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1.发明申请POLYELECTROLYTE MULTILAYER FILMS AT LIQUID-LIQUID INTERFACES AND METHODS FOR PROVIDING AND USING SAME 审中-公开液体界面上的聚电解多层薄膜及其提供和使用方法
公开(公告)号：WO2008039163A3
公开(公告)日：2009-05-07
申请号：PCT/US2006026530
申请日：2006-07-10
Applicant: WISCONSIN ALUMNI RES FOUND , ABBOTT NICHOLAS L , LOCKWOOD NATHAN A , CADWELL KATIE D , CARUSO FRANK , TJIPTO ELVIRA
Inventor： ABBOTT NICHOLAS L , LOCKWOOD NATHAN A , CADWELL KATIE D , CARUSO FRANK , TJIPTO ELVIRA
CPC classification number: C08J5/20 , G01N21/6428
Abstract: The present invention is directed to methods for providing a polyelectrolyte multilayer film at a liquid-liquid interface. Such methods include steps of sequentially-depositing layers of cationic and anionic polyelectrolytes at a liquid- liquid interface that is formed between immiscible first and second liquids whereby a polyelectrolyte multilayer film is provided at the liquid-liquid interface. In certain preferred embodiments, the first liquid is an aqueous solution and the second liquid is a liquid crystal. In alternative embodiments, the first liquid is an aqueous solution and the second liquid is an oil. The invention further encompasses polyelectrolyte multilayer films provided by the disclosed methods as well as applications utilizing such materials.
Abstract translation: 本发明涉及在液 - 液界面处提供聚电解质多层膜的方法。 这种方法包括以下步骤：在不混溶的第一和第二液体之间形成的液 - 液界面处依次沉积阳离子和阴离子聚电解质层，由此在液 - 液界面处提供聚电解质多层膜。 在某些优选实施方案中，第一液体是水溶液，第二液体是液晶。 在替代实施例中，第一液体是水溶液，第二液体是油。 本发明还包括通过所公开的方法提供的聚电解质多层膜以及利用这种材料的应用。
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公开(公告)号：WO2008042748A2
公开(公告)日：2008-04-10
申请号：PCT/US2007/079835
申请日：2007-09-28
Applicant: SURMODICS, INC. , LOCKWOOD, Nathan, A. , SLAGER, Joram , WALL, John, V. , DUQUETTE, Peter, H.
Inventor： LOCKWOOD, Nathan, A. , SLAGER, Joram , WALL, John, V. , DUQUETTE, Peter, H.
CPC classification number: A61L31/16 , A61L31/145 , A61L2300/606 , C08J7/047 , C08L25/18 , C09D105/08 , C09D105/10 , C09D125/18 , C09D139/02 , C09D189/00 , C08L2666/04
Abstract: The invention provides polyelectrolyte hydrogels, blends, and multilayers for the controlled release of bioactive agents from implantable medical devices coated with or containing such media.
Abstract translation: 本发明提供了聚电解质水凝胶，共混物和多层，用于由可涂覆或含有这种介质的可植入医疗装置控制释放生物活性剂。
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公开(公告)号：WO2007120302A2
公开(公告)日：2007-10-25
申请号：PCT/US2006/061414
申请日：2006-11-30
Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION , ABBOTT, Nicholas L. , DE PABLO, Juan J. , PALECEK, Sean P. , LOCKWOOD, Nathan A. , MOHR, Jeffrey C. , MURPHY, Christopher J. , HUANG, Elise
Inventor： ABBOTT, Nicholas L. , DE PABLO, Juan J. , PALECEK, Sean P. , LOCKWOOD, Nathan A. , MOHR, Jeffrey C. , MURPHY, Christopher J. , HUANG, Elise
IPC: C12N5/00
CPC classification number: C12N5/0068 , C12N5/0606 , C12N2533/50 , C12N2533/52 , C12N2533/54 , C12N2533/90
Abstract: The present invention is directed to liquid crystalline substrates useful in the culture of cells and methods of their use. In certain embodiments, the invention provides methods and devices for imaging changes (e.g., reorganization) of extracellular matrix components by living cells.
