公开(公告)号：WO2011062964A1

公开(公告)日：2011-05-26

申请号：PCT/US2010/056990

申请日：2010-11-17

Applicant: UNIVERSITY OF ROCHESTER ,  SOUTHERN RESEARCH INSTITUTE ,  GOLDFARB, David, S. ,  MADDRY, Joseph, A. ,  RASMUSSEN, Lynn ,  WHITE, Ellie, Lucile ,  WENNERBERG, Krister

Inventor： GOLDFARB, David, S. ,  MADDRY, Joseph, A. ,  RASMUSSEN, Lynn ,  WHITE, Ellie, Lucile ,  WENNERBERG, Krister

IPC: A01N35/00 ,  A61K31/13

CPC classification number: C07C49/657 ,  C07C49/403 ,  C07C49/417 ,  C07C49/543 ,  C07C49/553 ,  C07C49/567 ,  C07C49/573 ,  C07C49/577 ,  C07C49/613 ,  C07C49/753 ,  C07C49/792 ,  C07C69/743 ,  C07C69/757 ,  C07C225/22 ,  C07C235/82 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/42 ,  C07D209/12 ,  C07D307/46 ,  C07D307/54 ,  C07D317/54 ,  C07D319/18 ,  C07D333/22

Abstract: Provided are compounds which generally have a triketone structure. Examples of the compounds include derivatives of 1,3-cyclohexanedione, such as: 1,3-cyclohexanedione, 2-propanoyl-5-cyclohexyl-; 1,3-cyclohexanedione, 2-propanoyl-5-[4-fluorophenyl]-; 1,3-cyclohexanedione, 2-acetyl-5-[thien-2-yl]-; 1,3-cyclohexanedione, 2-acetyl-5 -butyl-; and 1,3-cyclohexanedione, 2-propanoyl-5-[bicyclo[2.2.1]hept-2-en-5-yl]-. The compounds can be used to alter the lifespan of eukaryotic organisms and treat inflammation.

Abstract translation: 提供通常具有三酮结构的化合物。 化合物的实例包括1,3-环己二酮的衍生物，例如：1,3-环己二酮，2-丙酰基-5-环己基 - 2-丙酰基-5- [4-氟苯基] - ; 1,3-环己二酮，2-乙酰基-5-〔噻吩-2-基] - 1,3-环己二酮，2-乙酰基-5-丁基 - 和1,3-环己二酮，2-丙酰基-5- [双环[2.2.1]庚-2-烯-5-基] - 。 这些化合物可用于改变真核生物的寿命并治疗炎症。

公开(公告)号：WO2008012758A3

公开(公告)日：2008-04-17

申请号：PCT/IB2007052924

申请日：2007-07-23

Applicant: PROCTER & GAMBLE ,  AOUAD YOUSEF GEORGES ,  BOURGEOIS DANIEL MARTIN ,  MIRACLE GREGORY SCOT ,  WEAVERS JEAN ,  GUNARATNE HARAMBAGE QUINTAS NI ,  SEDDON KENNETH RICHARD ,  BOROS EVA ,  KATDARE SUHAS PRABHAKAR ,  BELHOCINE TAYEB BELHOCINE

Inventor： AOUAD YOUSEF GEORGES ,  BOURGEOIS DANIEL MARTIN ,  MIRACLE GREGORY SCOT ,  WEAVERS JEAN ,  GUNARATNE HARAMBAGE QUINTAS NI ,  SEDDON KENNETH RICHARD ,  BOROS EVA ,  KATDARE SUHAS PRABHAKAR ,  BELHOCINE TAYEB BELHOCINE

IPC: C07C45/67 ,  C07C49/543 ,  C07C403/16

CPC classification number: C07C45/67 ,  C07C45/69 ,  C07C2601/18 ,  C07C49/543

Abstract: Processes for producing intermediate materials used for perfumery, specifically, epimerized cyclohexenyl ketones, are disclosed. Processes for employing the epimerising reaction in an Aldol condensation reaction are also disclosed. The process for epimerizing a cyclohexenyl ketone comprises the step of reacting epimerizable cyclohexenyl ketone with a metal hydride, preferably a hydride of Group 1 or Group 2 metals, more preferably wherein the metal hydride is selected from the group consisting of LiH, NaH, KH, CaH2 and mixtures thereof.

