公开(公告)号：WO2007092751A3

公开(公告)日：2007-12-27

申请号：PCT/US2007061515

申请日：2007-02-02

Applicant: LILLY CO ELI ,  BELL MICHAEL GREGORY ,  GENIN MICHAEL JAMES ,  LANDER PETER AMBROSE ,  STELZER LINDSAY SCOTT ,  DOTI ROBERT ANTHONY ,  AGEJAS-CHICHARRO FRANCISCO JAV ,  BUENO MELENDO ANA BELEN ,  MANNINEN PETER RUDOLPH ,  OCHOADA JASON MATTHEW ,  SHEN QUANRONG ,  WARSHAWSKY ALAN M ,  MA TIANWEI ,  STITES RYAN EDWARD

Inventor： BELL MICHAEL GREGORY ,  GENIN MICHAEL JAMES ,  LANDER PETER AMBROSE ,  STELZER LINDSAY SCOTT ,  DOTI ROBERT ANTHONY ,  AGEJAS-CHICHARRO FRANCISCO JAV ,  BUENO MELENDO ANA BELEN ,  MANNINEN PETER RUDOLPH ,  OCHOADA JASON MATTHEW ,  SHEN QUANRONG ,  WARSHAWSKY ALAN M ,  MA TIANWEI ,  STITES RYAN EDWARD

IPC: C07D413/12 ,  A61K31/42 ,  A61K31/427 ,  A61P3/06 ,  C07D413/14 ,  C07D417/12

CPC classification number: C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: Compounds of formula and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.

Abstract translation: 公开的化合物及其药物组合物和使用方法被公开用于治疗血脂异常和相关疾病。

公开(公告)号：WO2006069153A2

公开(公告)日：2006-06-29

申请号：PCT/US2005/046360

申请日：2005-12-19

Applicant: ELI LILLY AND COMPANY ,  GOSSETT, Lynn, Stacy ,  LOPEZ, Jose, Eduardo ,  WARSHAWSKY, Alan, M. ,  YEE, Ying, Kwong

Inventor： GOSSETT, Lynn, Stacy ,  LOPEZ, Jose, Eduardo ,  WARSHAWSKY, Alan, M. ,  YEE, Ying, Kwong

IPC: C07C65/40 ,  C07C65/24 ,  A61K31/165 ,  A61K31/19 ,  A61P3/14

CPC classification number: C07C235/42 ,  C07C65/24 ,  C07C65/40 ,  C07C217/80 ,  C07C271/30

Abstract: The present invention relates to novel, non-secosteroidal, phenyl-naphthalene compounds of Formula (I): wherein R, R1, RP, Z P , L P1 , L P2 L NP , RP 3 , RN, and Z NP are defined herein, their preparation, pharmaceutical compositions, and methods of use.

Abstract translation: 本发明涉及式（I）的新型非异构体苯基 - 萘化合物：其中R，R 1，R L，R 1，L，P 1， 本文定义了本文中定义的本文所述的其制备方法，药物组合物和/或制备方法 使用方法。

公开(公告)号：WO2005054176A1

公开(公告)日：2005-06-16

申请号：PCT/US2004/035528

申请日：2004-11-16

Applicant: ELI LILLY AND COMPANY ,  CANADA, Emily, Jane ,  GOSSETT, Lynn, Stacy ,  MANTELO, Nathan, Bryan ,  SHI, Qing ,  WANG, Minmin ,  WARSHAWSKY, Alan, M. ,  XU, Yanping

Inventor： CANADA, Emily, Jane ,  GOSSETT, Lynn, Stacy ,  MANTELO, Nathan, Bryan ,  SHI, Qing ,  WANG, Minmin ,  WARSHAWSKY, Alan, M. ,  XU, Yanping

IPC: C07C233/73

CPC classification number: C07D213/81 ,  C07C211/29 ,  C07C233/73 ,  C07C235/46 ,  C07C235/48 ,  C07C235/54 ,  C07C235/84 ,  C07C271/16 ,  C07C311/04 ,  C07C311/17 ,  C07C317/44 ,  C07C323/62 ,  C07D209/30 ,  C07D209/42 ,  C07D213/56 ,  C07D333/70

