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公开(公告)号：WO2011072199A3
公开(公告)日：2012-02-02
申请号：PCT/US2010059832
申请日：2010-12-10
Applicant: SURMODICS INC , SWAN DALE G , ROLFES MEYERING EMILY ROSE , KURDYUMOV ALEKSEY V , DUQUETTE PETER H , HERGENROTHER ROBERT W , HEYER TONI M
Inventor： SWAN DALE G , ROLFES MEYERING EMILY ROSE , KURDYUMOV ALEKSEY V , DUQUETTE PETER H , HERGENROTHER ROBERT W , HEYER TONI M
IPC: G03F7/031 , C07C309/44 , C07C333/08 , C08F2/50 , G03F7/16
CPC classification number: G03F7/031 , C07C309/42 , C07C333/08 , C08F2/50 , G03F7/165
Abstract: Described herein is a degradable linking agent that includes a core molecule with one or more charged groups; and one or more photoreactive groups covalently attached to the core molecule by one or more degradable linkers.
Abstract translation: 本文描述的是可降解的连接剂，其包括具有一个或多个带电基团的核心分子; 和一个或多个可通过一个或多个可降解接头与核心分子共价连接的光反应基团。
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公开(公告)号：WO2011123441A1
公开(公告)日：2011-10-06
申请号：PCT/US2011/030319
申请日：2011-03-29
Applicant: SURMODICS, INC. , KURDYUMOV, Aleksey V. , SWAN, Dale G.
Inventor： KURDYUMOV, Aleksey V. , SWAN, Dale G.
CPC classification number: C09D7/63 , A61L17/145 , A61L27/34 , A61L29/085 , A61L31/10 , A61L2400/18 , A61L2420/02 , C07F7/10 , C07F7/1804 , C07F7/184 , C07F9/06 , C07F9/12 , C07F9/145 , C07F9/4025 , C07F9/4084 , C08F2/48 , C08K5/51 , C08K5/5419 , C08K5/544 , C09D7/1233
Abstract: Described herein is a degradable linking agent of formula Photo 1 -LG-Photo 2 , wherein Photo 1 and Photo 2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.
Abstract translation: 本文描述了分子式为Photo1-LG-Photo2的可降解连接剂，其中Photo1和Photo2独立地表示至少一个光反应性基团，LG代表包含一个或多个硅原子或一个或多个磷原子的连接基团。 可降解交联剂包括至少一个光反应基团和连接基团之间的共价键，其中至少一个光反应基团和连接基团之间的共价键被至少一个杂原子中断。 还描述了用可降解的连接剂，涂覆的支撑表面和医疗装置涂覆支撑表面的方法。
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公开(公告)号：WO2011072199A2
公开(公告)日：2011-06-16
申请号：PCT/US2010/059832
申请日：2010-12-10
Applicant: SURMODICS, INC. , SWAN, Dale G. , ROLFES MEYERING, Emily Rose , KURDYUMOV, Aleksey V. , DUQUETTE, Peter H. , HERGENROTHER, Robert W. , HEYER, Toni M.
Inventor： SWAN, Dale G. , ROLFES MEYERING, Emily Rose , KURDYUMOV, Aleksey V. , DUQUETTE, Peter H. , HERGENROTHER, Robert W. , HEYER, Toni M.
IPC: G03F7/031
CPC classification number: G03F7/031 , C07C309/42 , C07C333/08 , C08F2/50 , G03F7/165
Abstract: Described herein is a degradable linking agent that includes a core molecule with one or more charged groups; and one or more photoreactive groups covalently attached to the core molecule by one or more degradable linkers.
Abstract translation: 本文描述的是可降解的连接剂，其包括具有一个或多个带电基团的核心分子; 和一个或多个可通过一个或多个可降解接头与核心分子共价连接的光反应基团。
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4.发明申请HYDROPHOBIC POLYSACCHARIDES WITH SILYL ETHER LINKAGES HAVING ENHANCED DEGRADATION AND MEDICAL ARTICLES MADE THEREFROM 审中-公开具有增强降解的SILYL以及其他链接的疏水性多糖与其制成的医学文章
公开(公告)号：WO2011041517A1
公开(公告)日：2011-04-07
申请号：PCT/US2010/050871
申请日：2010-09-30
Applicant: SURMODICS, INC. , KURDYUMOV, Aleksey, V.
