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    SILICONE-CONTAINING PREPOLYMERS WITH HYDROPHILIC POLYMERIC CHAINS
    1.
    发明申请
    SILICONE-CONTAINING PREPOLYMERS WITH HYDROPHILIC POLYMERIC CHAINS 审中-公开
    含硅氧烷聚合物的含硅酮的预聚物

    公开(公告)号：WO2008116132A3

    公开(公告)日：2008-12-11

    申请号：PCT/US2008057775

    申请日：2008-03-21

    Applicant: NOVARTIS AG ,  ZHOU JIAN S ,  CHANG FRANK ,  MEDINA ARTURO NORBERTO ,  SCOTT ROBERT

    Inventor： ZHOU JIAN S ,  CHANG FRANK ,  MEDINA ARTURO NORBERTO ,  SCOTT ROBERT

    IPC: G02B1/04 ,  A61L27/26 ,  C08F283/12 ,  C08G77/06

    CPC classification number: C08F283/12 ,  C08L51/085 ,  C08L2666/02

    Abstract: The invention provide a new class of silicone-containing prepolymers containing dangling hydrophilic polymer chains. This class of silicone-containing prepolymer is capable of being actinically crosslinked to form a silicone hydrogel material with a hydrophilic surface without post curing surface treatment. The present invention is also related to silicone hydrogel contact lenses made from this class of silicone-containing prepolymers and to methods for making the silicone hydrogel contact lenses.

    Abstract translation: 本发明提供了一类含有悬浮亲水聚合物链的含硅氧烷预聚物。 这种含硅氧烷的预聚物能够进行光化交联以形成具有亲水表面的硅氧烷水凝胶材料，而无需后固化表面处理。 本发明还涉及由这种含硅氧烷的预聚物制成的硅酮水凝胶隐形眼镜以及制备硅酮水凝胶隐形眼镜的方法。

    SILICONE-CONTAINING PREPOLYMERS WITH DANGLING HYDROPHILIC POLYMERIC CHAINS
    4.
    发明申请
    SILICONE-CONTAINING PREPOLYMERS WITH DANGLING HYDROPHILIC POLYMERIC CHAINS 审中-公开
    含有含硅烷烃聚合物链的含硅酮的预聚物

    公开(公告)号：WO2008116132A2

    公开(公告)日：2008-09-25

    申请号：PCT/US2008/057775

    申请日：2008-03-21

    Applicant: NOVARTIS AG ,  ZHOU, Jian S. ,  CHANG, Frank ,  MEDINA, Arturo Norberto ,  SCOTT, Robert

    Inventor： ZHOU, Jian S. ,  CHANG, Frank ,  MEDINA, Arturo Norberto ,  SCOTT, Robert

    CPC classification number: C08F283/12 ,  C08L51/085 ,  C08L2666/02

    Abstract: The invention provide a new class of silicone-containing prepolymers containing dangling hydrophilic polymer chains. This class of silicone-containing prepolymer is capable of being actinically crosslinked to form a silicone hydrogel material with a hydrophilic surface without post curing surface treatment. The present invention is also related to silicone hydrogel contact lenses made from this class of silicone-containing prepolymers and to methods for making the silicone hydrogel contact lenses.

    Abstract translation: 本发明提供了一类含有悬浮亲水聚合物链的含硅氧烷预聚物。 这种含硅氧烷的预聚物能够进行光化交联以形成具有亲水表面的硅氧烷水凝胶材料，而无需后固化表面处理。 本发明还涉及由这种含硅氧烷的预聚物制成的硅酮水凝胶隐形眼镜以及制备硅酮水凝胶隐形眼镜的方法。

    NOVEL POLYMERS
    5.
    发明申请
    NOVEL POLYMERS 审中-公开
    新型聚合物

    公开(公告)号：WO2008008752A2

    公开(公告)日：2008-01-17

    申请号：PCT/US2007/073119

    申请日：2007-07-10

    Applicant: NOVARTIS AG ,  CHANG, Frank ,  MEDINA, Arturo Norberto

    Inventor： CHANG, Frank ,  MEDINA, Arturo Norberto

    IPC: C08F2/46 ,  C08F8/00 ,  G02B1/04 ,  G02C7/04 ,  C08F220/00 ,  C08G77/442

    CPC classification number: C07C231/12 ,  C07C67/00 ,  C08F8/00 ,  C08F220/06 ,  C08F220/26 ,  C08F220/56 ,  C08F230/08 ,  C08F2220/286 ,  C08F2800/20 ,  C08F2810/20 ,  C08F2810/30 ,  C08G77/442 ,  C08J3/075 ,  C08J3/28 ,  C08J2433/04 ,  C08J2483/04 ,  G02B1/043 ,  C08L51/085 ,  C08F290/068 ,  C08F285/00

    Abstract: The invention relates to novel crosslinkable copolymers which are obtainable by (a) copolymerizing at least two different hydrophilic monomers selected from the group consisting of N,N-dimethyl acrylamide (DMA), 2-hydroxyethyl acrylate (HEA), glycidyl methacrylate (GMA), N-vinylpyrrolidone (NVP), acrylic acid (AA) and a C1-C4-alkoxy polyethylene glycol (meth)acrylate having a weight average molecular weight of from 200 to 1500, and at least one crosslinker comprising two or more ethylenically unsaturated double bonds in the presence of a chain transfer agent having a functional group; and (b) reacting one or more functional groups of the resulting copolymer with an organic compound having an ethylenically unsaturated group.

