公开(公告)号：WO2011072199A3

公开(公告)日：2012-02-02

申请号：PCT/US2010059832

申请日：2010-12-10

Applicant: SURMODICS INC ,  SWAN DALE G ,  ROLFES MEYERING EMILY ROSE ,  KURDYUMOV ALEKSEY V ,  DUQUETTE PETER H ,  HERGENROTHER ROBERT W ,  HEYER TONI M

Inventor： SWAN DALE G ,  ROLFES MEYERING EMILY ROSE ,  KURDYUMOV ALEKSEY V ,  DUQUETTE PETER H ,  HERGENROTHER ROBERT W ,  HEYER TONI M

IPC: G03F7/031 ,  C07C309/44 ,  C07C333/08 ,  C08F2/50 ,  G03F7/16

CPC classification number: G03F7/031 ,  C07C309/42 ,  C07C333/08 ,  C08F2/50 ,  G03F7/165

Abstract: Described herein is a degradable linking agent that includes a core molecule with one or more charged groups; and one or more photoreactive groups covalently attached to the core molecule by one or more degradable linkers.

Abstract translation: 本文描述的是可降解的连接剂，其包括具有一个或多个带电基团的核心分子; 和一个或多个可通过一个或多个可降解接头与核心分子共价连接的光反应基团。

公开(公告)号：WO2005115490A3

公开(公告)日：2006-02-09

申请号：PCT/US2005018452

申请日：2005-05-25

Applicant: SURMODICS INC ,  HEYER TONI M ,  SWAN DALE G ,  CHUDZIK STEPHEN J ,  CHINN JOSEPH A ,  CHAPPA RALPH A

Inventor： HEYER TONI M ,  SWAN DALE G ,  CHUDZIK STEPHEN J ,  CHINN JOSEPH A ,  CHAPPA RALPH A

IPC: A61L2/00 ,  A61L27/00 ,  A61L27/34 ,  A61L33/00 ,  B05D3/00

CPC classification number: A61L27/34 ,  A61L33/0029 ,  C08L33/06

Abstract: Polymeric coatings that include coupled biomolecules are formed on the surface of articles, such as medical devices. A coated layer that includes a synthetic polymer including a reactive group is formed on a surface and then a biomolecule is attached to the reactive group. The synthetic polymer can be an acrylate polymer or an amine-containing polymer having pendent photoreactive groups.

Abstract translation: 包括偶联的生物分子的聚合物涂层形成在诸如医疗装置的制品的表面上。 在表面上形成包括含有反应性基团的合成聚合物的涂层，然后将生物分子连接到反应性基团上。 合成聚合物可以是具有侧基光反应性基团的丙烯酸酯聚合物或含胺聚合物。

公开(公告)号：WO2011072199A2

公开(公告)日：2011-06-16

申请号：PCT/US2010/059832

申请日：2010-12-10

Applicant: SURMODICS, INC. ,  SWAN, Dale G. ,  ROLFES MEYERING, Emily Rose ,  KURDYUMOV, Aleksey V. ,  DUQUETTE, Peter H. ,  HERGENROTHER, Robert W. ,  HEYER, Toni M.

Inventor： SWAN, Dale G. ,  ROLFES MEYERING, Emily Rose ,  KURDYUMOV, Aleksey V. ,  DUQUETTE, Peter H. ,  HERGENROTHER, Robert W. ,  HEYER, Toni M.

IPC: G03F7/031

CPC classification number: G03F7/031 ,  C07C309/42 ,  C07C333/08 ,  C08F2/50 ,  G03F7/165

Abstract: Described herein is a degradable linking agent that includes a core molecule with one or more charged groups; and one or more photoreactive groups covalently attached to the core molecule by one or more degradable linkers.

Abstract translation: 本文描述的是可降解的连接剂，其包括具有一个或多个带电基团的核心分子; 和一个或多个可通过一个或多个可降解接头与核心分子共价连接的光反应基团。

公开(公告)号：WO2005115490A2

公开(公告)日：2005-12-08

申请号：PCT/US2005/018452

申请日：2005-05-25

Applicant: SURMODICS, INC. ,  HEYER, Toni, M. ,  SWAN, Dale, G. ,  CHUDZIK, Stephen, J. ,  CHINN, Joseph, A. ,  CHAPPA, Ralph, A.

Inventor： HEYER, Toni, M. ,  SWAN, Dale, G. ,  CHUDZIK, Stephen, J. ,  CHINN, Joseph, A. ,  CHAPPA, Ralph, A.

IPC: A61L27/00

CPC classification number: A61L27/34 ,  A61L33/0029 ,  C08L33/06

Abstract: Polymeric coatings that include coupled biomolecules are formed on the surface of articles, such as medical devices. A coated layer that includes a synthetic polymer including a reactive group is formed on a surface and then a biomolecule is attached to the reactive group. The synthetic polymer can be an acrylate polymer or an amine-containing polymer having pendent photoreactive groups.

Abstract translation: 包括偶联的生物分子的聚合物涂层形成在诸如医疗装置的制品的表面上。 在表面上形成包括含有反应性基团的合成聚合物的涂层，然后将生物分子连接到反应性基团上。 合成聚合物可以是具有侧基光反应性基团的丙烯酸酯聚合物或含胺聚合物。