公开(公告)号：WO2007149571A3

公开(公告)日：2008-06-26

申请号：PCT/US2007014618

申请日：2007-06-21

Applicant: SECOND SIGHT MEDICAL PROD INC ,  GREENBERG ROBERT J ,  TALBOT NEIL HAMILTON ,  NEYSMITH JORDAN ,  LITTLE JAMES S ,  MECH BRIAN V

Inventor： GREENBERG ROBERT J ,  TALBOT NEIL HAMILTON ,  NEYSMITH JORDAN ,  LITTLE JAMES S ,  MECH BRIAN V

IPC: A61N1/05

CPC classification number: A61N1/0543 ,  A61N1/36046 ,  H05K1/118 ,  H05K3/0014 ,  Y10T29/49002 ,  Y10T29/49117 ,  Y10T29/49155 ,  Y10T29/49156 ,  Y10T29/49158 ,  Y10T29/49174 ,  Y10T29/49176

Abstract: The present invention provides a flexible circuit electrode array adapted for neural stimulation, comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces at least one tack opening; wherein said polymer base layer, said metal traces and said polymer top layer are thermoformed in a three dimensional shape. The present invention provides further a method of making a flexible circuit electrode array comprising depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; preparing at least one tack opening; and heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array.

Abstract translation: 本发明提供了一种适用于神经刺激的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属迹线，包括适于刺激神经组织的电极; 沉积在所述聚合物基层上的聚合物顶层，并且所述金属跟踪至少一个开口; 其中所述聚合物基层，所述金属迹线和所述聚合物顶层以三维形状热成形。 本发明进一步提供一种制造柔性电路电极阵列的方法，该方法包括沉积聚合物基层; 在所述聚合物基底层上沉积金属; 图案化所述金属以形成金属迹线; 在所述聚合物基底层和所述金属迹线上沉积聚合物顶层; 准备至少一个平头开口; 以及在模具中加热所述柔性电路电极阵列以在所述柔性电路电极阵列中形成三维形状。

公开(公告)号：WO2007149571A2

公开(公告)日：2007-12-27

申请号：PCT/US2007/014618

申请日：2007-06-21

Applicant: SECOND SIGHT MEDICAL PRODUCTS, INC. ,  GREENBERG, Robert, J. ,  TALBOT, Neil, Hamilton ,  NEYSMITH, Jordan ,  LITTLE, James, S. ,  MECH, Brian, V.

Inventor： GREENBERG, Robert, J. ,  TALBOT, Neil, Hamilton ,  NEYSMITH, Jordan ,  LITTLE, James, S. ,  MECH, Brian, V.

CPC classification number: A61N1/0543 ,  A61N1/36046 ,  H05K1/036 ,  H05K1/0393 ,  H05K1/118 ,  H05K3/0014 ,  H05K2201/05 ,  H05K2201/053 ,  H05K2201/09063 ,  H05K2201/09409 ,  Y10T29/49002 ,  Y10T29/49117 ,  Y10T29/49155 ,  Y10T29/49156 ,  Y10T29/49158 ,  Y10T29/49174 ,  Y10T29/49176

Abstract: The present invention provides a flexible circuit electrode array adapted for neural stimulation, comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces at least one tack opening; wherein said polymer base layer, said metal traces and said polymer top layer are thermoformed in a three dimensional shape. The present invention provides further a method of making a flexible circuit electrode array comprising depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; preparing at least one tack opening; and heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array.

Abstract translation: 本发明提供一种适用于神经刺激的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基层上的聚合物顶层和所述金属迹线至少一个粘性开口; 其中所述聚合物基层，所述金属迹线和所述聚合物顶层被热成型为三维形状。 本发明还提供一种制造柔性电路电极阵列的方法，包括沉积聚合物基层; 在所述聚合物基层上沉积金属; 图案化所述金属以形成金属痕迹; 在所述聚合物基底层和所述金属迹线上沉积聚合物顶层; 准备至少一个开口; 并将所述柔性电路电极阵列加热到模具中，以在所述柔性电路电极阵列中形成三维形状。

公开(公告)号：WO2007149465A3

公开(公告)日：2007-12-27

申请号：PCT/US2007/014332

申请日：2007-06-19

Applicant: SECOND SIGHT MEDICAL PRODUCTS, INC. ,  ZHOU, Dao, Min ,  OK, Jerry ,  TALBOT, Neil, Hamilton ,  MECH, Brian, V. ,  LITTLE, James ,  GREENBERG, Robert, J.

Inventor： ZHOU, Dao, Min ,  OK, Jerry ,  TALBOT, Neil, Hamilton ,  MECH, Brian, V. ,  LITTLE, James ,  GREENBERG, Robert, J.