Abstract translation: 本发明涉及可用于细胞培养的液晶底物及其使用方法。 在某些实施方案中，本发明提供了用于通过活细胞对细胞外基质组分的变化（例如重组）成像的方法和装置。
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Patent Agency Ranking
公开(公告)号：WO2008042748A3
公开(公告)日：2009-06-04
申请号：PCT/US2007079835
申请日：2007-09-28
Applicant: SURMODICS INC , LOCKWOOD NATHAN A , SLAGER JORAM , WALL JOHN V , DUQUETTE PETER H
Inventor： LOCKWOOD NATHAN A , SLAGER JORAM , WALL JOHN V , DUQUETTE PETER H
IPC: A61L31/10 , A61L31/14 , A61L31/16 , C09D105/04 , C09D125/18 , C09D139/00
CPC classification number: A61L31/16 , A61L31/145 , A61L2300/606 , C08J7/047 , C08L25/18 , C09D105/08 , C09D105/10 , C09D125/18 , C09D139/02 , C09D189/00 , C08L2666/04
Abstract: The invention provides polyelectrolyte hydrogels, blends, and multilayers for the controlled release of bioactive agents from implantable medical devices coated with or containing such media.
Abstract translation: 本发明提供了聚电解质水凝胶，共混物和多层，用于由可涂覆或含有这种介质的可植入医疗装置控制释放生物活性剂。
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5.发明申请POLYELECTROLYTE MULTILAYER FILMS AT LIQUID-LIQUID INTERFACES AND METHODS FOR PROVIDING AND USING SAME 审中-公开液体界面上的聚电解多层薄膜及其提供和使用方法
公开(公告)号：WO2008039163A2
公开(公告)日：2008-04-03
申请号：PCT/US2006/026530
申请日：2006-07-10
Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION , ABBOTT, Nicholas L. , LOCKWOOD, Nathan A. , CADWELL, Katie D. , CARUSO, Frank , TJIPTO, Elvira
Inventor： ABBOTT, Nicholas L. , LOCKWOOD, Nathan A. , CADWELL, Katie D. , CARUSO, Frank , TJIPTO, Elvira
CPC classification number: C08J5/20 , G01N21/6428
Abstract: The present invention is directed to methods for providing a polyelectrolyte multilayer film at a liquid-liquid interface. Such methods include steps of sequentially-depositing layers of cationic and anionic polyelectrolytes at a liquid- liquid interface that is formed between immiscible first and second liquids whereby a polyelectrolyte multilayer film is provided at the liquid-liquid interface. In certain preferred embodiments, the first liquid is an aqueous solution and the second liquid is a liquid crystal. In alternative embodiments, the first liquid is an aqueous solution and the second liquid is an oil. The invention further encompasses polyelectrolyte multilayer films provided by the disclosed methods as well as applications utilizing such materials.
Abstract translation: 本发明涉及在液 - 液界面处提供聚电解质多层膜的方法。 这种方法包括以下步骤：在不混溶的第一和第二液体之间形成的液 - 液界面处依次沉积阳离子和阴离子聚电解质层，由此在液 - 液界面处提供聚电解质多层膜。 在某些优选实施方案中，第一液体是水溶液，第二液体是液晶。 在替代实施例中，第一液体是水溶液，第二液体是油。 本发明还包括通过所公开的方法提供的聚电解质多层膜以及利用这种材料的应用。
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6.发明申请SILANE-FUNCTIONALIZED HYDROPHOBIC a(1→4)GLUCOPYRANOSE POLYMERS AND POLYMERIC MATRICES FOR IMPLANTATION OR INJECTION 审中-公开硅烷官能化的疏水性（1→4）葡聚糖聚合物和用于植入或注射的聚合物
公开(公告)号：WO2010141553A1
公开(公告)日：2010-12-09
申请号：PCT/US2010/037027
申请日：2010-06-02
Applicant: SURMODICS, INC. , KURDYUMOV, Aleksey, V. , LOCKWOOD, Nathan, A. , SLAGER, Joram , SWAN, Dale, G. , HERGENROTHER, Robert
Inventor： KURDYUMOV, Aleksey, V. , LOCKWOOD, Nathan, A. , SLAGER, Joram , SWAN, Dale, G. , HERGENROTHER, Robert
CPC classification number: C08B37/0009 , C08B31/12 , C08B33/04 , C08B37/0012
Abstract: Silane-functionalized hydrophobic a(1→4)glucopyranose polymers and polymeric matrices are described. Biodegradable matrices can be formed from hydrophobic a(1→4)glucopyranose polymers with reactive pendent silyl ether groups. Reaction of the silyl ether groups provides improved matrix formation through bonding to a device surface of a device, polymer-polymer crosslinking, or both. Biodegradable matrices can be used for the preparation of implantable and injectable medical devices, including those that release a bioactive agent.
