公开(公告)号：WO2012063115A3

公开(公告)日：2012-10-26

申请号：PCT/IB2011002633

申请日：2011-11-09

Applicant: JUBILANT LIFE SCIENCES LTD ,  SINGH KHUSHWANT ,  SINGH ANAND KUMAR ,  SRIVASTAVA RAHUL ,  KUMAR PRAMOD ,  VIR DHARAM ,  AGARWAL ASHUTOSH

Inventor： SINGH KHUSHWANT ,  SINGH ANAND KUMAR ,  SRIVASTAVA RAHUL ,  KUMAR PRAMOD ,  VIR DHARAM ,  AGARWAL ASHUTOSH

IPC: C07D239/42

CPC classification number: C07D239/42

Abstract: The present invention, relates to novel amine salts of rosuvastatin and its process for the preparation. Moreover, the present invention also relates to improved process for the preparation of rosuvastatin calcium, employing novel amine salts as an intermediate.

Abstract translation: 本发明涉及罗苏伐他汀的新颖胺盐及其制备方法。 此外，本发明还涉及使用新的胺盐作为中间体来制备瑞舒伐他汀钙的改进方法。

公开(公告)号：WO2011055320A1

公开(公告)日：2011-05-12

申请号：PCT/IB2010/054996

申请日：2010-11-04

Applicant: PIRAMAL LIFE SCIENCES LIMITED ,  KUMAR, Sanjay ,  HARIHARAN, Sivaramakrishnan ,  BHONDE, Mandar ,  DAGIA, Nilesh ,  SHARMA, Rajiv ,  MANE, Pallavi Hanmantrao ,  KUMAR, Pramod Bhaskar

Inventor： KUMAR, Sanjay ,  HARIHARAN, Sivaramakrishnan ,  BHONDE, Mandar ,  DAGIA, Nilesh ,  SHARMA, Rajiv ,  MANE, Pallavi Hanmantrao ,  KUMAR, Pramod Bhaskar

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: The present invention relates to compounds of formula (I), wherein R a , R b , R c , R d , R e and R f are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases mediated by phosphatidylinositol-3-kinase (PBK), mammalian target of rapamycin (mTOR), Signal transducer and activator of transcription 3 (STAT 3), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) or a combination thereof particularly in the treatment of cancer and inflammation.

Abstract translation: 本发明涉及式（I）化合物，其中Ra，Rb，Rc，Rd，Re和Rf如本说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗由 磷脂酰肌醇-3-激酶（PBK），雷帕霉素哺乳动物靶（mTOR），信号转导和转录激活因子3（STAT3），肿瘤坏死因子-α（TNF-α），白细胞介素-6（IL-6）或 特别是在治疗癌症和炎症中的组合。

公开(公告)号：WO2011001212A1

公开(公告)日：2011-01-06

申请号：PCT/IB2009/052819

申请日：2009-06-30

Applicant: PIRAMAL LIFE SCIENCES LIMITED ,  KUMAR, Sanjay ,  VISHWAKARMA, Ram ,  MUNDADA, Ramswaroop ,  DEORE, Vijaykumar ,  KUMAR, Pramod ,  SHARMA, Somesh

Inventor： KUMAR, Sanjay ,  VISHWAKARMA, Ram ,  MUNDADA, Ramswaroop ,  DEORE, Vijaykumar ,  KUMAR, Pramod ,  SHARMA, Somesh

IPC: C07D471/04 ,  A61K31/437 ,  A61P17/06 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: The present invention provides the compounds of formula (I): (I) The present invention relates to imidazo[4,5-c]quinoline derivatives of formula (I), process for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases mediated by phosphatidylinositol-3-kinase (PBK) and/or mammalian target of rapamycin (mTOR) and/or tumor necrosis factor-α (TNF-oc) and/or interleukin-6 (IL-6), particularly in the treatment of cancer and inflammation.

Abstract translation: 本发明提供式（I）化合物：（I）本发明涉及式（I）的咪唑并[4,5-c]喹啉衍生物，其制备方法，含有它们的药物组合物及其在 治疗由磷脂酰肌醇-3-激酶（PBK）和/或哺乳动物雷帕霉素靶（mTOR）和/或肿瘤坏死因子-α（TNF-α）和/或白细胞介素-6（IL-6）介导的疾病，特别是在 治疗癌症和炎症。

