公开(公告)号：WO2009132296A1

公开(公告)日：2009-10-29

申请号：PCT/US2009/041701

申请日：2009-04-24

Applicant: SECOND SIGHT MEDICAL PRODUCTS ,  GREENBERG, Robert, J. ,  KHALDI, Mohamed ,  LITTLE, James, S. ,  NEYSMITH, Jordan, M. ,  TALBOT, Neil, Hamilton

Inventor： GREENBERG, Robert, J. ,  KHALDI, Mohamed ,  LITTLE, James, S. ,  NEYSMITH, Jordan, M. ,  TALBOT, Neil, Hamilton

IPC: A61N1/05 ,  A61N1/36

CPC classification number: A61N1/0543 ,  A61N1/36046

Abstract: The present invention is an electrode array for neural stimulation suitable to be attached to neural tissue such that the attachment point acts as a fulcrum like point and contact with an end of the array body presses the other end of the array body into the neural tissue to be stimulated. This invention is particularly useful in a retinal electrode array for a visual prosthesis. By curving an electrode portion of an array body to approximate but not exceed (never more tightly curved) the curvature of the retina and applying force to the array by external means at the fulcrum like point, approximately even pressure across all electrodes is achieved.

Abstract translation: 本发明是一种用于神经刺激的电极阵列，其适用于附着于神经组织，使得附着点作为支点，并且与阵列体的端部接触将阵列体的另一端压入神经组织， 被刺激。 本发明在用于视觉假体的视网膜电极阵列中特别有用。 通过将阵列体的电极部分弯曲成近似但不超过（从不更紧密地弯曲）视网膜的曲率并且通过外部装置在支点点处向阵列施加力，实现了跨所有电极的大致均匀的压力。

公开(公告)号：WO2009006636A3

公开(公告)日：2009-02-26

申请号：PCT/US2008069348

申请日：2008-07-07

Applicant: SECOND SIGHT MEDICAL PROD INC ,  GREENBERG ROBERT J ,  NEYSMITH JORDAN MATTHEW ,  TALBOT NEIL HAMILTON ,  LITTLE JAMES SINGLETON ,  MCCLURE KELLY H ,  MECH BRIAN V ,  DAI RONGQING ,  ZHOU DAVID DAOMIN ,  NOLAN GAILLARD R

Inventor： GREENBERG ROBERT J ,  NEYSMITH JORDAN MATTHEW ,  TALBOT NEIL HAMILTON ,  LITTLE JAMES SINGLETON ,  MCCLURE KELLY H ,  MECH BRIAN V ,  DAI RONGQING ,  ZHOU DAVID DAOMIN ,  NOLAN GAILLARD R

IPC: A61N1/36 ,  A61N1/05

CPC classification number: A61N1/0543 ,  A61N1/36046 ,  H05K1/118

Abstract: In a visual prosthesis electrodes stimulate retinal tissue to induce the perception of light to a user implanted with the prosthesis. The prosthesis must have a return, or common, electrode to make a complete circuit with the retinal tissue. To avoid stimulating tissue with the return electrode, it is advantageous if the electrode is large. The invention involver a flexible circuit electrode array comprising a polymer base layer, metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue a polymer top layer deposited on said polymer base layer and said metal traces, and a return electrode separate from said stimulating electrodes. The flexible circuit electrode array comprises a secondary coil for receiving visual data; an electronics package electrically coupled to said receiving coil, and a plurality of stimulating electrode electrically coupled to said electronics package.

Abstract translation: 在视觉假体中，电极刺激视网膜组织以诱导植入假体的使用者对光的感知。 假体必须具有返回或常见的电极以与视网膜组织形成完整的电路。 为了避免用返回电极刺激组织，如果电极很大，则是有利的。 本发明涉及柔性电路电极阵列，其包括聚合物基底层，沉积在所述聚合物基底层上的金属迹线，包括适于刺激沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层的神经组织的电极和分离的回流电极 从所述刺激电极。 柔性电路电极阵列包括用于接收视觉数据的次级线圈; 电耦合到所述接收线圈的电子封装，以及电耦合到所述电子封装的多个刺激电极。