Inventor： KURDYUMOV, Aleksey, V.
IPC: A61L27/20 , A61L29/14 , A61L27/34 , A61L31/04 , A61L27/58 , A61L31/10 , A61L29/04 , A61L31/14 , A61L29/08
CPC classification number: A61L29/043 , A61L15/28 , A61L27/20 , A61L31/042 , C08L5/00
Abstract: Hydrophobic α(1→4)glucopyranose polymers with enhanced degradation properties are described. Between the α(1→4)glucopyranose polymeric portion and the hydrophobic portion exists a linker portion having a silyl ether chemistry that facilitates degradation of the polymer. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo at an increased rate. Matrices including and capable of releasing a bioactive agent in vivo are also described.
Abstract translation: 描述了具有增强的降解性质的疏水性（1→4）吡喃葡萄糖聚合物。 在（1→4）吡喃葡萄糖聚合物部分和疏水部分之间存在具有促进聚合物降解的甲硅烷基醚化学性质的接头部分。 可以由这些聚合物形成可生物降解的基质，并且该基质可用于制备可植入和可注射的医疗装置，其中基质能够以增加的速率在体内降解。 还描述了包括和能够在体内释放生物活性剂的基质。
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公开(公告)号：WO2012170706A2
公开(公告)日：2012-12-13
申请号：PCT/US2012/041381
申请日：2012-06-07
Applicant: SurModics, Inc. , SWAN, Dale G. , KURDYUMOV, Aleksey V. , JELLE, Bruce M.
Inventor： SWAN, Dale G. , KURDYUMOV, Aleksey V. , JELLE, Bruce M.
CPC classification number: C09D4/00 , A61L27/34 , A61L27/50 , A61L29/085 , A61L29/14 , A61L31/10 , A61L31/14 , A61L2420/02 , C07F9/4078 , C08J7/16 , Y10T428/31938
Abstract: Embodiments of the invention include linking agents including photo groups and vinyl groups and coatings and devices that incorporate such linking agents, along with related methods. Exemplary methods herein include methods of priming substrates and methods of coating substrates using compounds having the formula R 1 - X - R 2 , wherein R 1 is a radical comprising a vinyl group, X is a radical comprising from about one to about twenty carbon atoms, and R 2 is a radical comprising a photoreactive group. Embodiments herein also include linking agents having the formula R 1 - X - R 2 , wherein R 1 is a radical comprising a vinyl group, X is a radical comprising from about one to about twenty carbon atoms, and R 2 is a radical comprising a photoreactive group. Other embodiments are also included herein.
Abstract translation: 本发明的实施方案包括包括光学基团和乙烯基的连接剂以及包含这种连接剂的涂层和装置以及相关方法。 本文的示例性方法包括引发底物的方法和使用具有式R1-X-R2的化合物涂覆底物的方法，其中R 1是包含乙烯基的基团，X是包含约1至约20个碳原子的基团，R 2 是包含光反应性基团的基团。 本文的实施方案还包括具有式R 1 -X-R 2的连接剂，其中R 1是包含乙烯基的基团，X是包含约1至约20个碳原子的基团，R 2是包含光反应性基团的基团。 本文还包括其它实施例。
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Patent Agency Ranking6.发明申请SILYL ETHER-MODIFIED HYDROPHILIC POLYMERS AND USES FOR MEDICAL ARTICLES 审中-公开SILYL改性水解聚合物及其用于医疗文章的用途
公开(公告)号：WO2011082296A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/062489
申请日：2010-12-30
Applicant: SURMODICS, INC. , KURDYUMOV, Aleksey, V. , HERGENROTHER, Robert , JELLE, Bruce, M.
Inventor： KURDYUMOV, Aleksey, V. , HERGENROTHER, Robert , JELLE, Bruce, M.
