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    SILANE COATING COMPOSITIONS, COATING SYSTEMS, AND METHODS
    1.
    发明申请
    SILANE COATING COMPOSITIONS, COATING SYSTEMS, AND METHODS 审中-公开

    公开(公告)号：WO2008103668A3

    公开(公告)日：2008-08-28

    申请号：PCT/US2008/054297

    申请日：2008-02-19

    Applicant: SURMODICS, INC. ,  JELLE, Bruce, M. ,  MACKLIN, Sara ,  HERGENROTHER, Robert, W.

    Inventor： JELLE, Bruce, M. ,  MACKLIN, Sara ,  HERGENROTHER, Robert, W.

    IPC: B05D7/00

    Abstract: The present invention relates to coating systems and coating systems on substrates. In an embodiment, the invention includes an article including a substrate, a base layer disposed on the substrate, the base layer comprising a silane compound with a photoreactive group, or the reaction product of a silane compound with a photoreactive group, and a polymer layer disposed on the base layer, the polymer layer comprising a polymer terminally anchored to the base layer. In an embodiment, the invention includes a coating for an article. In an embodiment, the invention includes a method of depositing a coating onto a substrate.

    PHOTO-VINYL LINKING AGENTS
    3.
    发明申请
    PHOTO-VINYL LINKING AGENTS 审中-公开
    紫胶连接剂

    公开(公告)号：WO2012170706A2

    公开(公告)日：2012-12-13

    申请号：PCT/US2012/041381

    申请日：2012-06-07

    Applicant: SurModics, Inc. ,  SWAN, Dale G. ,  KURDYUMOV, Aleksey V. ,  JELLE, Bruce M.

    Inventor： SWAN, Dale G. ,  KURDYUMOV, Aleksey V. ,  JELLE, Bruce M.

    IPC: C08J7/16 ,  A61L31/10

    CPC classification number: C09D4/00 ,  A61L27/34 ,  A61L27/50 ,  A61L29/085 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14 ,  A61L2420/02 ,  C07F9/4078 ,  C08J7/16 ,  Y10T428/31938

    Abstract: Embodiments of the invention include linking agents including photo groups and vinyl groups and coatings and devices that incorporate such linking agents, along with related methods. Exemplary methods herein include methods of priming substrates and methods of coating substrates using compounds having the formula R 1 - X - R 2 , wherein R 1 is a radical comprising a vinyl group, X is a radical comprising from about one to about twenty carbon atoms, and R 2 is a radical comprising a photoreactive group. Embodiments herein also include linking agents having the formula R 1 - X - R 2 , wherein R 1 is a radical comprising a vinyl group, X is a radical comprising from about one to about twenty carbon atoms, and R 2 is a radical comprising a photoreactive group. Other embodiments are also included herein.

    Abstract translation: 本发明的实施方案包括包括光学基团和乙烯基的连接剂以及包含这种连接剂的涂层和装置以及相关方法。 本文的示例性方法包括引发底物的方法和使用具有式R1-X-R2的化合物涂覆底物的方法，其中R 1是包含乙烯基的基团，X是包含约1至约20个碳原子的基团，R 2 是包含光反应性基团的基团。 本文的实施方案还包括具有式R 1 -X-R 2的连接剂，其中R 1是包含乙烯基的基团，X是包含约1至约20个碳原子的基团，R 2是包含光反应性基团的基团。 本文还包括其它实施例。

    IMPLANTABLE MEDICAL DEVICE WITH APERTURES FOR DELIVERY OF BIOACTIVE AGENTS
    7.
    发明申请
    IMPLANTABLE MEDICAL DEVICE WITH APERTURES FOR DELIVERY OF BIOACTIVE AGENTS 审中-公开
    具有用于输送生物剂的途径的可植入医疗装置

    公开(公告)号：WO2008060360A2

    公开(公告)日：2008-05-22

    申请号：PCT/US2007/020960

    申请日：2007-09-28

    Applicant: SURMODICS, INC. ,  JELLE, Bruce, M. ,  WALL, John, V. ,  ANDERSON, Aron, B.