Abstract: The present invention is directed to a compound of formula (I), or a pharmaceutically acceptable salt, solvate hydrate or stereoisomer thereof, which is useful in treating or preventing disorders mediated by a peroxisome proliferator activated receptor (PPAR) such as syndrome X, type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to syndrome X and cardiovascular diseases.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物水合物或立体异构体，其可用于治疗或预防由过氧化物酶体增殖物激活受体（PPAR）介导的病症，例如综合征X型 II型糖尿病，高血糖症，高脂血症，肥胖症，凝血病，高血压，动脉硬化以及与X综合症和心血管疾病有关的其他疾病。

公开(公告)号：WO2005051940A2

公开(公告)日：2005-06-09

申请号：PCT/US2004/037181

申请日：2004-11-16

Applicant: ELI LILLY AND COMPANY ,  LU, Jianliang ,  MA, Tainwei ,  NAGPAL, Sunil ,  SHEN, Quanrong ,  WARSHAWSKY, Alan, M. ,  YEE, Ying, Kwong ,  RUPP, Michael, John

Inventor： LU, Jianliang ,  MA, Tainwei ,  NAGPAL, Sunil ,  SHEN, Quanrong ,  WARSHAWSKY, Alan, M. ,  YEE, Ying, Kwong ,  RUPP, Michael, John

IPC: C07D333/00

CPC classification number: C07D333/68 ,  C07D333/70

Abstract: The present invention relates to novel, non-secosteroidal, phenyl-benzothiophene compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.

Abstract translation: 本发明涉及具有维生素D受体（VDR）调节活性的新型非 - 类固醇，苯基 - 苯并噻吩化合物，其比1α，25二羟基维生素D3的高钙血症少。 这些化合物可用于治疗骨疾病和牛皮癣。

公开(公告)号：WO2004000789A9

公开(公告)日：2004-03-11

申请号：PCT/US0316207

申请日：2003-06-11

Applicant: LILLY CO ELI ,  FERRITTO CRESPO RAFAEL ,  MARTIN JOSE ALFREDO ,  MARTIN-ORTEGA FINGER MARIA DOL ,  ROJO GARCIA ISABEL ,  SHEN QUANRONG ,  WARSHAWSKY ALAN M ,  XU YANPING

Inventor： FERRITTO CRESPO RAFAEL ,  MARTIN JOSE ALFREDO ,  MARTIN-ORTEGA FINGER MARIA DOL ,  ROJO GARCIA ISABEL ,  SHEN QUANRONG ,  WARSHAWSKY ALAN M ,  XU YANPING

IPC: C07D295/18 ,  A61K31/192 ,  A61K31/216 ,  A61K31/22 ,  A61K31/36 ,  A61K31/381 ,  A61K31/426 ,  A61K31/428 ,  A61K31/433 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/445 ,  A61K31/472 ,  A61K31/495 ,  A61P1/04 ,  A61P3/04 ,  A61P3/06 ,  A61P3/08 ,  A61P3/10 ,  A61P9/00 ,  A61P9/12 ,  A61P43/00 ,  C07C69/734 ,  C07C233/18 ,  C07C235/20 ,  C07C235/22 ,  C07C235/24 ,  C07C235/26 ,  C07C235/34 ,  C07C323/41 ,  C07D211/32 ,  C07D213/40 ,  C07D217/06 ,  C07D241/04 ,  C07D277/20 ,  C07D277/46 ,  C07D277/82 ,  C07D285/12 ,  C07D285/135 ,  C07D295/185 ,  C07D317/58 ,  C07D317/60 ,  C07D333/20 ,  A61K31/14 ,  A61K31/16 ,  A61K31/38 ,  A61K31/425 ,  A61K31/435

CPC classification number: C07C235/06 ,  C07C69/734 ,  C07C233/18 ,  C07C235/08 ,  C07C235/14 ,  C07C235/20 ,  C07C235/22 ,  C07C235/24 ,  C07C235/26 ,  C07C235/34 ,  C07C323/41 ,  C07C2601/04 ,  C07C2601/14 ,  C07D211/32 ,  C07D213/40 ,  C07D217/06 ,  C07D277/46 ,  C07D277/82 ,  C07D285/12 ,  C07D285/135 ,  C07D295/18 ,  C07D295/185 ,  C07D317/58 ,  C07D317/60 ,  C07D333/20

Abstract: The present invention is directed to compounds, compositions, and use of compounds the structural Formula (I).

