公开(公告)号：WO2007092751A2

公开(公告)日：2007-08-16

申请号：PCT/US2007/061515

申请日：2007-02-02

Applicant: ELI LILLY AND COMPANY ,  BELL, Michael, Gregory ,  GENIN, Michael, James ,  LANDER, Peter, Ambrose ,  STELZER, Lindsay, Scott ,  DOTI, Robert, Anthony ,  AGEJAS-CHICHARRO, Francisco, Javier ,  BUENO MELENDO, Ana, Belen ,  MANNINEN, Peter, Rudolph ,  OCHOADA, Jason, Matthew ,  SHEN, Quanrong ,  WARSHAWSKY, Alan, M. ,  MA, Tianwei ,  STITES, Ryan, Edward

Inventor： BELL, Michael, Gregory ,  GENIN, Michael, James ,  LANDER, Peter, Ambrose ,  STELZER, Lindsay, Scott ,  DOTI, Robert, Anthony ,  AGEJAS-CHICHARRO, Francisco, Javier ,  BUENO MELENDO, Ana, Belen ,  MANNINEN, Peter, Rudolph ,  OCHOADA, Jason, Matthew ,  SHEN, Quanrong ,  WARSHAWSKY, Alan, M. ,  MA, Tianwei ,  STITES, Ryan, Edward

IPC: C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  A61K31/42 ,  A61K31/427 ,  A61P3/06

CPC classification number: C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: Compounds of formula. wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.

Abstract translation: 式的化合物。 其中变量如本文所定义，并且其药物组合物和使用方法被公开用于治疗血脂异常和相关疾病。

公开(公告)号：WO2007140174A3

公开(公告)日：2008-03-20

申请号：PCT/US2007069416

申请日：2007-05-22

Applicant: LILLY CO ELI ,  BELL MICHAEL GREGORY ,  DOTI ROBERT ANTHONY ,  DOWLING MATTHEW SCOTT ,  GENIN MICHAEL JAMES ,  LANDER PETER AMBROSE ,  MA TIANWEI ,  MANTLO NATHAN BRYAN ,  OCHOADA JASON MATTHEW ,  STELZER LINDSAY SCOTT ,  STITES RYAN EDWARD ,  WARSHAWSKY ALAN M

Inventor： BELL MICHAEL GREGORY ,  DOTI ROBERT ANTHONY ,  DOWLING MATTHEW SCOTT ,  GENIN MICHAEL JAMES ,  LANDER PETER AMBROSE ,  MA TIANWEI ,  MANTLO NATHAN BRYAN ,  OCHOADA JASON MATTHEW ,  STELZER LINDSAY SCOTT ,  STITES RYAN EDWARD ,  WARSHAWSKY ALAN M

IPC: C07D249/12 ,  A61K31/4192 ,  A61P3/06 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12

CPC classification number: C07D249/06 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D417/12

Abstract: Compounds of formula (I) wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.

Abstract translation: 公开了其中变量如本文所定义的式（I）化合物及其药物组合物和使用方法用于治疗血脂异常和相关疾病。

公开(公告)号：WO2007140183A1

公开(公告)日：2007-12-06

申请号：PCT/US2007/069445

申请日：2007-05-22

Applicant: ELI LILLY AND COMPANY ,  BELL, Michael, Gregory ,  DOTI, Robert, Anthony ,  GENIN, Michael, James ,  LANDER, Peter, Ambrose ,  MA, Tianwei ,  MANNINEN, Peter, Rudolph ,  OCHOADA, Jason, Matthew ,  QU, Fucheng ,  STELZER, Lindsay, Scott ,  STITES, Ryan, Edward ,  WARSHAWSKY, Alan, M.

Inventor： BELL, Michael, Gregory ,  DOTI, Robert, Anthony ,  GENIN, Michael, James ,  LANDER, Peter, Ambrose ,  MA, Tianwei ,  MANNINEN, Peter, Rudolph ,  OCHOADA, Jason, Matthew ,  QU, Fucheng ,  STELZER, Lindsay, Scott ,  STITES, Ryan, Edward ,  WARSHAWSKY, Alan, M.

IPC: C07D231/12 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  A61P3/06

CPC classification number: C07D231/12 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: Compounds of formula wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.

