公开(公告)号：WO2014121169A1

公开(公告)日：2014-08-07

申请号：PCT/US2014/014357

申请日：2014-02-02

Applicant: MEDTRONIC, INC. ,  PUDIL, Bryant, J. ,  MEYER, Thomas, E. ,  LURA, David, B. ,  GERBER, Martin, T.

Inventor： PUDIL, Bryant, J. ,  MEYER, Thomas, E. ,  LURA, David, B. ,  GERBER, Martin, T.

IPC: G01N7/00 ,  G01N27/02 ,  G01N25/18

CPC classification number: A61M1/1656 ,  A61M1/1605 ,  A61M1/1658 ,  A61M1/1668 ,  A61M1/1696 ,  A61M1/287 ,  A61M2205/3317 ,  A61M2205/7518 ,  G01N33/84

Abstract: A pH-buffer measurement system that has at least one source for modifying the pH of a fluid entering the system, the source selected from an acid source and a base source. The acid source adds an acid equivalent to provide an acid reacted fluid and the base source adds a base equivalent to provide a base reacted fluid. The source is in fluid communication with a flow path and a component for determining a fluid characteristic of the acid reacted fluid or the base reacted fluid. The fluid characteristic that is measured is any one of a gas phase pressure, an electrical conductivity, or thermal conductivity.

Abstract translation: pH缓冲测量系统，其具有至少一个来源，用于改变进入系统的流体的pH，源选自酸源和碱源。 酸源添加酸当量以提供酸反应的流体，并且碱源添加碱当量以提供碱反应的流体。 源与流路和用于确定酸反应流体或基底反应流体的流体特性的部件流体连通。 测量的流体特性是气相压力，导电性或热导率中的任一种。

公开(公告)号：WO2014121168A1

公开(公告)日：2014-08-07

申请号：PCT/US2014/014356

申请日：2014-02-02

Applicant: MEDTRONIC, INC. ,  PUDIL, Bryant, J. ,  GERBER, Martin, T. ,  LURA, David, B. ,  MEYER, Thomas, E.

Inventor： PUDIL, Bryant, J. ,  GERBER, Martin, T. ,  LURA, David, B. ,  MEYER, Thomas, E.

IPC: A61M1/14

CPC classification number: A61M1/287 ,  A61M1/1656 ,  A61M1/1666 ,  A61M1/1668 ,  A61M1/1696 ,  A61M1/3406 ,  A61M1/3472

Abstract: Systems and methods for managing the sodium concentration of a dialysate fluid during hemodialysis therapy and adjusting sodium concentration using a sodium management system to generate a sodium-modified fluid. The systems and methods also provide a mechanism for controlled addition of sodium ions to the dialysate to generate a predetermined total sodium concentration in a dialysate.

Abstract translation: 用于在血液透析治疗期间管理透析液的钠浓度并使用钠管理系统调节钠浓度以产生钠改性流体的系统和方法。 所述系统和方法还提供了将钠离子控制加入到透析液中以在透析液中产生预定的总钠浓度的机制。

公开(公告)号：WO2014121163A1

公开(公告)日：2014-08-07

申请号：PCT/US2014/014349

申请日：2014-02-01

Applicant: MECTRONIC, INC. ,  MEYER, Thomas E. ,  LURA, David B. ,  PUDIL, Bryant J. ,  GERBER, Martin T.

Inventor： MEYER, Thomas E. ,  LURA, David B. ,  PUDIL, Bryant J. ,  GERBER, Martin T.

IPC: A61M1/14

CPC classification number: A61M1/3621 ,  A61M1/16 ,  A61M1/1605 ,  A61M1/165 ,  A61M1/1658 ,  A61M1/1666 ,  A61M1/3609 ,  A61M1/3627 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3334 ,  A61M2205/3368 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2230/65

Abstract: Systems and methods for using a sodium chloride source and a buffer source such as sodium bicarbonate in a controlled compliant flow path to generate from water a physiologically compatible fluid having a suitable level of a sodium ion and/or a buffer for use in hemodialysis, hemodiafiltration and hemofiltration. The system has a conditioning flow path that has at least a salination valve or salination pump, and at least one container has at least one solute in excess of the solubility of that solute. At least one of the solutes is a buffer source or sodium chloride. The conditioning flow path is in fluid communication with a controlled compliant flow path. The conditioning flow path can selectively meter fluid into and out of the controlled compliant flow path.