公开(公告)号：WO2008103195A3

公开(公告)日：2008-11-27

申请号：PCT/US2007083523

申请日：2007-11-02

Applicant: SECOND SIGHT MEDICAL PROD INC ,  NEYSMITH JORDAN ,  TALBOT NEIL HAMILTON ,  LITTLE JAMES SINGLETON ,  MECH BRIAN V ,  GREENBERG ROBERT J ,  QINGFANG YAO ,  ZHOU DAO MIN

Inventor： NEYSMITH JORDAN ,  TALBOT NEIL HAMILTON ,  LITTLE JAMES SINGLETON ,  MECH BRIAN V ,  GREENBERG ROBERT J ,  QINGFANG YAO ,  ZHOU DAO MIN

IPC: A61N1/05 ,  A61N1/36 ,  H05K1/00 ,  H05K1/11 ,  H05K1/18

CPC classification number: A61N1/0543 ,  A61N1/0541 ,  A61N1/36046 ,  H05K1/028 ,  H05K1/0353 ,  H05K1/09 ,  H05K1/111 ,  H05K1/115 ,  H05K1/118 ,  H05K3/0014 ,  H05K3/0017 ,  H05K3/0041 ,  H05K3/06 ,  H05K3/188 ,  H05K3/22 ,  H05K3/388 ,  H05K3/4644 ,  H05K2201/0129 ,  H05K2201/0133 ,  H05K2201/0141 ,  H05K2201/0154 ,  Y10T29/49156 ,  Y10T29/49158

Abstract: A flexible circuit electrode array with more than one layer of metal traces comprising: a polymer base layer; more than one layer of metal traces, separated by polymer layers, deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; and a polymer top layer deposited on said polymer base layer and said metal traces. Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow.

Abstract translation: 一种具有多于一层金属迹线的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基底层上的由聚合物层隔开的多于一层的金属痕迹层，包括适于刺激神经组织的电极; 以及沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层。 聚合物材料可用作神经刺激的电极阵列体。 它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。 通过电极阵列对视网膜或其他神经组织施加的压力至关重要。 太小的压力会导致电阻增加以及电场分散。 太大的压力可能会阻止血液流动。

公开(公告)号：WO2008101225A2

公开(公告)日：2008-08-21

申请号：PCT/US2008054181

申请日：2008-02-15

Applicant: SECOND SIGHT MEDICAL PROD INC ,  DOHENY EYE INST ,  GREENBERG ROBERT J ,  DE JUAN EUGENE ,  HUMAYUN MARK S ,  MCCLURE KELLY H ,  TALBOT NEIL HAMILTON ,  NEYSMITH JORDAN MATTHEW ,  MECH BRIAN V ,  LITTLE JAMES SINGLETON ,  KHALDI MOHAMED

Inventor： GREENBERG ROBERT J ,  DE JUAN EUGENE ,  HUMAYUN MARK S ,  MCCLURE KELLY H ,  TALBOT NEIL HAMILTON ,  NEYSMITH JORDAN MATTHEW ,  MECH BRIAN V ,  LITTLE JAMES SINGLETON ,  KHALDI MOHAMED

IPC: A61N1/05

CPC classification number: A61N1/0543 ,  A61N1/05 ,  A61N1/0541 ,  H05K1/0393 ,  H05K1/118

Abstract: The disclosure relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and at least one support embedded in said array. The disclosure further relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a folded flexible circuit cable connecting the electrode array with an interconnection pad. The disclosure further relates to a method of making a flexible circuit electrode array comprising: depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array, embedding a support at least in the base layer, top layer or between the base and top layer, and/or folding a flexible circuit cable at least once connecting the electrode array with an interconnection pad the array.

