公开(公告)号：WO2008063912A1

公开(公告)日：2008-05-29

申请号：PCT/US2007/084154

申请日：2007-11-08

Applicant: NOVARTIS AG ,  XIA, Yi ,  MENDENHALL, Kris G. ,  BARSANTI, Paul A. ,  WALTER, Annette O. ,  DUHL, David ,  RENHOWE, Paul A.

Inventor： XIA, Yi ,  MENDENHALL, Kris G. ,  BARSANTI, Paul A. ,  WALTER, Annette O. ,  DUHL, David ,  RENHOWE, Paul A.

IPC: C07D249/08 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  A61K31/55 ,  A61P35/00

CPC classification number: C07D401/12 ,  C07D249/08 ,  C07D403/12 ,  C07D413/12

Abstract: Disclosed are new substituted pyrazole and triazole compounds of Formula (I) and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the derivatives together with pharmaceutically acceptable carriers, and uses thereof:

Abstract translation: 公开了式（I）的新的取代的吡唑和三唑化合物及其药学上可接受的盐，酯或前药，衍生物的组合物和药学上可接受的载体，及其用途：

公开(公告)号：WO2006113498A3

公开(公告)日：2007-01-11

申请号：PCT/US2006014194

申请日：2006-04-14

Applicant: CHIRON CORP ,  MACHAJEWSKI TIMOTHY D ,  GAO ZHENHAI ,  LEVINE BARRY H ,  ANTONIOS-MCCREA WILLIAM ,  BELLAMACINA CORNELIA R ,  COSTALES ABRAN ,  DOUGHAN BRANDON M ,  FONG SUSAN ,  HENDRICKSON THOMAS ,  LIN XIAODONG ,  MCBRIDE CHRISTOPHER ,  MCKENNA MAUREEN ,  RICO ALICE C ,  SHAFER CYNTHIA M ,  WANG X MICHAEL ,  ZHOU YASHEEN ,  XIA YI ,  MENDENHALL KRIS G

Inventor： MACHAJEWSKI TIMOTHY D ,  GAO ZHENHAI ,  LEVINE BARRY H ,  ANTONIOS-MCCREA WILLIAM ,  BELLAMACINA CORNELIA R ,  COSTALES ABRAN ,  DOUGHAN BRANDON M ,  FONG SUSAN ,  HENDRICKSON THOMAS ,  LIN XIAODONG ,  MCBRIDE CHRISTOPHER ,  MCKENNA MAUREEN ,  RICO ALICE C ,  SHAFER CYNTHIA M ,  WANG X MICHAEL ,  ZHOU YASHEEN ,  XIA YI ,  MENDENHALL KRIS G

IPC: C07D239/84 ,  A61K31/517 ,  A61P35/00 ,  C07D401/04 ,  C07D401/10 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D413/10 ,  C07D417/10 ,  C07D417/12

CPC classification number: C07D401/14 ,  C07D239/84 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14

Abstract: 2-Amino-quinazolin-5-one compounds, stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-quinazolin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the 2-amino-quinazolin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cell proliferative diseases.

Abstract translation: 2-氨基 - 喹唑啉-5-酮化合物，立体异构体，互变异构体，其药学上可接受的盐和前药; 包括药学上可接受的载体和一种或多种2-氨基 - 喹唑啉-5-酮化合物的组合物，单独或与至少一种另外的治疗剂组合。 单独使用2-氨基 - 喹唑啉-5-酮化合物或与至少一种其它治疗剂组合使用的方法用于预防或治疗细胞增殖性疾病。

公开(公告)号：WO2007021794A1

公开(公告)日：2007-02-22

申请号：PCT/US2006/031129

申请日：2006-08-09

Applicant: NOVARTIS AG ,  BARSANTI, Paul A. ,  XIA, Yi ,  WANG, Weibo ,  MENDENHALL, Kris G. ,  LAGNITON, Liana M. ,  RAMURTHY, Savithri ,  PHILLIPS, Megan C. ,  SUBRAMANIAN, Sharadha ,  BOYCE, Rustum ,  BRAMMEIER, Nathan M. ,  CONSTANTINE, Ryan ,  DUHL, David ,  WALTER, Annette O. ,  ABRAMS, Tinya J. ,  RENHOWE, Paul A.

