公开(公告)号：WO2011072199A2

公开(公告)日：2011-06-16

申请号：PCT/US2010/059832

申请日：2010-12-10

Applicant: SURMODICS, INC. ,  SWAN, Dale G. ,  ROLFES MEYERING, Emily Rose ,  KURDYUMOV, Aleksey V. ,  DUQUETTE, Peter H. ,  HERGENROTHER, Robert W. ,  HEYER, Toni M.

Inventor： SWAN, Dale G. ,  ROLFES MEYERING, Emily Rose ,  KURDYUMOV, Aleksey V. ,  DUQUETTE, Peter H. ,  HERGENROTHER, Robert W. ,  HEYER, Toni M.

IPC: G03F7/031

CPC classification number: G03F7/031 ,  C07C309/42 ,  C07C333/08 ,  C08F2/50 ,  G03F7/165

Abstract: Described herein is a degradable linking agent that includes a core molecule with one or more charged groups; and one or more photoreactive groups covalently attached to the core molecule by one or more degradable linkers.

Abstract translation: 本文描述的是可降解的连接剂，其包括具有一个或多个带电基团的核心分子; 和一个或多个可通过一个或多个可降解接头与核心分子共价连接的光反应基团。

公开(公告)号：WO2010009122A1

公开(公告)日：2010-01-21

申请号：PCT/US2009/050535

申请日：2009-07-14

Applicant: SURMODICS, INC. ,  SLAGER, Joram ,  MCGONIGLE, Joseph, S. ,  ANDERSON, Aron, B. ,  HERGENROTHER, Robert, W.

Inventor： SLAGER, Joram ,  MCGONIGLE, Joseph, S. ,  ANDERSON, Aron, B. ,  HERGENROTHER, Robert, W.

IPC: A61F2/02 ,  A61K47/30 ,  A61K48/00 ,  A61L27/26 ,  A61L27/34 ,  A61L27/48 ,  A61L31/04 ,  A61L31/12

CPC classification number: A61L27/54 ,  A61K48/0041 ,  A61L27/34 ,  A61L2300/258 ,  A61L2300/606

Abstract: Embodiments of the invention include devices for the release of nucleic acids and related methods. In an embodiment, the invention includes an active agent eluting coating including a polymeric matrix, a cationic carrier agent disposed with the matrix, and an active agent disposed within the matrix, the active agent including nucleic acids substantially uncomplexed with the cationic carrier agent. In an embodiment, the invention includes a method of making an implantable medical device including selecting a concentration of a cationic carrier agent corresponding to a desired elution profile, combining a matrix forming polymer, an active agent, a solvent, and the cationic carrier agent to form a coating composition having the selected concentration of the cationic carrier agent, the active agent comprising nucleic acids, and depositing the coating composition onto the surface of a substrate. Other embodiments are included herein.

Abstract translation: 本发明的实施方案包括用于释放核酸的装置和相关方法。 在一个实施方案中，本发明包括活性剂洗脱涂层，其包括聚合物基质，与基质一起布置的阳离子载体剂和置于基质内的活性剂，所述活性剂包括与阳离子载体试剂基本上未复合的核酸。 在一个实施方案中，本发明包括制备可植入医疗装置的方法，包括选择对应于所需洗脱曲线的阳离子载体试剂的浓度，将形成基质的聚合物，活性剂，溶剂和阳离子载体试剂组合到 形成具有选定浓度的阳离子载体试剂，活性剂包含核酸并将该涂料组合物沉积在基材表面上的涂料组合物。 本文还包括其它实施例。

公开(公告)号：WO2008103668A3

公开(公告)日：2008-08-28

申请号：PCT/US2008/054297

申请日：2008-02-19

Applicant: SURMODICS, INC. ,  JELLE, Bruce, M. ,  MACKLIN, Sara ,  HERGENROTHER, Robert, W.

Inventor： JELLE, Bruce, M. ,  MACKLIN, Sara ,  HERGENROTHER, Robert, W.

IPC: B05D7/00

Abstract: The present invention relates to coating systems and coating systems on substrates. In an embodiment, the invention includes an article including a substrate, a base layer disposed on the substrate, the base layer comprising a silane compound with a photoreactive group, or the reaction product of a silane compound with a photoreactive group, and a polymer layer disposed on the base layer, the polymer layer comprising a polymer terminally anchored to the base layer. In an embodiment, the invention includes a coating for an article. In an embodiment, the invention includes a method of depositing a coating onto a substrate.

