公开(公告)号：WO2012040721A2

公开(公告)日：2012-03-29

申请号：PCT/US2011/053300

申请日：2011-09-26

Applicant: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK ,  KAUFMAN, Arie, E. ,  GU, Xianfeng, David ,  ZENG, Wei ,  MARINO, Joseph ,  GURIJALA, Krishna, Chaitanya

Inventor： KAUFMAN, Arie, E. ,  GU, Xianfeng, David ,  ZENG, Wei ,  MARINO, Joseph ,  GURIJALA, Krishna, Chaitanya

IPC: A61B1/31 ,  G06T15/00

CPC classification number: G06T7/0012 ,  A61B1/31 ,  G06T3/0068 ,  G06T7/33 ,  G06T2207/10081 ,  G06T2207/30028

Abstract: Disclosed is a method for registration of scans of an object, such as a biological organ, by obtaining scans of the object that includes a first scan obtained with the object in a first position and a second scan obtained with the object in a second position different from the first position, extracting landmarks within each of the scans, flattening each of the scans, detecting feature points of each of the flattened scans, matching corresponding feature points of each of the flattened scans, performing a harmonic map registration using the matched corresponding feature points and displaying the registered scans.

Abstract translation: 公开了一种用于通过获得对象的扫描来配准对象（诸如生物器官）的扫描的方法，该扫描包括用第一位置中的对象获得的第一扫描和获得的第二扫描 使物体处于与第一位置不同的第二位置;提取每个扫描内的地标;平滑每个扫描;检测每个展平扫描的特征点;匹配每个展平扫描的对应特征点; 使用匹配的相应特征点进行调和映射配准并显示已注册的扫描。

公开(公告)号：WO0229717A2

公开(公告)日：2002-04-11

申请号：PCT/US0130858

申请日：2001-10-02

Applicant: UNIV NEW YORK STATE RES FOUND ,  KAUFMAN ARIE E ,  LIANG ZHENGRONG ,  WAX MARK R ,  BITTER INGMAR ,  DACHILLE FRANK IX ,  KREEGER KEVIN ,  WAN MING

Inventor： KAUFMAN ARIE E ,  LIANG ZHENGRONG ,  WAX MARK R ,  BITTER INGMAR ,  DACHILLE FRANK IX ,  KREEGER KEVIN ,  WAN MING

IPC: G01R33/32 ,  A61B5/00 ,  A61B5/055 ,  A61B6/03 ,  A61B8/00 ,  G01R33/54 ,  G06K9/44 ,  G06T5/00 ,  G06T7/00 ,  G06T7/60 ,  G06T17/00 ,  G06T19/00 ,  G06T

CPC classification number: G06T19/20 ,  G06T7/12 ,  G06T7/62 ,  G06T7/64 ,  G06T15/08 ,  G06T15/10 ,  G06T2200/04 ,  G06T2207/10072 ,  G06T2207/20044 ,  G06T2207/20132 ,  G06T2207/30028 ,  G06T2207/30061 ,  G06T2207/30172 ,  G06T2210/41 ,  G06T2219/028 ,  G06T2219/2012

Abstract: In accordance with the present invention, a method for determining a centerline through a region of interest in a 3D image dataset is provided. The method includes identifying the boundaries of the region of interest and identifying the endpoints of the region of interest. For those points within the boundaries, a penalty value which is a function of the proximity of the point to a boundary is determined. A centerline is then identified by the path connecting the endpoints which has the minimum penalized distance wherein the penalized distance reflects the actual accumulated pathlength and the penalties associated with the points along the path. From the centerline, branches of a complete skeleton can be established by determining branch endpoints and then finding the minimum penalized distance from each endpoint the centerline or another intersecting branch.

