公开(公告)号：WO2007025059A1

公开(公告)日：2007-03-01

申请号：PCT/US2006/033109

申请日：2006-08-24

Applicant: SURMODICS, INC. ,  HERGENROTHER, Robert W. ,  JELLE, Bruce M.

Inventor： HERGENROTHER, Robert W. ,  JELLE, Bruce M.

IPC: C23C26/00 ,  A61L31/10 ,  C08L65/04

CPC classification number: C23C26/00 ,  A61L27/18 ,  B05D1/38 ,  B05D1/60 ,  B05D3/067 ,  B05D3/107 ,  B05D7/54 ,  C09D165/04 ,  Y10T428/31504 ,  Y10T428/31507 ,  Y10T428/31551 ,  Y10T428/31663 ,  Y10T428/31931 ,  Y10T428/31935 ,  C08L83/04

Abstract: The invention relates to coating systems having one or more hydrophobic layers bonded to a substrate with a silane composition and methods of making and using the same. In an embodiment, the invention includes an article having a substrate, a base coating layer covalently bonded to the surface of the substrate and a hydrophobic polymer layer disposed on the base coating layer. In an embodiment, the invention includes a method for forming an article including applying a base layer coating solution onto a substrate to form a base layer, applying a hydrophobic polymer layer onto the base layer, and applying actinic energy to the substrate.

Abstract translation: 本发明涉及具有一个或多个用硅烷组合物结合到基底上的疏水层的涂料体系及其制备和使用方法。 在一个实施方案中，本发明包括具有基底，共价结合到基底表面的基底涂层和设置在基底涂层上的疏水性聚合物层的制品。 在一个实施方案中，本发明包括一种用于形成制品的方法，包括将基底涂层溶液施加到基底上以形成基底层，在基底层上施加疏水性聚合物层，以及向基底施加光化能。

公开(公告)号：WO2012170706A2

公开(公告)日：2012-12-13

申请号：PCT/US2012/041381

申请日：2012-06-07

Applicant: SurModics, Inc. ,  SWAN, Dale G. ,  KURDYUMOV, Aleksey V. ,  JELLE, Bruce M.

Inventor： SWAN, Dale G. ,  KURDYUMOV, Aleksey V. ,  JELLE, Bruce M.

IPC: C08J7/16 ,  A61L31/10

CPC classification number: C09D4/00 ,  A61L27/34 ,  A61L27/50 ,  A61L29/085 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14 ,  A61L2420/02 ,  C07F9/4078 ,  C08J7/16 ,  Y10T428/31938

Abstract: Embodiments of the invention include linking agents including photo groups and vinyl groups and coatings and devices that incorporate such linking agents, along with related methods. Exemplary methods herein include methods of priming substrates and methods of coating substrates using compounds having the formula R 1 - X - R 2 , wherein R 1 is a radical comprising a vinyl group, X is a radical comprising from about one to about twenty carbon atoms, and R 2 is a radical comprising a photoreactive group. Embodiments herein also include linking agents having the formula R 1 - X - R 2 , wherein R 1 is a radical comprising a vinyl group, X is a radical comprising from about one to about twenty carbon atoms, and R 2 is a radical comprising a photoreactive group. Other embodiments are also included herein.

Abstract translation: 本发明的实施方案包括包括光学基团和乙烯基的连接剂以及包含这种连接剂的涂层和装置以及相关方法。 本文的示例性方法包括引发底物的方法和使用具有式R1-X-R2的化合物涂覆底物的方法，其中R 1是包含乙烯基的基团，X是包含约1至约20个碳原子的基团，R 2 是包含光反应性基团的基团。 本文的实施方案还包括具有式R 1 -X-R 2的连接剂，其中R 1是包含乙烯基的基团，X是包含约1至约20个碳原子的基团，R 2是包含光反应性基团的基团。 本文还包括其它实施例。

公开(公告)号：WO2013151991A1

公开(公告)日：2013-10-10

申请号：PCT/US2013/034937

申请日：2013-04-02

Applicant: SURMODICS, INC. ,  LOCKWOOD, Nathan A. ,  JELLE, Bruce M. ,  KURDYUMOV, Aleksey V.

Inventor： LOCKWOOD, Nathan A. ,  JELLE, Bruce M. ,  KURDYUMOV, Aleksey V.

IPC: A61L29/08 ,  A61L29/12 ,  A61L29/14

CPC classification number: C09D5/22 ,  A61L29/085 ,  A61L29/14 ,  A61L29/18 ,  A61L2420/02 ,  B05D3/067 ,  C09D5/00 ,  Y10T428/31725 ,  Y10T428/31938 ,  C08L39/06

Abstract: The invention is directed to medical device coatings, such as coated guidewires and catheters, containing a visualization moiety providing color to the coating in ambient or applied light. The coating allows for visual or machine inspection of coating properties such as uniformity of coverage. In some embodiments the coatings include the visualization moiety and an activated UV photogroup, which is used to provide covalent bonding in the coating. The visualization moiety can be in particulate form and entrained in the coating, or can be covalently bonded to the hydrophilic polymer backbone. In other embodiments the visualization moiety includes a stilbene chemical group. Exemplary coatings include a hydrophilic vinyl pyrrolidone polymer, which can provide lubricity to the device surface, along with the colored properties.