    Abstract translation: 本发明涉及可通过（a）共聚选自N，N-二甲基丙烯酰胺（DMA），丙烯酸2-羟基乙酯（HEA），甲基丙烯酸缩水甘油酯（GMA））的至少两种不同亲水性单体的新型可交联共聚物， ，N-乙烯基吡咯烷酮（NVP），丙烯酸（AA）和重均分子量为200〜1500的C1-C4-烷氧基聚乙二醇（甲基）丙烯酸酯，以及至少一种包含两种或更多种烯键式不饱和双 在具有官能团的链转移剂的存在下进行键合; 和（b）使所得共聚物的一种或多种官能团与具有烯属不饱和基团的有机化合物反应。

    METHOD FOR MAKING CONTACT LENSES
    7.
    发明申请
    METHOD FOR MAKING CONTACT LENSES 审中-公开
    制造接触镜的方法

    公开(公告)号：WO2005025843A3

    公开(公告)日：2005-06-16

    申请号：PCT/EP2004010135

    申请日：2004-09-10

    Applicant: NOVARTIS AG ,  NOVARTIS PHARMA GMBH ,  DEVLIN BRIAN GERRARD ,  MEDINA ARTURO NORBERTO ,  TENA MIREILLE

    Inventor： DEVLIN BRIAN GERRARD ,  MEDINA ARTURO NORBERTO ,  TENA MIREILLE

    IPC: B29C35/08 ,  B29D11/00

    CPC classification number: B29D11/0099 ,  B29C35/0894 ,  B29C2035/0827 ,  B29C2035/0833 ,  B29D11/00057 ,  B29D11/00125 ,  B29L2011/0041

    Abstract: The instant invention pertains to a method and a fluid composition for producing contact lenses with relatively high edge quality and with relatively high precision and fidelity in reproducing a desired lens design. The method of the invention involves: a mold which has a first mold half with a first molding surface and a second mold half with a second molding surface, wherein the first and second mold halves are configured to receive each other such that the cavity is formed between the first and second molding surfaces which define the opposite two surfaces of a contact lens to be produced; a spatial limitation of actinic radiation to define the edge of the contact lens to be produced; and addition of a radical scavenger in a fluid composition comprising a lens-forming material to reduce substantially the crosslinking/polymerizing, caused by diffused, scattered and/or reflected incident actinic radiation, of the fluid composition outside of and around the spatial limitation of actinic radiation.

    Abstract translation: 本发明涉及一种用于制造具有相对高的边缘质量并且在再现期望的透镜设计时具有相对高的精度和保真度的隐形眼镜的方法和流体组合物。 本发明的方法包括：模具，其具有具有第一模制表面的第一模具半部和具有第二模制表面的第二模具半部，其中第一和第二半模构造成彼此接收，使得形成空腔 在限定待制造的隐形眼镜的相对的两个表面的第一和第二模制表面之间; 光化辐射的空间限制，以限定要产生的隐形眼镜的边缘; 以及在包含透镜形成材料的流体组合物中添加自由基清除剂，以减少由光化学的空间限制之外和周围的流体组合物的扩散，散射和/或反射入射光化辐射引起的交联/聚合 辐射。

    METHOD FOR MAKING CONTACT LENSES
    8.
    发明申请
    METHOD FOR MAKING CONTACT LENSES 审中-公开
    制造隐形眼镜的方法

    公开(公告)号：WO2005025843A2

    公开(公告)日：2005-03-24

    申请号：PCT/EP2004/010135

    申请日：2004-09-10

    Applicant: NOVARTIS AG ,  NOVARTIS PHARMA GMBH ,  DEVLIN, Brian, Gerrard ,  MEDINA, Arturo, Norberto ,  TENA, Mireille

    Inventor： DEVLIN, Brian, Gerrard ,  MEDINA, Arturo, Norberto ,  TENA, Mireille

    IPC: B29D11/00

    CPC classification number: B29D11/0099 ,  B29C35/0894 ,  B29C2035/0827 ,  B29C2035/0833 ,  B29D11/00057 ,  B29D11/00125 ,  B29L2011/0041

    Abstract: The instant invention pertains to a method and a fluid composition for producing contact lenses with relatively high edge quality and with relatively high precision and fidelity in reproducing a desired lens design. The method of the invention involves: a mold which has a first mold half with a first molding surface and a second mold half with a second molding surface, wherein the first and second mold halves are configured to receive each other such that the cavity is formed between the first and second molding surfaces which define the opposite two surfaces of a contact lens to be produced; a spatial limitation of actinic radiation to define the edge of the contact lens to be produced; and addition of a radical scavenger in a fluid composition comprising a lens-forming material to reduce substantially the crosslinking/polymerizing, caused by diffused, scattered and/or reflected incident actinic radiation, of the fluid composition outside of and around the spatial limitation of actinic radiation.

    Abstract translation: 本发明涉及一种用于制造隐形眼镜的方法和流体组合物，所述隐形眼镜具有相对高的边缘质量并且在再现期望的镜片设计时具有相对高的精度和保真度。 本发明的方法包括：模具，其具有带第一模制表面的第一半模和带有第二模制表面的第二半模，其中第一和第二半模配置为彼此接收，使得空腔形成 在限定要制造的隐形眼镜的相对两个表面的第一和第二模制表面之间; 光化辐射的空间限制，以限定要生产的隐形眼镜的边缘; 以及在包含透镜形成材料的流体组合物中添加自由基清除剂以基本上减少流体组合物在光化学空间限制之外和其周围的由扩散，散射和/或反射的入射光化辐射引起的交联/聚合 辐射。

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