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    HETEROCYCLIC PPAR MODULATORS
    6.
    发明申请
    HETEROCYCLIC PPAR MODULATORS 审中-公开
    杂环PPAR调节剂

    公开(公告)号：WO2004063166A1

    公开(公告)日：2004-07-29

    申请号：PCT/US2003/039119

    申请日：2003-12-31

    Applicant: ELI LILLY AND COMPANY ,  CONNER, Scott, Eugene ,  MA, Tianwei ,  MANTLO, Nathan, Bryan ,  MAYHUGH, Daniel, Ray ,  SCHKERYANTZ, Jeffrey, Michael ,  WARSHAWSKY, Alan, M. ,  ZHU, Guoxin

    Inventor： CONNER, Scott, Eugene ,  MA, Tianwei ,  MANTLO, Nathan, Bryan ,  MAYHUGH, Daniel, Ray ,  SCHKERYANTZ, Jeffrey, Michael ,  WARSHAWSKY, Alan, M. ,  ZHU, Guoxin

    IPC: C07D231/12

    CPC classification number: C07D231/12 ,  C07D233/20 ,  C07D233/22 ,  C07D233/64 ,  C07D249/06 ,  C07D253/04 ,  C07D261/08

    Abstract: The present invention is directed to compounds represented by the following structural formula, Formula I: wherein: (a) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (b) U is an aliphatic linker; (c) Y is selected from the group consisting of O, C, S, NH and a single bond; (d) E is C(R3)(R4)A or A and wherein (i) A is selected from the group consisting of carboxyl, tetrazole, C1-C6 alkylnitrile, carboxamide, sulfonamide and acylsulfonamide; (e) Z1 and Z2 are each independently selected from the group consisting of N, O, and C with the proviso that at least one of Z1 and Z2 is N; (f) Z3 is selected from the group consisting of N, O, and C. (g) R8 is selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C4 alkylenyl and halo; (h) R9 is selected from the group consisting of hydrogen, C1-C4 alkyl, C1-C4 alkylenyl, halo, aryl- C0-C4 alkyl, heteroaryl, C1-C6 allyl, and OR29.

    Abstract translation: 本发明涉及由以下结构式（I）表示的化合物：其中：（a）X选自单键，O，S，S（O）2和N; （b）U是脂族连接体; （c）Y选自O，C，S，NH和单键; （d）E是C（R3）（R4）A或A，其中（i）A选自羧基，四唑，C 1 -C 6烷基腈，甲酰胺，磺酰胺和酰基磺酰胺; （e）Z1和Z2各自独立地选自N，O和C，条件是Z1和Z2中的至少一个是N; （f）Z 3选自N，O和C.（g）R 8选自氢，C 1 -C 6烷基，C 1 -C 4亚烷基和卤素; （h）R 9选自氢，C 1 -C 4烷基，C 1 -C 4亚烷基，卤素，芳基-C 0 -C 4烷基，杂芳基，C 1 -C 6烯丙基和OR 29。

    PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS
    9.
    发明申请
    PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS 审中-公开
    过氧化物促进剂激活受体调节剂

    公开(公告)号：WO2008103574A3

    公开(公告)日：2008-12-18

    申请号：PCT/US2008053653

    申请日：2008-02-12

    Applicant: LILLY CO ELI ,  PFEIFER LANCE ALLEN ,  MA TIANWEI ,  MANTLO NATHAN BRYAN ,  MICHAEL LAURA FREY ,  MOKUBE FESE MAMBO ,  MONTROSE-RAFIZADEH CHAHRZAD

    Inventor： PFEIFER LANCE ALLEN ,  MA TIANWEI ,  MANTLO NATHAN BRYAN ,  MICHAEL LAURA FREY ,  MOKUBE FESE MAMBO ,  MONTROSE-RAFIZADEH CHAHRZAD

    IPC: C07D249/12 ,  A61K31/4196 ,  A61K31/4439 ,  A61P3/00 ,  C07D401/06

    CPC classification number: C07D401/06 ,  C07D249/12

    Abstract: The present invention is directed to compounds of the structural Formula: wherein: R1 is H or -C1-C3 alkyl; R2 is selected from the group consisting of -H, -C1-C4 alkyl, -C1-C3 alkyl-CF3, phenyl, and pyridinyl; and R3 is selected from the group consisting of -H, -C1-C4 alkyl, -C1-C3 alkyl-O-CH3, -CH2-cyclopropyl, -CH2-C=CH2, -CH2CH2-(2-F-phenyl), and phenyl substituted with from 1 to 2 fluorines; provided that when R1 and R2 are each H, then R3 is selected from the group consisting of -C1-C4 alkyl, -C1-C3 alkyl-O-CH3, -CH2-cyclopropyl, -CH2-C=CH2, -CH2CH2-(2-F-phenyl), and phenyl substituted with from 1 to 2 fluorines; or stereoisomers and pharmaceutically acceptable salts thereof.

    Abstract translation: 本发明涉及结构式的化合物：其中：R 1是H或-C 1 -C 3烷基; R 2选自-H，-C 1 -C 4烷基，-C 1 -C 3烷基-CF 3，苯基和吡啶基; 并且R 3选自-H，-C 1 -C 4烷基，-C 1 -C 3烷基-O-CH 3，-CH 2 - 环丙基，-CH 2 -C = CH 2，-CH 2 CH 2 - （2-F-苯基） 和被1至2个氟取代的苯基; 条件是当R 1和R 2各自为H时，R 3选自-C 1 -C 4烷基，-C 1 -C 3烷基-O-CH 3，-CH 2 - 环丙基，-CH 2 -C = CH 2，-CH 2 CH 2 - （2-F-苯基）和被1至2个氟取代的苯基; 或其立体异构体及其药学上可接受的盐。

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