Abstract translation: 公开了其中变量如本文所定义的式及其药物组合物和使用方法的化合物被公开用于治疗血脂异常和相关疾病。

公开(公告)号：WO2005097806A1

公开(公告)日：2005-10-20

申请号：PCT/US2005/009301

申请日：2005-03-17

Applicant: ELI LILLY AND COMPANY ,  BELL, Michael, Gregory ,  CAO, Guoqing ,  ESCRIBANO, Ana, Maria ,  FERNANDEZ, Maria, Carmen ,  LANDER, Peter, Ambrose ,  MANTLO, Nathan, Bryan ,  MARTIN DE LA NAVA, Eva, Maria ,  MATEO HERRANZ, Ana, Isabel ,  MAYHUGH, Daniel, Ray ,  WANG, Xiaodong

Inventor： BELL, Michael, Gregory ,  CAO, Guoqing ,  ESCRIBANO, Ana, Maria ,  FERNANDEZ, Maria, Carmen ,  LANDER, Peter, Ambrose ,  MANTLO, Nathan, Bryan ,  MARTIN DE LA NAVA, Eva, Maria ,  MATEO HERRANZ, Ana, Isabel ,  MAYHUGH, Daniel, Ray ,  WANG, Xiaodong

IPC: C07D495/04

CPC classification number: C07D495/04 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention discloses compounds of formula (I) wherein A, n, q, K, W, X, Y, Z, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and its sequelae.

Abstract translation: 本发明公开了式（I）的化合物，其中A，n，q，K，W，X，Y，Z，R 1，R 2，R 3，R 4，R 5 >和R 6如本文所定义，并且其药物组合物和使用方法被公开用于治疗血脂异常及其后遗症。

公开(公告)号：WO2007140174A2

公开(公告)日：2007-12-06

申请号：PCT/US2007/069416

申请日：2007-05-22

Applicant: ELI LILLY AND COMPANY ,  BELL, Michael, Gregory ,  DOTI, Robert, Anthony ,  DOWLING, Matthew, Scott ,  GENIN, Michael, James ,  LANDER, Peter, Ambrose ,  MA, Tianwei ,  MANTLO, Nathan, Bryan ,  OCHOADA, Jason, Matthew ,  STELZER, Lindsay, Scott ,  STITES, Ryan, Edward ,  WARSHAWSKY, Alan, M

Inventor： BELL, Michael, Gregory ,  DOTI, Robert, Anthony ,  DOWLING, Matthew, Scott ,  GENIN, Michael, James ,  LANDER, Peter, Ambrose ,  MA, Tianwei ,  MANTLO, Nathan, Bryan ,  OCHOADA, Jason, Matthew ,  STELZER, Lindsay, Scott ,  STITES, Ryan, Edward ,  WARSHAWSKY, Alan, M

IPC: C07D249/12 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  A61K31/4192 ,  A61P3/06

CPC classification number: C07D249/06 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D417/12

Abstract: Compounds of formula (I) wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.

Abstract translation: 公开了其中变量如本文所定义的式（I）化合物及其药物组合物和使用方法用于治疗血脂异常和相关疾病。

公开(公告)号：WO0127116A3

公开(公告)日：2001-11-22

申请号：PCT/US0021980

申请日：2000-09-22

Applicant: LILLY CO ELI ,  BONJOUKLIAN ROSANNE ,  JOHNSON DOUGLAS WEBB ,  LANDER PETER AMBROSE ,  LOHMAN MARK CHRISTOPHER ,  PATEL VINOD FRANCIS ,  VEPACHEDU SREENIVASARAO ,  XIE YONGPING

Inventor： BONJOUKLIAN ROSANNE ,  JOHNSON DOUGLAS WEBB ,  LANDER PETER AMBROSE ,  LOHMAN MARK CHRISTOPHER ,  PATEL VINOD FRANCIS ,  VEPACHEDU SREENIVASARAO ,  XIE YONGPING

IPC: A61P35/00 ,  C07D471/04 ,  C07D498/04 ,  A61K31/4741 ,  A61K31/4745

CPC classification number: C07D471/04

Abstract: The present invention relates to a compound of formula (I), which are useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.

Abstract translation: 本发明涉及式（I）化合物，其可用于抑制MRP1部分或全部赋予抗性的抗性肿瘤。

公开(公告)号：WO2004067529A1

公开(公告)日：2004-08-12

申请号：PCT/US2004/000017

申请日：2004-01-20

Applicant: ELI LILLY AND COMPANY ,  BELL, Michael, Gregory ,  GAVARDINAS, Konstantinos ,  GERNERT, Douglas, Linn ,  GRESE, Timothy, Alan ,  JADHAV, Prabhakar, Kondaji ,  LANDER, Peter, Ambrose ,  STEINBERG, Mitchell, Irvin

Inventor： BELL, Michael, Gregory ,  GAVARDINAS, Konstantinos ,  GERNERT, Douglas, Linn ,  GRESE, Timothy, Alan ,  JADHAV, Prabhakar, Kondaji ,  LANDER, Peter, Ambrose ,  STEINBERG, Mitchell, Irvin

IPC: C07D409/06

CPC classification number: C07D401/06 ,  C07D209/08 ,  C07D209/10 ,  C07D333/56 ,  C07D333/68 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06 ,  C07D491/04 ,  C07F5/003 ,  C07F5/069 ,  C07F7/0836

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient, and methods for treating physiological disorders, particularly congestive heart disease, comprising administering to a patient in thereof an effective amount of a compound of Formula I.

