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    ENANTIOSELECTIVE TRANSFORMATION OF α, β-UNSATURATED ALDEHYDES USING CHIRAL ORGANIC CATALYSTS
    3.
    发明申请
    ENANTIOSELECTIVE TRANSFORMATION OF α, β-UNSATURATED ALDEHYDES USING CHIRAL ORGANIC CATALYSTS 审中-公开
    手性有机催化剂对α，β-不饱和醛的非等温选择性转化

    公开(公告)号：WO2003002491A2

    公开(公告)日：2003-01-09

    申请号：PCT/US2002/020858

    申请日：2002-07-01

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  MACMILLAN, David, W., C.

    Inventor： MACMILLAN, David, W., C.

    IPC: C07C

    CPC classification number: C07D207/333 ,  C07B2200/07 ,  C07C45/69 ,  C07C327/22 ,  C07D209/12 ,  C07D209/18 ,  C07D209/22 ,  C07D209/24 ,  C07D233/32 ,  C07D261/02 ,  C07D295/155 ,  C07D307/58 ,  C07D311/20 ,  C07D333/32 ,  C07D487/04 ,  C07C47/453 ,  C07C47/445

    Abstract: Nonmetallic organic catalysts are provided that facilitate the enantioselective reaction of α, β-unsaturated aldehydes. The catalysts are chiral imidazolidinone compounds having the structure of formula (IIA) or (IIB) or are acid addition salts thereof, wherein, in one preferred embodiment, R 1 is C 1 -C 6 alkyl, R 2 is tri(C 1 -C 6 alkyl)substituted methyl, R 3 and R 4 are hydrogen, and R 5 is phenyl optionally substituted with one 1 or 2 substituents selected from the group consisting of halo, hydroxyl, and C 1 -C 6 alkyl. The chiral imidazolidinones are useful in catalyzing a wide variety of reactions, including cycloaddition reactions, Friedel-Crafts alkylation reactions, and Michael additions.

    Abstract translation: 提供了促进α，β-不饱和醛的对映选择性反应的非金属有机催化剂。 该催化剂是具有式（IIA）或（IIB）结构的手性咪唑啉酮化合物或其酸加成盐，其中在一个优选实施方案中，R 1是C 1 / C 1 -C 6烷基，R 2是三（C 1 -C 6烷基）取代的甲基，R R 3和R 4是氢，R 5是任选被1或2个选自下列的取代基取代的苯基：卤素，羟基 ，和C 1 -C 6烷基。 手性咪唑啉酮可用于催化各种各样的反应，包括环加成反应，Friedel-Crafts烷基化反应和迈克尔加成反应。

    ENANTIOSELECTIVE TRANSFORMATION OF α,β-UNSATURATED KETONES USING CHIRAL ORGANIC CATALYSTS
    4.
    发明申请
    ENANTIOSELECTIVE TRANSFORMATION OF α,β-UNSATURATED KETONES USING CHIRAL ORGANIC CATALYSTS 审中-公开
    用手性有机催化剂对α，β-不饱和酮进行等离子体转化

    公开(公告)号：WO2003047740A2

    公开(公告)日：2003-06-12

    申请号：PCT/US2002/039065

    申请日：2002-12-05

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  MACMILLAN, David, W., C. ,  NORTHRUP, Alan, B.

    Inventor： MACMILLAN, David, W., C. ,  NORTHRUP, Alan, B.

    IPC: B01J

    CPC classification number: C07D405/04 ,  B01J31/0237 ,  B01J31/0247 ,  B01J2231/326 ,  C07B2200/07 ,  C07C45/69 ,  C07C49/543 ,  C07C49/553 ,  C07C49/557 ,  C07C49/577 ,  C07C49/643 ,  C07C269/06 ,  C07D233/32 ,  C07C271/24

    Abstract: Nonmetallic organic catalysts are provided that facilitate the enantioselective reaction of α,β-unsaturated ketones. The catalysts are chiral imidazolidinone compounds having the structure of formula (IIA): or (IIB): or are acid addition salts thereof, wherein, in one preferred embodiment, R 1 is C 1 -C 6 alkyl, R 2 is phenyl or 2-methylfuryl, R 3 and R 4 are hydrogen, and R 5 is phenyl optionally substituted with 1 or 2 substituents selected from the group consisting of halo, hydroxyl, and C 1 -C 6 alkyl. The chiral imidazolinones are useful in catalyzing a wide variety of reactions, including cycloaddition reactions, Friedel-Crafts alkylation reactions, and Michael additions.

    Abstract translation: 提供了促进α，β-不饱和酮的对映选择性反应的非金属有机催化剂。 所述催化剂是具有式（IIA）或（IIB）结构的手性咪唑烷酮化合物：或其酸加成盐，其中在一个优选实施方案中，R 1是C 1， C 1 -C 6烷基，R 2为苯基或2-甲基呋喃基，R 3和R 4为氢， 是氢，而R 5是任选被1或2个选自卤素，羟基和C 1 -C 6烷基的取代基取代的苯基， 烷基。 手性咪唑啉酮可用于催化多种反应，包括环加成反应，Friedel-Crafts烷基化反应和Michael加成。

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