公开(公告)号：WO2015039748A1

公开(公告)日：2015-03-26

申请号：PCT/EP2014/002519

申请日：2014-09-17

Applicant: ALTERGON S.A.

Inventor： PAGLIUCA, Maurizio ,  MILEO, Antonio ,  TRUPPA, Danilo ,  BERGAMO, Giuseppe

IPC: A61K9/06 ,  A61F13/00 ,  A61K36/00 ,  A61K9/00

CPC classification number: A61K9/0014 ,  A61F13/02 ,  A61F2013/00187 ,  A61F2013/00191 ,  A61F2013/00676 ,  A61F2013/0071 ,  A61F2013/00748 ,  A61F2013/00919 ,  A61K9/06 ,  A61K9/7023 ,  A61K31/045 ,  A61K31/085 ,  A61K36/45 ,  A61K47/32 ,  A61K47/38 ,  A61K47/42

Abstract: A composition for topical application characterized in that it includes, in a hydrogel base, vanillyl butyl ether and menthol. The composition described herein produces an ordered development of cold and warm sensations, obtaining effects that are particularly useful in the treatment of painful disorders of neurological and/ or muscular origin. The composition has further moisturizing and soothing effects that concur to an effect that is also curative, i.e., not simply symptomatic, of rheumatic and muscular pain, trauma and bruises. The composition is compatible with each administration form, being preferably and advantageously formulated as a plaster.

Abstract translation: 一种用于局部应用的组合物，其特征在于其在水凝胶基质中包含香草基丁基醚和薄荷醇。 本文描述的组合物产生冷感和温暖感觉的有序发展，获得特别可用于治疗神经和/或肌肉起源的疼痛障碍的效果。 该组合物具有进一步的保湿和舒缓作用，其同时具有风湿性和肌肉疼痛，创伤和瘀伤的疗效也不是简单的症状。 该组合物与每种给药形式相容，优选和有利地配制成石膏。

公开(公告)号：WO2009108884A2

公开(公告)日：2009-09-03

申请号：PCT/US2009/035524

申请日：2009-02-27

Applicant: KCI LICENSING INC. ,  ROBINSON, Timothy, Mark ,  KIESWETTER, Kristine ,  McNULTY, Amy

Inventor： ROBINSON, Timothy, Mark ,  KIESWETTER, Kristine ,  McNULTY, Amy

IPC: A61L15/58 ,  A61F13/02

CPC classification number: A61L15/58 ,  A61F13/00051 ,  A61F13/0203 ,  A61F13/0246 ,  A61F17/00 ,  A61F2013/00655 ,  A61F2013/0071 ,  A61F2013/00795 ,  A61F2013/00825 ,  A61F2013/00838 ,  A61F2013/00842 ,  A61L15/42 ,  Y10T156/1158 ,  Y10T156/1917

Abstract: Provided herein is a system and method for facilitating removal of a drape from a tissue site. One aspect provides a system comprising a drape, and adhesive layer, and a release agent, where the system is adapted to be coupled to a tissue site and released therefrom upon or after exposure to an external stimulus. Another aspect provides a method for application and removal of a drape using less force than required with a conventional drape.

Abstract translation: 本文提供了用于促进从组织部位去除盖布的系统和方法。 一个方面提供了一种系统，该系统包括盖布，粘合剂层和释放剂，其中系统适于在暴露于外部刺激时或之后与组织部位偶联并从其释放。 另一方面提供了一种使用比传统披盖所需力更小的力施加和移除披盖的方法。

公开(公告)号：WO2005091852A3

公开(公告)日：2005-12-22

申请号：PCT/US2005005223

申请日：2005-02-18

Applicant: MYLAN TECHNOLOGIES INC ,  JACKSON KRISTIN ,  MILLER II KENNETH JAMES

Inventor： JACKSON KRISTIN ,  MILLER II KENNETH JAMES

IPC: A61F13/02 ,  A61K9/70 ,  A61L15/16

CPC classification number: A61K9/7092 ,  A61F13/00 ,  A61F2013/00646 ,  A61F2013/00655 ,  A61F2013/0071 ,  A61F2013/00906 ,  A61K9/0014 ,  A61K9/7053 ,  A61K9/7061 ,  A61K31/565 ,  A61K31/567 ,  A61M37/00 ,  Y10T156/10