公开(公告)号：WO2007025059A1

公开(公告)日：2007-03-01

申请号：PCT/US2006/033109

申请日：2006-08-24

Applicant: SURMODICS, INC. ,  HERGENROTHER, Robert W. ,  JELLE, Bruce M.

Inventor： HERGENROTHER, Robert W. ,  JELLE, Bruce M.

IPC: C23C26/00 ,  A61L31/10 ,  C08L65/04

CPC classification number: C23C26/00 ,  A61L27/18 ,  B05D1/38 ,  B05D1/60 ,  B05D3/067 ,  B05D3/107 ,  B05D7/54 ,  C09D165/04 ,  Y10T428/31504 ,  Y10T428/31507 ,  Y10T428/31551 ,  Y10T428/31663 ,  Y10T428/31931 ,  Y10T428/31935 ,  C08L83/04

Abstract: The invention relates to coating systems having one or more hydrophobic layers bonded to a substrate with a silane composition and methods of making and using the same. In an embodiment, the invention includes an article having a substrate, a base coating layer covalently bonded to the surface of the substrate and a hydrophobic polymer layer disposed on the base coating layer. In an embodiment, the invention includes a method for forming an article including applying a base layer coating solution onto a substrate to form a base layer, applying a hydrophobic polymer layer onto the base layer, and applying actinic energy to the substrate.

Abstract translation: 本发明涉及具有一个或多个用硅烷组合物结合到基底上的疏水层的涂料体系及其制备和使用方法。 在一个实施方案中，本发明包括具有基底，共价结合到基底表面的基底涂层和设置在基底涂层上的疏水性聚合物层的制品。 在一个实施方案中，本发明包括一种用于形成制品的方法，包括将基底涂层溶液施加到基底上以形成基底层，在基底层上施加疏水性聚合物层，以及向基底施加光化能。

公开(公告)号：WO2003105920A1

公开(公告)日：2003-12-24

申请号：PCT/US2003/019343

申请日：2003-06-18

Applicant: SURMODICS, INC. ,  CHUDZIK, Stephen, J. ,  KLOKE, Timothy, M. ,  LAWIN, Laurie, R. ,  OFSTEAD, Ronald, F. ,  CHAPPA, Ralph, A. ,  HERGENROTHER, Robert, W. ,  ANDERSON, Aron, B. ,  TRAN, Linh, V.

Inventor： CHUDZIK, Stephen, J. ,  KLOKE, Timothy, M. ,  LAWIN, Laurie, R. ,  OFSTEAD, Ronald, F. ,  CHAPPA, Ralph, A. ,  HERGENROTHER, Robert, W. ,  ANDERSON, Aron, B. ,  TRAN, Linh, V.

IPC: A61L27/34

CPC classification number: A61L31/16 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/606 ,  C08L33/06

Abstract: A coating composition, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a combination of a first polymer component such as polyalyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).

Abstract translation: 涂料组合物以及在受控湿度条件下施用这种组合物的方法，用于涂覆装置表面以控制和/或提高其在水性体系中释放生物活性剂的能力。 涂料组合物特别适用于在其递送和/或使用过程中经历显着弯曲和/或膨胀的医疗装置，例如支架和导管。 组合物包括与第一聚合物组分如（甲基）丙烯酸聚芳酯，（甲基）丙烯酸聚芳酯，（甲基）丙烯酸聚烷基酯或（甲基）丙烯酰氧基烷基酯）和第二聚合物组分如聚 （乙烯 - 共 - 乙酸乙烯酯）。

公开(公告)号：WO2008003043A3

公开(公告)日：2009-02-12

申请号：PCT/US2007072357

申请日：2007-06-28

Applicant: SURMODICS INC ,  CHAPPA RALPH A ,  HERGENROTHER ROBERT W ,  BUSHENDORF PAULA ,  SLAGER JORAM

Inventor： CHAPPA RALPH A ,  HERGENROTHER ROBERT W ,  BUSHENDORF PAULA ,  SLAGER JORAM

IPC: A61L27/26 ,  A61L27/34 ,  A61L27/48 ,  A61L31/04 ,  A61L31/12

CPC classification number: A61L27/58 ,  A61L27/48 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/256 ,  A61L2300/604 ,  C08L23/0853 ,  C08L23/0869 ,  C08L33/08 ,  C08L71/02 ,  C08L2201/06 ,  C08L2666/22