    Inventor： JELLE, Bruce, M. ,  WALL, John, V. ,  ANDERSON, Aron, B.

    IPC: A61K9/00

    CPC classification number: A61K9/0024 ,  A61F2250/0068 ,  A61K9/0092 ,  A61L27/54 ,  A61L27/56 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/45

    Abstract: An implantable medical device for the release of bioactive agents at desired rates is described. The device includes a body member with two or more aperture sets and an inner space. The bioactive agents are arranged within the inner space of the body member so that each bioactive agent present in the inner space is individually releasable through their respective aperture set. The aperture sets modulate the release of the bioactive agents from the body member. Arrangement of apertures and bioactive agents within the inner portion chosen to provide desired and independent release rates from the device.

    Abstract translation: 描述了用于以所需速率释放生物活性剂的可植入医疗装置。 该装置包括具有两个或更多孔径组件和内部空间的本体构件。 生物活性剂布置在主体构件的内部空间内，使得存在于内部空间中的每个生物活性剂可以通过它们各自的孔组件单独地释放。 孔径组调节生物活性剂从身体成分的释放。 内部部分中的孔和生物活性剂的布置被选择以从装置提供期望的和独立的释放速率。

    HYDROPHILIC POLYMERIC COATINGS FOR MEDICAL ARTICLES WITH VISUALIZATION MOIETY
    8.
    发明申请
    HYDROPHILIC POLYMERIC COATINGS FOR MEDICAL ARTICLES WITH VISUALIZATION MOIETY 审中-公开
    用于视觉化的医学文章的水性聚合物涂料

    公开(公告)号：WO2013151991A1

    公开(公告)日：2013-10-10

    申请号：PCT/US2013/034937

    申请日：2013-04-02

    Applicant: SURMODICS, INC. ,  LOCKWOOD, Nathan A. ,  JELLE, Bruce M. ,  KURDYUMOV, Aleksey V.

    Inventor： LOCKWOOD, Nathan A. ,  JELLE, Bruce M. ,  KURDYUMOV, Aleksey V.

    IPC: A61L29/08 ,  A61L29/12 ,  A61L29/14

    CPC classification number: C09D5/22 ,  A61L29/085 ,  A61L29/14 ,  A61L29/18 ,  A61L2420/02 ,  B05D3/067 ,  C09D5/00 ,  Y10T428/31725 ,  Y10T428/31938 ,  C08L39/06

    Abstract: The invention is directed to medical device coatings, such as coated guidewires and catheters, containing a visualization moiety providing color to the coating in ambient or applied light. The coating allows for visual or machine inspection of coating properties such as uniformity of coverage. In some embodiments the coatings include the visualization moiety and an activated UV photogroup, which is used to provide covalent bonding in the coating. The visualization moiety can be in particulate form and entrained in the coating, or can be covalently bonded to the hydrophilic polymer backbone. In other embodiments the visualization moiety includes a stilbene chemical group. Exemplary coatings include a hydrophilic vinyl pyrrolidone polymer, which can provide lubricity to the device surface, along with the colored properties.

    Abstract translation: 本发明涉及医疗器械涂层，例如涂覆的导线和导管，其包含在环境或应用光下为涂层提供颜色的可视化部分。 涂层允许对涂层性能进行视觉或机器检查，例如覆盖的均匀性。 在一些实施方案中，涂层包括可视化部分和活化的UV光电子组，其用于在涂层中提供共价键合。 可视化部分可以是颗粒形式并夹带在涂层中，或者可以共价键合到亲水性聚合物主链上。 在其它实施方案中，可视化部分包括茋化学基团。 示例性涂层包括亲水性乙烯基吡咯烷酮聚合物，其可以提供对器件表面的润滑性以及着色性质。

