公开(公告)号：WO2010088270A3

公开(公告)日：2010-11-25

申请号：PCT/US2010022229

申请日：2010-01-27

Applicant: M I SWACO NORGE AS ,  M I DRILLING FLUIDS UK LTD ,  MI LLC ,  LOGAN GORDON M ,  EIA JAN THORE ,  HUNTER MARTIN ,  BINGHAM RICHARD ,  LAUDER COLIN

Inventor： LOGAN GORDON M ,  EIA JAN THORE ,  HUNTER MARTIN ,  BINGHAM RICHARD ,  LAUDER COLIN

IPC: B08B9/053 ,  B08B9/032 ,  B08B9/057 ,  B08B9/08 ,  B63B35/44 ,  B65D19/02 ,  B65D88/26 ,  B65G53/04

CPC classification number: B65D88/30 ,  B01D21/02 ,  B01D21/26 ,  B08B9/08 ,  B08B9/093 ,  B63B27/20 ,  B63B27/25 ,  B63B27/34 ,  B65D88/128 ,  B65D88/32 ,  B65D88/54 ,  B65D88/548 ,  B65D90/0033 ,  B65D90/34 ,  B65D90/36 ,  B65D2590/547

Abstract: A method for cleaning a reactor, the method including circulating a fluid inside the reactor, pumping the fluid from the reactor into an inlet of a tank cleaner, and removing solids from the fluid to produce a clean fluid. The method further includes transferring the clean fluid to the reactor and transferring pneumatically the removed solids to a pressurized vessel. Also, a method for transferring spent granular material, the method including providing a vacuum system disposed at a hydrocarbon production site to remove spent material from a reactor, transferring the spent material through the vacuum system into a pressurized vessel, and conveying pneumatically the spent material from the pressurized vessel to a second pressurized vessel.

Abstract translation: 一种用于清洁反应器的方法，该方法包括在反应器内循环流体，将来自反应器的流体泵入罐清洁器的入口，以及从流体中除去固体以产生清洁流体。 该方法进一步包括将清洁流体转移到反应器并气动地将去除的固体转移到加压容器。 此外，还提供了一种用于转移废颗粒材料的方法，该方法包括提供设置在碳氢化合物生产场所的真空系统以从反应器移除废弃材料，将废弃材料通过真空系统转移到加压容器中，并且气动输送废弃材料 从加压容器输送到第二加压容器。

公开(公告)号：WO2009059072A2

公开(公告)日：2009-05-07

申请号：PCT/US2008081894

申请日：2008-10-30

Applicant: UNIV TUFTS ,  LEVITT JONATHAN ,  MUJAT CLAUDIA ,  HUNTER MARTIN ,  GEORGAKOUDI IRENE

Inventor： LEVITT JONATHAN ,  MUJAT CLAUDIA ,  HUNTER MARTIN ,  GEORGAKOUDI IRENE

IPC: G06K9/00

CPC classification number: G06K9/00536 ,  G01N21/6456 ,  G06K9/00147

Abstract: Methods and computer program products for analyzing tissue are provided. The tissue is exposed to light at the appropriate wavelengths for inducing fluorescence. Images of the fluorescing tissue are taken at two or more depths within the tissue. The PSD function is determined for each image at a different depth within the tissue. A characteristic of each PSD function determined is compared, and it is determined whether or not the tissue exhibits a pre-cancerous characteristic.

