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    FRACTION OF MELISSA LEAF EXTRACT HAVING ANGIOGENESIS AND MMP INHIBITORY ACTIVITIES, AND COMPOSITION COMPRISING THE SAME
    6.
    发明申请
    FRACTION OF MELISSA LEAF EXTRACT HAVING ANGIOGENESIS AND MMP INHIBITORY ACTIVITIES, AND COMPOSITION COMPRISING THE SAME 审中-公开
    具有血管生成和MMP抑制活性的MELISSA叶提取物的分类及包含其的组合物

    公开(公告)号：WO2009025532A2

    公开(公告)日：2009-02-26

    申请号：PCT/KR2008004938

    申请日：2008-08-25

    Applicant: ANGIOLAB INC ,  KIM MIN YOUNG ,  HAHM JONG CHEON ,  PARK BYUNG YOUNG ,  PARK EUN KYU ,  LEE HEE SUK

    Inventor： KIM MIN YOUNG ,  HAHM JONG CHEON ,  PARK BYUNG YOUNG ,  PARK EUN KYU ,  LEE HEE SUK

    IPC: A61K36/53

    CPC classification number: A61K36/53

    Abstract: The present invention relates to an ethyl acetate fraction of Melissa leaf having excellent an- giogenesis and MMP inhibitory activities, and a composition comprising the same. In particular, the ethyl acetate fraction of Melissa leaf is characterized that Melissa leaf is extracted with 50-100% C1-C6 alcohol, and concentrated, and then the concentrated alcohol extract is suspended in water, and fractionated with ethyl acetate, and dried to obtain the ethyl acetate fraction of Melissa leaf. The ethyl acetate fraction of Melissa leaf of the present invention has strong and excellent anti- angiogenic and MMP inhibitory activities. Therefore, the composition comprising the ethyl acetate fraction of Melissa leaf of the present invention can be used as an agent for the treatment or prevention of angiogenesis -related diseases and MMP-mediated diseases.

    Abstract translation: 本发明涉及具有优异的生成和MMP抑制活性的梅利莎叶的乙酸乙酯级分及其组合物。 特别地，梅利莎叶的乙酸乙酯部分的特征在于，用50-100％的C1-C6醇提取梅利莎叶，浓缩，然后将浓缩的醇提取物悬浮在水中，并用乙酸乙酯分级，并干燥至 获得梅利莎叶的乙酸乙酯级分。 本发明的梅利莎叶的乙酸乙酯级分具有强而优异的抗血管生成和MMP抑制活性。 因此，包含本发明Melissa叶的乙酸乙酯部分的组合物可以用作治疗或预防血管生成相关疾病和MMP介导的疾病的药剂。

    ANTIOBESITY COMPOSITION
    7.
    发明申请
    ANTIOBESITY COMPOSITION 审中-公开
    抗菌成分

    公开(公告)号：WO2007040377A1

    公开(公告)日：2007-04-12

    申请号：PCT/KR2006/004049

    申请日：2006-10-09

    Applicant: ANGIO-LAB., INC. ,  KIM, Min-Young ,  LEE, Hee-Suk ,  KIM, Joon-Sik ,  HAHM, Jong-Cheon

    Inventor： KIM, Min-Young ,  LEE, Hee-Suk ,  KIM, Joon-Sik ,  HAHM, Jong-Cheon

    IPC: A61K36/53 ,  A61K36/282 ,  A61K36/605 ,  A23L1/29 ,  A61P3/04

    CPC classification number: A61K36/82 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/258 ,  A61K36/282 ,  A61K36/53 ,  A61K36/605 ,  A61K36/68 ,  A61K2300/00 ,  A23V2250/21 ,  A23V2250/5114 ,  A23V2250/5066

    Abstract: The present invention provides antiobesity composition comprising extract of Melissa as an active ingredient, use of Melissa extract, and a method for suppressing obesity using the composition. Also, the present invention provides an antiobesity composition comprising extract of Melissa and extract of Mori Folium as active ingredients, use of a mixture of Melissa extract and Mori Folium extract, and a method for suppressing obesity using the composition. Further, the present invention provides an antiobesity composition comprising extract of Melissa, extract of Artemisia and extract of Mori Folium as active ingredients, use of a mixture of Melissa extract, Artemisia extract and Mori Folium extract, and a method for suppressing obesity using the composition. When the present compositions are administrated into genetically obese mice or high fat diet-induced obese mice, the present compositions reduced body weight, body fat and gonadal fat, and reduce blood cholesterol level and obesity-related blood glucose level. Also, the present compositions suppress hypertrophy of adipocytes, and inhibit the accumulation of lipid in the liver by reducing the size and number of lipid vacuoles. Furthermore, in human clinial trial the present compositions show that body weight, PIBW, body fat, especially visceral fat, apolipoprotin B concentration, ratio of total cholesterol/HDL cholesterol and ratio of LDL cholesterol /HDL cholesterol are significantly decreased, and atherogenic index is improved and muscle mass is increased. Thus, the present compositions can be usefully applied as antiobesity composition for reduction of body weight and suppression of abdominal fat, particularly, visceral fat.

