公开(公告)号：WO2014105971A1

公开(公告)日：2014-07-03

申请号：PCT/US2013/077840

申请日：2013-12-26

Applicant: MEDI-PHYSICS, INC.

Inventor： HELLE, Kevin M. ,  REED, Jay C. ,  CHISHOLM, Robert F.

IPC: A61M36/08 ,  B65D41/00 ,  G21F5/00

CPC classification number: G21F5/015 ,  A61J1/16 ,  G21F5/12

Abstract: The present invention provides a radiation-shielding container for a radiopharmaceutical that allows or a product fluid to be dispensed from a base component thereof.

Abstract translation: 本发明提供了一种用于放射性药物的辐射屏蔽容器，其允许或从其基底部件分配产品流体。

公开(公告)号：WO2012092110A2

公开(公告)日：2012-07-05

申请号：PCT/US2011066765

申请日：2011-12-22

Applicant: GE HEALTHCARE LTD ,  MEDI PHYSICS INC ,  STEEL COLIN ,  LUTHRA SAJINDER KAUR ,  FORTT ROBIN ,  SHAH FARAH

Inventor： STEEL COLIN ,  LUTHRA SAJINDER KAUR ,  FORTT ROBIN ,  SHAH FARAH

IPC: B65B3/00 ,  G21F5/015 ,  G21F5/02 ,  G21G1/00

CPC classification number: B65B3/003 ,  G21F3/00 ,  G21F5/015 ,  G21F5/02 ,  G21G1/0005 ,  G21G2001/0015

Abstract: Components and systems for a PET radiopharmacy include a transport shield for a radioisotope cartridge, a cassette for dispensing from a transport shield, a cassette synthesis platform for a cassette, and a synthesizer shield.

Abstract translation: 用于PET放射性药物的组件和系统包括用于放射性同位素盒的传输屏蔽，用于从传送屏蔽分配的盒，用于盒的盒合成平台和合成器屏蔽。

公开(公告)号：WO2012087908A1

公开(公告)日：2012-06-28

申请号：PCT/US2011/065794

申请日：2011-12-19

Applicant: GE HEALTHCARE LIMITED ,  MEDI-PHYSICS, INC. ,  HISCOCK, Duncan ,  INDREVOLL, Bard ,  IVESON, Peter ,  GLASER, Matthias, Eberhard ,  BHALLA, Rajiv ,  WILSON, Anthony

Inventor： HISCOCK, Duncan ,  INDREVOLL, Bard ,  IVESON, Peter ,  GLASER, Matthias, Eberhard ,  BHALLA, Rajiv ,  WILSON, Anthony

IPC: A61K51/08 ,  A61K101/02 ,  C07K14/31

CPC classification number: A61K51/088 ,  C07B59/008 ,  C07K14/31 ,  C07K14/71 ,  C07K16/32

Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.

Abstract translation: 包含与放射性核素和螯合剂缀合的分离的多肽的成像剂; 其中所述分离的多肽特异性结合HER2或其变体; 以及制备和使用这些成像剂的方法。

公开(公告)号：WO2012087725A1

公开(公告)日：2012-06-28

申请号：PCT/US2011/065036

申请日：2011-12-15

Applicant: GE HEALTHCARE LIMITED ,  MEDI-PHYSICS, INC. ,  ENGELL, Torgrim ,  OSBORN, Nigel

Inventor： ENGELL, Torgrim ,  OSBORN, Nigel

IPC: A61K47/48 ,  A61K51/04 ,  A61K51/08

CPC classification number: C07K7/64 ,  A61K47/50 ,  A61K51/0497

Abstract: A method of radiostabilizing an oxime ligation or imine formation reaction using aniline is described.