CPC classification number: C09D201/10 , A61L29/085 , A61L2400/10 , C09D143/04 , C08L101/10 , C08L39/06
Abstract: Silane-functionalized hydrophilic polymers and polymeric matrices are described. Hydrophilic matrices can be formed from the polymers, and can be used in association with the preparation of implantable and injectable medical devices. Exemplary devices include those having a durable lubricious coating formed from the hydrophilic polymers.
Abstract translation: 描述了硅烷官能化的亲水聚合物和聚合物基质。 亲水基质可以由聚合物形成，并且可以与可植入和可注射的医疗装置的制备相结合使用。 示例性的装置包括具有由亲水性聚合物形成的耐久润滑涂层的装置。
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7.发明申请SILANE-FUNCTIONALIZED HYDROPHOBIC a(1→4)GLUCOPYRANOSE POLYMERS AND POLYMERIC MATRICES FOR IMPLANTATION OR INJECTION 审中-公开硅烷官能化的疏水性（1→4）葡聚糖聚合物和用于植入或注射的聚合物
公开(公告)号：WO2010141553A1
公开(公告)日：2010-12-09
申请号：PCT/US2010/037027
申请日：2010-06-02
Applicant: SURMODICS, INC. , KURDYUMOV, Aleksey, V. , LOCKWOOD, Nathan, A. , SLAGER, Joram , SWAN, Dale, G. , HERGENROTHER, Robert
Inventor： KURDYUMOV, Aleksey, V. , LOCKWOOD, Nathan, A. , SLAGER, Joram , SWAN, Dale, G. , HERGENROTHER, Robert
CPC classification number: C08B37/0009 , C08B31/12 , C08B33/04 , C08B37/0012
Abstract: Silane-functionalized hydrophobic a(1→4)glucopyranose polymers and polymeric matrices are described. Biodegradable matrices can be formed from hydrophobic a(1→4)glucopyranose polymers with reactive pendent silyl ether groups. Reaction of the silyl ether groups provides improved matrix formation through bonding to a device surface of a device, polymer-polymer crosslinking, or both. Biodegradable matrices can be used for the preparation of implantable and injectable medical devices, including those that release a bioactive agent.
Abstract translation: 描述了硅烷官能化的疏水性（1→4）吡喃葡萄糖聚合物和聚合物基质。 可生物降解的基质可由疏水性（1→4）吡喃葡萄糖聚合物与反应性侧挂甲硅烷基基团形成。 甲硅烷基醚基团的反应通过结合到器件的器件表面，聚合物 - 聚合物交联或两者来提供改进的基质形成。 可生物降解基质可用于制备可植入和可注射的医疗器械，包括那些释放生物活性剂的医疗器械。
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公开(公告)号：WO2014004512A1
公开(公告)日：2014-01-03
申请号：PCT/US2013/047623
申请日：2013-06-25
Applicant: SURMODICS, INC. , EASTENSON, Kyle , KURDYUMOV, Aleksey V. , DUMEZ, Darin , WORMUTH, Klaus
Inventor： EASTENSON, Kyle , KURDYUMOV, Aleksey V. , DUMEZ, Darin , WORMUTH, Klaus
CPC classification number: A61L31/10 , A61K47/6957 , A61L27/18 , A61L27/34 , A61L27/52 , A61L27/54 , A61L27/58 , A61L31/06 , A61L31/145 , A61L31/148 , A61L31/16 , A61L2400/06 , C08G69/40 , C08G69/44 , C08L77/06 , C08L77/12
Abstract: Bioerodable poly(etheresteramides) and matrices formed therefrom, such as medical device coatings, are described. The matrices show desirable erosion properties desirable for therapeutic use. The matrices can include a bioactive agent which can be used to treat medical conditions.