Abstract translation: 本发明涉及医疗器械涂层，例如涂覆的导线和导管，其包含在环境或应用光下为涂层提供颜色的可视化部分。 涂层允许对涂层性能进行视觉或机器检查，例如覆盖的均匀性。 在一些实施方案中，涂层包括可视化部分和活化的UV光电子组，其用于在涂层中提供共价键合。 可视化部分可以是颗粒形式并夹带在涂层中，或者可以共价键合到亲水性聚合物主链上。 在其它实施方案中，可视化部分包括茋化学基团。 示例性涂层包括亲水性乙烯基吡咯烷酮聚合物，其可以提供对器件表面的润滑性以及着色性质。

公开(公告)号：WO2017172609A1

公开(公告)日：2017-10-05

申请号：PCT/US2017/024289

申请日：2017-03-27

Applicant: SURMODICS, INC.

Inventor： JELLE, Bruce M. ,  SLAGER, Joram ,  MCGONIGLE, Joseph Schmidt ,  LOCKWOOD, Nathan A.

IPC: A61M25/06 ,  A61M25/00

CPC classification number: A61M25/0662 ,  A61M25/0023 ,  A61M25/0045 ,  A61M25/0097 ,  A61M25/0668 ,  A61M39/06 ,  A61M2025/0024 ,  A61M2025/0046 ,  A61M2025/0047 ,  A61M2025/006 ,  A61M2025/0681 ,  A61M2025/0687 ,  A61M2039/064 ,  A61M2039/0666 ,  A61M2207/00

Abstract: An insertion tool 100 for inserting a medical device into another medical device, such as a hemostasis sealing valve. The insertion tool includes a guide sheath 101 and a protection tube 105. The guide sheath includes a flared proximal end. The guide sheath can further include a central lumen. The guide sheath further includes a locking notch 104 disposed on the inner surface between the proximal end and the distal end. The protection tube includes a flared proximal end 108. A portion of the protection tube can be situated within the central lumen of the guide sheath. The flared proximal end of the protection tube is sized to fit within the locking notch and can have an outer diameter larger than portions of the inner surface immediately adjacent to the locking notch. Other embodiments are also included herein.

Abstract translation: 用于将医疗装置插入另一医疗装置（例如止血密封阀）中的插入工具100。 插入工具包括引导护套101和保护管105.引导护套包括扩大的近端。 引导护套可以进一步包括中央内腔。 引导护套还包括设置在近端和远端之间的内表面上的锁定凹口104。 保护管包括张开的近端108.保护管的一部分可以位于引导护套的中心腔内。 保护管的张开的近端的尺寸设置成配合在锁定凹口内并且可以具有比紧邻锁定凹口的内表面的部分更大的外径。 其他实施例也包括在本文中。

公开(公告)号：WO2014110407A3

公开(公告)日：2014-07-17

申请号：PCT/US2014/011096

申请日：2014-01-10

Applicant: SURMODICS, INC.

Inventor： JELLE, Bruce M. ,  KURDYUMOV, Aleksey V. ,  MCGONIGLE, Joseph Schmidt ,  HERGENROTHER, Robert W. ,  LOCKWOOD, Nathan A. ,  VENTURA, Joseph ,  STUCKE, Sean M.

IPC: A61B5/04 ,  A61N1/04 ,  A61N1/05 ,  C08G61/12 ,  C07D495/04 ,  C07D519/00 ,  C09D5/24 ,  C08G61/02 ,  C08G73/02 ,  H01B1/12

Abstract: Disclosed herein are activatable conductive compositions and methods of making and using activatable conductive compositions. In particular, activatable conductive monomers and polymers are described and electrically conductive coatings that include activatable conductive polymers.

Abstract translation: 本文公开了可活化的导电组合物和制备和使用可活化的导电组合物的方法。 具体而言，描述了可活化的导电单体和聚合物以及包含可活化导电聚合物的导电涂层。

公开(公告)号：WO2015031265A1

公开(公告)日：2015-03-05

申请号：PCT/US2014/052542

申请日：2014-08-25

Applicant: SURMODICS, INC. ,  HENDRICKS, Jeffrey L. ,  RICHARDSON-BURNS, Sarah M. ,  MALLIRES, Kyle ,  SPANNINGA, Sarah A.

Inventor： HENDRICKS, Jeffrey L. ,  RICHARDSON-BURNS, Sarah M. ,  MALLIRES, Kyle ,  SPANNINGA, Sarah A. ,  LOCKWOOD, Nathan A. ,  HERGENROTHER, Robert W. ,  JELLE, Bruce M.

IPC: C09D5/44 ,  A61L27/34 ,  A61L31/10 ,  A61L33/06

CPC classification number: C09D5/24 ,  A61B5/6846 ,  A61B18/12 ,  A61B2018/00071 ,  A61B2018/00136 ,  A61N1/05 ,  C09D5/4476

Abstract: The invention includes conductive polymeric coatings, medical device, coating solutions and methods of making the same. A coating solution for forming a conductive polymer layer can include a conductive monomer, at least one photoreactive component comprising an anionic photoreactive cross-linking agent or an anionic photoreactive hydrophilic polymer, and a solvent. A medical device can include an electrode and an electrically conductive coating disposed over the electrode. The electrically conductive coating can include a reaction product of the conductive monomer and the at least one photoreactive component. Other aspects are included herein.

Abstract translation: 本发明包括导电聚合物涂层，医疗装置，涂层溶液及其制备方法。 用于形成导电聚合物层的涂布溶液可以包括导电单体，至少一种包含阴离子光反应性交联剂或阴离子光反应性亲水性聚合物的光反应性组分和溶剂。 医疗装置可以包括设置在电极上的电极和导电涂层。 导电涂层可以包括导电单体和至少一种光反应组分的反应产物。 本文还包括其他方面。