公开(公告)号：WO2013134133A1

公开(公告)日：2013-09-12

申请号：PCT/US2013/028886

申请日：2013-03-04

Applicant: MEDTRONIC ARDIAN LUXEMBOURG SARL ,  BALLAKUR, Sowmya ,  WU, Andrew ,  GEORGE, William, R. ,  LEWIS, Charles, Richard, Jr. ,  MINAMI, Don, S.

Inventor： BALLAKUR, Sowmya ,  WU, Andrew ,  GEORGE, William, R. ,  LEWIS, Charles, Richard, Jr. ,  MINAMI, Don, S. ,  CADOURI, Hadar ,  FRIEDRICHS, Paul ,  SHAH, JignesH ,  TRUDEL, Julie ,  DOERKSEN, Kyle ,  HARBOUN, Michael ,  KING, Simon ,  VONDLE, Dave

IPC: A61B18/12 ,  A61B18/14

CPC classification number: A61B18/1206 ,  A61B18/1492 ,  A61B50/10 ,  A61B50/13 ,  A61B90/98 ,  A61B2017/00115 ,  A61B2017/00199 ,  A61B2017/00212 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577

Abstract: Generator assemblies and systems for neuromodulation therapies are disclosed herein. A generator system configured in accordance with a particular embodiment of the present technology can include, for example, a generator console and a stand assembly configured to releasably carry the generator console. The generator console can include a plurality of radiofrequency (RF) channels configured to deliver energy to a plurality of electrodes of a neuromodulation device. The generator console can also include a display configured to indicate operating conditions of the RF channels during energy delivery. The stand assembly can include a recessed portion having a plurality of spring-loaded locking members and a release mechanism operably coupled to the locking members. The release mechanism can be configured to move the locking members from a locked arrangement to an unlocked arrangement to disengage the generator console from the stand assembly.

Abstract translation: 用于神经调节治疗的发生器组件和系统在本文中公开。 根据本技术的特定实施例配置的发电机系统可以包括例如发电机控制台和配置成可释放地携带发电机控制台的支架组件。 发电机控制台可以包括被配置为向神经调节装置的多个电极输送能量的多个射频（RF）通道。 发电机控制台还可以包括配置为在能量传递期间指示RF信道的操作条件的显示器。 支架组件可以包括具有多个弹簧加载的锁定构件的凹部和可操作地联接到锁定构件的释放机构。 释放机构可以被配置为将锁定构件从锁定装置移动到解锁装置，以将发生器控制台与支架组件分离。

公开(公告)号：WO2011139589A3

公开(公告)日：2012-03-15

申请号：PCT/US2011033491

申请日：2011-04-21

Applicant: MEDTRONIC ARDIAN LLC ,  LEUNG MARK S ,  CLARK BENJAMIN J ,  MICHLITSCH KENNETH ,  THAI ERIK ,  WU ANDREW ,  ZARINS DENISE

Inventor： LEUNG MARK S ,  CLARK BENJAMIN J ,  MICHLITSCH KENNETH ,  THAI ERIK ,  WU ANDREW ,  ZARINS DENISE

IPC: A61B18/14

CPC classification number: A61B18/082 ,  A61B17/320068 ,  A61B18/02 ,  A61B18/0206 ,  A61B18/10 ,  A61B18/1492 ,  A61B18/1815 ,  A61B18/20 ,  A61B2018/00023 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00714 ,  A61B2018/00744 ,  A61B2018/00791 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00875 ,  A61B2018/1861 ,  H04L29/12066 ,  H04L61/1511

Abstract: Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver an energy delivery element to a renal artery via an intravascular path. Thermal or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

Abstract translation: 本文公开了用于通过血管内通路实现肾神经调节的导管设备，系统和方法。 例如，本申请的一个方面涉及结合包括细长轴的导管治疗装置的装置，系统和方法。 细长轴的尺寸和构造被设定为经由血管内路径将能量输送元件输送到肾动脉。 可以通过直接和/或通过间接应用热和/或电能来加热或冷却或以其他方式电调节有助于肾功能的神经纤维，或者通过给予或灌注 神经纤维。

公开(公告)号：WO2011130005A2

公开(公告)日：2011-10-20

申请号：PCT/US2011/030496

申请日：2011-03-30

Applicant: MEDTRONIC ARDIAN LLC ,  CLARK, Benjamin, C. ,  GEORGE, William, R. ,  MICHLITSCH, Kenneth, J. ,  SAM, John, Paul ,  THAI, Erik ,  WU, Andrew

Inventor： CLARK, Benjamin, C. ,  GEORGE, William, R. ,  MICHLITSCH, Kenneth, J. ,  SAM, John, Paul ,  THAI, Erik ,  WU, Andrew