Abstract translation: 描述了使用苯胺对肟连接或亚胺形成反应进行放射稳定化的方法。

公开(公告)号：WO2012061353A1

公开(公告)日：2012-05-10

申请号：PCT/US2011/058733

申请日：2011-11-01

Applicant: GE HEALTHCARE LIMITED ,  MEDI-PHYSICS, INC. ,  DE MARCO, Emiliano

Inventor： DE MARCO, Emiliano

IPC: A61B19/00

CPC classification number: B65B3/003 ,  A61J1/06 ,  A61J1/1412 ,  A61J1/2037 ,  A61J1/2075 ,  A61J1/2082 ,  A61J1/2096 ,  B65B55/02

Abstract: A sterile dispense system provides for transfer of a fluid from a disposable fluid-path to a vial without needles piercing the vial stopper, for disconnecting the vial from the disposable fluid-path while keeping integrity of the solution filled into the vial and to enable withdrawing of the solution from the vial. The pressure valve and luer valve are provided in serial connection to a fluid vial to enable clean filling and dispensing from the vial.

Abstract translation: 无菌分配系统提供将流体从一次性流体路径转移到小瓶，而不用针刺穿瓶塞，用于将小瓶与一次性流体路径断开，同时保持溶液填充到小瓶中的完整性并使得能够退出 的小瓶溶液。 压力阀和鲁尔阀与流体小瓶串联提供，以便能够从小瓶中清洁填充和分配。

公开(公告)号：WO2012040151A3

公开(公告)日：2012-03-29

申请号：PCT/US2011/052275

申请日：2011-09-20

Applicant: GE HEALTHCARE LIMITED ,  IMPERIAL COLLEGE ,  MEDI-PHYSICS, INC. ,  ABOAGYE, Eric, Ofori ,  ROBINS, Edward George ,  SMITH, Graham ,  LUTHRA, Sajinder

Inventor： ABOAGYE, Eric, Ofori ,  ROBINS, Edward George ,  SMITH, Graham ,  LUTHRA, Sajinder

IPC: C07C213/00 ,  C07C213/02 ,  C07C213/06 ,  C07C215/08 ,  C07C217/10

Abstract: Novel choline - derived radiotracer (s) having an isotopic carbon for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g., tumor imaging of prostate, breast, brain, esophageal, ovarian, endometrial, lung and prostate cancer - primary tumor, nodal disease or metastases).

公开(公告)号：WO2012040138A2

公开(公告)日：2012-03-29

申请号：PCT/US2011052253

申请日：2011-09-20

Applicant: GE HEALTHCARE LTD ,  IMPERIAL COLLEGE ,  MEDI PHYSICS INC ,  ABOAGYE ERIC OFORI ,  ROBINS EDWARD GEORGE ,  SMITH GRAHAM ,  ZHAO YONGJUN ,  LEYTON JULIUS ,  TURTON DAVID ,  WILSON ANTHONY ,  BHALLA RAJIV ,  BRICKUTE DIANA

Inventor： ABOAGYE ERIC OFORI ,  ROBINS EDWARD GEORGE ,  SMITH GRAHAM ,  ZHAO YONGJUN ,  LEYTON JULIUS ,  TURTON DAVID ,  WILSON ANTHONY ,  BHALLA RAJIV ,  BRICKUTE DIANA

IPC: C07C213/00 ,  C07C213/02 ,  C07C213/06 ,  C07C215/08 ,  C07C217/10

CPC classification number: A61K51/04 ,  C07B59/001 ,  C07B2200/05 ,  C07C213/08 ,  C07C215/08 ,  C07C215/40 ,  Y10T428/13

Abstract: Novel radiotracer(s) for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g., tumor imaging of prostate, breast, brain, esophageal, ovarian, endometrial, lung and prostate cancer - primary tumor, nodal disease or metastases). The present invention also describes intermediate(s), pre-cursor(s), pharmaceutical composition(s), methods of making, and methods of use of the novel radiotracer(s).

Abstract translation: 用于正电子发射断层扫描（PET）或单光子发射计算机断层扫描（SPECT）的新型放射性示踪剂与改变的胆碱代谢相关的疾病状态（例如，前列腺，乳腺，脑，食管，卵巢，子宫内膜，肺和 前列腺癌 - 原发性肿瘤，淋巴结转移或转移）。 本发明还描述了新型放射性示踪剂的中间体，前体，药物组合物，制备方法和使用方法。