    PHOTO-VINYL LINKING AGENTS
    9.
    发明申请
    PHOTO-VINYL LINKING AGENTS 审中-公开
    紫胶连接剂

    公开(公告)号：WO2012170706A3

    公开(公告)日：2013-04-25

    申请号：PCT/US2012041381

    申请日：2012-06-07

    Applicant: SURMODICS INC ,  SWAN DALE G ,  KURDYUMOV ALEKSEY V ,  JELLE BRUCE M

    Inventor： SWAN DALE G ,  KURDYUMOV ALEKSEY V ,  JELLE BRUCE M

    IPC: C08J7/16 ,  A61L31/10

    CPC classification number: C09D4/00 ,  A61L27/34 ,  A61L27/50 ,  A61L29/085 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14 ,  A61L2420/02 ,  C07F9/4078 ,  C08J7/16 ,  Y10T428/31938

    Abstract: Embodiments of the invention include linking agents including photo groups and vinyl groups and coatings and devices that incorporate such linking agents, along with related methods. Exemplary methods herein include methods of priming substrates and methods of coating substrates using compounds having the formula R1 - X - R2, wherein R1 is a radical comprising a vinyl group, X is a radical comprising from about one to about twenty carbon atoms, and R2 is a radical comprising a photoreactive group. Embodiments herein also include linking agents having the formula R1 - X - R2, wherein R1 is a radical comprising a vinyl group, X is a radical comprising from about one to about twenty carbon atoms, and R2 is a radical comprising a photoreactive group. Other embodiments are also included herein.

    Abstract translation: 本发明的实施方案包括包括光学基团和乙烯基的连接剂以及包含这种连接剂的涂层和装置以及相关方法。 本文的示例性方法包括引发底物的方法和使用具有式R1-X-R2的化合物涂覆底物的方法，其中R 1是包含乙烯基的基团，X是包含约1至约20个碳原子的基团，R 2 是包含光反应性基团的基团。 本文的实施方案还包括具有式R1-X-R2的连接剂，其中R 1是包含乙烯基的基团，X是包含约1至约20个碳原子的基团，R 2是包含光反应性基团的基团。 本文还包括其它实施例。

    IMPLANTABLE MEDICAL DEVICE WITH APERTURES FOR DELIVERY OF BIOACTIVE AGENTS
    10.
    发明申请
    IMPLANTABLE MEDICAL DEVICE WITH APERTURES FOR DELIVERY OF BIOACTIVE AGENTS 审中-公开
    具有用于输送生物剂的途径的可植入医疗装置

    公开(公告)号：WO2008060360A3

    公开(公告)日：2009-02-12

    申请号：PCT/US2007020960

    申请日：2007-09-28

    Applicant: SURMODICS INC ,  JELLE BRUCE M ,  WALL JOHN V ,  ANDERSON ARON B

    Inventor： JELLE BRUCE M ,  WALL JOHN V ,  ANDERSON ARON B

    IPC: A61K9/24

    CPC classification number: A61K9/0024 ,  A61F2250/0068 ,  A61K9/0092 ,  A61L27/54 ,  A61L27/56 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/45

    Abstract: An implantable medical device for the release of bioactive agents at desired rates is described. The device includes a body member with two or more aperture sets and an inner space. The bioactive agents are arranged within the inner space of the body member so that each bioactive agent present in the inner space is individually releasable through their respective aperture set. The aperture sets modulate the release of the bioactive agents from the body member. Arrangement of apertures and bioactive agents within the inner portion chosen to provide desired and independent release rates from the device.

    Abstract translation: 描述了用于以所需速率释放生物活性剂的可植入医疗装置。 该装置包括具有两个或更多孔径组件和内部空间的本体构件。 生物活性剂布置在主体构件的内部空间内，使得存在于内部空间中的每个生物活性剂可以通过它们各自的孔组件单独地释放。 孔径组调节生物活性剂从身体成分的释放。 内部部分中的孔和生物活性剂的布置被选择以从装置提供期望的和独立的释放速率。

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