Abstract translation: 本发明涉及柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 以及嵌入在所述阵列中的至少一个支撑。 本发明还涉及一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 以及将电极阵列与互连垫连接的折叠柔性电路电缆。 本公开还涉及一种制造柔性电路电极阵列的方法，包括：沉积聚合物基层; 在所述聚合物基层上沉积金属; 图案化所述金属以形成金属痕迹; 在所述聚合物基底层和所述金属迹线上沉积聚合物顶层; 将所述柔性电路电极阵列加热到模具中以在所述柔性电路电极阵列中形成三维形状，至少在基层，顶层或基底与顶层之间嵌入支撑件，和/或折叠柔性电路电缆 至少一次将电极阵列与互连衬垫连接在一起。

公开(公告)号：WO2007149571A9

公开(公告)日：2008-02-14

申请号：PCT/US2007014618

申请日：2007-06-21

Applicant: SECOND SIGHT MEDICAL PROD INC ,  GREENBERG ROBERT J ,  TALBOT NEIL HAMILTON ,  NEYSMITH JORDAN ,  LITTLE JAMES S ,  MECH BRIAN V

Inventor： GREENBERG ROBERT J ,  TALBOT NEIL HAMILTON ,  NEYSMITH JORDAN ,  LITTLE JAMES S ,  MECH BRIAN V

CPC classification number: A61N1/0543 ,  A61N1/36046 ,  H05K1/118 ,  H05K3/0014 ,  Y10T29/49002 ,  Y10T29/49117 ,  Y10T29/49155 ,  Y10T29/49156 ,  Y10T29/49158 ,  Y10T29/49174 ,  Y10T29/49176

Abstract: The present invention provides a flexible circuit electrode array adapted for neural stimulation, comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces at least one tack opening; wherein said polymer base layer, said metal traces and said polymer top layer are thermoformed in a three dimensional shape. The present invention provides further a method of making a flexible circuit electrode array comprising depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; preparing at least one tack opening; and heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array.

Abstract translation: 本发明提供一种适用于神经刺激的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基层上的聚合物顶层和所述金属迹线至少一个粘性开口; 其中所述聚合物基层，所述金属迹线和所述聚合物顶层被热成型为三维形状。 本发明还提供一种制造柔性电路电极阵列的方法，包括沉积聚合物基层; 在所述聚合物基层上沉积金属; 图案化所述金属以形成金属痕迹; 在所述聚合物基底层和所述金属迹线上沉积聚合物顶层; 准备至少一个开口; 并将所述柔性电路电极阵列加热到模具中，以在所述柔性电路电极阵列中形成三维形状。

公开(公告)号：WO2011137298A3

公开(公告)日：2011-11-03

申请号：PCT/US2011/034471

申请日：2011-04-29

Applicant: SECOND SIGHT MEDICAL PRODUCTS,INC. ,  FARAJI, Boozarjomehr ,  ZHOU, David, Daomin ,  GREENBERG, Robert, J. ,  OK, Jerry ,  TALBOT, Neil, Hamilton ,  LITTLE, James, Singleton

Inventor： FARAJI, Boozarjomehr ,  ZHOU, David, Daomin ,  GREENBERG, Robert, J. ,  OK, Jerry ,  TALBOT, Neil, Hamilton ,  LITTLE, James, Singleton

IPC: A61N1/36 ,  A61N1/375 ,  H01L21/60 ,  H01L21/56 ,  A61B5/04

Abstract: The invention is a device and method for connecting a hermetic package to a flexible circuit such as for an electrode array in an implantable device. Attaching metal pads on a flexible circuit to metal pads on a hermetic device by conductive adhesive is known. A smooth metal, such as platinum, does not bond well to conductive epoxy. The invention provides a roughened surface, such as by etching or by applying high surface area platinum gray, to improve adhesion to platinum or other metal pads.

公开(公告)号：WO2007149571A3

公开(公告)日：2008-06-26

申请号：PCT/US2007014618

申请日：2007-06-21

Applicant: SECOND SIGHT MEDICAL PROD INC ,  GREENBERG ROBERT J ,  TALBOT NEIL HAMILTON ,  NEYSMITH JORDAN ,  LITTLE JAMES S ,  MECH BRIAN V