公开(公告)号：WO2011087823A1

公开(公告)日：2011-07-21

申请号：PCT/US2010/061697

申请日：2010-12-22

Applicant: GE HEALTHCARE LIMITED ,  MEDI-PHYSICS, INC. ,  KUNIYIL KULANGARA, Vijaya Raj ,  CUTHBERTSON, Alan ,  IVESON, Peter ,  RANGASWAMY, Chitralekha ,  RAO, Venna ,  BHALLA, Rajiv

Inventor： KUNIYIL KULANGARA, Vijaya Raj ,  CUTHBERTSON, Alan ,  IVESON, Peter ,  RANGASWAMY, Chitralekha ,  RAO, Venna ,  BHALLA, Rajiv

IPC: A61K51/04 ,  A61K31/136 ,  A61P35/00

CPC classification number: A61K31/136 ,  A61K51/04

Abstract: The present invention claims fluoro- & iodo- containing aldehydes as ALDH substrates for use as diagnostic imaging agents or as therapeutic agents. The aldehydes are both directly and indirectly attached to an aromatic or a straight chain ring. ALDH activity was monitored either by the formation of acid-product or consumption of aldehyde substrates.

Abstract translation: 本发明要求氟 - 碘基醛作为ALDH底物，用作诊断显像剂或作为治疗剂。 醛直接和间接连接到芳环或直链环上。 通过酸产物的形成或醛底物的消耗来监测ALDH活性。

公开(公告)号：WO2010127054A3

公开(公告)日：2011-01-06

申请号：PCT/US2010032870

申请日：2010-04-29

Applicant: GE HEALTHCARE LTD ,  MEDI PHYSICS INC ,  SORENSEN JENS ,  JOHANSSON SILVIA ,  SUN AIJUN

Inventor： SORENSEN JENS ,  JOHANSSON SILVIA ,  SUN AIJUN

IPC: A61K51/04

CPC classification number: A61K51/0402

Abstract: The present invention provides methods of using optimal PET tracers for diagnosing head and neck cancer. Non-invasive methods for assessing tumor perfusion and oxidative metabolism for in vivo imaging with PET tracers that are suitable for uses in radiation therapy (RT) in head and neck cancer and evaluation of salivary gland function are provided. A pharmaceutical comprising the PET tracer and a kit for the preparation of the pharmaceutical are provided as well.

Abstract translation: 本发明提供了使用最佳PET示踪剂来诊断头颈癌的方法。 提供了适用于头颈部癌症放射治疗（RT）和唾液腺功能评估的PET示踪剂的体内成像评估肿瘤灌注和氧化代谢的非侵入性方法。 还提供了包含PET示踪剂的药物和用于制备药物的试剂盒。

公开(公告)号：WO2010132523A1

公开(公告)日：2010-11-18

申请号：PCT/US2010/034477

申请日：2010-05-12

Applicant: GE HEALTHCARE LIMITED ,  MEDI-PHYSICS, INC. ,  LANGSTROM, Bengt ,  RAZIFAR, Pasha

Inventor： LANGSTROM, Bengt ,  RAZIFAR, Pasha

IPC: G06T7/00

CPC classification number: A61B6/037 ,  A61B6/03 ,  G06T5/003 ,  G06T2207/10084 ,  G06T2207/10104 ,  G06T2207/20016 ,  G06T2207/30016

Abstract: The invention relates to a system and method for enhancing image data obtained from a positron emission tomography (PET) scan. In various embodiments, the method comprises transforming an original image data set to provide a first modified image data set by performing a masked volume-wise principal component analysis (MVW-PCA) on the original image data set. The first modified image data set is then transformed to provide a second modified image data set by performing a masked volume-wise independent component analysis (MVW-ICA) on the first modified image data set, the second modified image data set thereby comprising enhanced image data.

Abstract translation: 本发明涉及一种用于增强从正电子发射断层摄影（PET）扫描获得的图像数据的系统和方法。 在各种实施例中，该方法包括通过在原始图像数据集上执行屏蔽的体积主成分分析（MVW-PCA）来变换原始图像数据集以提供第一修改图像数据集。 然后，对第一修改图像数据集进行变换以提供第二修改图像数据集，通过对第一修改图像数据集执行掩蔽的体积独立分量分析（MVW-ICA），由此包括增强图像 数据。