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    AQUEOUS FORMULATIONS BASED ON SODIUM HYALURONATE FOR PARENTERAL USE
    1.
    发明申请
    AQUEOUS FORMULATIONS BASED ON SODIUM HYALURONATE FOR PARENTERAL USE 审中-公开
    基于氢氧化钠的水质配方用于家庭用途

    公开(公告)号：WO2006067608A1

    公开(公告)日：2006-06-29

    申请号：PCT/IB2005/003918

    申请日：2005-12-14

    Applicant: LABORATOIRE MEDIDOM S.A. ,  CARLINO, Stefano

    Inventor： CARLINO, Stefano

    IPC: A61K31/728 ,  A61K47/18 ,  A61K47/24

    CPC classification number: A61K47/183 ,  A61K9/0019 ,  A61K31/728 ,  A61K47/24

    Abstract: An aqueous formulation for parenteral use, comprises sodium hyaluronate having a molecular weight from 500,000 to 5,000,000 D in an amount from 0.01 to 3 % w/v, based on the aqueous formulation, a non saline physiologically acceptable osmogen in an effective amount to impart to the aqueous formulation a physiological osmolarity of from 270-330 mOsm/l, and an amphoter acting as an inhibitor of hyaluronidase activity.

    Abstract translation: 用于胃肠外使用的水性制剂包含基于水性制剂，分子量为500,000至5,000,000D的量为0.01至3％w / v的透明质酸钠，有效量的非盐生理学可接受的渗透剂 水性制剂的生理渗透压为270-330mOsm / l，和作为透明质酸酶活性抑制剂的两性体。

    PROCESS FOR PREPARING RHEIN
    3.
    发明申请
    PROCESS FOR PREPARING RHEIN 审中-公开
    制备RHEIN的方法

    公开(公告)号：WO2009106908A1

    公开(公告)日：2009-09-03

    申请号：PCT/IB2008/000447

    申请日：2008-02-29

    Applicant: LABORATOIRE MEDIDOM S.A. ,  DI NAPOLI, Guido ,  DI NAPOLI, Alessandro

    Inventor： DI NAPOLI, Guido ,  DI NAPOLI, Alessandro

    IPC: C07C51/285 ,  C07C65/40

    CPC classification number: C07C51/285 ,  C07C66/02

    Abstract: Process for the preparation of rhein or diacerein comprising oxidising aloe-emodin with hydrogen peroxide or an alkali-metal peroxide oxidant in a basic reaction medium, optionally in the presence of an organic solvent, to obtain rhein. Optionally followed by acetylating the rhein thus obtained using an acetylating agent to obtain diacerein.

    Abstract translation: 用于制备大黄酸或双醋瑞因的方法，其包括在碱性反应介质中，任选在有机溶剂的存在下用过氧化氢或碱金属过氧化物氧化剂氧化芦荟大黄素，以获得大黄酸。 然后任选地使用乙酰化剂乙酰化如此获得的大黄酸以获得双醋瑞因。

    PROCESS FOR PREPARING ALOE-EMODIN
    4.
    发明申请
    PROCESS FOR PREPARING ALOE-EMODIN 审中-公开
    制备ALOE-EMODIN的方法

    公开(公告)号：WO2006051400A1

    公开(公告)日：2006-05-18

    申请号：PCT/IB2005/003375

    申请日：2005-11-11

    Applicant: LABORATOIRE MEDIDOM S.A. ,  CARLINO, Stefano ,  DI NAPOLI, Guido

    Inventor： CARLINO, Stefano ,  DI NAPOLI, Guido

    IPC: C07C51/27 ,  C07C66/02 ,  C07C67/08 ,  C07C69/16

    CPC classification number: C07C66/02

    Abstract: A process for preparing aloe-emodin from aloin by oxidizing aloin by treatment with an oxygen-containing gas in the presence of an acid. The aloe-emodin may be used for the production of rhein and diacerein by oxidizing aloe-emodin by treatment with a chromium-free oxidizing medium to obtain rhein and purifying the rhein obtained. The rhein may be acetylated to obtain diacerein.

    Abstract translation: 一种通过在酸存在下用含氧气体处理氧化芦荟来从芦荟中制备芦荟大黄素的方法。 芦荟大黄素可用于通过用无铬氧化介质处理氧化芦荟大黄素来生产大黄酸和双醋瑞因，以获得大黄酸并纯化获得的大黄酸。 可以将大黄酸乙酰化以获得双醋瑞因。

    DIOXOANTHRACENE SULPHONATE DERIVATIVES
    7.
    发明申请
    DIOXOANTHRACENE SULPHONATE DERIVATIVES 审中-公开
    二氧化硫酸盐衍生物

    公开(公告)号：WO2009063427A1

    公开(公告)日：2009-05-22

    申请号：PCT/IB2008/054777

    申请日：2008-11-14

    Applicant: LABORATOIRE MEDIDOM S.A. ,  CARLINO, Stefano ,  DI NAPOLI, Alessandro

    Inventor： CARLINO, Stefano ,  DI NAPOLI, Alessandro

    IPC: C07C317/46 ,  A61K31/10 ,  A61P29/00

    CPC classification number: C07C309/60 ,  C07C2603/24

    Abstract: Compounds that may have anti-inflammatory activity have the general formula (I): Wherein R 1 , R 2 , R 3 are each independently H or a C 1-4 alkyl group or a C 2-4 acyl group; R 4 and R 5 are each independently H or a group of formula -SO 3 R 6 , wherein R 6 is H or a C 1-4 alkyl group or a C 2-4 acyl group; with the proviso that at least one of R 4 and R 5 is a group of formula -SO 3 R 6 , or a pharmaceutically acceptable salt thereof.

