESS AND ANIONIC ORGANIC COMPOUNDS FOR USE AS DISPLACER COMPOUNDS IN ANION-EXCHANGE DISPLACEMENT CHROMATOGRAPHY PROCESS 审中-公开
    阴离子交换色谱法和阴离子交换色谱法中用作离子化合物的阴离子有机化合物

    公开(公告)号：WO2007064809A2

    公开(公告)日：2007-06-07

    申请号：PCT/US2006045872

    申请日：2006-11-30

    申请人： SACHEM INC ,  LITTLE CHARLES J ,  HAYMORE BARRY L

    发明人： LITTLE CHARLES J ,  HAYMORE BARRY L

    IPC分类号： B01D15/42 ,  C07C309/32 ,  C07C309/34 ,  C07C309/38

    CPC分类号： B01D15/422 ,  B01D15/363 ,  C07C309/11 ,  C07C309/32 ,  C07C309/39 ,  C07C309/42 ,  C07C309/58 ,  C07C309/60 ,  C07C2603/26 ,  C07D251/70 ,  C07D263/57

    摘要： A displacement chromatography process, including: loading onto a stationary phase comprising an anion-exchange material a mixture comprising one or more component to be separated; displacing at least one of the one or more component from the stationary phase by applying to the stationary phase a mixture comprising an polyaromatic polyanionic displacer compound having a general formula Cen (Ar)w, in which Cen is a central bond or group, Ar is an aromatic nucleus, w = 2 to the maximum number of sites one Cen, and Ar is substituted with a plurality of An - , in which each An - is independently defined as sulfonate, carboxylate, phosphonate, phosphate, sulfate; and Ar is further substituted with a plurality of G, in which G is defined as independently H, C1-C6 alkyl, halogen, nitro, hydroxy, C1-C6 alkoxy In addition, a group of polyaromatic polyanionic displacer compounds useful in the process is disclosed.

    摘要翻译： 一种置换色谱方法，包括：将包含一种或多种待分离组分的混合物的包含阴离子交换材料的固定相载入; 通过向固定相施加包含具有通式Cen（Ar）w的多芳族聚阴离子置换剂化合物的混合物，其中Cen是中心键或基团，Ar是从固定相中取代一种或多种组分中的至少一种 一个芳香核，w = 2到最大数目的一个Cen，Ar被多个An取代，其中每个An -O - 独立地被定义为 磺酸盐，羧酸盐，膦酸盐，磷酸盐，硫酸盐; 并且Ar进一步被多个G取代，其中G独立地定义为H，C 1 -C 6烷基，卤素，硝基，羟基，C 1 -C 6烷氧基。另外，用于该方法的一组多芳族聚阴离子置换剂化合物是 披露。