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    METHODS AND COMPOSITIONS FOR PREVENTING INFECTION BY A VIBRIO SPECIES
    1.
    发明申请
    METHODS AND COMPOSITIONS FOR PREVENTING INFECTION BY A VIBRIO SPECIES 审中-公开
    预防纤维虫种类感染的方法和组合物

    公开(公告)号：WO2017173229A1

    公开(公告)日：2017-10-05

    申请号：PCT/US2017/025305

    申请日：2017-03-31

    申请人： TUFTS UNIVERSITY

    发明人： CAMILLI, Andrew ,  CAIRNS, Lynne ,  YEN, Minmin

    IPC分类号： C12R1/91 ,  A01N63/02 ,  C12N7/00

    摘要： Compositions and methods are provided for preventing, ameliorating, or treating a disease caused by a species of bacterial genus Vibrio, for example, cholera caused by V. cholerae, the compositions containing two or more strains of lytic bacteriophage that infect and kill Vibrio cells. The bacteriophage are virulent, which replicate intracellularly and lyse and kill the bacteria. Use of two or more strains in a single treatment, as a result of a rate of mutation of the bacteria to simultaneous resistance to all of the bacteriophage to be so low as to be negligible, reduces appearance of phage-resistant bacteria to statistical negligibility. Normal human microbial flora species were not affected. In alternative embodiments of the method and the composition, antibiotic agents or other treatment agents can be administered with a cocktail of the plurality of bacteriophage strains.

    摘要翻译： 提供组合物和方法用于预防，改善或治疗由弧菌属细菌种类引起的疾病，例如由霍乱弧菌引起的霍乱，含有两种或更多种溶解菌株的组合物 噬菌体感染和杀死弧菌细胞。 噬菌体是强毒的，它在细胞内复制并裂解并杀死细菌。 由于细菌突变率与同时对所有噬菌体的抗性低至可忽略不计的程度，使得在单一处理中使用两种或更多种菌株，从而减少了抗噬菌体细菌出现统计学上的可忽略性。 正常的人类微生物菌群不受影响。 在该方法和组合物的可选实施方案中，抗生素剂或其他治疗剂可以与多种噬菌体菌株的混合物一起施用。

    SILK-BASED ADHESIVES
    2.
    发明申请
    SILK-BASED ADHESIVES 审中-公开
    基于丝绸的粘合剂

    公开(公告)号：WO2017095782A1

    公开(公告)日：2017-06-08

    申请号：PCT/US2016/063932

    申请日：2016-11-29

    申请人： TUFTS UNIVERSITY

    发明人： BURKE, Kelly A. ,  KAPLAN, David L.

    IPC分类号： A61L27/36 ,  A61L33/06

    CPC分类号： A61L24/0005

    摘要： In some embodiments, the present invention provides compositions including silk fibroin, at least one hydrophilic agent, and at least one catechol donating agent, wherein the at least one hydrophilic agent and at least one catechol donating agent are conjugated to the silk fibroin. According to various embodiments, at least a portion of the silk fibroin may be crosslinked. In some embodiments, the silk fibroin is at least 50% (e.g., 60%, 70%, 80%, 90%, 95% or more) crosslinked. In some embodiments, the present invention also provides methods for making such compositions.

    摘要翻译： 在一些实施方案中，本发明提供包含丝心蛋白，至少一种亲水剂和至少一种儿茶酚供体剂的组合物，其中所述至少一种亲水剂和至少一种儿茶酚供体剂是 与丝素蛋白缀合。 根据各种实施方案，丝素蛋白的至少一部分可以交联。 在一些实施方案中，丝素蛋白是交联的至少50％（例如，60％，70％，80％，90％，95％或更多）。 在一些实施方案中，本发明还提供了制备这种组合物的方法。

    COMPOSITIONS, METHODS AND KITS FOR TREATING COMPLEMENT RELATED DISORDERS
    6.
    发明申请
    COMPOSITIONS, METHODS AND KITS FOR TREATING COMPLEMENT RELATED DISORDERS 审中-公开
    用于治疗补充相关疾病的组合物，方法和试剂盒

    公开(公告)号：WO2016033444A1

    公开(公告)日：2016-03-03

    申请号：PCT/US2015/047405

    申请日：2015-08-28

    申请人： TUFTS UNIVERSITY

    发明人： KUMAR-SINGH, Rajendra ,  LEADERER, Derek ,  CASHMAN, Siobhan

    IPC分类号： C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  C07K14/745 ,  C07K14/705 ,  C07K19/00

    CPC分类号： A61K38/177 ,  A47K7/026 ,  A61K45/06 ,  A61P37/00 ,  B08B7/02 ,  B25G1/04 ,  B25G1/06 ,  C07K14/70596 ,  G01N33/6893 ,  G01N2333/4716

    摘要： Compositions, methods and kits are provided for treating complement related disorders in a subject with protein in combination having protein fusions of at least two of a CD46 protein, a CD55 protein and a CD59 protein or with a recombinant chimeric protein having at least two of a CD46 protein, a CD55 protein and a CD59 protein or with nucleic acids encoding these proteins. The composition negatively modulates classical and alternative complement pathways thereby treating complement related disorder such as macular degeneration, age-related macular degeneration, diabetic retinopathy, inflammatory bowel disease, thyroiditis, cryoglobulinaemia, fetal loss, organ graft rejection, cancer, etc.

    摘要翻译： 提供组合物，方法和试剂盒，用于治疗受试者中补体相关疾病，其中蛋白质组合具有至少两种CD46蛋白，CD55蛋白和CD59蛋白的蛋白质融合物，或与具有至少两种 CD46蛋白，CD55蛋白和CD59蛋白或编码这些蛋白的核酸。 组合物负调节经典和替代补体途径，从而治疗补体相关疾病如黄斑变性，年龄相关性黄斑变性，糖尿病性视网膜病变，炎性肠病，甲状腺炎，冷球蛋白血症，胎儿丧失，器官移植排斥，癌症等。