Abstract translation: 根据本发明，提供了一种通过3D图像数据集中的感兴趣区域确定中心线的方法。 该方法包括识别感兴趣区域的边界并识别感兴趣区域的端点。 对于边界内的那些点，确定作为点到边界的接近度的函数的惩罚值。 然后通过连接具有最小惩罚距离的端点的路径来识别中心线，其中惩罚距离反映实际累积路径长度和与沿着路径的点相关联的惩罚。 从中心线，可以通过确定分支端点，然后从中心线或另一个相交分支的每个端点找到最小惩罚距离来建立完整骨架的分支。

公开(公告)号：WO0156491A3

公开(公告)日：2002-02-21

申请号：PCT/US0103746

申请日：2001-02-05

Applicant: UNIV NEW YORK STATE RES FOUND ,  LIANG ZHENGRONG ,  LI BIN ,  CHEN DONGQING ,  SMOUHA ERIC E ,  ROQUE CLEMENTE T ,  KAUFMAN ARIE E ,  WAX MARK R ,  KREEGER KEVIN

Inventor： LIANG ZHENGRONG ,  LI BIN ,  CHEN DONGQING ,  SMOUHA ERIC E ,  ROQUE CLEMENTE T ,  KAUFMAN ARIE E ,  WAX MARK R ,  KREEGER KEVIN

IPC: A61B10/00 ,  A61B10/02 ,  A61B19/00 ,  A61F2/00 ,  A61F2/18 ,  G06F19/00

CPC classification number: A61B90/36 ,  A61B10/02 ,  A61B34/10 ,  A61B2090/374 ,  A61F2/00 ,  A61F2002/183 ,  G06F19/324 ,  G06F19/3481 ,  G16H50/50

Abstract: A method of computer aided treatment planning is performed by generating and manipulating a three dimensional (3D) image of a region which includes at least one anatomical structure for which treatment, such as surgery, biopsy, tissue component analysis, prothesis implantation, radiation, chemotherapy and the like, is contemplated. A virtual intervention, which simulates at least a portion of the contemplated treatment, is performed in the 3D image. The user can then determine the effect of the intervention and interactively modify the intervention for improved treatment results. Preferably, a warning is automatically provided if the intervention posses a risk of detrimental effect. The user can navigate through the contemplated region in the 3D image and asses the results. The treatment plans can be saved for comparison and post treatment evaluation.

Abstract translation: 计算机辅助治疗计划的方法是通过生成和操纵包括至少一个解剖结构的区域的三维（3D）图像来进行的，对于该解剖结构，诸如手术，活组织检查，组织成分分析，假体植入，放射，化疗 等等。 在3D图像中执行模拟预期治疗的至少一部分的虚拟介入。 然后，用户可以确定干预的效果并交互地修改干预以改善治疗结果。 优选地，如果干预具有有害影响的风险，则自动提供警告。 用户可以浏览3D图像中的预期区域并评估结果。 治疗计划可以节省进行比较和治疗后评估。

公开(公告)号：WO2012040721A3

公开(公告)日：2012-06-28

申请号：PCT/US2011053300

申请日：2011-09-26

Applicant: UNIV NEW YORK STATE RES FOUND ,  KAUFMAN ARIE E ,  GU XIANFENG DAVID ,  ZENG WEI ,  MARINO JOSEPH ,  GURIJALA KRISHNA CHAITANYA

Inventor： KAUFMAN ARIE E ,  GU XIANFENG DAVID ,  ZENG WEI ,  MARINO JOSEPH ,  GURIJALA KRISHNA CHAITANYA

IPC: A61B1/31 ,  G06T15/00

CPC classification number: G06T7/0012 ,  A61B1/31 ,  G06T3/0068 ,  G06T7/33 ,  G06T2207/10081 ,  G06T2207/30028

Abstract: Disclosed is a method for registration of scans of an object, such as a biological organ, by obtaining scans of the object that includes a first scan obtained with the object in a first position and a second scan obtained with the object in a second position different from the first position, extracting landmarks within each of the scans, flattening each of the scans, detecting feature points of each of the flattened scans, matching corresponding feature points of each of the flattened scans, performing a harmonic map registration using the matched corresponding feature points and displaying the registered scans.