Abstract: A transdermal drug-containing dosage unit comprises: a backing layer substantially impervious to the drug to be delivered transdermally; a first polymeric adhesive matrix, in contact with the backing layer, having dispersed therein the drug and having a first delivery profile of the drug; a second polymeric adhesive matrix, in contact with said first polymeric adhesive matrix, having dispersed therein the drug and having a second delivery profile of the drug, wherein said second delivery profile is different from said first delivery profile; and a release liner in contact with the second polymeric adhesive matrix. The first polymeric adhesive matrix can release the drug more quickly or more slowly than the second polymeric adhesive matrix. Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled.

Abstract translation: 含透皮药物的剂量单位包括：基本上不透过经皮递送的药物的背衬层; 与背衬层接触的第一聚合物粘合剂基质，其中分散有药物并具有药物的第一递送曲线; 与所述第一聚合物粘合剂基质接触的第二聚合物粘合剂基质，其中分散有药物并具有药物的第二递送分布，其中所述第二递送分布与所述第一递送分布不同; 以及与第二聚合物粘合剂基质接触的剥离衬垫。 第一聚合物粘合剂基质可以比第二聚合物粘合剂基质更快或更慢地释放药物。 通过选择两个基质，可以选择性地改变和控制药物通过皮肤的递送特征。

公开(公告)号：WO1997005171A1

公开(公告)日：1997-02-13

申请号：PCT/US1996010532

申请日：1996-06-17

Applicant: MINNESOTA MINING AND MANUFACTURING COMPANY

Inventor： MINNESOTA MINING AND MANUFACTURING COMPANY ,  DIETZ, Timothy, M. ,  LU, Ying-Yuh ,  UY, Rosa ,  YOUNG, Chung, I.

IPC: C08F02/22

CPC classification number: C09J157/00 ,  A61F13/023 ,  A61F2013/00659 ,  A61F2013/0071 ,  A61F2013/00906 ,  A61F2013/0091 ,  A61F2013/00914 ,  A61K9/7023 ,  A61K9/7038 ,  A61L15/58 ,  A61L15/585 ,  A61L24/043 ,  A61L26/0014 ,  A61N1/0428 ,  A61N1/0456 ,  A61N1/0468 ,  A61N1/0496 ,  A61N1/0551 ,  A61N1/30 ,  C08F220/12 ,  C09J7/20 ,  C23F2201/02 ,  Y10T428/28 ,  Y10T428/2848 ,  C08L33/00

Abstract: A polymerized microemulsion pressure sensitive adhesive composition is described. The composition has peel adhesion of at least 3 Newtons/100 mm as measured according to a PSTC-1 Test. The composition preferably has a bicontinuous structure of a continuous phase of a hydrophobic pressure sensitive adhesive polymer and a continuous phase of a hydrophilic polymer. The bulk properties of both polymers are retained in the bicontinuous structure. The composition is prepared from a microemulsion comprising a free-radically ethylenically unsaturated polar amphiphilic or hydrophilic monomer or oligomer in the aqueous phase, a free-radically ethylenically unsaturated hydrophobic monomer, having a glass transition temperature suitable for forming a pressure sensitive adhesive, in the oil phase, water, and surfactant. Uses for the pressure sensitive adhesive composition include biomedical articles, such as biomedical electrodes, medical skin coverings, and pharmaceutical delivery devices, and industrial articles, such as zinc/adhesive tapes used for cathodic protection of rebars embedded in concrete.