IPC: A61B18/14 ,  A61B19/00 ,  A61B17/00

CPC classification number: A61B18/08 ,  A61B34/74 ,  A61B2017/003 ,  A61B2018/00916

Abstract: The present disclosure comprises handle assemblies for intravascular treatment devices. In one embodiment, a handle assembly comprises an actuator for deflecting a distal region of an intravascular treatment device. In one embodiment, a handle assembly comprises a rotator for rotating an intravascular treatment device independently of the handle assembly. In one embodiment, a handle assembly comprises a rotation limiting element for limiting independent rotation of an intravascular treatment device relative to the handle assembly. Methods and systems for intravascular delivery, deflection and placement of an intravascular treatment device via a handle assembly of the present invention are also provided.

Abstract translation: 本公开包括用于血管内治疗装置的手柄组件。 在一个实施例中，手柄组件包括用于偏转血管内治疗装置的远侧区域的致动器。 在一个实施例中，手柄组件包括用于独立于手柄组件旋转血管内治疗装置的旋转器。 在一个实施例中，手柄组件包括旋转限制元件，用于限制血管内治疗装置相对于手柄组件的独立旋转。 还提供了通过本发明的手柄组件进行血管内递送，偏转和放置血管内治疗装置的方法和系统。

公开(公告)号：WO2010068930A1

公开(公告)日：2010-06-17

申请号：PCT/US2009/067777

申请日：2009-12-11

Applicant: SUGARCRM INC. ,  HSU, Yun-Ping ,  ITANI, Majed ,  GUPTA, Ajay ,  SMITH, Roger ,  AAGAARD, Rob ,  WU, Andrew ,  LEE, Collin ,  TRETIKOV, Lila

Inventor： HSU, Yun-Ping ,  ITANI, Majed ,  GUPTA, Ajay ,  SMITH, Roger ,  AAGAARD, Rob ,  WU, Andrew ,  LEE, Collin ,  TRETIKOV, Lila

IPC: G06F15/16

CPC classification number: G06Q30/02

Abstract: A business software application system and method are provided that include a feed system for distributing changes about the application/module to a group of users and a cloud connector system that links external data sources to the business software application system and method.

Abstract translation: 提供了一种商业软件应用系统和方法，其包括用于将关于应用/模块的改变分发给一组用户的馈送系统和将外部数据源连接到商业软件应用系统和方法的云连接器系统。

公开(公告)号：WO2012061164A1

公开(公告)日：2012-05-10

申请号：PCT/US2011/057761

申请日：2011-10-25

Applicant: MAUCH, Kevin ,  ALVARADO, Mario ,  BEETEL, Robert, J. ,  COLE, Juanita, Sanchez ,  CHANG, William ,  GOSHGARIAN, Justin ,  RIVERA, Leonila ,  SHIN, Sukyoung ,  SILVER, Michele ,  SOM, Sina ,  WU, Andrew ,  ZARINS, Denise ,  ABOYTES, Maria, G.

Inventor： MAUCH, Kevin ,  ALVARADO, Mario ,  BEETEL, Robert, J. ,  COLE, Juanita, Sanchez ,  CHANG, William ,  GOSHGARIAN, Justin ,  RIVERA, Leonila ,  SHIN, Sukyoung ,  SILVER, Michele ,  SOM, Sina ,  WU, Andrew ,  ZARINS, Denise ,  ABOYTES, Maria, G.

IPC: A61B18/14

CPC classification number: A61B18/1492 ,  A61B2018/00023 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/1435 ,  A61B2018/1467 ,  A61M25/0041 ,  A61M25/0074 ,  A61M25/0133 ,  A61M25/0138 ,  A61M25/0147

Abstract: Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel. The array is selectively transformable between a delivery or low-profile state (e.g., a generally straight shape) and a deployed state (e.g., a radially expanded, generally helical shape). The multi-electrode array is sized and shaped so that the electrodes or energy delivery elements contact an interior wall of the renal blood vessel when the array is in the deployed (e.g., helical) state. The electrodes or energy delivery elements are configured for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function or of vascular structures that feed or perfused the neural fibers.