Abstract translation: 描述了硅烷官能化的疏水性（1→4）吡喃葡萄糖聚合物和聚合物基质。 可生物降解的基质可由疏水性（1→4）吡喃葡萄糖聚合物与反应性侧挂甲硅烷基基团形成。 甲硅烷基醚基团的反应通过结合到器件的器件表面，聚合物 - 聚合物交联或两者来提供改进的基质形成。 可生物降解基质可用于制备可植入和可注射的医疗器械，包括那些释放生物活性剂的医疗器械。
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7.发明申请HYDROPHILIC POLYMERIC COATINGS FOR MEDICAL ARTICLES WITH VISUALIZATION MOIETY 审中-公开用于视觉化的医学文章的水性聚合物涂料
公开(公告)号：WO2013151991A1
公开(公告)日：2013-10-10
申请号：PCT/US2013/034937
申请日：2013-04-02
Applicant: SURMODICS, INC. , LOCKWOOD, Nathan A. , JELLE, Bruce M. , KURDYUMOV, Aleksey V.
Inventor： LOCKWOOD, Nathan A. , JELLE, Bruce M. , KURDYUMOV, Aleksey V.
CPC classification number: C09D5/22 , A61L29/085 , A61L29/14 , A61L29/18 , A61L2420/02 , B05D3/067 , C09D5/00 , Y10T428/31725 , Y10T428/31938 , C08L39/06
Abstract: The invention is directed to medical device coatings, such as coated guidewires and catheters, containing a visualization moiety providing color to the coating in ambient or applied light. The coating allows for visual or machine inspection of coating properties such as uniformity of coverage. In some embodiments the coatings include the visualization moiety and an activated UV photogroup, which is used to provide covalent bonding in the coating. The visualization moiety can be in particulate form and entrained in the coating, or can be covalently bonded to the hydrophilic polymer backbone. In other embodiments the visualization moiety includes a stilbene chemical group. Exemplary coatings include a hydrophilic vinyl pyrrolidone polymer, which can provide lubricity to the device surface, along with the colored properties.
Abstract translation: 本发明涉及医疗器械涂层，例如涂覆的导线和导管，其包含在环境或应用光下为涂层提供颜色的可视化部分。 涂层允许对涂层性能进行视觉或机器检查，例如覆盖的均匀性。 在一些实施方案中，涂层包括可视化部分和活化的UV光电子组，其用于在涂层中提供共价键合。 可视化部分可以是颗粒形式并夹带在涂层中，或者可以共价键合到亲水性聚合物主链上。 在其它实施方案中，可视化部分包括茋化学基团。 示例性涂层包括亲水性乙烯基吡咯烷酮聚合物，其可以提供对器件表面的润滑性以及着色性质。
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公开(公告)号：WO2007120302A3
公开(公告)日：2007-12-06
申请号：PCT/US2006061414
申请日：2006-11-30
Applicant: WISCONSIN ALUMNI RES FOUND , ABBOTT NICHOLAS L , DE PABLO JUAN J , PALECEK SEAN P , LOCKWOOD NATHAN A , MOHR JEFFREY C , MURPHY CHRISTOPHER J , HUANG ELISE
Inventor： ABBOTT NICHOLAS L , DE PABLO JUAN J , PALECEK SEAN P , LOCKWOOD NATHAN A , MOHR JEFFREY C , MURPHY CHRISTOPHER J , HUANG ELISE
IPC: C12N5/00 , C12M3/00 , C12N5/0735
CPC classification number: C12N5/0068 , C12N5/0606 , C12N2533/50 , C12N2533/52 , C12N2533/54 , C12N2533/90
Abstract: The present invention is directed to liquid crystalline substrates useful in the culture of cells and methods of their use. In certain embodiments, the invention provides methods and devices for imaging changes (e.g., reorganization) of extracellular matrix components by living cells.
Abstract translation: 本发明涉及可用于细胞培养的液晶底物及其使用方法。 在某些实施方案中，本发明提供用于成像活细胞对细胞外基质组分的改变（例如，重组）的方法和装置。
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