Abstract translation: 在受控的顺应性流动路径中使用氯化钠源和缓冲源（例如碳酸氢钠）的系统和方法，以从水中产生具有适合水平的钠离子和/或缓冲液的生理学相容的液体，用于血液透析，血液透析 和血液滤过。 该系统具有至少具有盐化阀或盐化泵的调节流动路径，并且至少一个容器具有超过该溶质的溶解度的至少一个溶质。 至少一种溶质是缓冲液或氯化钠。 调节流动路径与受控制的顺应流动路径流体连通。 调节流动路径可以选择性地将流体进入和流出被控制的顺应流动路径。

公开(公告)号：WO2014121162A1

公开(公告)日：2014-08-07

申请号：PCT/US2014/014348

申请日：2014-02-01

Applicant: MEDTRONIC, INC. ,  MEYER, Thomas, E ,  LURA, David, B ,  PUDIL, Bryant, J. ,  GERBER, Martin, T.

Inventor： MEYER, Thomas, E ,  LURA, David, B ,  PUDIL, Bryant, J. ,  GERBER, Martin, T.

IPC: A61M1/14

CPC classification number: A61M1/1617 ,  A61M1/1605 ,  A61M1/1609 ,  A61M1/1619 ,  A61M1/165 ,  A61M1/1696 ,  A61M1/28 ,  A61M2205/3317 ,  A61M2205/3334 ,  A61M2230/20

Abstract: A sorbent based monitoring system for measuring the solute concentration of at least one component of a fluid. The system has a sorbent regeneration system for regeneration of the fluid and has a sorbent cartridge that has at least one material layer. The fluid is conveyed through the sorbent cartridge and contacts at least one sensor after having contacted at least one material layer.

Abstract translation: 一种用于测量流体至少一种组分的溶质浓度的基于吸附剂的监测系统。 该系统具有用于再生流体的吸附剂再生系统，并具有至少一个材料层的吸附剂盒。 流体通过吸附剂药筒输送，并且在接触至少一个材料层之后接触至少一个传感器。

公开(公告)号：WO2014121161A1

公开(公告)日：2014-08-07

申请号：PCT/US2014/014347

申请日：2014-02-01

Applicant: MEDTRONIC, INC. ,  PUDIL, Bryant, J. ,  MEYER, Thomas, E. ,  LURA, David, B. ,  GERBER, Martin, T

Inventor： PUDIL, Bryant, J. ,  MEYER, Thomas, E. ,  LURA, David, B. ,  GERBER, Martin, T

IPC: A61M1/14

CPC classification number: A61M1/1605 ,  A61B5/14503 ,  A61B5/14546 ,  A61B5/6866 ,  A61M1/1619 ,  A61M1/1696 ,  A61M1/28 ,  A61M2205/3317 ,  A61M2205/3334

Abstract: A blood based solute monitoring system for measuring at least one blood solute species that has a first recirculation flow path in fluid communication with a dialyzer. The first recirculation flow path is configured to allow a fluid to recirculate through a dialyzer such that the concentration of at least one solute species in the fluid becomes equilibrated to the solute species concentration of the blood in a blood compartment of the dialyzer. The blood solute monitoring system has at least one sensor to measure a fluid characteristic.

Abstract translation: 一种用于测量至少一种具有与透析器流体连通的第一再循环流动路径的血液溶质物质的基于血液的溶质监测系统。 第一再循环流动路径被配置为允许流体通过透析器再循环，使得流体中至少一种溶质物质的浓度变得平衡到透析器血液隔室中的血液的溶质物质浓度。 血液溶质监测系统至少有一个传感器来测量流体特性。

公开(公告)号：WO2014121160A1

公开(公告)日：2014-08-07

申请号：PCT/US2014/014346

申请日：2014-02-01

Applicant: MEDTRONIC, INC. ,  LURA, David, B. ,  MEYER, Thomas, E. ,  PUDIL, Bryant, J. ,  GERBER, Martin, T. ,  COLLIER, Kenneth, J.