Abstract translation: 提供了用于分析组织的方法和计算机程序产品。 将组织以适当的波长暴露于光以诱导荧光。 荧光组织的图像在组织内的两个或更多深度拍摄。 为组织内不同深度的每个图像确定PSD功能。 比较确定的每个PSD功能的特征，并确定组织是否呈现癌前特征。

公开(公告)号：WO2006116637A3

公开(公告)日：2007-03-01

申请号：PCT/US2006016107

申请日：2006-04-27

Applicant: MASSACHUSETTS INST TECHNOLOGY ,  HUNTER MARTIN ,  ENEJDER ANNIKA M ,  SCECINA THOMAS ,  FELD MICHAEL S ,  SHIH WEI-CHUAN

Inventor： HUNTER MARTIN ,  ENEJDER ANNIKA M ,  SCECINA THOMAS ,  FELD MICHAEL S ,  SHIH WEI-CHUAN

IPC: G01N21/65

CPC classification number: A61B5/14532 ,  A61B5/1455 ,  G01N21/65

Abstract: The present invention relates to the use of Raman spectroscopy for quantitative, non-invasive transcutaneous measurement of blood analytes, such as glucose. Raman spectroscopy is used to measure glucose trans cutaneously, in patients whose blood glucose levels were monitored. Raman spectra were collected trans cutaneously along with glucose reference values provided by standard capillary blood analysis. A partial least squares calibration was created from the data from each subject and validated using leave-one-out cross validation.

Abstract translation: 本发明涉及拉曼光谱法用于定量，非侵入性经皮测量血液分析物如葡萄糖的用途。 在监测血糖水平的患者中，拉曼光谱法用于经皮测量葡萄糖。 通过标准毛细血管分析提供的葡萄糖参考值，经皮收集拉曼光谱。 从每个受试者的数据创建偏最小二乘法校准，并使用离开一对交叉验证进行验证。

公开(公告)号：WO2010088270A8

公开(公告)日：2011-04-28

申请号：PCT/US2010022229

申请日：2010-01-27

Applicant: SCHLUMBERGER NORGE AS ,  M I DRILLING FLUIDS UK LTD ,  MI LLC ,  LOGAN GORDON M ,  EIA JAN THORE ,  HUNTER MARTIN ,  BINGHAM RICHARD ,  LAUDER COLIN

Inventor： LOGAN GORDON M ,  EIA JAN THORE ,  HUNTER MARTIN ,  BINGHAM RICHARD ,  LAUDER COLIN

IPC: B08B9/053 ,  B08B9/032 ,  B08B9/057 ,  B08B9/08 ,  B63B35/44 ,  B65D19/02 ,  B65D88/26 ,  B65G53/04

CPC classification number: B65D88/30 ,  B01D21/02 ,  B01D21/26 ,  B08B9/08 ,  B08B9/093 ,  B63B27/20 ,  B63B27/25 ,  B63B27/34 ,  B65D88/128 ,  B65D88/32 ,  B65D88/54 ,  B65D88/548 ,  B65D90/0033 ,  B65D90/34 ,  B65D90/36 ,  B65D2590/547

Abstract: A method for cleaning a reactor, the method including circulating a fluid inside the reactor, pumping the fluid from the reactor into an inlet of a tank cleaner, and removing solids from the fluid to produce a clean fluid. The method further includes transferring the clean fluid to the reactor and transferring pneumatically the removed solids to a pressurized vessel. Also, a method for transferring spent granular material, the method including providing a vacuum system disposed at a hydrocarbon production site to remove spent material from a reactor, transferring the spent material through the vacuum system into a pressurized vessel, and conveying pneumatically the spent material from the pressurized vessel to a second pressurized vessel.

Abstract translation: 一种用于清洁反应器的方法，所述方法包括使反应器内部的流体循环，将流体从反应器泵入罐清洁器的入口，以及从流体中除去固体以产生清洁的流体。 该方法还包括将清洁流体转移到反应器中并将去除的固体气动地传递到加压容器。 另外，一种用于转移废弃颗粒材料的方法，该方法包括提供设置在烃生产现场的真空系统以从反应器中除去废料，将废料通过真空系统转移到加压容器中，并气动输送废料 从加压容器到第二加压容器。

公开(公告)号：WO2009105537A3

公开(公告)日：2009-08-27

申请号：PCT/US2009/034516

申请日：2009-02-19

Applicant: TRUSTEES OF TUFTS COLLEGE ,  GEORGAKOUDI, Irene ,  GUPTA, Sharad ,  HUNTER, Martin ,  KAPLAN, David, L.