Abstract translation: 公开了用于制造用于香料的中间体材料，特别是差向异构环己烯酮的方法。 还公开了在醛缩醇缩合反应中使用差向异构化反应的方法。 差向异构化环己烯基酮的方法包括使可分解的环己烯基酮与金属氢化物，优选第1族或第2族金属的氢化物反应的步骤，更优选其中金属氢化物选自LiH，NaH，KH， CaH 2及其混合物。

公开(公告)号：WO2010080504A1

公开(公告)日：2010-07-15

申请号：PCT/US2009/068497

申请日：2009-12-17

Applicant: THE PROCTER & GAMBLE COMPANY ,  BOURGEOIS, Daniel, Martin ,  MIRACLE, Gregory, Scot ,  PORTER, Philip, John ,  BOROS, Eva ,  SEDDON, Kenneth, Richard ,  GUNARATNE, Harambage, Quintus Nimal

Inventor： BOURGEOIS, Daniel, Martin ,  MIRACLE, Gregory, Scot ,  PORTER, Philip, John ,  BOROS, Eva ,  SEDDON, Kenneth, Richard ,  GUNARATNE, Harambage, Quintus Nimal

IPC: C07C45/67 ,  C07C403/16 ,  C07C49/453

CPC classification number: C07C403/16 ,  C07C45/67 ,  C07C2601/16 ,  Y02P20/582 ,  C07C49/543

Abstract: The present disclosure describes processes for the epimerization of a cyclohexene comprising the steps of providing to a reactor a first isomer of a 1-(2-alkyl-3-cyclohexen-1-yl)-alkanone compound according to Formula I I wherein R1 ad R2 are each independently C1-C4 alkyl, and R3, R4, R5, R6, R7, and R8 are each independently selected from the group consisting of H and C1-C4 alkyl; and epimerizing the first isomer of the 1-(2-alkyl-3-cyclohexen-1-yl)-alkanone with a metal alkoxide base to form a second isomer of the 1-(2-alkyl-3-cyclohexen-1-yl)-alkanone.

Abstract translation: 本公开描述了环己烯差向异构化的方法，包括以下步骤：向反应器提供根据式II的1-（2-烷基-3-环己烯-1-基） - 烷酮化合物的第一异构体，其中R1至R2 各自独立地为C 1 -C 4烷基，R 3，R 4，R 5，R 6，R 7和R 8各自独立地选自H和C 1 -C 4烷基; 并用金属醇盐碱使1-（2-烷基-3-环己烯-1-基） - 烷酮的第一异构体差向异构化，以形成1-（2-烷基-3-环己烯-1-基 ）-alkanone。

公开(公告)号：WO2003047740A2

公开(公告)日：2003-06-12

申请号：PCT/US2002/039065

申请日：2002-12-05

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  MACMILLAN, David, W., C. ,  NORTHRUP, Alan, B.

Inventor： MACMILLAN, David, W., C. ,  NORTHRUP, Alan, B.

IPC: B01J

CPC classification number: C07D405/04 ,  B01J31/0237 ,  B01J31/0247 ,  B01J2231/326 ,  C07B2200/07 ,  C07C45/69 ,  C07C49/543 ,  C07C49/553 ,  C07C49/557 ,  C07C49/577 ,  C07C49/643 ,  C07C269/06 ,  C07D233/32 ,  C07C271/24

Abstract: Nonmetallic organic catalysts are provided that facilitate the enantioselective reaction of α,β-unsaturated ketones. The catalysts are chiral imidazolidinone compounds having the structure of formula (IIA): or (IIB): or are acid addition salts thereof, wherein, in one preferred embodiment, R 1 is C 1 -C 6 alkyl, R 2 is phenyl or 2-methylfuryl, R 3 and R 4 are hydrogen, and R 5 is phenyl optionally substituted with 1 or 2 substituents selected from the group consisting of halo, hydroxyl, and C 1 -C 6 alkyl. The chiral imidazolinones are useful in catalyzing a wide variety of reactions, including cycloaddition reactions, Friedel-Crafts alkylation reactions, and Michael additions.

Abstract translation: 提供了促进α，β-不饱和酮的对映选择性反应的非金属有机催化剂。 所述催化剂是具有式（IIA）或（IIB）结构的手性咪唑烷酮化合物：或其酸加成盐，其中在一个优选实施方案中，R 1是C 1， C 1 -C 6烷基，R 2为苯基或2-甲基呋喃基，R 3和R 4为氢， 是氢，而R 5是任选被1或2个选自卤素，羟基和C 1 -C 6烷基的取代基取代的苯基， 烷基。 手性咪唑啉酮可用于催化多种反应，包括环加成反应，Friedel-Crafts烷基化反应和Michael加成。

公开(公告)号：WO2016197000A1

公开(公告)日：2016-12-08

申请号：PCT/US2016/035829

申请日：2016-06-03

Applicant: P2 SCIENCE, INC.