    Abstract translation: 本发明提供了包含Melissa的提取物作为活性成分的抗肥胖组合物，使用Melissa提取物，以及使用该组合物抑制肥胖症的方法。 另外，本发明提供一种抗肥胖组合物，其包含梅利莎提取物和森叶提取物作为活性成分，使用梅利莎提取物和山楂提取物的混合物，以及使用该组合物抑制肥胖的方法。 此外，本发明提供一种抗肥胖组合物，其包含梅利莎提取物，艾蒿提取物和森林提取物作为活性成分，使用梅利莎提取物，艾蒿提取物和山楂提取物的混合物，以及使用该组合物抑制肥胖的方法 。 当本发明组合物施用于遗传性肥胖小鼠或高脂饮食诱导的肥胖小鼠时，本发明的组合物降低体重，体脂肪和性腺脂肪，并降低血液胆固醇水平和肥胖相关的血糖水平。 此外，本发明的组合物抑制脂肪细胞的肥大，并通过减少脂质空泡的大小和数量来抑制脂质在肝脏中的积聚。 此外，在人体临床试验中，本发明的组合物显示，体重，PIBW，体脂肪，特别是内脏脂肪，载脂蛋白B浓度，总胆固醇/ HDL胆固醇的比例和LDL胆固醇/ HDL胆固醇的比例显着降低，而致动脉粥样化指数为 改善肌肉质量。 因此，本发明的组合物可有效地用作抗肥胖组合物，用于减轻体重和抑制腹部脂肪，特别是内脏脂肪。

    METHOD OF PRODUCING EXTRACT OF HORSE CHESTNUT LEAF
    9.
    发明申请
    METHOD OF PRODUCING EXTRACT OF HORSE CHESTNUT LEAF 审中-公开
    生产菠菜叶提取物的方法

    公开(公告)号：WO2008093958A1

    公开(公告)日：2008-08-07

    申请号：PCT/KR2008/000412

    申请日：2008-01-23

    Applicant: ANGIOLAB., INC. ,  KIM, Min-Young ,  HAHM, Jong-Cheon ,  PARK, Byung-Young ,  PARK, Eun-Kyu ,  LEE, Hee-Suk

    Inventor： KIM, Min-Young ,  HAHM, Jong-Cheon ,  PARK, Byung-Young ,  PARK, Eun-Kyu ,  LEE, Hee-Suk

    IPC: A61K36/185 ,  A61K8/97

    CPC classification number: A61K8/97 ,  A61K36/185 ,  A61Q11/00 ,  A61Q19/08

    Abstract: The present invention provide a method of producing extract of Horse chestnut leaf comprising following steps: 1) drying and crushing horse chestnut leaves; 2) subjecting crushed horse chestnut leaves to extraction with a 25% aqueous alcohol with heating; 3) filtering the aqueous extract from step 2); and 4) concentrating the filtrate from step 3) to recover the extract, and a composition comprising the extract as an active ingredient for treating or preventing MMPs-dependent diseases including periodontal disease.

    Abstract translation: 本发明提供了一种生产马蹄叶提取物的方法，包括以下步骤：1）干燥和粉碎马蹄叶; 2）用粉碎的马蹄叶用加热的25％酒精提取; 3）过滤来自步骤2）的水提取物; 和4）浓缩来自步骤3）的滤液以回收提取物，以及包含提取物作为活性成分的组合物，用于治疗或预防MMPs依赖性疾病，包括牙周病。

    USE OF THE EXTRACT OF CAESALPINIA SAPPAN L. AND COMPOUNDS THEREFROM
    10.
    发明申请
    USE OF THE EXTRACT OF CAESALPINIA SAPPAN L. AND COMPOUNDS THEREFROM 审中-公开
    芍药提取物的使用及其化合物

    公开(公告)号：WO2007066928A1

    公开(公告)日：2007-06-14

    申请号：PCT/KR2006/005084

    申请日：2006-11-29

    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  YANG, Hyun Ok ,  KIM, Min Young ,  KWON, Young-Guen ,  CHOI, Yeon Hee

    Inventor： YANG, Hyun Ok ,  KIM, Min Young ,  KWON, Young-Guen ,  CHOI, Yeon Hee

    IPC: A61K36/48 ,  A61K31/352 ,  A23L1/29 ,  A61P19/02 ,  A61P17/00 ,  A61P25/28 ,  A61P3/04 ,  A61P35/00 ,  A61P27/02

    CPC classification number: A61K36/48 ,  A23L33/105 ,  A61K2300/00

    Abstract: The present invention relates to an extract of Caesalpinia sappan L. having an angiogenesis inhibition activity and a use of the compound isolated therefrom, more precisely an extract of Caesalpinia sappan L. extracted by using water, alcohol or a mixture thereof , and a use of brazilin, sappanchalcone and brazilein isolated from the extract as an angiogenesis inhibitor. The extract of Caesalpinia sappan L. of the invention and a compound isolated therefrom have angiogenesis inhibition activity, so that they can be effectively used for the prevention and treatment of angiogenesis associated diseases such as vascular diseases, cardiovascular diseases, ophthalmic diseases, chronic inflammatory diseases, dermatological diseases, Alzheimer's disease, obesity and cancer.

    Abstract translation: 本发明涉及具有血管生成抑制活性的Caesalpinia sappan L.的提取物和使用从其分离的化合物，更准确地说，是使用水，醇或其混合物提取的Caesalpinia sappan L.提取物，以及使用 巴西，sappanchalcone和brazilein作为血管发生抑制剂从提取物中分离出来。 本发明的Caesalpinia sappan L.提取物及其分离的化合物具有血管生成抑制活性，因此可有效地用于预防和治疗血管生成相关疾病如血管疾病，心血管疾病，眼科疾病，慢性炎性疾病 ，皮肤病，阿尔茨海默病，肥胖症和癌症。

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