Abstract translation: 描述聚合的微乳液压敏粘合剂组合物。 根据PSTC-1试验测得，该组合物具有至少3牛顿/ 100mm的剥离粘合力。 组合物优选具有疏水性压敏粘合剂聚合物的连续相和亲水性聚合物的连续相的双连续结构。 两种聚合物的整体性质保持在双连续结构中。 该组合物由包含在水相中的自由基烯属不饱和极性两亲或亲水单体或低聚物的微乳液制备，具有适于形成压敏粘合剂的玻璃化转变温度的自由基烯键式不饱和疏水性单体， 油相，水和表面活性剂。 压敏粘合剂组合物的用途包括生物医学制品，例如生物医学电极，医疗皮肤覆盖物和药物递送装置，以及工业制品，例如用于阴极保护嵌入在混凝土中的钢筋的锌/胶带。

公开(公告)号：WO2016038111A1

公开(公告)日：2016-03-17

申请号：PCT/EP2015/070650

申请日：2015-09-09

Applicant: MÖLNLYCKE HEALTH CARE AB

Inventor： FLACH, Niclas ,  HAMBERG, Kristina ,  JOHANNISON, Ulf ,  SÖDERSTRÖM, Bengt

IPC: A61F13/00 ,  A61F13/02 ,  A61L15/00

CPC classification number: A61L15/58 ,  A61F13/00063 ,  A61F13/00991 ,  A61F13/0206 ,  A61F13/0213 ,  A61F13/0246 ,  A61F13/0253 ,  A61F2013/00519 ,  A61F2013/0071 ,  A61F2013/0074 ,  A61F2013/0091 ,  A61L15/26 ,  A61L15/44 ,  A61L15/46 ,  A61L2300/104 ,  A61L2300/202 ,  A61L2300/206 ,  A61L2300/208 ,  A61L2300/404 ,  A61L2420/02 ,  B05D1/02 ,  B05D3/0254

Abstract: A medical dressing (30) is disclosed, comprising an adhesive layer (3) having skin-facing surface (6) to adhere the medical dressing to a dermal surface, wherein said adhesive layer comprises a first chemical compound incorporated within said adhesive layer, and wherein at least a portion of said skin- facing surface comprises a coating (9) comprising second chemical compound. Also disclosed is a method of manufacturing such a medical dressing.

Abstract translation: 公开了一种医用敷料（30），其包括具有面向皮肤表面（6）的粘合剂层（3），以将医用敷料粘附到真皮表面，其中所述粘合剂层包括结合在所述粘合剂层内的第一化学化合物，以及 其中所述面向皮肤的表面的至少一部分包括包含第二化合物的涂层（9）。 还公开了制造这种医用敷料的方法。

公开(公告)号：WO2013184944A1

公开(公告)日：2013-12-12

申请号：PCT/US2013/044558

申请日：2013-06-06

Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： LAULICHT, Bryan ,  KARP, Jeffrey M. ,  LANGER, Robert S.

IPC: A61F13/02

CPC classification number: A61F13/024 ,  A61F13/0246 ,  A61F13/025 ,  A61F13/0253 ,  A61F13/0256 ,  A61F13/0259 ,  A61F13/0269 ,  A61F2013/00412 ,  A61F2013/00676 ,  A61F2013/00685 ,  A61F2013/00702 ,  A61F2013/0071 ,  A61F2013/00748 ,  A61F2013/008 ,  A61F2013/00804 ,  A61F2013/00838 ,  A61F2013/15569 ,  B29C65/5021 ,  B32B37/26 ,  B32B38/10 ,  B32B2037/268 ,  C09J7/255 ,  C09J2205/302 ,  C09J2467/006 ,  Y10T428/24851 ,  Y10T428/2839

Abstract: Methods and compositions for securing to and removing adhesive tapes from substrates, e.g., delicate substrates such as skin, are described. The methods include providing an adhesive tape comprising an adhesive layer and a support layer in contact with the adhesive layer. A first adhesion level between the adhesive layer and the support layer is, or can be controlled to be, less than a second adhesion level between the adhesive layer and the substrate. The methods further include applying the adhesive tape to the substrate by contacting the adhesive layer to the substrate while the support layer remains in contact with the adhesive layer; and removing the support layer from the substrate by separating the support layer from the adhesive layer.