IPC: A61N1/05 ,  A61N1/36

Abstract: The present invention provides an implantable electrode with increased stability having a clustered structure wherein the surface of the electrode is covered with a material comprising openings which are filled with sticks or posts. The present invention provides an implantable electrode with increased stability wherein the surface is of the electrode comprises mesh grids which are filled with sticks which are filed with a conducting or insulating material. The present invention provides a method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying photoresist layer on the metal layer; patterning the photoresist layer providing openings; electroplating the openings with metal; removing the photoresist layer leaving spaces; and filling the spaces with polymer. The present invention provides a method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying a polymer layer on the metal layer; applying photoresist layer on the polymer layer; patterning the photoresist layer providing openings; electroplating the openings with metal; and removing the photoresist layer.

公开(公告)号：WO2006116765A2

公开(公告)日：2006-11-02

申请号：PCT/US2006016655

申请日：2006-04-28

Applicant: SECOND SIGHT MEDICAL PROD INC ,  GREENBERG ROBERT JAY ,  TALBOT NEIL ,  NEYSMITH JORDAN ,  LITTLE JAMES S ,  MECH BRIAN V ,  HUMAYAN MARK ,  GUVEN DILEK ,  RIPLEY ANN MARIE DE MERLIER

Inventor： GREENBERG ROBERT JAY ,  TALBOT NEIL ,  NEYSMITH JORDAN ,  LITTLE JAMES S ,  MECH BRIAN V ,  HUMAYAN MARK ,  GUVEN DILEK ,  RIPLEY ANN MARIE DE MERLIER

IPC: A61N1/05

CPC classification number: H05K3/0011 ,  A61N1/0541 ,  A61N1/0543 ,  A61N1/36036 ,  A61N1/36046 ,  Y10T29/49124

Abstract: Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.

Abstract translation: 聚合物材料可用作神经刺激的电极阵列体。 它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。 通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。 太小的压力会导致电阻增加以及电场分散。 太大的压力可能会阻止血液流动。 通常的柔性电路制造技术通常需要使柔性电路电极阵列平坦。 由于神经组织几乎从不平坦，平面阵列必然会施加不均匀的压力。 此外，柔性电路聚合物阵列的边缘可以是尖锐的并切割精细的神经组织。 通过将适量的热应用于完整的阵列，可以引起曲线。 对于热塑性聚合物，可以进一步有利的是在多个模具中反复加热柔性电路，每个模具具有减小的半径。 此外，沿着边缘添加材料是有利的。 在柔性电路阵列中提供折叠或扭曲是更有利的。 可以在折叠内部和外部添加附加材料以促进与组织的良好密封。

公开(公告)号：WO2012158834A8

公开(公告)日：2013-07-18

申请号：PCT/US2012038200

申请日：2012-05-16

Applicant: SECOND SIGHT MEDICAL PROD INC ,  GREENBERG ROBERT J ,  ZHOU DAVID DAOMIN ,  MECH BRIAN V ,  TALBOT NEIL HAMILTON ,  DAI RONGQING ,  CASTRO RICHARD AGUSTIN ,  MCCLURE KELLY

Inventor： GREENBERG ROBERT J ,  ZHOU DAVID DAOMIN ,  MECH BRIAN V ,  TALBOT NEIL HAMILTON ,  DAI RONGQING ,  CASTRO RICHARD AGUSTIN ,  MCCLURE KELLY

IPC: A61N1/05

CPC classification number: A61N1/36082 ,  A61B5/04001 ,  A61B5/4064 ,  A61B5/6868 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/375 ,  H01L2224/05599 ,  H01L2224/45144 ,  H01L2224/48227 ,  H01L2224/48465 ,  H01L2224/85099 ,  H01L2224/85399 ,  H01L2924/3011 ,  H05K1/118 ,  H05K1/189 ,  H05K2201/0154 ,  H05K2201/10098 ,  H01L2924/00 ,  H01L2924/00014

Abstract: The present application describes an implantable device with at least one package (214) that houses electronics that sends and receives data or signals, and optionally power, from an external system through at least one coil (216) attached to the at least one package and processes the data, including recordings of neural activity, and delivers electrical pulses to neural tissue through at least one array of multiple electrodes (210) attached to the at least one package. The device is intended to be installed in the head, or on or in the cranium or on the dura, or on or in the brain and is adapted to electrocorticographic (ECoG) and local field potential (LFP) signals.