Abstract translation: 公开了一种用于通过获得包括在第一位置中获得的物体的第一扫描的对象的扫描以及在与第二位置不同的第二位置获得的第二扫描的对象的生物器官的扫描的注册的方法 从第一位置，提取每个扫描内的地标，使每个扫描平坦化，检测每个平坦扫描的特征点，匹配每个平坦化扫描的相应特征点，使用匹配的相应特征执行谐波地图注册 点并显示注册的扫描。

公开(公告)号：WO2005036457A3

公开(公告)日：2008-11-20

申请号：PCT/US2004033888

申请日：2004-10-12

Applicant: VIATRONIX INC ,  CHEN DONGQING ,  LAKARE SARANG ,  KREEGER KEVIN ,  WAX MARK R ,  KAUFMAN ARIE E ,  LIANG ZHENGRONG

Inventor： CHEN DONGQING ,  LAKARE SARANG ,  KREEGER KEVIN ,  WAX MARK R ,  KAUFMAN ARIE E ,  LIANG ZHENGRONG

IPC: G06K9/00 ,  G06K9/34 ,  G06T20060101

CPC classification number: G06T7/12 ,  G06T2207/10081 ,  G06T2207/20132 ,  G06T2207/30032

Abstract: Imaging systems and methods for processing and rendering volumetric images of a selected organ for virtual endoscopy applications are provided, which enable visualization and navigation of the imaged organ from within a lumen/cavity of the organ. For example, methods are provided for preparing 3D volumetric images of colons for virtual endoscopy application which do not require administration of oral laxatives or suppositories for patient bowel preparation. In particular, an imaging method which can be implemented for virtual colonoscopy applications, includes a process of obtaining an image dataset comprising image data of a colon (step 11) that is prepared (step 10) to tag regions of colonic residue in a manner that enhances a contrast between tagged regions of colonic residue in a lumen of the colon and a colon wall; segmenting (step 12) a region of interest in the image dataset, the region of interest comprising the colon lumen, the colon wall, and regions of tagged residue in the colon lumen; electronically cleaning (step 13) the tagged residue in the colon lumen using a gradient feature data obtained from the image dataset using a maximum directional gradient feature analysis; and rendering (step 14) a volumetric image comprising an endoluminal view at a region within the imaged colon.

Abstract translation: 提供用于处理和渲染用于虚拟内窥镜检查应用的所选器官的体积图像的成像系统和方法，其使得能够从器官的腔/腔内可视化和导航成像的器官。 例如，提供了用于制备用于虚拟内窥镜检查应用的冒烟的3D体积图像的方法，其不需要口服泻药或栓剂用于患者肠道准备。 特别地，可以实现用于虚拟结肠镜检查应用的成像方法包括获得包括结肠图像数据（步骤11）的图像数据集的处理（步骤11），其被制备（步骤10），以以下方式标记结肠残基的区域： 增加结肠腔中结肠残留的标记区域与结肠壁之间的对比度; 分割（步骤12）图像数据集中的感兴趣区域，感兴趣区域包括结肠腔，结肠壁和结肠腔中标记残基的区域; 使用最大方向梯度特征分析从图像数据集获得的梯度特征数据电子清洗（步骤13）结肠腔中的标记残基; 以及渲染（步骤14）包括在成像的结肠内的区域的腔内视图的体积图像。

公开(公告)号：WO2002029717A3

公开(公告)日：2002-04-11

申请号：PCT/US2001/030858

申请日：2001-10-02

Applicant: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK ,  KAUFMAN, Arie, E. ,  LIANG, Zhengrong ,  WAX, Mark, R. ,  BITTER, Ingmar ,  DACHILLE, Frank, IX ,  KREEGER, Kevin ,  WAN, Ming

Inventor： KAUFMAN, Arie, E. ,  LIANG, Zhengrong ,  WAX, Mark, R. ,  BITTER, Ingmar ,  DACHILLE, Frank, IX ,  KREEGER, Kevin ,  WAN, Ming

IPC: G06K9/00

Abstract: In accordance with the present invention, a method for determining a centerline through a region of interest in a 3D image database is provided (Figure 1). The method includes identifying the boundaries of the region of interest and identifying the endpoints of the region of interest. For those points within the boundaries, a penalty value which is a function of the proximity of the point to a boundary is determined. A centerline is then identified by the path connecting the endpoints which has the minimum penalized distance wherein the penalized distance reflects the actual accumulated pathlength and the penalties associated with the points along the path (Figure 9A). From the centerline, branches of a complete skeleton can be established by determining branch endpoints and then finding the minimum penalized distance from each endpoint the centerline or another intersecting branch (Figure 9b).