Abstract translation: 本发明提供式I化合物或其药学上可接受的盐，药物组合物，其包含有效量的式I化合物与合适的载体，稀释剂或赋形剂的组合，以及用于治疗生理障碍，特别是充血性心脏的方法 包括向其中的患者施用有效量的式I化合物。

公开(公告)号：WO2007092751A3

公开(公告)日：2007-12-27

申请号：PCT/US2007061515

申请日：2007-02-02

Applicant: LILLY CO ELI ,  BELL MICHAEL GREGORY ,  GENIN MICHAEL JAMES ,  LANDER PETER AMBROSE ,  STELZER LINDSAY SCOTT ,  DOTI ROBERT ANTHONY ,  AGEJAS-CHICHARRO FRANCISCO JAV ,  BUENO MELENDO ANA BELEN ,  MANNINEN PETER RUDOLPH ,  OCHOADA JASON MATTHEW ,  SHEN QUANRONG ,  WARSHAWSKY ALAN M ,  MA TIANWEI ,  STITES RYAN EDWARD

Inventor： BELL MICHAEL GREGORY ,  GENIN MICHAEL JAMES ,  LANDER PETER AMBROSE ,  STELZER LINDSAY SCOTT ,  DOTI ROBERT ANTHONY ,  AGEJAS-CHICHARRO FRANCISCO JAV ,  BUENO MELENDO ANA BELEN ,  MANNINEN PETER RUDOLPH ,  OCHOADA JASON MATTHEW ,  SHEN QUANRONG ,  WARSHAWSKY ALAN M ,  MA TIANWEI ,  STITES RYAN EDWARD

IPC: C07D413/12 ,  A61K31/42 ,  A61K31/427 ,  A61P3/06 ,  C07D413/14 ,  C07D417/12

CPC classification number: C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: Compounds of formula and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.

Abstract translation: 公开的化合物及其药物组合物和使用方法被公开用于治疗血脂异常和相关疾病。

公开(公告)号：WO2003078394A1

公开(公告)日：2003-09-25

申请号：PCT/US2003/006152

申请日：2003-03-11

Applicant: ELI LILLY AND COMPANY ,  GRESE, Timothy, Alan ,  JADHAV, Prabhakar, Kondaji ,  NEEL, David, Andrew ,  STEINBERG, Mitchell, Irvin ,  LANDER, Peter, Ambrose

Inventor： GRESE, Timothy, Alan ,  JADHAV, Prabhakar, Kondaji ,  NEEL, David, Andrew ,  STEINBERG, Mitchell, Irvin ,  LANDER, Peter, Ambrose

IPC: C07D209/34

CPC classification number: C07D401/04 ,  C07D209/34 ,  C07D401/06 ,  C07D403/04 ,  C07D413/06 ,  C07D417/06

Abstract: he present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation, particularly congestive heart failure, comprising administering to a patient in need thereof an effective amount of a compound of the formula: I or a pharmaceutically acceptable salt thereof. In addition, the present invention provides novel pharmaceutical compounds of Formula I, including the pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions which comprise as an active ingredient a compound of Formula I.

Abstract translation: 本发明涉及治疗对类固醇激素核受体调节敏感的病理学障碍，特别是充血性心力衰竭的方法，其包括向有需要的患者施用有效量的式I化合物或其药学上可接受的盐。 此外，本发明提供了新颖的式I的药物化合物，包括其药学上可接受的盐，以及包含式I化合物作为活性成分的药物组合物。

公开(公告)号：WO2002081481A1

公开(公告)日：2002-10-17

申请号：PCT/US2002/006664

申请日：2002-03-27

Applicant: ELI LILLY AND COMPANY ,  LANDER, Peter, Ambrose ,  LOHMAN, Mark, Christopher

Inventor： LANDER, Peter, Ambrose ,  LOHMAN, Mark, Christopher

IPC: C07D498/14

CPC classification number: C07D498/04

Abstract: The present invention relates to a compound of formula (I) which are useful for inhibiting resistant neoplasms where the resistance is conferred in part or in total by MRP1.

Abstract translation: 本发明涉及式（I）化合物，其可用于抑制MRP1部分或全部赋予抗性的抗性赘生物。