Abstract translation: 本文公开了通过血管内通路实现肾脏神经调节的导管装置，系统和方法。 例如，本技术的一个方面涉及具有被配置为输送到肾血管的多电极阵列的治疗装置。 阵列可以在传送或低轮廓状态（例如，大致直线形状）和展开状态（例如，径向膨胀，大致螺旋形状）之间选择性地变换。 多电极阵列的尺寸和形状使得当阵列处于部署（例如螺旋状态）时，电极或能量递送元件接触肾血管的内壁。 电极或能量递送元件构造成用于直接和/或间接施加热和/或电能以加热或以其他方式电调制有助于肾功能的神经纤维或者供给或灌注神经纤维的血管结构。

公开(公告)号：WO2012061153A1

公开(公告)日：2012-05-10

申请号：PCT/US2011/057740

申请日：2011-10-25

Applicant: BALLAKUR, Sowmya ,  BEETEL, Robert, J. ,  FRIEDRICHS, Paul ,  HERZFELD, David ,  WU, Andrew ,  ZARINS, Denise ,  LEUNG, Mark, S. ,  MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L.

Inventor： BALLAKUR, Sowmya ,  BEETEL, Robert, J. ,  FRIEDRICHS, Paul ,  HERZFELD, David ,  WU, Andrew ,  ZARINS, Denise ,  LEUNG, Mark, S.

IPC: A61B18/12 ,  A61B18/10 ,  A61F7/12 ,  A61B18/14 ,  A61B18/00 ,  A61B17/00 ,  A61N1/06 ,  A61N1/32 ,  A61B18/08

CPC classification number: A61B18/1206 ,  A61B18/10 ,  A61B18/1492 ,  A61B2017/00075 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00648 ,  A61B2018/00672 ,  A61B2018/00678 ,  A61B2018/00702 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00863 ,  A61B2018/00875 ,  A61F7/12 ,  A61F2007/0093 ,  A61F2007/126

Abstract: The present disclosure relates to devices, systems and methods for evaluating the success of a treatment applied to tissue in a patient, such as a radio frequency ablative treatment used to neuromodulate nerves associated with the renal artery. A system monitors parameters or values generated during the course of a treatment. Feedback provided to an operator is based on the monitored values and relates to an assessment of the likelihood that a completed treatment was technically successful. In other embodiments, parameters or values generated during the course of an incomplete treatment (such as due to high temperature or high impedance conditions) may be evaluated to provide additional instructions or feedback to an operator.

Abstract translation: 本公开涉及用于评估应用于患者组织的治疗成功的装置，系统和方法，例如用于神经调节与肾动脉相关的神经的射频消融治疗。 系统监视在治疗过程中产生的参数或值。 提供给运营商的反馈是基于监测值，并且涉及对完成的处理在技术上成功的可能性的评估。 在其他实施例中，可以评估在不完全处理过程中产生的参数或值（例如由于高温或高阻抗条件），以向操作者提供额外的指令或反馈。

公开(公告)号：WO2011139589A9

公开(公告)日：2011-12-29

申请号：PCT/US2011033491

申请日：2011-04-21

Applicant: MEDTRONIC ARDIAN LLC ,  LEUNG MARK S ,  CLARK BENJAMIN J ,  MICHLITSCH KENNETH ,  THAI ERIK ,  WU ANDREW ,  ZARINS DENISE

Inventor： LEUNG MARK S ,  CLARK BENJAMIN J ,  MICHLITSCH KENNETH ,  THAI ERIK ,  WU ANDREW ,  ZARINS DENISE

IPC: A61B18/14

CPC classification number: A61B18/082 ,  A61B17/320068 ,  A61B18/02 ,  A61B18/0206 ,  A61B18/10 ,  A61B18/1492 ,  A61B18/1815 ,  A61B18/20 ,  A61B2018/00023 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00714 ,  A61B2018/00744 ,  A61B2018/00791 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00875 ,  A61B2018/1861 ,  H04L29/12066 ,  H04L61/1511

Abstract: Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver an energy delivery element to a renal artery via an intravascular path. Thermal or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

Abstract translation: 本文公开了通过血管内通路实现肾脏神经调节的导管装置，系统和方法。 本申请的一个方面，例如，涉及包括细长轴的导管治疗装置的装置，系统和方法。 细长轴的尺寸和构造被设计成经由血管内路径将能量递送元件递送到肾动脉。 热或电性肾神经调节可以通过直接和/或通过间接施加热和/或电能来加热或冷却或以其他方式电调制有助于肾功能的神经纤维或者供给或灌注 神经纤维。

公开(公告)号：WO2011091069A1

公开(公告)日：2011-07-28

申请号：PCT/US2011/021757

申请日：2011-01-19

Applicant: ARDIAN, INC. ,  BEETEL, Robert, J. ,  BARMAN, Neil, C. ,  CLARK, Benjamin, J. ,  FRIEDRICHS, Paul ,  MICHLITSCH, Kenneth, J. ,  NAGA, Karun, D. ,  WU, Andrew ,  ZARINS, Denise