公开(公告)号：WO2007002146A3

公开(公告)日：2007-05-03

申请号：PCT/US2006024072

申请日：2006-06-21

Applicant: UNIV NEW YORK STATE RES FOUND ,  KAUFMAN ARIE E ,  HONG WEI ,  GU XIANFENG ,  QIU FENG

Inventor： KAUFMAN ARIE E ,  HONG WEI ,  GU XIANFENG ,  QIU FENG

IPC: A61B5/05 ,  G06T15/08

CPC classification number: G06K9/342 ,  G06K2209/053 ,  G06T3/0037 ,  G06T7/0012 ,  G06T15/08 ,  G06T2207/30028

Abstract: In the present methods, the automatic detection of polyps is converted into a 2D pattern recognition problem using conformal mapping and direct volume rendering. The colon surface is first segmented and extracted from the CT data set of the abdomen, which is then mapped to a 2D plane using conformal mapping. Ray casting is used to determine sub-surface density values and the flattened image is rendered using a volume rendering technique with a translucent electronic biopsy transfer function. Polyp candidates are detected by a clustering method which identifies regions of elevated sub-surface density. The potential for false positives is reduced by analyzing the volumetric shape and texture features of the polyp candidate regions.

Abstract translation: 在目前的方法中，使用共形映射和直接体绘制将息肉的自动检测转换成2D模式识别问题。 首先分割并从腹部的CT数据集中提取结肠表面，然后使用共形映射将其映射到2D平面。 光线投射用于确定亚表面密度值，并且使用具有半透明电子活检传递函数的体积渲染技术来渲染平坦图像。 通过聚类方法来检测候选方案，该方法识别高于地下表面密度的区域。 通过分析息肉候选区域的体积形状和纹理特征来减少假阳性的可能性。

公开(公告)号：WO0193745A3

公开(公告)日：2002-08-29

申请号：PCT/US0118353

申请日：2001-06-06

Applicant: UNIV NEW YORK STATE RES FOUND ,  LIANG ZHENGRONG ,  CHEN DONGQING ,  LI BIN ,  ROQUE CLEMENTE T ,  SMOUHA ERIC E ,  KAUFMAN ARIE E ,  WAX MARK R ,  KREEGER KEVIN

Inventor： LIANG ZHENGRONG ,  CHEN DONGQING ,  LI BIN ,  ROQUE CLEMENTE T ,  SMOUHA ERIC E ,  KAUFMAN ARIE E ,  WAX MARK R ,  KREEGER KEVIN

IPC: A61B5/055 ,  A61B19/00 ,  A61B5/05

CPC classification number: A61B5/055 ,  A61B5/726 ,  A61B90/36 ,  A61B2090/364

Abstract: Figure 5 is a pictorial diagram illustrating a branched section of a blood vessel with plaque build-up resulting in stenosis. From step 315, the lumen of the artery (500) can be extracted and the regions of possible stenosis (505) can be identified. The artery exhibits a first arterial section (510) which branches at a bifurcation point (515) into an internal arterial branch (520) and an external arterial branch (525). The bifurcation point (515) can be determined and selected as the control point for subsequent registration operations.

