公开(公告)号：WO2017019642A3

公开(公告)日：2017-03-09

申请号：PCT/US2016043950

申请日：2016-07-25

Applicant: MEDTRONIC INC ,  LURA DAVID B ,  HOBOT CHRISTOPHER M ,  GERBER MARTIN T ,  MEYER THOMAS E

Inventor： LURA DAVID B ,  HOBOT CHRISTOPHER M ,  GERBER MARTIN T ,  MEYER THOMAS E

IPC: A61M1/16

CPC classification number: A61M1/169 ,  A61M1/1656 ,  A61M1/1666 ,  A61M1/1668 ,  A61M1/267 ,  A61M39/12 ,  A61M39/223 ,  A61M2205/3337 ,  A61M2205/6018 ,  A61M2209/08 ,  A61M2209/082

Abstract: The invention relates to fluid flow paths and fluid connectors for use with detachable containers that can be seated in an infusate caddy for use in a dialysis machine. The detachable containers can contain infusates or other solutes or materials such as disinfectants or cleaners, and can be conveniently seated in the infusate caddy. The detachable containers can be removed from the infusate caddy for restocking, cleaning, or resupply, as needed. The infusate caddy can be positioned or seated in a receiving compartment of a dialysis machine, and can also be removed, as needed. The fluid path and fluid connectors of the present invention provide the required fluid fittings, valve arrangements, pumps, and paddle assemblies for using the infusate caddy.

Abstract translation: 本发明涉及用于可拆卸容器的流体流动路径和流体连接器，所述可拆卸容器可安放在输注容器中用于透析机中。 可拆卸的容器可以包含输注液或其他溶质或材料，例如消毒剂或清洁剂，并且可以方便地坐在输注容器中。 根据需要，可以将可分离的容器从输注容器中取出以进行补充，清洁或再补给。 输注容器可以被放置或安置在透析机的接收室中，并且也可以根据需要被移除。 本发明的流体路径和流体连接器提供了用于使用注入液盒的所需的流体配件，阀装置，泵和桨叶组件。

公开(公告)号：WO2015080895A1

公开(公告)日：2015-06-04

申请号：PCT/US2014/065950

申请日：2014-11-17

Applicant: MEDTRONIC, INC. ,  PUDIL, Bryant, J. ,  GERBER, Martin, T. ,  LURA, David, B. ,  MEYER, Thomas, E.

Inventor： PUDIL, Bryant, J. ,  GERBER, Martin, T. ,  LURA, David, B. ,  MEYER, Thomas, E.

IPC: A61M1/32 ,  B01J20/02

CPC classification number: A61M1/14 ,  A61M1/1605 ,  A61M1/1696 ,  A61M2205/3306 ,  A61M2205/3334 ,  A61M2205/50 ,  B01J20/00 ,  B01J20/0211 ,  B01J20/0292 ,  B01J20/06 ,  B01J20/08 ,  B01J20/20 ,  B01J20/28052 ,  B01J20/3433 ,  B01J39/08 ,  B01J39/12 ,  B01J2220/42 ,  B01J2220/46 ,  B01J2220/62

Abstract: A detachable module for optionally recharging sorbent materials, including zirconium phosphate, with an optional bypass and conduits for a sorbent cartridge. The sorbent cartridge can have one or more modules contained therein having connectors connecting each of the modules. One or more of the modules can be reusable and the sorbent materials therein recharged.

Abstract translation: 可拆卸模块，用于可选地对包括磷酸锆在内的吸附剂材料进行再充电，其中可选旁路和用于吸附剂盒的导管。 吸附剂盒可以具有包含连接每个模块的连接器的一个或多个模块。 一个或多个模块可以是可重复使用的，并且其中的吸附剂材料被再充电。

公开(公告)号：WO2014121158A1

公开(公告)日：2014-08-07

申请号：PCT/US2014/014344

申请日：2014-02-01

Applicant: MEDTRONIC, INC. ,  MEYER, Thomas, E. ,  LURA, David, B. ,  PUDIL, Bryant, J. ,  GERBER, Martin, T.