Inventor： LURA, David, B. ,  MEYER, Thomas, E. ,  PUDIL, Bryant, J. ,  GERBER, Martin, T. ,  COLLIER, Kenneth, J.

IPC: A61M1/14

CPC classification number: A61M1/1605 ,  A61M1/1619 ,  A61M1/1696 ,  A61M1/28 ,  A61M2205/3317 ,  A61M2205/3334 ,  A61M2230/20

Abstract: A sorbent cartridge that has at least one sensor located within the sorbent cartridge.

Abstract translation: 吸附剂盒，其至少有一个位于吸附剂盒内的传感器。

公开(公告)号：WO2014121163A8

公开(公告)日：2015-10-15

申请号：PCT/US2014014349

申请日：2014-02-01

Applicant: MEDTRONIC INC ,  MEYER THOMAS E ,  LURA DAVID B ,  PUDIL BRYANT J ,  GERBER MARTIN T

Inventor： MEYER THOMAS E ,  LURA DAVID B ,  PUDIL BRYANT J ,  GERBER MARTIN T

IPC: A61M1/14

CPC classification number: A61M1/3621 ,  A61M1/16 ,  A61M1/1605 ,  A61M1/165 ,  A61M1/1658 ,  A61M1/1666 ,  A61M1/3609 ,  A61M1/3627 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3334 ,  A61M2205/3368 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2230/65

Abstract: Systems and methods for using a sodium chloride source and a buffer source such as sodium bicarbonate in a controlled compliant flow path to generate from water a physiologically compatible fluid having a suitable level of a sodium ion and/or a buffer for use in hemodialysis, hemodiafiltration and hemofiltration. The system has a conditioning flow path that has at least a salination valve or salination pump, and at least one container has at least one solute in excess of the solubility of that solute. At least one of the solutes is a buffer source or sodium chloride. The conditioning flow path is in fluid communication with a controlled compliant flow path. The conditioning flow path can selectively meter fluid into and out of the controlled compliant flow path.

Abstract translation: 在受控的顺应性流动路径中使用氯化钠源和缓冲源（例如碳酸氢钠）的系统和方法，以从水中产生具有适合水平的钠离子和/或缓冲液的生理学相容的液体，用于血液透析，血液透析 和血液滤过。 该系统具有至少具有盐化阀或盐化泵的调节流动路径，并且至少一个容器具有超过该溶质的溶解度的至少一个溶质。 至少一种溶质是缓冲源或氯化钠。 调节流动路径与受控制的顺应流动路径流体连通。 调节流动路径可以选择性地将流体进入和流出被控制的顺应流动路径。

公开(公告)号：WO2015126879A1

公开(公告)日：2015-08-27

申请号：PCT/US2015/016273

申请日：2015-02-18

Applicant: MEDTRONIC, INC. ,  PUDIL, Bryant, J. ,  GERBER, Martin, T. ,  LURA, David, B. ,  MEYER, Thomas, E.

Inventor： PUDIL, Bryant, J. ,  GERBER, Martin, T. ,  LURA, David, B. ,  MEYER, Thomas, E.

IPC: A61M1/16 ,  A61M1/14

CPC classification number: A61M1/1696 ,  A61M2205/3306 ,  A61M2205/3334 ,  B01J20/0211 ,  B01J20/0292 ,  B01J20/06 ,  B01J20/08 ,  B01J20/20 ,  B01J20/28052 ,  B01J39/08 ,  B01J2220/603 ,  B01J2220/62

Abstract: This disclosure generally relates to at least one reusable module of a sorbent cartridge in a sorbent dialysis system. One of the drawbacks of a conventional sorbent dialysis system is the high cost. In one aspect of the invention, the sorbent cartridge contains at least one module for optionally recharging sorbent materials in-line, including zirconium phosphate, with an optional bypass and conduits for the sorbent cartridge. The sorbent cartridge can have two or more modules that are connected to one another through connectors. The modules can be reusable and the sorbent materials contained in the modules can be recharged, which reduce the cost of the sorbent dialysis system.

