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33 条记录 (耗时 0.016 秒)

    3-HETEROARYLMETHYL-IMIDAZO[1,2-B]PYRIDAZIN-6-YL DERIVATIVES AS C-MET TYROSINE KINASE MODULATORS
    1.
    发明申请
    3-HETEROARYLMETHYL-IMIDAZO[1,2-B]PYRIDAZIN-6-YL DERIVATIVES AS C-MET TYROSINE KINASE MODULATORS 审中-公开
    作为C-MET酪氨酸激酶调节剂的3-异丙基甲基咪唑并[1,2-B]吡啶-6-基衍生物

    公开(公告)号：WO2011015652A1

    公开(公告)日：2011-02-10

    申请号：PCT/EP2010/061485

    申请日：2010-08-06

    申请人： NOVARTIS AG ,  FURET, Pascal ,  McCARTHY, Clive ,  SCHOEPFER, Joseph ,  STUTZ, Stefan

    发明人： FURET, Pascal ,  McCARTHY, Clive ,  SCHOEPFER, Joseph ,  STUTZ, Stefan

    IPC分类号： C07D487/04 ,  A61K31/5025 ,  A61P35/00

    CPC分类号： C07D487/04

    摘要： The invention relates to compounds of formula (I) and salts thereof, wherein the substituents are as defined in the specification, the application of a compound of formula (I) in a process for the treatment of the human or animal body, in particular with regard to C-Met tyrosine kinase mediated disease; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharamaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner; processes for the preparation of a compound of formula (I).

    摘要翻译： 本发明涉及式（I）化合物及其盐，其中取代基如本说明书中所定义，式（I）化合物在治疗人或动物体的方法中的应用，特别是用 涉及C-Met酪氨酸激酶介导的疾病; 使用式（I）化合物制备用于治疗这些疾病的药物; 药物组合物，其包含式（I）的化合物，任选地在组合配偶体的存在下; 制备式（I）化合物的方法。

    DISUBSTITUTED UREAS AS KINASE INHIBITORS
    8.
    发明申请
    DISUBSTITUTED UREAS AS KINASE INHIBITORS 审中-公开
    DISUTSTITUTED UREAS作为激酶抑制剂

    公开(公告)号：WO2006072589A2

    公开(公告)日：2006-07-13

    申请号：PCT/EP2006/000098

    申请日：2006-01-09

    申请人： NOVARTIS AG ,  NOVARTIS PHARMA GMBH ,  FURET, Pascal ,  MARTINY-BARON, Georg ,  MCCARTHY, Clive ,  RASETTI, Vittorio ,  VAUPEL, Andrea

    发明人： FURET, Pascal ,  MARTINY-BARON, Georg ,  MCCARTHY, Clive ,  RASETTI, Vittorio ,  VAUPEL, Andrea

    CPC分类号： C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14

    摘要： The invention relates to compounds of the formula (I), their use as kinase inhibitors, new pharmaceutical formulations comprising said compounds, said compounds for use in the diagnostic or therapeutic treatment of warm-blooded animals, especially humans, their use in the treatment of diseases or for the manufacture of pharmaceutical formulations useful in the treatment of diseases that respond to modulation of kinase activity, methods of treatment comprising administration of said compounds to a warm-blooded animal, especially a human, and processes for the manufacture of said compounds.

    摘要翻译： 本发明涉及式（I）化合物，它们作为激酶抑制剂的用途，包含所述化合物的新型药物制剂，所述化合物用于诊断或治疗温血动物，特别是 人类，它们在治疗疾病中的用途或用于制造用于治疗对调节激酶活性有响应的疾病的药物制剂的方法，治疗方法包括将所述化合物给予温血动物，特别是人类，以及 制造所述化合物的方法。