Abstract translation: 描述了用于固定和移除基材（例如，诸如皮肤等精细基材）的胶带的方法和组合物。 所述方法包括提供包括粘合剂层和与粘合剂层接触的支撑层的胶带。 粘合剂层和支撑层之间的第一粘合水平是或可以被控制为小于粘合剂层和基材之间的第二粘合水平。 所述方法还包括通过使粘合剂层与基底接触而将粘合带施加到基底，同时支撑层保持与粘合剂层接触; 以及通过将支撑层与粘合剂层分离而从支撑层移除支撑层。

公开(公告)号：WO2013029160A3

公开(公告)日：2013-06-06

申请号：PCT/CA2012000806

申请日：2012-08-30

Applicant: VALA PHILIP

Inventor： VALA PHILIP

IPC: A61H19/00 ,  A47K7/00 ,  A61F13/02 ,  A61K9/70 ,  A61M37/00 ,  A61P15/10

CPC classification number: A61H19/30 ,  A61F2013/0028 ,  A61F2013/00387 ,  A61F2013/00544 ,  A61F2013/00646 ,  A61F2013/0071 ,  A61F2013/15097 ,  A61H7/002 ,  A61H19/40 ,  A61H19/50 ,  A61H2201/105 ,  A61H2201/165 ,  A61H2201/1692 ,  A61H2205/067

Abstract: A patch for cutaneous application to the external surface of an elongated member of a human body for purposes of cleansing or for tactile stimulation and/or delivery of a transdermal pharmaceutical agent during sexual activity, has an underside having at least a portion thereof coated with a human skin compatible adhesive, for application to the skin of an elongated member of a human body. The patch has a dimension of length which is greater than its dimension of width, and has an outer surface which is distal from the skin when applied to a finger of a human hand or to a human male penis. The outer surface of the patch may be a textured surface or a smooth surface. At least one transdermal agent may be applied to the underside of the patch, and is typically an erectogenic agent.

Abstract translation: 用于皮肤应用于人体细长构件的外表面的贴剂用于在性活动期间清洁或用于触敏刺激和/或递送透皮药剂，其具有至少一部分涂覆有 人皮肤相容的粘合剂，用于人体细长构件的皮肤应用。 贴片具有大于其宽度尺寸的长度尺寸，并且具有当施用于人手或人类男性阴茎的手指时远离皮肤的外表面。 贴剂的外表面可以是纹理表面或光滑表面。 至少一种透皮剂可以施用于贴剂的下侧，并且通常是勃起剂。

公开(公告)号：WO2010057189A1

公开(公告)日：2010-05-20

申请号：PCT/US2009/064804

申请日：2009-11-17

Applicant: MYLAN PHARMACEUTICALS, INC. ,  JACKSON, Kristin ,  MILLER, Kenneth, J., II

Inventor： JACKSON, Kristin ,  MILLER, Kenneth, J., II

IPC: A61K9/70

CPC classification number: A61K9/7092 ,  A61F2013/00646 ,  A61F2013/0071 ,  A61F2013/00906 ,  A61K8/0208 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7069 ,  A61K9/7084

Abstract: A transdermal drug-containing dosage unit comprises: a backing layer substantially impervious to the drug to be delivered transdermally; a first polymeric adhesive matrix, in contact with the backing layer, having dispersed therein the drug and having a first delivery profile of the drug; a second polymeric adhesive matrix, in contact with said first polymeric adhesive matrix, having dispersed therein the drug and having a second delivery profile of the drug, wherein said second delivery profile is different from said first delivery profile; and a release liner in contact with the second polymeric adhesive matrix. The first polymeric adhesive matrix can release the drug more quickly or more slowly than the second polymeric adhesive matrix. Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled.