Inventor： GREENBERG ROBERT J ,  TALBOT NEIL HAMILTON ,  NEYSMITH JORDAN ,  LITTLE JAMES S ,  MECH BRIAN V

IPC: A61N1/05

CPC classification number: A61N1/0543 ,  A61N1/36046 ,  H05K1/118 ,  H05K3/0014 ,  Y10T29/49002 ,  Y10T29/49117 ,  Y10T29/49155 ,  Y10T29/49156 ,  Y10T29/49158 ,  Y10T29/49174 ,  Y10T29/49176

Abstract: The present invention provides a flexible circuit electrode array adapted for neural stimulation, comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces at least one tack opening; wherein said polymer base layer, said metal traces and said polymer top layer are thermoformed in a three dimensional shape. The present invention provides further a method of making a flexible circuit electrode array comprising depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; preparing at least one tack opening; and heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array.

Abstract translation: 本发明提供了一种适用于神经刺激的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属迹线，包括适于刺激神经组织的电极; 沉积在所述聚合物基层上的聚合物顶层，并且所述金属跟踪至少一个开口; 其中所述聚合物基层，所述金属迹线和所述聚合物顶层以三维形状热成形。 本发明进一步提供一种制造柔性电路电极阵列的方法，该方法包括沉积聚合物基层; 在所述聚合物基底层上沉积金属; 图案化所述金属以形成金属迹线; 在所述聚合物基底层和所述金属迹线上沉积聚合物顶层; 准备至少一个平头开口; 以及在模具中加热所述柔性电路电极阵列以在所述柔性电路电极阵列中形成三维形状。

公开(公告)号：WO2008021524A2

公开(公告)日：2008-02-21

申请号：PCT/US2007018315

申请日：2007-08-18

Applicant: SECOND SIGHT MEDICAL PROD INC ,  OK JERRY ,  GREENBERG ROBERT J ,  TALBOT NEIL HAMILTON ,  LITTLE JAMES SINGLETON ,  DAI RONGQING ,  NEYSMITH JORDAN MATTHEW ,  MCCLURE KELLY H

Inventor： OK JERRY ,  GREENBERG ROBERT J ,  TALBOT NEIL HAMILTON ,  LITTLE JAMES SINGLETON ,  DAI RONGQING ,  NEYSMITH JORDAN MATTHEW ,  MCCLURE KELLY H

IPC: A61N1/00

CPC classification number: A61N1/36046 ,  A61F15/001 ,  A61N1/0529 ,  A61N1/0543 ,  A61N1/36125 ,  A61N1/375 ,  H01L23/055 ,  H01L23/06 ,  H01L23/08 ,  H01L23/10 ,  H01L24/16 ,  H01L24/48 ,  H01L25/18 ,  H01L2224/16225 ,  H01L2224/45144 ,  H01L2224/48091 ,  H01L2224/48106 ,  H01L2224/48225 ,  H01L2924/00014 ,  H01L2924/00 ,  H01L2224/0401

Abstract: The present invention is an improved hermetic package for implantation in the human body. The implantable device comprises an electrically non-conductive substrate; a plurality of electrically conductive vias through said electrically non-conductive substrate; a flip-chip circuit attached to said electrically non-conductive substrate using conductive bumps and electrically connected to a first subset of said plurality of electrically conductive vias, wherein said flip-chip circuit contains one or more stacks or a folded stack; a wire bonded circuit attached to said electrically non-conductive substrate and electrically connected to a second subset of said electrically conductive vias; and a cover bonded to said electrically non-conductive substrate, said cover, said electrically non-conductive substrate and said electrically conductive vias forming a hermetic package.

Abstract translation: 本发明是用于植入人体的改进的密封包装。 可植入装置包括非导电基底; 通过所述非导电衬底的多个导电通孔; 使用导电凸块连接到所述非导电衬底并电连接到所述多个导电通孔的第一子集的倒装芯片电路，其中所述倒装芯片电路包含一个或多个堆叠或折叠堆叠; 连接到所述非导电衬底并电连接到所述导电通孔的第二子集的引线键合电路; 以及盖，其结合到所述非导电衬底，所述盖，所述非导电衬底和所述导电通孔形成气密封装。