Abstract translation: 描述了由生物可侵蚀的聚（醚醚酰胺）和由其形成的基质，例如医疗器械涂层。 基质显示理想的治疗用途所需的侵蚀性质。 基质可包括可用于治疗医疗状况的生物活性剂。
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9.发明申请HYDROPHILIC POLYMERIC COATINGS FOR MEDICAL ARTICLES WITH VISUALIZATION MOIETY 审中-公开用于视觉化的医学文章的水性聚合物涂料
公开(公告)号：WO2013151991A1
公开(公告)日：2013-10-10
申请号：PCT/US2013/034937
申请日：2013-04-02
Applicant: SURMODICS, INC. , LOCKWOOD, Nathan A. , JELLE, Bruce M. , KURDYUMOV, Aleksey V.
Inventor： LOCKWOOD, Nathan A. , JELLE, Bruce M. , KURDYUMOV, Aleksey V.
CPC classification number: C09D5/22 , A61L29/085 , A61L29/14 , A61L29/18 , A61L2420/02 , B05D3/067 , C09D5/00 , Y10T428/31725 , Y10T428/31938 , C08L39/06
Abstract: The invention is directed to medical device coatings, such as coated guidewires and catheters, containing a visualization moiety providing color to the coating in ambient or applied light. The coating allows for visual or machine inspection of coating properties such as uniformity of coverage. In some embodiments the coatings include the visualization moiety and an activated UV photogroup, which is used to provide covalent bonding in the coating. The visualization moiety can be in particulate form and entrained in the coating, or can be covalently bonded to the hydrophilic polymer backbone. In other embodiments the visualization moiety includes a stilbene chemical group. Exemplary coatings include a hydrophilic vinyl pyrrolidone polymer, which can provide lubricity to the device surface, along with the colored properties.
Abstract translation: 本发明涉及医疗器械涂层，例如涂覆的导线和导管，其包含在环境或应用光下为涂层提供颜色的可视化部分。 涂层允许对涂层性能进行视觉或机器检查，例如覆盖的均匀性。 在一些实施方案中，涂层包括可视化部分和活化的UV光电子组，其用于在涂层中提供共价键合。 可视化部分可以是颗粒形式并夹带在涂层中，或者可以共价键合到亲水性聚合物主链上。 在其它实施方案中，可视化部分包括茋化学基团。 示例性涂层包括亲水性乙烯基吡咯烷酮聚合物，其可以提供对器件表面的润滑性以及着色性质。
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公开(公告)号：WO2012170706A3
公开(公告)日：2013-04-25
申请号：PCT/US2012041381
申请日：2012-06-07
Applicant: SURMODICS INC , SWAN DALE G , KURDYUMOV ALEKSEY V , JELLE BRUCE M
Inventor： SWAN DALE G , KURDYUMOV ALEKSEY V , JELLE BRUCE M
CPC classification number: C09D4/00 , A61L27/34 , A61L27/50 , A61L29/085 , A61L29/14 , A61L31/10 , A61L31/14 , A61L2420/02 , C07F9/4078 , C08J7/16 , Y10T428/31938
Abstract: Embodiments of the invention include linking agents including photo groups and vinyl groups and coatings and devices that incorporate such linking agents, along with related methods. Exemplary methods herein include methods of priming substrates and methods of coating substrates using compounds having the formula R1 - X - R2, wherein R1 is a radical comprising a vinyl group, X is a radical comprising from about one to about twenty carbon atoms, and R2 is a radical comprising a photoreactive group. Embodiments herein also include linking agents having the formula R1 - X - R2, wherein R1 is a radical comprising a vinyl group, X is a radical comprising from about one to about twenty carbon atoms, and R2 is a radical comprising a photoreactive group. Other embodiments are also included herein.
Abstract translation: 本发明的实施方案包括包括光学基团和乙烯基的连接剂以及包含这种连接剂的涂层和装置以及相关方法。 本文的示例性方法包括引发底物的方法和使用具有式R1-X-R2的化合物涂覆底物的方法，其中R 1是包含乙烯基的基团，X是包含约1至约20个碳原子的基团，R 2 是包含光反应性基团的基团。 本文的实施方案还包括具有式R1-X-R2的连接剂，其中R 1是包含乙烯基的基团，X是包含约1至约20个碳原子的基团，R 2是包含光反应性基团的基团。 本文还包括其它实施例。
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