Abstract translation: 本发明涉及结构式（I）的化合物，组合物和化合物的用途。

公开(公告)号：WO2009012125A1

公开(公告)日：2009-01-22

申请号：PCT/US2008/069719

申请日：2008-07-11

Applicant: ELI LILLY AND COMPANY ,  GENIN, Michael, James ,  AGEJAS-CHICHARRO, Francisco, Javier ,  BUENO MELENDO, Ana, Belen ,  MANNINEN, Peter, Rudolph ,  WARSHAWSKY, Alan, M.

Inventor： GENIN, Michael, James ,  AGEJAS-CHICHARRO, Francisco, Javier ,  BUENO MELENDO, Ana, Belen ,  MANNINEN, Peter, Rudolph ,  WARSHAWSKY, Alan, M.

IPC: C07D261/08 ,  C07D413/12 ,  A61K31/42 ,  A61P3/06

CPC classification number: C07D261/08 ,  C07D413/12

Abstract: Compounds of formula (I): formula (I) wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and diseases related to dyslipidemia.

Abstract translation: 公开了式（I）化合物：其中变量如本文所定义的式（I）及其药物组合物和使用方法用于治疗血脂异常和与血脂异常有关的疾病。

公开(公告)号：WO2006069153A3

公开(公告)日：2006-09-14

申请号：PCT/US2005046360

申请日：2005-12-19

Applicant: LILLY CO ELI ,  GOSSETT LYNN STACY ,  LOPEZ JOSE EDUARDO ,  WARSHAWSKY ALAN M ,  YEE YING KWONG

Inventor： GOSSETT LYNN STACY ,  LOPEZ JOSE EDUARDO ,  WARSHAWSKY ALAN M ,  YEE YING KWONG

IPC: C07C65/40 ,  A61K31/165 ,  A61K31/19 ,  A61P3/14 ,  C07C65/24

CPC classification number: C07C235/42 ,  C07C65/24 ,  C07C65/40 ,  C07C217/80 ,  C07C271/30

Abstract: The present invention relates to novel, non-secosteroidal, phenyl-naphthalene compounds of Formula (I): wherein R, R1, RP, Z P , L P1 , L P2 L NP , RP 3 , RN, and Z NP are defined herein, their preparation, pharmaceutical compositions, and methods of use.

Abstract translation: 本发明涉及式（I）的新型非异构体苯基 - 萘化合物：其中R，R 1，R L，R 1，L，P 1， 本文定义了本文中定义的本文所述的其制备方法，药物组合物和/或制备方法 使用方法。

公开(公告)号：WO2004063166A1

公开(公告)日：2004-07-29

申请号：PCT/US2003/039119

申请日：2003-12-31

Applicant: ELI LILLY AND COMPANY ,  CONNER, Scott, Eugene ,  MA, Tianwei ,  MANTLO, Nathan, Bryan ,  MAYHUGH, Daniel, Ray ,  SCHKERYANTZ, Jeffrey, Michael ,  WARSHAWSKY, Alan, M. ,  ZHU, Guoxin

Inventor： CONNER, Scott, Eugene ,  MA, Tianwei ,  MANTLO, Nathan, Bryan ,  MAYHUGH, Daniel, Ray ,  SCHKERYANTZ, Jeffrey, Michael ,  WARSHAWSKY, Alan, M. ,  ZHU, Guoxin

IPC: C07D231/12

CPC classification number: C07D231/12 ,  C07D233/20 ,  C07D233/22 ,  C07D233/64 ,  C07D249/06 ,  C07D253/04 ,  C07D261/08