Inventor： FOLEY, Patrick ,  YANG, Yonghua

IPC: C11B9/00 ,  A61Q13/00 ,  A61P43/00 ,  A61K31/045 ,  C07C29/143 ,  C07C33/14

CPC classification number: C11B9/0034 ,  A23L27/203 ,  A23V2002/00 ,  A61K8/34 ,  A61Q13/00 ,  C07C29/143 ,  C07C33/14 ,  C07C43/162 ,  C07C45/69 ,  C07C45/72 ,  C07C49/543 ,  C07C69/007 ,  C07C69/24 ,  C07C2601/16

Abstract: The present application relates to the preparation of cyclohexyl-alkyl carbinols, including 1 -(cyclohex-3-en-1-yl)-2-methylpropan-1-ol, which possesses a minty aroma that can be described as fresh, invigorating, and menthol-like, and also possesses cooling properties. The use of cyclohexyl-alkyl carbinols as readily accessible and cost effective fragrance, flavor, and cooling ingredients, and potential applications thereof is also described.

Abstract translation: 本申请涉及环己基 - 烷基甲醇的制备，包括1-（环己-3-烯-1-基）-2-甲基丙-1-醇，其具有可被描述为新鲜，活力， 和薄荷醇，也具有冷却性能。 还描述了使用环己基 - 烷基甲醇容易获得和成本有效的香料，风味剂和冷却成分及其潜在应用。

公开(公告)号：WO2010043522A1

公开(公告)日：2010-04-22

申请号：PCT/EP2009/063024

申请日：2009-10-07

Applicant: DSM IP Assets B.V. ,  BONRATH, Werner ,  LETINOIS, Ulla ,  SCHÜTZ, Jan

Inventor： BONRATH, Werner ,  LETINOIS, Ulla ,  SCHÜTZ, Jan

IPC: C07C45/61 ,  C07C29/42 ,  C07C403/16 ,  C11B9/00 ,  A23L1/22

CPC classification number: C07C45/512 ,  A23L27/88 ,  C07C29/42 ,  C07C45/61 ,  C07C403/16 ,  C07C2601/14 ,  C11B9/0034 ,  C07C35/17 ,  C07C49/543 ,  C07C49/403

Abstract: A process for the preparation of 1-ethynyl-3,3-dimethylcyclohexan-1-ol from dimedone by a reaction sequence of reduction and ethynylation and its further transformation into green ketone.

Abstract translation: 通过还原和乙炔化的反应顺序从二酮制备1-乙炔基-3,3-二甲基环己烷-1-醇并进一步转化成绿酮的方法。

公开(公告)号：WO2008012758A2

公开(公告)日：2008-01-31

申请号：PCT/IB2007/052924

申请日：2007-07-23

Applicant: THE PROCTER & GAMBLE COMPANY ,  AOUAD, Yousef, Georges ,  BOURGEOIS, Daniel, Martin ,  MIRACLE, Gregory, Scot ,  WEAVERS, Jean ,  GUNARATNE, Harambage, Quintas Nimal ,  SEDDON, Kenneth, Richard ,  BOROS, Eva ,  KATDARE, Suhas, Prabhakar ,  BELHOCINE, Tayeb, Belhocine

Inventor： AOUAD, Yousef, Georges ,  BOURGEOIS, Daniel, Martin ,  MIRACLE, Gregory, Scot ,  WEAVERS, Jean ,  GUNARATNE, Harambage, Quintas Nimal ,  SEDDON, Kenneth, Richard ,  BOROS, Eva ,  KATDARE, Suhas, Prabhakar ,  BELHOCINE, Tayeb, Belhocine

IPC: C07C45/67 ,  C07C49/543 ,  C07C403/16

CPC classification number: C07C45/67 ,  C07C45/69 ,  C07C2601/18 ,  C07C49/543

Abstract: Processes for producing intermediate materials used for perfumery, specifically, epimerized cyclohexenyl ketones, are disclosed. Processes for employing the epimerising reaction in an Aldol condensation reaction are also disclosed.

Abstract translation: 公开了用于制造用于香料的中间体材料，特别是差向异构环己烯酮的方法。 还公开了在醛缩醇缩合反应中使用差向异构化反应的方法。

公开(公告)号：WO2017088031A1

公开(公告)日：2017-06-01

申请号：PCT/AU2016/051162

申请日：2016-11-28

Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION

Inventor： RYAN, John ,  YORK, Mark

IPC: C07D211/70 ,  C07D211/78 ,  C07D211/80 ,  C07D213/50 ,  C07D241/04 ,  C07D241/08 ,  C09D5/32 ,  A61K8/40

CPC classification number: C07D211/70 ,  A61K8/4926 ,  A61Q17/04 ,  C07C49/543 ,  C07C49/792 ,  C07C49/807 ,  C07D211/82 ,  C07D401/10 ,  C09D5/32 ,  C09K15/30

Abstract: The present invention describes compounds and uses thereof in applications relating to absorption of electromagnetic energy. Preferred compounds are double bond-containing cyclic compounds capable of absorbing electromagnetic radiation energy and having improved photostability due to the presence and location of one or more fluorine groups in relation to the double bond of the ring.