Abstract translation: 含透皮药物的剂量单位包括：基本上不透过透皮药物的背层; 与背衬层接触的第一聚合物粘合剂基质，其中分散有药物并具有药物的第一递送曲线; 与所述第一聚合物粘合剂基质接触的第二聚合物粘合剂基质，其中分散有药物并具有药物的第二递送分布，其中所述第二递送分布与所述第一递送分布不同; 以及与第二聚合物粘合剂基质接触的剥离衬垫。 第一聚合物粘合剂基质可以比第二聚合物粘合剂基质更快或更慢地释放药物。 通过选择两个基质，可以选择性地改变和控制药物通过皮肤的递送特征。

公开(公告)号：WO2007011596A2

公开(公告)日：2007-01-25

申请号：PCT/US2006026995

申请日：2006-07-13

Applicant: MEDICAL DEVICE GROUP INC ,  WRIGHT CLIFFORD A ,  STEWART GENE

Inventor： WRIGHT CLIFFORD A ,  STEWART GENE

IPC: A61F13/00

CPC classification number: A61F15/004 ,  A61F13/023 ,  A61F2013/00412 ,  A61F2013/00421 ,  A61F2013/00544 ,  A61F2013/00553 ,  A61F2013/0057 ,  A61F2013/0071 ,  A61F2013/00846 ,  A61F2013/0091 ,  A61M25/02 ,  A61M2025/0246

Abstract: A protective device (10) having a substantially rigid casing (11) for placement on a patient's skin, wherein the casing has a hollow interior facing the patient's skin and a lip (16). The casing (11) can be spanned across its hollow interior by a membrane (14). The casing can have a first adhesive seal (15) attached to a bottom surface of the lip of the casing (16), and a second adhesive seal (12) attached to the top surface of the lip of the casing (16).

Abstract translation: 一种保护装置（10），其具有用于放置在患者皮肤上的基本刚性的外壳（11），其中所述外壳具有面向患者皮肤的中空内部和唇部（16）。 外壳（11）可以通过隔膜（14）跨越其中空的内部跨越。 壳体可以具有附接到壳体（16）的唇缘的底表面的第一粘合密封件（15）和附接到壳体（16）的唇缘的顶表面的第二粘合密封件（12）。

公开(公告)号：WO01049228A1

公开(公告)日：2001-07-12

申请号：PCT/US2001/000130

申请日：2001-01-03

IPC: A61F13/00 ,  A61F20060101 ,  A61F13/02 ,  A61L15/16

CPC classification number: A61F13/0246 ,  A61F13/00017 ,  A61F13/00029 ,  A61F13/00034 ,  A61F13/00991 ,  A61F13/0209 ,  A61F13/022 ,  A61F13/0223 ,  A61F13/023 ,  A61F2013/00157 ,  A61F2013/00182 ,  A61F2013/00217 ,  A61F2013/00659 ,  A61F2013/00702 ,  A61F2013/0071 ,  A61F2013/00723 ,  A61F2013/0074 ,  A61F2013/00804

Abstract: A wound dressing is provided that serves unique dual-purpose role. One surface of the dressing is comprised of a polyurethane foam (20) and the other surface is comprised of a non-adherent thin-film (30) of polydimethylsiloxane and polytetrafluoroethylene interpenetrating polymer networks ("IPN"). With the foam side of the dressing down against the wound, the product provides an adhesive surface for difficult fixation conditions. With the IPN side of the dressing against the wound, the dressing provides non-adherent covering for fragile and sensitive wounds.

Abstract translation: 提供伤口敷料，具有独特的双重作用。 敷料的一个表面由聚氨酯泡沫（20）组成，另一个表面由聚二甲基硅氧烷和聚四氟乙烯互穿聚合物网络（“IPN”）的非粘附薄膜（30）组成。 随着敷料的泡沫面向下冲击伤口，产品提供了一种难以固定条件的粘合剂表面。 随着敷料的IPN面对伤口，敷料为易碎和敏感的伤口提供不粘附的覆盖物。