Inventor： BEETEL, Robert, J. ,  BARMAN, Neil, C. ,  CLARK, Benjamin, J. ,  FRIEDRICHS, Paul ,  MICHLITSCH, Kenneth, J. ,  NAGA, Karun, D. ,  WU, Andrew ,  ZARINS, Denise

IPC: A61B6/00

CPC classification number: A61N5/1042 ,  A61B6/506 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61N5/1067 ,  A61N7/02 ,  A61N2005/1061

Abstract: The present disclosure describes methods and apparatus for renal neuromodulation via stereotactic radiotherapy for the treatment of hypertension, heart failure, chronic kidney disease, diabetes, insulin resistance, metabolic disorder or other ailments. Renal neuromodulation may be achieved by locating renal nerves and then utilizing stereotactic radiotherapy to expose the renal nerves to a radiation dose sufficient to reduce neural activity. A neural location element may be provided for locating target renal nerves, and a stereotactic radiotherapy system may be provided for exposing the located renal nerves to a radiation dose sufficient to reduce the neural activity, with reduced or minimized radiation exposure in adjacent tissue. Renal nerves may be located and targeted at the level of the ganglion and/or at postganglionic positions, as well as at pre-ganglionic positions.

Abstract translation: 本公开描述了通过立体定向放射治疗高血压，心力衰竭，慢性肾脏疾病，糖尿病，胰岛素抵抗，代谢紊乱或其它疾病的肾神经调节的方法和装置。 肾神经调节可以通过定位肾神经，然后利用立体定向放射治疗来将肾神经暴露于足以减少神经活动的辐射剂量来实现。 可以提供用于定位目标肾神经的神经位置元件，并且可以提供立体定向放射治疗系统，用于将所定位的肾神经暴露于足以减少或最小化相邻组织中的辐射暴露的神经活动的辐射剂量。 肾神经可能位于神经节水平和/或神经节后位置以及神经节前位置。

公开(公告)号：WO2008003058A8

公开(公告)日：2008-01-03

申请号：PCT/US2007/072396

申请日：2007-06-28

Applicant: ARDIAN, INC. ,  DEMARAIS, Denise ,  ZADNO, Nicolas ,  CLARK, Benjamin, J. ,  THAI, Erik ,  LEVIN, Howard, R. ,  GELFAND, Mark ,  WU, Andrew ,  GIFFORD, Hanson ,  DEEM, Mark

Inventor： DEMARAIS, Denise ,  ZADNO, Nicolas ,  CLARK, Benjamin, J. ,  THAI, Erik ,  LEVIN, Howard, R. ,  GELFAND, Mark ,  WU, Andrew ,  GIFFORD, Hanson ,  DEEM, Mark

IPC: A61F2/00

Abstract: Methods and system are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.

公开(公告)号：WO2015138708A1

公开(公告)日：2015-09-17

申请号：PCT/US2015/020152

申请日：2015-03-12

Applicant: PROXIMED, LLC ,  HUELMAN, Justin ,  WU, Andrew ,  JUNG, Michael ,  CHILD, Marc ,  SHARMA, Vidit ,  MCCASLIN, Addason

Inventor： HUELMAN, Justin ,  WU, Andrew ,  JUNG, Michael ,  CHILD, Marc ,  SHARMA, Vidit ,  MCCASLIN, Addason

IPC: A61B17/00 ,  A61B19/00

CPC classification number: A61B34/20 ,  A61B2017/00022 ,  A61B2017/00119 ,  A61B2017/00876 ,  A61B2017/4216 ,  A61B2034/2051 ,  A61B2034/2072 ,  A61B2090/3954 ,  A61B2562/0223 ,  A61B2562/0257

Abstract: Surgical systems and methods for avoiding injury to an anatomical structure are disclosed. According to some aspects, an implantable device configured to emit a detectable field may be attached to the anatomical structure. A proximity sensor may be attached to a distal end of a surgical instrument and may be configured to detect the detectable field. A control unit in communication with the proximity sensor may be configured to use the proximity sensor to determine if the distal end of the surgical instrument is within a predetermined distance of the implantable device. If so, a notification such as a vibration or alarm may be provided to a user of the surgical instrument so that the user can maneuver the surgical instrument to limit or prevent contact with the anatomical structure.

Abstract translation: 公开了用于避免对解剖结构的损伤的手术系统和方法。 根据一些方面，构造成发射可检测区域的可植入装置可以附接到解剖结构。 接近传感器可以附接到手术器械的远端，并且可以被配置为检测可检测的场。 与接近传感器通信的控制单元可以被配置为使用接近传感器来确定外科器械的远端是否在可植入装置的预定距离内。 如果是这样，可以向外科器械的使用者提供诸如振动或警报的通知，使得用户能够操纵外科器械来限制或阻止与解剖结构的接触。