Inventor： GEORGAKOUDI, Irene ,  GUPTA, Sharad ,  HUNTER, Martin ,  KAPLAN, David, L.

IPC: G01N21/25 ,  G01N21/47 ,  G01N21/21 ,  G01N33/48

Abstract: In one aspect, the present invention generally provides methods for characterizing mineralization of a material, e.g., a biomaterial, by illuminating the material with radiation and analyzing radiation scattered from the material in response to the illumination. For example, in some embodiments, a material can be illuminated with polarized radiation at a plurality of wavelengths and the elastically scattered radiation corresponding to two or more of those wavelengths can be collected at two polarizations: one parallel and the other perpendicular to the illumination polarization. A differential intensity of the scattered radiation at the two polarizations can be analyzed as a function of wavelength to obtain information regarding the morphology of mineral deposits in the sample. Further, the total scattered radiation can be analyzed to derive information regarding the level of mineralization.

公开(公告)号：WO2009105537A2

公开(公告)日：2009-08-27

申请号：PCT/US2009034516

申请日：2009-02-19

Applicant: TUFTS COLLEGE ,  GEORGAKOUDI IRENE ,  GUPTA SHARAD ,  HUNTER MARTIN ,  KAPLAN DAVID L

Inventor： GEORGAKOUDI IRENE ,  GUPTA SHARAD ,  HUNTER MARTIN ,  KAPLAN DAVID L

IPC: G01N21/25 ,  G01N21/21 ,  G01N21/47 ,  G01N33/48

CPC classification number: G01N21/47 ,  G01N21/21 ,  G01N2021/4792

Abstract: In one aspect, the present invention generally provides methods for characterizing mineralization of a material, e.g., a biomaterial, by illuminating the material with radiation and analyzing radiation scattered from the material in response to the illumination. For example, in some embodiments, a material can be illuminated with polarized radiation at a plurality of wavelengths and the elastically scattered radiation corresponding to two or more of those wavelengths can be collected at two polarizations: one parallel and the other perpendicular to the illumination polarization. A differential intensity of the scattered radiation at the two polarizations can be analyzed as a function of wavelength to obtain information regarding the morphology of mineral deposits in the sample. Further, the total scattered radiation can be analyzed to derive information regarding the level of mineralization.

Abstract translation: 在一个方面，本发明通常提供用于通过用辐射照射材料来表征材料（例如生物材料）的矿化的方法，并且响应于照明分析从材料散射的辐射。 例如，在一些实施例中，可以以多个波长的偏振辐射照射材料，并且可以以两个极化收集对应于这些波长中的两个或更多个的弹性散射辐射：一个平行且另一个垂直于照明偏振 。 可以将两个极化处的散射辐射的差分强度作为波长的函数进行分析，以获得关于样品中矿物沉积物形态的信息。 此外，可以分析总散射辐射以得到关于矿化水平的信息。

公开(公告)号：WO2010075385A3

公开(公告)日：2010-10-14

申请号：PCT/US2009069196

申请日：2009-12-22

Applicant: UNIV TUFTS ,  GEORGAKOUDI IRENE ,  HUANG PONG-YU ,  HUNTER MARTIN

Inventor： GEORGAKOUDI IRENE ,  HUANG PONG-YU ,  HUNTER MARTIN

IPC: G01N23/203 ,  G01B11/24 ,  G01N21/47

CPC classification number: G01B11/24 ,  A61B5/0059 ,  A61B5/0068 ,  G01J3/4412 ,  G01N21/31 ,  G01N21/474 ,  G02B21/0064 ,  G02B21/0092

Abstract: The present invention is generally directed to imaging methods and apparatus that employ angular and/or wavelength distribution of light backscattered from multiple portions of a sample in response to illumination by electromagnetic radiation to generate one, two or three dimensional images of the sample. In many embodiments, confocal imaging can be employed to detect the backscattered radiation, e.g., to measure spectral signals of layered samples (such as biological samples) through optical sectioning. The methods of the invention can be applied to a variety of samples including, without limitation, biological and non-biological samples, organic and inorganic samples, to obtain information, e.g., regarding morphological, compositional, and/or structural variations among different portions of the sample. By way of example, in some applications the methods of invention can be employed to obtain light scattering signals from cells or tissues buried under the skin.