Abstract: The present invention relates to combination degradable and non- degradable matrices and related methods. In an embodiment, the invention includes an active agent delivery matrix including a degradable polymer network, a non-degradable polymer network, the non-degradable polymer network interspersed within the degradable polymer network, and an active agent. In an embodiment, the invention includes an active agent elution control matrix including a degradable polymer; and a non-degradable polymer interspersed with the degradable polymer. In an embodiment, the invention includes a method of making an active agent delivery matrix including mixing a degradable polymer with a first solvent to form a degradable polymer solution; mixing a non-degradable polymer with a second solvent to form a non-degradable polymer solution; and simultaneously depositing the degradable polymer solution and the non-degradable polymer solution onto a substrate.

Abstract translation: 本发明涉及可降解和不可降解的组合和相关方法。 在一个实施方案中，本发明包括活性剂递送基质，其包括可降解聚合物网络，不可降解聚合物网络，散布在可降解聚合物网络内的不可降解聚合物网络和活性剂。 在一个实施方案中，本发明包括包含可降解聚合物的活性剂洗脱控制基质; 和散布有可降解聚合物的不可降解聚合物。 在一个实施方案中，本发明包括制备活性剂递送基质的方法，包括将可降解聚合物与第一溶剂混合以形成可降解聚合物溶液; 将不可降解的聚合物与第二溶剂混合以形成不可降解的聚合物溶液; 同时将可降解聚合物溶液和不可降解聚合物溶液沉积在基材上。

公开(公告)号：WO2008003043A2

公开(公告)日：2008-01-03

申请号：PCT/US2007/072357

申请日：2007-06-28

Applicant: SURMODICS, INC. ,  CHAPPA, Ralph, A. ,  HERGENROTHER, Robert, W. ,  BUSHENDORF, Paula ,  SLAGER, Joram

Inventor： CHAPPA, Ralph, A. ,  HERGENROTHER, Robert, W. ,  BUSHENDORF, Paula ,  SLAGER, Joram

IPC: A61K9/00 ,  A61L27/48 ,  A61L27/54 ,  A61L27/58 ,  C08L33/06

CPC classification number: A61L27/58 ,  A61L27/48 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/256 ,  A61L2300/604 ,  C08L23/0853 ,  C08L23/0869 ,  C08L33/08 ,  C08L71/02 ,  C08L2201/06 ,  C08L2666/22

Abstract: The present invention relates to relates to combination degradable and non- degradable matrices and related methods. In an embodiment, the invention includes an active agent delivery matrix including a degradable polymer network, a non-degradable polymer network, the non-degradable polymer network interspersed within the degradable polymer network, and an active agent. In an embodiment, the invention includes an active agent elution control matrix including a degradable polymer; and a non-degradable polymer interspersed with the degradable polymer. In an embodiment, the invention includes a method of making an active agent delivery matrix including mixing a degradable polymer with a first solvent to form a degradable polymer solution; mixing a non-degradable polymer with a second solvent to form a non-degradable polymer solution; and simultaneously depositing the degradable polymer solution and the non-degradable polymer solution onto a substrate.

Abstract translation: 本发明涉及可降解和不可降解的组合和相关方法。 在一个实施方案中，本发明包括活性剂递送基质，其包括可降解聚合物网络，不可降解聚合物网络，散布在可降解聚合物网络内的不可降解聚合物网络和活性剂。 在一个实施方案中，本发明包括包含可降解聚合物的活性剂洗脱控制基质; 和散布有可降解聚合物的不可降解聚合物。 在一个实施方案中，本发明包括制备活性剂递送基质的方法，包括将可降解聚合物与第一溶剂混合以形成可降解聚合物溶液; 将不可降解的聚合物与第二溶剂混合以形成不可降解的聚合物溶液; 同时将可降解聚合物溶液和不可降解聚合物溶液沉积在基材上。