公开(公告)号：WO2007058975A3

公开(公告)日：2008-01-24

申请号：PCT/US2006043863

申请日：2006-11-10

Applicant: SECOND SIGHT MEDICAL PROD INC ,  DOHENY EYE INST ,  LAUDE LUCIEN ,  TALBOT NEIL HAMILTON ,  GREENBERG ROBERT J

Inventor： LAUDE LUCIEN ,  TALBOT NEIL HAMILTON ,  GREENBERG ROBERT J

IPC: C23C18/16 ,  C23C18/20 ,  G03F7/20

CPC classification number: G03F7/265 ,  C23C18/1608 ,  C23C18/1612 ,  C23C18/1868 ,  C23C18/31 ,  H05K1/0283 ,  H05K1/0289 ,  H05K1/032 ,  H05K1/0373 ,  H05K1/0393 ,  H05K3/007 ,  H05K3/107 ,  H05K3/185 ,  H05K3/28 ,  H05K2201/0133 ,  H05K2201/0162 ,  H05K2201/0209 ,  H05K2203/016

Abstract: The present invention relates to a process for embedding at least one layer of at least one metal trace in a silicone containing polymer, comprising: a) applying a non adhering on a substrate; b) applying a polymer layer on the non adhering agent; c) irradiation at least one surface area of said polymer with a light beam emitted by an excimer laser; d) immersing said irradiated polymer in at least one autocatalytic bath containing metal ions of at least one metal and metallizing the polymer; e) thermally treating said metallized polymer; f) applying a polymer layer on said thermally treated metallized polymer; and g) thermally treating said metallized polymer.

Abstract translation: 本发明涉及一种在含硅氧烷聚合物中嵌入至少一层至少一种金属迹线的方法，包括：a）将不粘附在基底上; b）在非粘合剂上施加聚合物层; c）用由准分子激光器发射的光束照射所述聚合物的至少一个表面积; d）将所述照射的聚合物浸入至少一种含有至少一种金属的金属离子并使聚合物金属化的自催化浴; e）热处理所述金属化聚合物; f）将聚合物层施加在所述热处理的金属化聚合物上; 和g）热处理所述金属化聚合物。

公开(公告)号：WO2007149571A2

公开(公告)日：2007-12-27

申请号：PCT/US2007/014618

申请日：2007-06-21

Applicant: SECOND SIGHT MEDICAL PRODUCTS, INC. ,  GREENBERG, Robert, J. ,  TALBOT, Neil, Hamilton ,  NEYSMITH, Jordan ,  LITTLE, James, S. ,  MECH, Brian, V.

Inventor： GREENBERG, Robert, J. ,  TALBOT, Neil, Hamilton ,  NEYSMITH, Jordan ,  LITTLE, James, S. ,  MECH, Brian, V.

CPC classification number: A61N1/0543 ,  A61N1/36046 ,  H05K1/036 ,  H05K1/0393 ,  H05K1/118 ,  H05K3/0014 ,  H05K2201/05 ,  H05K2201/053 ,  H05K2201/09063 ,  H05K2201/09409 ,  Y10T29/49002 ,  Y10T29/49117 ,  Y10T29/49155 ,  Y10T29/49156 ,  Y10T29/49158 ,  Y10T29/49174 ,  Y10T29/49176

Abstract: The present invention provides a flexible circuit electrode array adapted for neural stimulation, comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces at least one tack opening; wherein said polymer base layer, said metal traces and said polymer top layer are thermoformed in a three dimensional shape. The present invention provides further a method of making a flexible circuit electrode array comprising depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; preparing at least one tack opening; and heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array.

Abstract translation: 本发明提供一种适用于神经刺激的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基层上的聚合物顶层和所述金属迹线至少一个粘性开口; 其中所述聚合物基层，所述金属迹线和所述聚合物顶层被热成型为三维形状。 本发明还提供一种制造柔性电路电极阵列的方法，包括沉积聚合物基层; 在所述聚合物基层上沉积金属; 图案化所述金属以形成金属痕迹; 在所述聚合物基底层和所述金属迹线上沉积聚合物顶层; 准备至少一个开口; 并将所述柔性电路电极阵列加热到模具中，以在所述柔性电路电极阵列中形成三维形状。