公开(公告)号：WO2008012837A8

公开(公告)日：2008-05-08

申请号：PCT/IN2007000307

申请日：2007-07-24

Applicant: JUBILANT ORGANOSYS LTD ,  SINGH HARNAM ,  GUPTA NITIN ,  KUMAR PRAMOD ,  DUBEY SUSHIL KUMAR

Inventor： SINGH HARNAM ,  GUPTA NITIN ,  KUMAR PRAMOD ,  DUBEY SUSHIL KUMAR

IPC: C07D223/26 ,  C07D223/28

CPC classification number: C07D223/26 ,  C07D223/28

Abstract: Disclosed herein is a process for producing 10-oxo-10,11-dihydro-5H-dibenz[bf] azepine-5-carboxamide of formula I via novel intermediates 11-alkoxy-10-halo-10,11-dihydro-5H-dibenzo [b,f ] azepine-5-carbonitrile [XIX] or 10-alkoxy-5H-dibenz [b,f] azepine -5-carbonitrile [XX]. Further the present invention also provides a process for preparation of said intermediates.

Abstract translation: 本文公开了通过新的中间体11-烷氧基-10-卤代-10,11-二氢-5H-咪唑并[1,2-a]所示的式I的10-氧代-10,11-二氢-5H-二苯并[bf]吖庚因-5-甲酰胺的制备方法， 二苯并[b，f]吖庚因-5-甲腈[XIX]或10-烷氧基-5H-二苯并[b，f]吖庚因-5-甲腈[XX]。 此外，本发明还提供了制备所述中间体的方法。

公开(公告)号：WO2006013550A3

公开(公告)日：2006-04-13

申请号：PCT/IB2005052611

申请日：2005-08-04

Applicant: RANBAXY LAB LTD ,  BOSE PROSENJIT ,  KUMAR PRAMOD ,  MITTAL SHILPI ,  KUMAR YATENDRA

Inventor： BOSE PROSENJIT ,  KUMAR PRAMOD ,  MITTAL SHILPI ,  KUMAR YATENDRA

IPC: C07D409/14

CPC classification number: C07D409/14

Abstract: Processes for preparing pure tiagabine, a piperidine carboxylic acid, using pharmaceutically acceptable acid addition salts of tiagabine esters are provided. L(+)-­tartaric acid, oxalic acid and dibenzoyl L(+)-tartaric acid addition salts of tiagabine esters are also provided. Further, processes for preparing acid addition salts of tiagabine esters are provided. Formula (I).

Abstract translation: 提供了使用噻加滨酯的药学上可接受的酸加成盐来制备纯噻加宾，哌啶羧酸的方法。 还提供了噻加滨酯的L（+） - 酒石酸，草酸和二苯甲酰L（+） - 酒石酸加成盐。 此外，提供了制备噻加滨酯的酸加成盐的方法。 式（I）。

公开(公告)号：WO2005066120A2

公开(公告)日：2005-07-21

申请号：PCT/IB2004/004281

申请日：2004-12-23

Applicant: RANBAXY LABORATORIES LIMITED ,  KUMAR, Yatendra ,  MEERAN, Hashim, Nizar, Poovanathi, Nagoor ,  SINGH, Shailendra, Kumar ,  RATHOD, Parendu, Dhirajlal ,  GANAGAKHEDKAR, Kiran, Kumar ,  BOSE, Prosenjit ,  KUMAR, Pramod

Inventor： KUMAR, Yatendra ,  MEERAN, Hashim, Nizar, Poovanathi, Nagoor ,  SINGH, Shailendra, Kumar ,  RATHOD, Parendu, Dhirajlal ,  GANAGAKHEDKAR, Kiran, Kumar ,  BOSE, Prosenjit ,  KUMAR, Pramod

IPC: C07D205/00

CPC classification number: C07D205/08 ,  C07C67/31 ,  C07D263/22 ,  C07C69/732

Abstract: Provided herein are processes for asymmetric synthesis of hydroxyalkyl-substituted azetidinone derivatives or intermediates thereof via stereoselective reduction of benzylic ketone using (-)-B-chlorodiisopinocampheylborane. Also provided herein are processes for preparing ezetimibe.

Abstract translation: 本文提供了通过使用（ - ） - B-氯二氧杂环己烷硼烷通过苄基酮的立体选择性还原来不对称合成羟烷基取代的氮杂环丁酮衍生物或其中间体的方法。 本文还提供了制备依泽替米贝的方法。

公开(公告)号：WO2012131451A1

公开(公告)日：2012-10-04

申请号：PCT/IB2012/000403

申请日：2012-03-05

Applicant: JUBILANT LIFE SCIENCES LIMITED ,  GUPTA, Vijay Shankar ,  KUMAR, Pramod ,  VIR, Dharam

Inventor： GUPTA, Vijay Shankar ,  KUMAR, Pramod ,  VIR, Dharam

IPC: C07D215/227

CPC classification number: C07D215/227

Abstract: Disclosed herein is an improved process for the preparation of anpiprazole in anhydrous Type I crystals, substantially free of other polymorphic forms of aripiprazole via improved drying technique.