Abstract translation: 本公开内容通常涉及吸附剂透析系统中吸附剂盒的至少一个可重复使用的模块。 常规吸附剂透析系统的缺点之一是成本高。 在本发明的一个方面，吸附剂盒包含至少一个模块，用于任选地对吸附剂材料进行在线包括磷酸锆的充填，以及可选的旁路以及用于吸附剂盒的导管。 吸附剂盒可以具有通过连接器彼此连接的两个或更多个模块。 模块可以是可重复使用的，并且包含在模块中的吸附剂材料可以被再充电，这降低了吸附剂透析系统的成本。

公开(公告)号：WO2015126877A1

公开(公告)日：2015-08-27

申请号：PCT/US2015/016270

申请日：2015-02-18

Applicant: MEDTRONIC, INC. ,  PUDIL, Bryant, J. ,  GERBER, Martin, T. ,  LURA, David, B. ,  MEYER, Thomas, E.

Inventor： PUDIL, Bryant, J. ,  GERBER, Martin, T. ,  LURA, David, B. ,  MEYER, Thomas, E.

IPC: A61M1/16 ,  A61M1/14

CPC classification number: A61M1/1696 ,  A61M2205/3306 ,  A61M2205/3334 ,  B01J20/0211 ,  B01J20/0292 ,  B01J20/08 ,  B01J20/20 ,  B01J20/28052 ,  B01J47/024 ,  B01J2220/606 ,  B01J2220/62

Abstract: This disclosure generally relates to at least one reusable module of a sorbent cartridge in a sorbent dialysis system. Given the cost of sorbent cartridges and sorbent materials, it would be advantageous if parts of the cartridge could be reused or recharged. In one aspect of the invention, the sorbent cartridge has parallel modules for in-line recharging of sorbent materials using alternate duty cycles. The sorbent cartridge can have two or more modules positioned parallel to one another, and the modules are fluidly connected to one another through connectors. The modules can be reusable and the sorbent materials contained in the modules can be recharged.

Abstract translation: 本公开内容通常涉及吸附剂透析系统中吸附剂盒的至少一个可重复使用的模块。 鉴于吸附剂盒和吸附剂材料的成本，如果盒的部分可以被重新使用或再充电将是有利的。 在本发明的一个方面，吸附剂盒具有并联模块，用于使用替代的占空比对吸附剂材料进行在线再充电。 吸附剂盒可以具有彼此平行定位的两个或多个模块，并且模块通过连接器彼此流体连接。 模块可以重复使用，并且包含在模块中的吸附剂材料可以被充电。

公开(公告)号：WO2014121238A1

公开(公告)日：2014-08-07

申请号：PCT/US2014/014513

申请日：2014-02-03

Applicant: MEDTRONIC, INC. ,  PUDIL, Bryant, J. ,  MEYER, Thomas, E. ,  LURA, David, B. ,  GERBER, Martin, T.

Inventor： PUDIL, Bryant, J. ,  MEYER, Thomas, E. ,  LURA, David, B. ,  GERBER, Martin, T.

IPC: A61M1/14 ,  A61M1/16

CPC classification number: A61M1/1656 ,  A61M1/1654 ,  A61M1/1668 ,  A61M1/167 ,  A61M1/1696 ,  A61M1/287 ,  A61M1/3486 ,  A61M2205/02 ,  B01D15/08

Abstract: A regeneration system that has a first regeneration module containing a first chosen regenerative substance; a second regeneration module containing the first chosen regenerative substance; and a first mixing chamber. A first outlet stream of a fluid sequentially exits the first mixing chamber, flows through the first regeneration module in fluid communication with the first chosen regenerative substance and returns to the first mixing chamber, and a second outlet stream of the fluid sequentially exits the first mixing chamber and flows through the second regeneration module in fluid communication with the first chosen regenerative substance.

Abstract translation: 一种再生系统，其具有包含第一选择再生物质的第一再生模块; 包含第一选择再生物质的第二再生模块; 和第一混合室。 流体的第一出口流顺序地离开第一混合室，流过第一再生模块与第一选择的再生物质流体连通并返回到第一混合室，并且流体的第二出口流依次离开第一混合 并且与第一选择的再生物质流体连通地流过第二再生模块。