公开(公告)号：WO2010132765A9

公开(公告)日：2011-10-13

申请号：PCT/US2010034893

申请日：2010-05-14

Applicant: ACHAOGEN INC ,  DOZZO PAOLA ,  GOLDBLUM ADAM AARON ,  AGGEN JAMES BRADLEY ,  LINSELL MARTIN SHERINGHAM

Inventor： DOZZO PAOLA ,  GOLDBLUM ADAM AARON ,  AGGEN JAMES BRADLEY ,  LINSELL MARTIN SHERINGHAM

IPC: C07H15/236 ,  A61K31/7036 ,  A61P31/04

CPC classification number: C07H15/236

Abstract: Antibacterial compounds of structures (I) and (II) are disclosed, including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R1, R2, R3, R11 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract translation: 公开了结构（I）和（II）的抗菌化合物，包括立体异构体，其药学上可接受的盐和前药，其中Q1，Q2，Q3，R1，R2，R3，R11如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

公开(公告)号：WO2011031740A1

公开(公告)日：2011-03-17

申请号：PCT/US2010/048104

申请日：2010-09-08

Applicant: ACHAOGEN, INC. ,  WAGMAN, Allan, Scott ,  MOSER, Heinz, Ernst ,  MCENROE, Glenn, A. ,  AGGEN, James, Bradley ,  LINSELL, Martin, Sheringham ,  GOLDBLUM, Adam, Aaron ,  SIMONS, Lloyd, J. ,  BELLIOTTI, Thomas, R. ,  HARRIS, Christina, R. ,  POEL, Toni-Jo ,  MELNICK, Michael, J. ,  GASTON, Ricky, D. ,  GRIFFIN, John, H.

Inventor： WAGMAN, Allan, Scott ,  MOSER, Heinz, Ernst ,  MCENROE, Glenn, A. ,  AGGEN, James, Bradley ,  LINSELL, Martin, Sheringham ,  GOLDBLUM, Adam, Aaron ,  SIMONS, Lloyd, J. ,  BELLIOTTI, Thomas, R. ,  HARRIS, Christina, R. ,  POEL, Toni-Jo ,  MELNICK, Michael, J. ,  GASTON, Ricky, D. ,  GRIFFIN, John, H.

IPC: C07D471/14 ,  C07D491/14 ,  A61K31/4353 ,  A61P31/04

CPC classification number: C07D471/14 ,  C07D491/14

Abstract: Compounds having antibacterial activity are disclosed. The compounds have one of the following structures (I) or (II): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein A, B, D, E, G, W, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract translation: 公开了具有抗菌活性的化合物。 所述化合物具有以下结构（I）或（II）之一：其包括立体异构体，其药学上可接受的盐和前药，其中A，B，D，E，G，W，R 1，R 2，R 3，R 4，R 5，R 6 和R7如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

公开(公告)号：WO2010132765A2

公开(公告)日：2010-11-18

申请号：PCT/US2010034893

申请日：2010-05-14

Applicant: ACHAOGEN INC ,  DOZZO PAOLA ,  GOLDBLUM ADAM AARON ,  AGGEN JAMES BRADLEY ,  LINSELL MARTIN SHERINGHAM

Inventor： DOZZO PAOLA ,  GOLDBLUM ADAM AARON ,  AGGEN JAMES BRADLEY ,  LINSELL MARTIN SHERINGHAM

IPC: C07H15/224

CPC classification number: C07H15/236

Abstract: Antibacterial compounds of structures (I) and (II) are disclosed, including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R1, R2, R3, R11 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract translation: 公开了结构（I）和（II）的抗菌化合物，包括立体异构体，其药学上可接受的盐和前药，其中Q1，Q2，Q3，R1，R2，R3，R11如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

公开(公告)号：WO2009067692A1

公开(公告)日：2009-05-28

申请号：PCT/US2008/084399

申请日：2008-11-21

Applicant: ACHAOGEN, INC. ,  AGGEN, James ,  GOLDBLUM, Adam, Aaron ,  LINSELL, Martin ,  DOZZO, Paola ,  MOSER, Heinz, Ernst ,  HILDEBRANDT, Darin ,  GLIEDT, Micah

Inventor： AGGEN, James ,  GOLDBLUM, Adam, Aaron ,  LINSELL, Martin ,  DOZZO, Paola ,  MOSER, Heinz, Ernst ,  HILDEBRANDT, Darin ,  GLIEDT, Micah

IPC: C07H15/222 ,  A61K31/7036 ,  A61P31/04

CPC classification number: C07H15/224 ,  A61K31/7036 ,  C07H15/222 ,  C07H15/236 ,  Y02A50/473

Abstract: Compounds of structure (I): having antibacterial activity are disclosed, including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q 1 , Q 2 , Q 3 , R 8 and R 9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract translation: 公开了具有抗菌活性的结构（I）的化合物，包括立体异构体，其药学上可接受的盐和前药，其中Q1，Q2，Q3，R8和R9如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

公开(公告)号：WO2006031556A3

公开(公告)日：2006-04-13

申请号：PCT/US2005031824

申请日：2005-09-08

Applicant: THERAVANCE INC ,  LINSELL MARTIN S ,  JACOBSEN JOHN R ,  XU NINGNING

Inventor： LINSELL MARTIN S ,  JACOBSEN JOHN R ,  XU NINGNING

IPC: C07C257/18 ,  A61K31/136 ,  A61K31/4704 ,  A61P43/00 ,  C07D215/26 ,  C07D413/02

CPC classification number: C07F7/1856 ,  C07C257/18 ,  C07D215/26 ,  C07D413/12

Abstract: The invention provides novel ß 2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with ß 2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明提供了新的β2肾上腺素能受体激动剂化合物。 本发明还提供了包含这些化合物的药物组合物，使用这些化合物治疗与β2肾上腺素能受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。