Abstract translation: 本申请描述了具有至少一个封装（214）的可植入装置，所述封装（214）容纳通过附接到所述至少一个封装件的至少一个线圈（216）从外部系统发送和接收数据或信号并且可选地供电的电子器件，以及 处理数据，包括记录神经活动，并通过连接到至少一个包装的多个电极（210）的至少一个阵列将电脉冲传递给神经组织。 该装置旨在安装在头部，或在头颅或硬脑膜上或脑中或脑中或脑中，并适用于皮质电图（ECoG）和局部场电位（LFP）信号。

公开(公告)号：WO2012158834A1

公开(公告)日：2012-11-22

申请号：PCT/US2012/038200

申请日：2012-05-16

Applicant: SECOND SIGHT MEDICAL PRODUCTS, INC. ,  GREENBERG, Robert, J. ,  ZHOU, David, Daomin ,  MECH, Brian, V. ,  TALBOT, Neil, Hamilton ,  DAI, Rongqing ,  CASTRO, Richard, Agustin ,  MCCLURE, Kelly

Inventor： GREENBERG, Robert, J. ,  ZHOU, David, Daomin ,  MECH, Brian, V. ,  TALBOT, Neil, Hamilton ,  DAI, Rongqing ,  CASTRO, Richard, Agustin ,  MCCLURE, Kelly

IPC: A61N1/05

CPC classification number: A61N1/36082 ,  A61B5/04001 ,  A61B5/4064 ,  A61B5/6868 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/375 ,  H01L2224/05599 ,  H01L2224/45144 ,  H01L2224/48227 ,  H01L2224/48465 ,  H01L2224/85099 ,  H01L2224/85399 ,  H01L2924/3011 ,  H05K1/118 ,  H05K1/189 ,  H05K2201/0154 ,  H05K2201/10098 ,  H01L2924/00 ,  H01L2924/00014

Abstract: CORTICAL INTERFACE FOR MOTOR SIGNAL RECORDING AND SENSORY SIGNAL STIMULATION The present application describes an implantable device with at least one package (214) that houses electronics that sends and receives data or signals, and optionally power, from an external system through at least one coil (216) attached to the at least one package and processes the data, including recordings of neural activity, and delivers electrical pulses to neural tissue through at least one array of multiple electrodes (210) attached to the at least one package. The device is intended to be installed in the head, or on or in the cranium or on the dura, or on or in the brain and is adapted to electrocorticographic (ECoG) and local field potential (LFP) signals.

Abstract translation: 用于电动机信号记录和感测信号刺激的紧密接口本申请描述了具有至少一个封装（214）的可植入装置，该封装装置容纳电子装置，该电子装置通过至少一个线圈从外部系统发送和接收数据或信号， 216），并且处理包括神经活动记录在内的数据，并且通过连接到所述至少一个封装的多个电极（210）的至少一个阵列将电脉冲传送到神经组织。 该装置旨在安装在头部，或在头颅或硬脑膜上，或在脑中或脑中，并适用于皮质皮层（ECoG）和局部场电位（LFP）信号。

公开(公告)号：WO2009018172A2

公开(公告)日：2009-02-05

申请号：PCT/US2008/071260

申请日：2008-07-25

Applicant: SECOND SIGHT MEDICAL PRODUCTS ,  GREENBERG, Robert, J. ,  MECH, Brian, V. ,  MCCLURE, Kelly, H.

Inventor： GREENBERG, Robert, J. ,  MECH, Brian, V. ,  MCCLURE, Kelly, H.

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/375

CPC classification number: A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/36082 ,  A61N1/37229 ,  A61N1/375 ,  A61N1/3758 ,  A61N1/3787 ,  H05K1/028 ,  H05K1/111 ,  H05K1/141 ,  H05K1/147 ,  H05K3/284

Abstract: The present invention consists of an implantable device with at least one package that houses electronics that receives input data or signals, and optionally power, from an external system through at least one coil attached to the at least one package, processes the input data and delivers electrical pulses to neural tissue through at least one array of multiple electrodes that is/are attached to the at least one package. The invention, or components thereof, is/are intended to be installed in the head, or on or in the cranium or on the dura, or on or in the brain.

Abstract translation: 本发明包括具有至少一个封装的可植入装置，所述至少一个封装容纳电子装置，所述电子装置通过连接到所述至少一个封装件的至少一个线圈从外部系统接收输入数据或信号以及可选地供电，处理所述输入数据并传送 通过至少一个连接到至少一个封装的多个电极阵列的电脉冲到神经组织。 本发明或其组分旨在安装在头部，或在头颅或硬脑膜上，或脑中或脑中。

公开(公告)号：WO2009006636A2

公开(公告)日：2009-01-08

申请号：PCT/US2008/069348

申请日：2008-07-07

Applicant: SECOND SIGHT MEDICAL PRODUCTS ,  GREENBERG, Robert, J. ,  NEYSMITH, Jordan, Matthew ,  TALBOT, Neil, Hamilton ,  LITTLE, James, Singleton ,  MCCLURE, Kelly, H. ,  MECH, Brian, V. ,  DAI, Rongqing ,  ZHOU, David, Daomin ,  NOLAN, Gaillard, R.