Abstract translation: 本发明描述了化合物及其在涉及电磁能量吸收的应用中的用途。 优选的化合物是能够吸收电磁辐射能并且由于一个或多个氟基团相对于环的双键的存在和位置而具有改进的光稳定性的含双键环状化合物。

公开(公告)号：WO2017019196A1

公开(公告)日：2017-02-02

申请号：PCT/US2016/037802

申请日：2016-06-16

Applicant: EXXONMOBIL CHEMICAL PATENTS INC.

Inventor： POUCHER, Ashley, J. ,  WEBER, Jörg, F.W. ,  LEAL, Medrado, M.

IPC: C07C45/00 ,  C07C45/53 ,  C07C45/82

CPC classification number: C07C49/543 ,  C07C45/006 ,  C07C45/53 ,  C07C45/82 ,  C07C2601/14 ,  C07C49/403

Abstract: Disclosed are novel cyclohexanone compositions, and processes for making such cyclohexanone compositions, from a mixture comprising phenol, cyclohexanone, and cyclohexylbenzene. Such cyclohexanone compositions comprise at least 99 wt% cyclohexanone, at most 0.15 wt% water, and at most 500 wppm combined of certain cyclohexanone impurities selected from the group consisting of: benzene, cyclohexene, pentanal, cyclopentanol, cyclohexanol, and phenol.

Abstract translation: 公开了由包含苯酚，环己酮和环己基苯的混合物制备这种环己酮组合物的新型环己酮组合物和方法。 这种环己酮组合物包含选自苯，环己烯，戊醛，环戊醇，环己醇和苯酚的至少99重量％的环己酮，至多0.15重量％的水和至多500重量ppm的某些环己酮杂质。

公开(公告)号：WO03047740A3

公开(公告)日：2003-09-04

申请号：PCT/US0239065

申请日：2002-12-05

Applicant: CALIFORNIA INST OF TECHN ,  MACMILLAN DAVID W C ,  NORTHRUP ALAN B

Inventor： MACMILLAN DAVID W C ,  NORTHRUP ALAN B

IPC: B01J31/02 ,  C07C45/69 ,  C07C49/543 ,  C07C49/553 ,  C07C49/557 ,  C07C49/577 ,  C07C49/643 ,  C07C269/06 ,  C07C271/24 ,  C07D233/32 ,  C07D405/04 ,  C07D233/02

CPC classification number: C07D405/04 ,  B01J31/0237 ,  B01J31/0247 ,  B01J2231/326 ,  C07B2200/07 ,  C07C45/69 ,  C07C49/543 ,  C07C49/553 ,  C07C49/557 ,  C07C49/577 ,  C07C49/643 ,  C07C269/06 ,  C07D233/32 ,  C07C271/24

Abstract: Nonmetallic organic catalysts are provided that facilitate the enantioselective reaction of alpha,beta-unsaturated ketones. The catalysts are chiral imidazolidinone compounds having the structure of formula IIA: or IIB: or are acid addition salts thereof, wherein, in one preferred embodiment, R1 is C1-C6 alkyl, R2 is phenyl or 2-methylfuryl, R3 and R4 are hydrogen, and R5 is phenyl optionally substituted with 1 or 2 substituents selected from the group consisting of halo, hydroxyl, and C1-C6 alkyl. The chiral imidazolinones are useful in catalyzing a wide variety of reactions, including cycloaddition reactions, Friedel-Crafts alkylation reactions, and Michael additions.

Abstract translation: 提供了促进α，β-不饱和酮的对映选择性反应的非金属有机催化剂。 催化剂是具有结构式IIA或IIB的手性咪唑烷酮化合物：或其酸加成盐，其中在一个优选的实施方案中，R 1是C 1 -C 6烷基，R 2是苯基或2-甲基呋喃基，R 3和R 4是氢 R 5是任选地被1或2个选自卤素，羟基和C 1 -C 6烷基的取代基取代的苯基。 手性咪唑啉酮可用于催化多种反应，包括环加成反应，Friedel-Crafts烷基化反应和迈克尔加成。