Inventor： BARSANTI, Paul A. ,  XIA, Yi ,  WANG, Weibo ,  MENDENHALL, Kris G. ,  LAGNITON, Liana M. ,  RAMURTHY, Savithri ,  PHILLIPS, Megan C. ,  SUBRAMANIAN, Sharadha ,  BOYCE, Rustum ,  BRAMMEIER, Nathan M. ,  CONSTANTINE, Ryan ,  DUHL, David ,  WALTER, Annette O. ,  ABRAMS, Tinya J. ,  RENHOWE, Paul A.

IPC: C07D401/14 ,  C07D233/54 ,  C07D403/12 ,  C07D403/06 ,  C07D409/12 ,  C07D413/12 ,  C07D407/12 ,  A61K31/4178 ,  A61K31/4545 ,  A61P35/00

CPC classification number: C07D401/14 ,  C07D233/64 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

Abstract: The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the derivatives together with pharmaceutically acceptable carriers, and uses of the compounds. The compounds of the invention have the following general formula (I).

Abstract translation: 本发明涉及新的取代的咪唑化合物及其药学上可接受的盐，酯或前药，衍生物的组合物和药学上可接受的载体，以及该化合物的用途。 本发明的化合物具有以下通式（I）。

公开(公告)号：WO2006113498A2

公开(公告)日：2006-10-26

申请号：PCT/US2006/014194

申请日：2006-04-14

Applicant: CHIRON CORPORATION ,  MACHAJEWSKI, Timothy, D. ,  GAO, Zhenhai ,  LEVINE, Barry, H. ,  ANTONIOS-MCCREA, William ,  BELLAMACINA, Cornelia, R. ,  COSTALES, Abran ,  DOUGHAN, Brandon, M. ,  FONG, Susan ,  HENDRICKSON, Thomas ,  LIN, Xiaodong ,  MCBRIDE, Christopher ,  MCKENNA, Maureen ,  RICO, Alice, C. ,  SHAFER, Cynthia, M. ,  WANG, X., Michael ,  ZHOU, Yasheen ,  XIA, Yi ,  MENDENHALL, Kris, G.

Inventor： MACHAJEWSKI, Timothy, D. ,  GAO, Zhenhai ,  LEVINE, Barry, H. ,  ANTONIOS-MCCREA, William ,  BELLAMACINA, Cornelia, R. ,  COSTALES, Abran ,  DOUGHAN, Brandon, M. ,  FONG, Susan ,  HENDRICKSON, Thomas ,  LIN, Xiaodong ,  MCBRIDE, Christopher ,  MCKENNA, Maureen ,  RICO, Alice, C. ,  SHAFER, Cynthia, M. ,  WANG, X., Michael ,  ZHOU, Yasheen ,  XIA, Yi ,  MENDENHALL, Kris, G.

CPC classification number: C07D401/14 ,  C07D239/84 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14

Abstract: 2-Amino-quinazolin-5-one compounds, stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-quinazolin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the 2-amino-quinazolin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cell proliferative diseases.

Abstract translation: 2-氨基 - 喹唑啉-5-酮化合物，立体异构体，互变异构体，药用盐和前药; 包括药学上可接受的载体和一种或多种2-氨基 - 喹唑啉-5-酮化合物的组合物，单独或与至少一种另外的治疗剂组合。 将2-氨基 - 喹唑啉-5-酮化合物单独使用或与至少一种另外的治疗剂组合使用的方法用于预防或治疗细胞增殖性疾病。