Abstract translation: 图5是示出导致狭窄的具有斑块积聚的血管的分支部分的示意图。 从步骤315，可以提取动脉（500）的内腔，并且可以识别出可能的狭窄区域（505）。 动脉呈现在分叉点（515）处分支到内部动脉分支（520）和外部动脉分支（525）中的第一动脉部分（510）。 可以确定分岔点（515）并将其选为后续注册操作的控制点。

公开(公告)号：WO0055814A3

公开(公告)日：2001-06-28

申请号：PCT/US0007352

申请日：2000-03-17

Applicant: UNIV NEW YORK STATE RES FOUND ,  KAUFMAN ARIE E ,  LIANG ZHENGRONG ,  WAX MARK R ,  WAN MING ,  CHEN DONGQING

Inventor： KAUFMAN ARIE E ,  LIANG ZHENGRONG ,  WAX MARK R ,  WAN MING ,  CHEN DONGQING

IPC: A61B6/03 ,  A61B5/055 ,  G06T1/00 ,  G06T5/00 ,  G06T7/00 ,  G06T15/04 ,  G06T15/08 ,  G06T15/40 ,  G06T17/00 ,  G06T15/20 ,  G06T17/40

CPC classification number: G06T15/08 ,  G06K9/209 ,  G06K9/38 ,  G06K2209/05 ,  G06T7/0012 ,  G06T7/11 ,  G06T15/04 ,  G06T19/20 ,  G06T2207/10081 ,  G06T2207/20156 ,  G06T2207/30032 ,  G06T2210/28 ,  G06T2210/41 ,  G06T2219/2021

Abstract: A system and method for generating a three-dimensional visualization image of an object such as an organ using volume visualization techniques and exploring the image using a guided navigation system which allows the operator to travel along a flight path and to adjust the view to a particular portion of the image of interest in order, for example, to identify polyps, cysts or other abnormal features in the visualized organ. An electronic biopsy can also be performed on an identified growth or mass in the visualized object. Virtual colonoscopy can be enhanced by electronically removing residual stool, fluid and non-colonic tissue from the image of the colon, by employing bowel preparation followed by image segmentation operations. Methods are also employed for virtually expanding regions of colon collapse using image segmentation results.

Abstract translation: 一种用于使用体积可视化技术生成诸如器官的物体的三维可视化图像的系统和方法，并且使用导航系统探索图像，所述导航系统允许操作者沿着飞行路径行进并且将视图调整到特定的 例如，为了识别可视化器官中的息肉，囊肿或其他异常特征，感兴趣的图像的一部分。 电子活检也可以对可视化物体中的识别生长或质量进行。 通过使用排便，然后进行图像分割操作，可以通过电子方式从结肠图像中去除残留的粪便，流体和非结肠组织来增强虚拟结肠镜检查。 方法也用于使用图像分割结果实际扩大结肠崩溃区域。

公开(公告)号：WO2007002146A2

公开(公告)日：2007-01-04

申请号：PCT/US2006/024072

申请日：2006-06-21

Applicant: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK ,  KAUFMAN, Arie, E. ,  HONG, Wei ,  GU, Xianfeng ,  QIU, Feng

Inventor： KAUFMAN, Arie, E. ,  HONG, Wei ,  GU, Xianfeng ,  QIU, Feng

IPC: G06F19/00

CPC classification number: G06K9/342 ,  G06K2209/053 ,  G06T3/0037 ,  G06T7/0012 ,  G06T15/08 ,  G06T2207/30028

Abstract: In the present methods, the automatic detection of polyps is converted into a 2D pattern recognition problem using conformal mapping and direct volume rendering. The colon surface is first segmented and extracted from the CT data set of the abdomen, which is then mapped to a 2D plane using conformal mapping. Ray casting is used to determine sub-surface density values and the flattened image is rendered using a volume rendering technique with a translucent electronic biopsy transfer function. Polyp candidates are detected by a clustering method which identifies regions of elevated sub-surface density. The potential for false positives is reduced by analyzing the volumetric shape and texture features of the polyp candidate regions.

Abstract translation: 在本方法中，使用保形映射和直接体绘制，将息肉的自动检测转换为2D模式识别问题。 首先将结肠表面分割并从腹部的CT数据集中提取，然后使用保形图映射到2D平面。 Ray铸造用于确定亚表面密度值，并且使用具有半透明电子活检传递函数的体绘制技术来渲染平坦化图像。 通过聚类方法检测Polyp候选物，其识别升高的亚表面密度的区域。 通过分析息肉候选区域的体积形状和纹理特征来减少假阳性的潜力。