    Abstract translation: 可具有抗炎活性的化合物具有通式（I）：其中R1，R2，R3各自独立为H或C1-4烷基或C2-4酰基; R4和R5各自独立地为H或式-SO3R6的基团，其中R6为H或C1-4烷基或C2-4酰基; 条件是R 4和R 5中的至少一个是式-SO 3 R 6的基团，或其药学上可接受的盐。

    IN SITU SYSTEM FOR INTRA-ARTICULAR CHONDRAL AND OSSEOUS TISSUE REPAIR
    8.
    发明申请
    IN SITU SYSTEM FOR INTRA-ARTICULAR CHONDRAL AND OSSEOUS TISSUE REPAIR 审中-公开
    用于内科手术和OSSEOUS组织修复的原位系统

    公开(公告)号：WO2008078166A2

    公开(公告)日：2008-07-03

    申请号：PCT/IB2007/004067

    申请日：2007-12-21

    Applicant: LABORATOIRE MEDIDOM S.A. ,  BURKHARD, MATHIES

    Inventor： BURKHARD, MATHIES

    IPC: A61L27/20 ,  A61F2/30 ,  A61L27/24 ,  A61L27/54 ,  A61L27/58 ,  A61L31/04 ,  A61L31/14 ,  A61L31/16

    CPC classification number: A61F2/30756 ,  A61F2002/30677 ,  A61F2002/30766 ,  A61F2002/30971 ,  A61F2310/00365 ,  A61L2/20 ,  A61L27/20 ,  A61L27/58 ,  C08L5/08

    Abstract: Disclosed is a device and method which provide a surgical therapy for in situ treatment and repair of intra-articular cartilage lesions and/or defects. The device is an implantable laminate cartilage repair patch which is bio-compatible and physiologically absorbable. The cartilage repair patch has a first outer cell occlusive layer; a second outer, cell porous layer adapted to be disposed proximate a subchondral bone wound site; and a cartilagenic matrix disposed between the first and second layers. The cartilagenic matrix is a sink for diffusion of autologous stem cells and includes chemical components promoting generation of hyaline-like cartilage in the presence of the autologous stem cells. The method of the present invention provides the autologous compositions, which when used in combination with the repair patch provides a therapeutic system to regenerate replacement hyaline-like intraarticular cartilage.

    Abstract translation: 公开了提供用于原位治疗和修复关节内软骨损伤和/或缺陷的手术治疗的装置和方法。 该装置是可植入的层压软骨修复贴片，其生物相容性和生理学吸收性。 软骨修复贴片具有第一外细胞封闭层; 第二外细胞多孔层，适于设置在软骨下骨创伤部位附近; 以及设置在第一和第二层之间的软骨基质。 软骨基质是自体干细胞扩散的沉淀物，包括在自体干细胞存在下促进产生透明样软骨的化学成分。 本发明的方法提供了自体组合物，当与修复贴片组合使用时，提供了再生替代性透明样关节内软骨的治疗系统。

    PROCESS FOR PREPARING A STERILE HIGH MOLECULAR WEIGHT HYALURONIC ACID FORMULATION
    9.
    发明申请
    PROCESS FOR PREPARING A STERILE HIGH MOLECULAR WEIGHT HYALURONIC ACID FORMULATION 审中-公开
    制备无规高分子量羟丙酸配方的方法

    公开(公告)号：WO2004014399A1

    公开(公告)日：2004-02-19

    申请号：PCT/IB2003/003524

    申请日：2003-08-04

    Applicant: LABORATOIRE MEDIDOM S.A. ,  CARLINO, Stefano

    Inventor： CARLINO, Stefano

    IPC: A61K31/728

    CPC classification number: C08B37/0072 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/728 ,  A61K47/36

    Abstract: A process for preparing a sterile ready-to-use aqueous pharmaceutical formulation comprises a high molecular weight hyaluronic acid salt (HA) at a specified concentration, comprising the steps of: providing an aqueous formulation comprising high molecular weight HAat a concentration of less than the specified final concentration; passing said aqueous formulation through a filter having a pore sizeless than 0.45 pm; concentrating said aqueous formulation by applying a vacuum and boiling off water until said specified concentration is reached.

    Abstract translation: 一种制备无菌即用型水性药物制剂的方法包括一种特定浓度的高分子量透明质酸盐（HA），其包括以下步骤：提供含有低分子量HA 规定终浓度; 使所述水性制剂通过具有0.45μm以下的孔的过滤器; 通过施加真空和沸腾的水浓缩所述水性制剂直到达到所述指定的浓度。

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