Abstract translation: 本发明一般涉及成像方法和装置，其采用来自样品的多个部分的反向散射的光的角度和/或波长分布，以响应于电磁辐射的照射而产生样品的一维，二维或三维图像。 在许多实施例中，可以采用共焦成像来检测反向散射辐射，例如通过光学切片来测量分层样品（例如生物样品）的光谱信号。 本发明的方法可以应用于各种样品，包括但不限于生物和非生物样品，有机和无机样品，以获得关于例如关于不同部分之间的形态，组成和/或结构变化的信息 例子。 作为示例，在一些应用中，可以采用本发明的方法来从掩埋在皮肤下的细胞或组织获得光散射信号。

公开(公告)号：WO2010088270A2

公开(公告)日：2010-08-05

申请号：PCT/US2010/022229

申请日：2010-01-27

Applicant: M-I SWACO NORGE AS ,  M-I DRILLING FLUIDS UK LIMITED ,  M-I L.L.C. ,  LOGAN, Gordon, M. ,  EIA, Jan, Thore ,  HUNTER, Martin ,  BINGHAM, Richard ,  LAUDER, Colin

Inventor： LOGAN, Gordon, M. ,  EIA, Jan, Thore ,  HUNTER, Martin ,  BINGHAM, Richard ,  LAUDER, Colin

IPC: B08B9/053 ,  B08B9/057 ,  B08B9/032 ,  B08B9/08 ,  B65G53/04 ,  B63B35/44 ,  B65D88/26 ,  B65D19/02

CPC classification number: B65D88/30 ,  B01D21/02 ,  B01D21/26 ,  B08B9/08 ,  B08B9/093 ,  B63B27/20 ,  B63B27/25 ,  B63B27/34 ,  B65D88/128 ,  B65D88/32 ,  B65D88/54 ,  B65D88/548 ,  B65D90/0033 ,  B65D90/34 ,  B65D90/36 ,  B65D2590/547

Abstract: A method for cleaning a reactor, the method including circulating a fluid inside the reactor, pumping the fluid from the reactor into an inlet of a tank cleaner, and removing solids from the fluid to produce a clean fluid. The method further includes transferring the clean fluid to the reactor and transferring pneumatically the removed solids to a pressurized vessel. Also, a method for transferring spent granular material, the method including providing a vacuum system disposed at a hydrocarbon production site to remove spent material from a reactor, transferring the spent material through the vacuum system into a pressurized vessel, and conveying pneumatically the spent material from the pressurized vessel to a second pressurized vessel.

Abstract translation: 一种用于清洁反应器的方法，所述方法包括使反应器内的流体循环，将流体从反应器泵送到罐清洁器的入口中，以及从流体中除去固体以产生清洁的流体。 该方法还包括将清洁流体转移到反应器中并将去除的固体气动地传递到加压容器。 另外，一种用于转移废弃颗粒材料的方法，该方法包括提供一个设置在烃生产现场的真空系统，以从反应器中除去废料，将废料通过真空系统转移到加压容器中，并气动输送废料 从加压容器到第二加压容器。

公开(公告)号：WO2003087793A1

公开(公告)日：2003-10-23

申请号：PCT/US2003/010307

申请日：2003-04-04

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  MOTZ, Jason, T. ,  GALINDO, Luis, H. ,  HUNTER, Martin ,  HAKA, Abigail, S. ,  GANDHI, Saumil ,  DASARI, Ramachandra ,  FELD, Michael, S.