公开(公告)号：WO2005121065A3

公开(公告)日：2006-02-09

申请号：PCT/US2005019549

申请日：2005-06-02

Applicant: THERAVANCE INC ,  LINSELL MARTIN S

Inventor： LINSELL MARTIN S

IPC: A61K31/137 ,  A61K31/16 ,  A61K31/4706 ,  C07C215/00 ,  C07D215/22 ,  C07D215/227 ,  C07C215/30 ,  A61K31/13 ,  C07C215/34 ,  C07C215/68

CPC classification number: C07D215/227 ,  C07D215/26

Abstract: The invention provides novel ß 2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with ß 2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明提供了新的β2肾上腺素能受体激动剂化合物。 本发明还提供了包含这些化合物的药物组合物，使用这些化合物治疗与β2肾上腺素能受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。

公开(公告)号：WO03029270A3

公开(公告)日：2003-09-04

申请号：PCT/US0226853

申请日：2002-08-23

Applicant: THERAVANCE INC ,  LEADBETTER MICHAEL ,  LINSELL MARTIN ,  LEE JUNNING ,  LIU JYANWEI

Inventor： LEADBETTER MICHAEL ,  LINSELL MARTIN ,  LEE JUNNING ,  LIU JYANWEI

IPC: A61K38/00 ,  C07K1/113 ,  C07K9/00 ,  A61K38/14

CPC classification number: C07K9/008 ,  A61K38/00

Abstract: Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without isolation of intermediate reaction products, thereby generating less waste and improving the overall efficiency and yield of the process.

Abstract translation: 公开了制备具有含氨基侧链的糖肽膦酸酯衍生物的方法。 若干工艺步骤在单一反应容器中进行而不分离中间反应产物，由此产生较少的废物并提高该方法的整体效率和产量。

公开(公告)号：WO0183521A3

公开(公告)日：2002-09-19

申请号：PCT/US0114017

申请日：2001-05-01

Applicant: ADVANCED MEDICINE INC ,  LINSELL MARTIN S

Inventor： LINSELL MARTIN S

IPC: A61K9/00 ,  A61K38/00 ,  A61K47/40 ,  C07K1/113 ,  C07K9/00

CPC classification number: B82Y5/00 ,  A61K9/0014 ,  A61K9/0019 ,  A61K38/00 ,  A61K47/40 ,  C07K9/008

Abstract: The invention provides a novel reductive alkylation method useful for selectively alkylating saccharide-amines of glycopeptide antibiotics.

Abstract translation: 本发明提供了一种可用于选择性烷基化糖肽抗生素的糖胺的还原性烷基化方法。

公开(公告)号：WO2010132760A9

公开(公告)日：2011-11-03

申请号：PCT/US2010034888

申请日：2010-05-14

Applicant: ACHAOGEN INC ,  DOZZO PAOLA ,  GOLDBLUM ADAM AARON ,  AGGEN JAMES BRADLEY ,  LINSELL MARTIN SHERINGHAM

Inventor： DOZZO PAOLA ,  GOLDBLUM ADAM AARON ,  AGGEN JAMES BRADLEY ,  LINSELL MARTIN SHERINGHAM

IPC: C07H15/234 ,  A61K31/7036 ,  A61P31/04

CPC classification number: C07H15/234 ,  A61K31/7036

Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract translation: 公开了具有抗细菌活性的化合物。 所述化合物具有以下结构（I）：包括立体异构体，其药学上可接受的盐和前药，其中Q1，Q2，Q3，R1，R2和R3如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

公开(公告)号：WO2011031745A1

公开(公告)日：2011-03-17

申请号：PCT/US2010/048110

申请日：2010-09-08

Applicant: ACHAOGEN, INC. ,  WAGMAN, Allan, Scott ,  MOSER, Heinz, Ernst ,  MCENROE, Glenn, A. ,  AGGEN, James, Bradley ,  LINSELL, Martin, Sheringham ,  GOLDBLUM, Adam, Aaron ,  GRIFFIN, John, H.

Inventor： WAGMAN, Allan, Scott ,  MOSER, Heinz, Ernst ,  MCENROE, Glenn, A. ,  AGGEN, James, Bradley ,  LINSELL, Martin, Sheringham ,  GOLDBLUM, Adam, Aaron ,  GRIFFIN, John, H.

IPC: C07D471/14 ,  C07D471/22 ,  C07D487/14 ,  C07D498/14 ,  C07D498/22 ,  C07D513/22 ,  A61K31/4741 ,  A61K31/4743 ,  A61K31/55 ,  A61P31/04

CPC classification number: C07D513/22 ,  C07D471/14 ,  C07D471/22 ,  C07D487/14 ,  C07D498/14 ,  C07D498/22

Abstract: Compounds having antibacterial activity are disclosed. The compounds have one of the following structures (I)-(X): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein A, B, D, E, G, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 9 and R 10 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract translation: 公开了具有抗细菌活性的化合物。 所述化合物具有以下结构之一（I） - （X）：包括立体异构体，其药学上可接受的盐和前药，其中A，B，D，E，G，R 1，R 2，R 3，R 4，R 5，R 6，R 7 ，R9和R10如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。