Abstract:
The present invention relates to a conjugate comprising oxyntomodulin, an immunoglobulin Fc region, and non-peptidyl polymer wherein the conjugate being obtainable by covalently linking oxyntomodulin to immunoglobulin Fc region via non-peptidyl polymer, and a pharmaceutical composition for the prevention or treatment of obesity comprising the conjugates. The conjugate comprising oxyntomodulin and the immunoglobulin Fc of the present invention reduces food intake, suppresses gastric emptying, and facilitates lipolysis without side-effects, unlike native oxyntomodulin, and also shows excellent receptor-activating effects and long-term sustainability, compared to native oxyntomodulin. Thus, it can be widely used in the treatment of obesity with safety and efficacy.
Abstract:
The present invention relates to a conjugate comprising oxyntomodulin, an immunoglobulin Fc region, and non-peptidyl polymer wherein the conjugate being obtainable by covalently linking oxyntomodulin to immunoglobulin Fc region via non-peptidyl polymer, and a pharmaceutical composition for the prevention or treatment of obesity comprising the conjugates. The conjugate comprising oxyntomodulin and the immunoglobulin Fc of the present invention reduces food intake, suppresses gastric emptying, and facilitates lipolysis without side-effects, unlike native oxyntomodulin, and also shows excellent receptor-activating effects and long-term sustainability, compared to native oxyntomodulin. Thus, it can be widely used in the treatment of obesity with safety and efficacy.
Abstract:
The present invention relates to a cytokine-bipodal peptide binder specifically binding to cytokine, comprising (a) a structure stabilizing region comprising parallel, antiparallel, or parallel and antiparallel amino acid strands in which an interstrand noncovalent bond is formed; and (b) a cytokine-target binding region I and a cytokine-target binding region II which bind to both ends of the structure stabilizing region and comprise n and m amino acids randomly selected, respectively. The cytokine-bipodal peptide binder of the present invention shows a very low level (for example, nM level) of KD value (dissociation constant) to cytokine, thereby showing very high affinity to a cytokine target. The cytokine-bipodal peptide binder of the present invention has medical use, can be used for in vivo molecular imaging and targeting for drug delivery, and is very useful as an escort molecule.
Abstract:
The present invention relates to a long-acting interferon beta formulation having improved in vivo duration and stability, comprising an interferon beta conjugate that is prepared by covalently linking interferon beta with an immunoglobulin Fc region via a non-peptidyl polymer, and a preparation method thereof. The long-acting interferon beta formulation of the present invention maintains in vivo activity of interferon beta at a relatively high level and remarkably increases the serum half-life thereof, thereby being used for various diseases, for which interferon is efficacious.
Abstract:
The present invention relates to a method for manufacturing a dye-sensitized solar cell module using a foil and to a dye-sensitized solar cell manufactured by the method. The present invention relates to a method for manufacturing a dye-sensitized solar cell module using a foil and to a dye-sensitized solar cell manufactured by the method, wherein the dye-sensitized solar cell module is formed by integrating dye-sensitized solar cells, each of which comprises a working electrode substrate and a catalyst electrode substrate opposite each other, and an electrolyte which fills the space between the substrates; and an electrical connection between electrodes of the working electrode substrate and the catalyst electrode substrate is carried out such that a metal foil is inserted between the opposite portions of the electrodes of the two substrates, and the two substrates are compressed against each other so as to enable the two substrates to contact each other, and the metal foil is electrified and melted to couple the electrodes of the two substrates together. According to the present invention, a uniform and high-quality electrical contact between electrodes is achieved during the integration of dye-sensitized solar cells, and therefore contact resistance between electrodes during the integration of dye-sensitized solar cells is prevented in order to achieve improved efficiency of solar cells.
Abstract:
A method and system to enable a computer to estimate calibration parameters autonomously so that accurate stereopsis can be performed. The present invention automatically calibrates two or more cameras with unknown parameters with respect to a robot or robotic appendage (e.g., articulated robot arm) with a light source that can be turned on and off at one end. A pair of cameras (e.g., digital cameras) are positioned and aimed so as to give stereoptic coverage of the robot's workspace. The procedure determines the positions and orientations of the pair of cameras with respect to a robot (i.e., exterior orientations) and the focal lengths, optical centers, and distortion coefficients of each camera (i.e., intrinsic parameters) automatically from a set of known positions of the robot arm, and a set of images from the right and left cameras of the robot arm in each position as the light is turned on and off.
Abstract:
The present invention relates to an organic framework comprising a plurality of platy layers formed by successively connecting building blocks arranged in the vicinity of each other, wherein each of said building blocks is formed through a covalent bonding of two or three C6-C204 aromatic ring groups to a linear or annular boron-containing cluster; and a Lewis base which is coordinate covalent bonded to the boron-containing cluster in said platy layers.
Abstract:
The present invention provides a system for processing a semiconductor substrate using a laser beam, the system including: a storing unit storing a process control data set for a slot for loading the semiconductor substrate therein; a process controlling unit detecting identification information of the slot in which the semiconductor substrate is loaded, and reading the control data, which is set for the detected identification information, from the storing unit to control a process of the semiconductor substrate; and a substrate processing unit processing the semiconductor substrate on the basis of the read control data using the laser beam with a predetermined energy.
Abstract:
Disclosed is a light diffusion resin composition that is prepared by adding a bead type light diffusion resin comprised of PMMA as a light diffuser to a polyester resin according to the present invention. The light diffusion resin composition can be molded into a cover for lightings or sign boards by a processing method such as injection molding, extrusion molding or compression molding, so that the cover has a high haze and high light transmittance, making lamps of the lightings or the sign boards, interior lamps of buildings and contents invisible with a high light transmittance and hence a high level of luminance, provides a low surface resistance to prevent dust-attraction caused by static electricity, and minimizes a deterioration of impact strength, thereby allowing the manufacture of the cover irrespective of size.
Abstract:
The present invention relates to a digital system performing tagging and a method for providing same. The digital system performing tagging includes: a communication unit that carries out first tagging with a predetermined device and second tagging with a predetermined financial transaction device; and a control module that controls the communication unit, wherein, when the second tagging is carried out, the control module performs controlling to transmit, to the financial transaction device, a financial transaction requiring information which was received through the first tagging, or based on financial information pre-stored in the digital system in order to allow a financial transaction to be performed.