Inventor： MOTZ, Jason, T. ,  GALINDO, Luis, H. ,  HUNTER, Martin ,  HAKA, Abigail, S. ,  GANDHI, Saumil ,  DASARI, Ramachandra ,  FELD, Michael, S.

IPC: G01N21/65

CPC classification number: A61B5/02007 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/0091 ,  A61B5/415 ,  A61B5/4312 ,  A61B5/4519 ,  A61B5/7232 ,  G01N21/474 ,  G01N21/65 ,  G01N2021/4745 ,  G01N2021/4759 ,  G01N2021/656

Abstract: A system for measuring tissue includes a fiber optic probe having a diameter of 2 mm or less. This small diameter allows the system to be used for the diagnosis of coronary artery disease or other small lumens or soft tissue with minimal trauma. A delivery optical fiber is included in the probe coupled at the proximal end to a light source. A filter for the delivery fibers is included at the distal end. The system includes a collection optical fiber (or fibers) in the probe that collects Raman scattered radiation from tissue, the collection optical fiber is coupled at the proximal end to a detector. A second filter is disposed at the distal end of the collection fibers. An optical lens system is disposed at the distal end of the probe including a delivery waveguide coupled to the delivery fiber, a collection waveguide coupled to the collection fiber and a lens.

Abstract translation: 用于测量组织的系统包括直径为2mm或更小的光纤探针。 这种小直径允许系统用于诊断冠状动脉疾病或其他小腔或软组织，具有最小的创伤。 输送光纤包括在近端耦合到光源的探针中。 用于输送纤维的过滤器包括在远端。 该系统包括在探针中收集来自组织的拉曼散射辐射的收集光纤（或纤维），收集光纤在近端耦合到检测器。 第二过滤器设置在收集纤维的远端。 光学透镜系统设置在探头的远端，包括耦合到输送纤维的输送波导，耦合到收集光纤的收集波导和透镜。

公开(公告)号：WO2010075385A2

公开(公告)日：2010-07-01

申请号：PCT/US2009/069196

申请日：2009-12-22

Applicant: TUFTS UNIVERSITY ,  GEORGAKOUDI, Irene ,  HUANG, Pong-yu ,  HUNTER, Martin

Inventor： GEORGAKOUDI, Irene ,  HUANG, Pong-yu ,  HUNTER, Martin

IPC: G01N23/203 ,  G01N21/47 ,  G01B11/24

CPC classification number: G01B11/24 ,  A61B5/0059 ,  A61B5/0068 ,  G01J3/4412 ,  G01N21/31 ,  G01N21/474 ,  G02B21/0064 ,  G02B21/0092

Abstract: The present invention is generally directed to imaging methods and apparatus that employ angular and/or wavelength distribution of light backscattered from multiple portions of a sample in response to illumination by electromagnetic radiation to generate one, two or three dimensional images of the sample. In many embodiments, confocal imaging can be employed to detect the backscattered radiation, e.g., to measure spectral signals of layered samples (such as biological samples) through optical sectioning. The methods of the invention can be applied to a variety of samples including, without limitation, biological and non-biological samples, organic and inorganic samples, to obtain information, e.g., regarding morphological, compositional, and/or structural variations among different portions of the sample. By way of example, in some applications the methods of invention can be employed to obtain light scattering signals from cells or tissues buried under the skin.

Abstract translation: 本发明总体上针对成像方法和设备，其采用响应于电磁辐射照射而从样品的多个部分反向散射的光的角度和/或波长分布，以产生一个，两个或三个 三维图像的样本。 在许多实施例中，可以采用共焦成像来检测反向散射辐射，例如通过光学切片来测量分层样本（诸如生物样本）的频谱信号。 本发明的方法可以应用于各种样品，包括但不限于生物和非生物样品，有机和无机样品，以获得例如关于不同部分之间的形态，组成和/或结构变化的信息 例子。 举例来说，在一些应用中，本发明的方法可以用于从埋在皮肤下的细胞或组织获得光散射信号。