公开(公告)号：WO2008103668A2

公开(公告)日：2008-08-28

申请号：PCT/US2008054297

申请日：2008-02-19

Applicant: SURMODICS INC ,  JELLE BRUCE M ,  MACKLIN SARA ,  HERGENROTHER ROBERT W

Inventor： JELLE BRUCE M ,  MACKLIN SARA ,  HERGENROTHER ROBERT W

IPC: B05D7/00

CPC classification number: C08J7/047 ,  B05D1/185 ,  B05D3/065 ,  B05D3/067 ,  B05D7/52 ,  B82Y30/00 ,  B82Y40/00 ,  C08J2483/00 ,  Y10T428/31663

Abstract: The present invention relates to coating systems and coating systems on substrates. In an embodiment, the invention includes an article including a substrate, a base layer disposed on the substrate, the base layer comprising a silane compound with a photoreactive group, or the reaction product of a silane compound with a photoreactive group, and a polymer layer disposed on the base layer, the polymer layer comprising a polymer terminally anchored to the base layer. In an embodiment, the invention includes a coating for an article. In an embodiment, the invention includes a method of depositing a coating onto a substrate.

Abstract translation: 本发明涉及基材上的涂料体系和涂料体系。 在一个实施方案中，本发明包括一种制品，其包括基材，设置在基材上的基层，包含具有光反应性基团的硅烷化合物的基层或硅烷化合物与光反应性基团的反应产物，以及聚合物层 设置在基底层上，聚合物层包含末端固定在基底层上的聚合物。 在一个实施方案中，本发明包括用于制品的涂层。 在一个实施方案中，本发明包括在基材上沉积涂层的方法。

公开(公告)号：WO2006002366A3

公开(公告)日：2006-03-16

申请号：PCT/US2005022456

申请日：2005-06-24

Applicant: SURMODICS INC ,  VARNER SIGNE E ,  GUIRE PATRICK E ,  TATON KRISTIN S ,  WEN JIE ,  BEELEY NATHAN R F ,  LAWIN LAURIE R ,  HERGENROTHER ROBERT W ,  CHAPPA RALPH C ,  ANDERSON ARON B

Inventor： VARNER SIGNE E ,  GUIRE PATRICK E ,  TATON KRISTIN S ,  WEN JIE ,  BEELEY NATHAN R F ,  LAWIN LAURIE R ,  HERGENROTHER ROBERT W ,  CHAPPA RALPH C ,  ANDERSON ARON B

IPC: A61L31/06 ,  A61F2/14 ,  A61F9/00 ,  A61K9/00

CPC classification number: A61K9/0051 ,  A61F9/0017 ,  A61F2210/0004 ,  A61L31/06 ,  C08L67/025

Abstract: The invention provides implantable medical devices that are fabricated of biodegradable materials for delivery of bioactive agent to limited access regions of a patient's body, such as the eye. The invention further provides methods of treatment utilizing the devices.

Abstract translation: 本发明提供了由生物可降解材料制成的用于将生物活性剂递送至患者身体的有限接入区域（例如眼睛）的可植入医疗装置。 本发明进一步提供了利用这些装置的治疗方法。

公开(公告)号：WO2003105918A1

公开(公告)日：2003-12-24

申请号：PCT/US2003/019249

申请日：2003-06-18

Applicant: SURMODICS, INC. ,  LAWIN, Laurie, R. ,  OFSTEAD, Ronald, F. ,  CHAPPA, Ralph, A. ,  HERGENROTHER, Robert, W. ,  ANDERSON, Aron, B. ,  TRAN, Linh, V.

Inventor： LAWIN, Laurie, R. ,  OFSTEAD, Ronald, F. ,  CHAPPA, Ralph, A. ,  HERGENROTHER, Robert, W. ,  ANDERSON, Aron, B. ,  TRAN, Linh, V.

IPC: A61L27/26

CPC classification number: A61L31/16 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/602 ,  A61L2300/606 ,  C08L33/08

Abstract: A coating composition, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a combination of a first polymer component such as polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).

Abstract translation: 涂料组合物以及在受控湿度条件下施用这种组合物的方法，用于涂覆装置表面以控制和/或提高其在水性体系中释放生物活性剂的能力。 涂料组合物特别适用于在其递送和/或使用过程中经历显着弯曲和/或膨胀的医疗装置，例如支架和导管。 该组合物包括与第一聚合物组分如（甲基）丙烯酸聚芳酯，（甲基）丙烯酸聚烷基酯或（甲基）丙烯酰氧基烷基酯）和第二聚合物组分如聚（乙烯 - 共 - 乙烯基） 乙酸盐）。