Inventor： GREENBERG, Robert, J. ,  NEYSMITH, Jordan, Matthew ,  TALBOT, Neil, Hamilton ,  LITTLE, James, Singleton ,  MCCLURE, Kelly, H. ,  MECH, Brian, V. ,  DAI, Rongqing ,  ZHOU, David, Daomin ,  NOLAN, Gaillard, R.

CPC classification number: A61N1/0543 ,  A61N1/36046 ,  H05K1/118

Abstract: In a visual prosthesis electrodes stimulate retinal tissue to induce the perception of light to a user implanted with the prosthesis. The prosthesis must have a return, or common, electrode to make a complete circuit with the retinal tissue. To avoid stimulating tissue with the return electrode, it is advantageous if the electrode is large. The invention involver a flexible circuit electrode array comprising a polymer base layer, metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue a polymer top layer deposited on said polymer base layer and said metal traces, and a return electrode separate from said stimulating electrodes. The flexible circuit electrode array comprises a secondary coil for receiving visual data; an electronics package electrically coupled to said receiving coil, and a plurality of stimulating electrode electrically coupled to said electronics package.

Abstract translation: 在视觉假体中，电极刺激视网膜组织以诱导植入假体的使用者对光的感知。 假体必须有一个返回或共同的电极来与视网膜组织形成完整的电路。 为了避免用返回电极刺激组织，如果电极很大，则是有利的。 本发明涉及一种柔性电路电极阵列，其包括聚合物基层，沉积在所述聚合物基层上的金属迹线，包括适于刺激神经组织的电极，沉积在所述聚合物基层和所述金属迹线上的聚合物顶层，以及返回电极分离 来自所述刺激电极。 柔性电路电极阵列包括用于接收视觉数据的次级线圈; 电耦合到所述接收线圈的电子封装，以及电耦合到所述电子封装的多个激励电极。

公开(公告)号：WO2008109862A3

公开(公告)日：2008-12-24

申请号：PCT/US2008056301

申请日：2008-03-07

Applicant: SECOND SIGHT MEDICAL PROD INC ,  DOHENY EYE INST ,  AGRAWAL RAJAT ,  GREENBERG ROBERT J ,  HUMAYUN MARK S ,  LITTLE JAMES SINGLETON ,  MECH BRIAN V ,  NEYSMITH JORDAN MATTHEW ,  TALBOT NEIL HAMILTON ,  ZHOU DAO MIN

Inventor： AGRAWAL RAJAT ,  GREENBERG ROBERT J ,  HUMAYUN MARK S ,  LITTLE JAMES SINGLETON ,  MECH BRIAN V ,  NEYSMITH JORDAN MATTHEW ,  TALBOT NEIL HAMILTON ,  ZHOU DAO MIN

IPC: A61N1/05

CPC classification number: A61N1/05 ,  A61N1/0541 ,  A61N1/0543

Abstract: A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a central opening in the area of the metal traces. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a soft polymer filling an attachment point. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a hump to avoid a touching of the flexible electrode array and the optic nerve.

公开(公告)号：WO2008109862A2

公开(公告)日：2008-09-12

申请号：PCT/US2008/056301

申请日：2008-03-07

Applicant: SECOND SIGHT MEDICAL PRODUCTS, INC. ,  DOHENY EYE INSTITUTE ,  AGRAWAL, Rajat ,  GREENBERG, Robert, J. ,  HUMAYUN, Mark, S. ,  LITTLE, James, Singleton ,  MECH, Brian, V. ,  NEYSMITH, Jordan, Matthew ,  TALBOT, Neil, Hamilton ,  ZHOU, Dao, Min

Inventor： AGRAWAL, Rajat ,  GREENBERG, Robert, J. ,  HUMAYUN, Mark, S. ,  LITTLE, James, Singleton ,  MECH, Brian, V. ,  NEYSMITH, Jordan, Matthew ,  TALBOT, Neil, Hamilton ,  ZHOU, Dao, Min

IPC: A61N1/05

CPC classification number: A61N1/05 ,  A61N1/0541 ,  A61N1/0543

Abstract: A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a central opening in the area of the metal traces. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a soft polymer filling an attachment point. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a hump to avoid a touching of the flexible electrode array and the optic nerve.

Abstract translation: 一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和金属痕迹区域的中心开口。 一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和填充附着点的软质聚合物。 一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和一个驼峰以避免触摸柔性电极阵列和视神经。