Abstract: The present invention is directed to compounds represented by the following structural formula, Formula I: wherein: (a) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (b) U is an aliphatic linker; (c) Y is selected from the group consisting of O, C, S, NH and a single bond; (d) E is C(R3)(R4)A or A and wherein (i) A is selected from the group consisting of carboxyl, tetrazole, C1-C6 alkylnitrile, carboxamide, sulfonamide and acylsulfonamide; (e) Z1 and Z2 are each independently selected from the group consisting of N, O, and C with the proviso that at least one of Z1 and Z2 is N; (f) Z3 is selected from the group consisting of N, O, and C. (g) R8 is selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C4 alkylenyl and halo; (h) R9 is selected from the group consisting of hydrogen, C1-C4 alkyl, C1-C4 alkylenyl, halo, aryl- C0-C4 alkyl, heteroaryl, C1-C6 allyl, and OR29.

Abstract translation: 本发明涉及由以下结构式（I）表示的化合物：其中：（a）X选自单键，O，S，S（O）2和N; （b）U是脂族连接体; （c）Y选自O，C，S，NH和单键; （d）E是C（R3）（R4）A或A，其中（i）A选自羧基，四唑，C 1 -C 6烷基腈，甲酰胺，磺酰胺和酰基磺酰胺; （e）Z1和Z2各自独立地选自N，O和C，条件是Z1和Z2中的至少一个是N; （f）Z 3选自N，O和C.（g）R 8选自氢，C 1 -C 6烷基，C 1 -C 4亚烷基和卤素; （h）R 9选自氢，C 1 -C 4烷基，C 1 -C 4亚烷基，卤素，芳基-C 0 -C 4烷基，杂芳基，C 1 -C 6烯丙基和OR 29。

公开(公告)号：WO1995021839A1

公开(公告)日：1995-08-17

申请号：PCT/US1994014235

申请日：1994-12-13

Applicant: MERRELL DOW PHARMACEUTICALS INC. ,  FLYNN, Gary, A. ,  BEIGHT, Douglas, W. ,  WARSHAWSKY, Alan, M. ,  MEHDI, Shujaath ,  FRENCH, John, F. ,  KEHNE, John, H.

Inventor： MERRELL DOW PHARMACEUTICALS INC.

IPC: C07D471/04

CPC classification number: C07D471/04 ,  A61K31/55 ,  A61K38/00 ,  C07K5/06139

Abstract: The present invention relates to certain novel mercaptoacetylamide disulfide derivatives of formula (I) useful as inhibitors of enkephalinase and of ACE.

Abstract translation: 本发明涉及可用作脑啡肽酶和ACE抑制剂的式（I）的某些新型巯基乙酰胺二硫化​​物衍生物。

公开(公告)号：WO2007092751A2

公开(公告)日：2007-08-16

申请号：PCT/US2007/061515

申请日：2007-02-02

Applicant: ELI LILLY AND COMPANY ,  BELL, Michael, Gregory ,  GENIN, Michael, James ,  LANDER, Peter, Ambrose ,  STELZER, Lindsay, Scott ,  DOTI, Robert, Anthony ,  AGEJAS-CHICHARRO, Francisco, Javier ,  BUENO MELENDO, Ana, Belen ,  MANNINEN, Peter, Rudolph ,  OCHOADA, Jason, Matthew ,  SHEN, Quanrong ,  WARSHAWSKY, Alan, M. ,  MA, Tianwei ,  STITES, Ryan, Edward

Inventor： BELL, Michael, Gregory ,  GENIN, Michael, James ,  LANDER, Peter, Ambrose ,  STELZER, Lindsay, Scott ,  DOTI, Robert, Anthony ,  AGEJAS-CHICHARRO, Francisco, Javier ,  BUENO MELENDO, Ana, Belen ,  MANNINEN, Peter, Rudolph ,  OCHOADA, Jason, Matthew ,  SHEN, Quanrong ,  WARSHAWSKY, Alan, M. ,  MA, Tianwei ,  STITES, Ryan, Edward

IPC: C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  A61K31/42 ,  A61K31/427 ,  A61P3/06

CPC classification number: C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: Compounds of formula. wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.

Abstract translation: 式的化合物。 其中变量如本文所定义，并且其药物组合物和使用方法被公开用于治疗血脂异常和相关疾病。