Abstract translation: 本文公开了一种通过改进的干燥技术制备无水I型晶体中的阿哌唑的改进方法，其基本上不含阿立哌唑的其它多晶型物。

公开(公告)号：WO2012012880A1

公开(公告)日：2012-02-02

申请号：PCT/CA2011/000862

申请日：2011-07-26

Applicant: POLYCORP LTD. ,  KUMAR, Pramod ,  PAGE, David J. ,  MEPHAM, Robert

Inventor： KUMAR, Pramod ,  PAGE, David J. ,  MEPHAM, Robert

IPC: B02C17/22

CPC classification number: B02C17/22

Abstract: A liner assembly mountable to a shell of a grinding mill, the shell being rotatable around an axis thereof. The liner assembly includes a number of wear plates, a number of lifter bars securable to the shell with the wear plates positioned between respective pairs of the lifter bars, and a number of fastening subassemblies. The liner assembly also includes a number of wear elements, each wear element being positioned at least partially in a liner portion selected from the group consisting of the lifter bars, the wear plates, and combinations thereof, for resisting wear of a leading intermediate portion located substantially between a leading face of the lifter bar and a lifter channel therein. The liner portion includes one or more liner portion body materials in which each wear element is at least partially embedded. The wear elements are substantially more abrasion-resistant than the liner portion body material.

Abstract translation: 可安装到研磨机壳体的衬套组件，所述壳体可绕其轴线旋转。 衬套组件包括多个耐磨板，多个提升杆可固定在外壳上，耐磨板位于各对提升杆之间，以及多个紧固组件。 衬套组件还包括多个磨损元件，每个磨损元件至少部分地定位在选自由提升杆，耐磨板及其组合组成的组中的衬套部分中，用于抵抗位于 基本上在升降杆的前导面和其中的升降器通道之间。 衬套部分包括一个或多个衬垫部分主体材料，其中每个磨损元件至少部分地嵌入其中。 磨损元件比衬垫部分主体材料基本上更耐磨。

公开(公告)号：WO2011042804A2

公开(公告)日：2011-04-14

申请号：PCT/IB2010002553

申请日：2010-10-08

Applicant: JUBLIANT LIFE SCIENCES LTD ,  ACHARYA HRISHIKESH DILIP ,  SRIVASTAVA JAYANT ,  KUMAR SATISH ,  AWASTHI ARUN KUMAR ,  KUMAR PRAMOD ,  VIR DHARAM

Inventor： ACHARYA HRISHIKESH DILIP ,  SRIVASTAVA JAYANT ,  KUMAR SATISH ,  AWASTHI ARUN KUMAR ,  KUMAR PRAMOD ,  VIR DHARAM

IPC: C07D495/04

CPC classification number: C07D495/04

Abstract: Disclosed herein an improved process for the preparation of polymorphic Form I of clopidogrel hydrogen sulfate.

Abstract translation: 本文公开了制备氯吡格雷硫酸氢盐的多晶型I的改进方法。

公开(公告)号：WO2010012105A1

公开(公告)日：2010-02-04

申请号：PCT/CA2009/001085

申请日：2009-07-30

Applicant: POLYCORP LTD. ,  PAGE, David J. ,  KUMAR, Pramod ,  MEPHAM, Robert

Inventor： PAGE, David J. ,  KUMAR, Pramod ,  MEPHAM, Robert

IPC: B02C13/286 ,  B02C17/18 ,  B02C23/02 ,  B02C23/08 ,  D21D1/02

CPC classification number: B02C17/1855

Abstract: A discharge grate assembly for at least partially guiding slurry from a mill shell chamber in a rotating mill shell to a discharge trunnion thereof via a pulp lifter chamber. The discharge grate assembly includes a body having a number of apertures for permitting the slurry to flow from the mill shell chamber into the pulp lifter chamber. The discharge grate assembly also includes a number of louvers movable between a closed position, in which the apertures in the body are at least partially covered by the louvers, and an open position, in which the apertures are at least partially unobstructed by the louvers.

Abstract translation: 排气格栅组件，其用于至少部分地将浆料从旋转磨机壳体中的轧机壳室引导到经由纸浆提升室的排出耳轴。 排放格栅组件包括具有多个孔的主体，用于允许浆料从研磨室室流入纸浆提升室。 排放格栅组件还包括可在闭合位置之间移动的多个百叶窗，其中主体中的孔至少部分地被百叶窗覆盖，并且打开位置，孔中至少部分地不被百叶窗遮挡。