Inventor： MEYER, Thomas, E. ,  LURA, David, B. ,  PUDIL, Bryant, J. ,  GERBER, Martin, T.

IPC: A61M1/14 ,  A61M1/16

CPC classification number: A61M1/3627 ,  A61M1/16 ,  A61M1/1605 ,  A61M1/165 ,  A61M1/1658 ,  A61M1/1666 ,  A61M1/3609 ,  A61M1/3626 ,  A61M5/36 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3368 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2205/7536 ,  A61M2209/00 ,  B01D19/0031

Abstract: A degassing module for removal of air and other gases during operation of a medical therapy device that delivers any one of hemodialysis, hemodiafiltration and hemofiltration. The degassing module has a flow-through first chamber that has a hydrophobic vent membrane that has an exterior and interior side forming a portion of the flow-through chamber. The hydrophobic vent membrane is positioned at a higher elevation on the flow- through chamber than a fluid outlet. Fluid flows through the flow-through chamber in a downward direction relative to the hydrophobic vent membrane. A flow-through chamber has a cross sectional area configured to provide for a downward flow velocity of the fluid to be less than the upward rise velocity of a smallest bubble to be removed from the fluid.

Abstract translation: 用于在输送任何一种血液透析，血液透析滤过和血液滤过的医疗治疗装置的操作期间去除空气和其它气体的脱气模块。 脱气模块具有流过第一室，其具有疏水排气膜，其具有形成流通室的一部分的外部和内侧。 疏水排气膜在流通室上的位置比流体出口更高。 流体相对于疏水通气膜沿向下的方向流过流通室。 流通室具有被配置为提供流体的向下流动速度的横截面积小于要从流体移除的最小气泡的向上升速。

公开(公告)号：WO2017019642A2

公开(公告)日：2017-02-02

申请号：PCT/US2016/043950

申请日：2016-07-25

Applicant: MEDTRONIC, INC. ,  LURA, David, B. ,  HOBOT, Christopher, M. ,  GERBER, Martin, T. ,  MEYER, Thomas, E.

Inventor： LURA, David, B. ,  HOBOT, Christopher, M. ,  GERBER, Martin, T. ,  MEYER, Thomas, E.

IPC: A61M1/16

CPC classification number: A61M1/169 ,  A61M1/1656 ,  A61M1/1666 ,  A61M1/1668 ,  A61M1/267 ,  A61M39/12 ,  A61M39/223 ,  A61M2205/3337 ,  A61M2205/6018 ,  A61M2209/08 ,  A61M2209/082

Abstract: The invention relates to fluid flow paths and fluid connectors for use with detachable containers that can be seated in an infusate caddy for use in a dialysis machine. The detachable containers can contain infusates or other solutes or materials such as disinfectants or cleaners, and can be conveniently seated in the infusate caddy. The detachable containers can be removed from the infusate caddy for restocking, cleaning, or resupply, as needed. The infusate caddy can be positioned or seated in a receiving compartment of a dialysis machine, and can also be removed, as needed. The fluid path and fluid connectors of the present invention provide the required fluid fittings, valve arrangements, pumps, and paddle assemblies for using the infusate caddy.

Abstract translation: 本发明涉及用于与可拆卸容器一起使用的流体流动路径和流体连接器，该可分离容器可以坐落在用于透析机中的输液管道中。 可拆卸的容器可以容纳输入物或其他溶质或材料，例如消毒剂或清洁剂，并且可以方便地安置在输液罐中。 根据需要，可拆卸的容器可从输液罐中取出，用于补充，清洗或补给。 输液罐可以定位或坐在透析机的接收室中，并且还可以根据需要移除。 本发明的流体路径和流体连接器提供了所需的流体配件，阀门装置，泵和用于使用输送槽的桨组件。

公开(公告)号：WO2014121167A1

公开(公告)日：2014-08-07

申请号：PCT/US2014/014355

申请日：2014-02-02

Applicant: MEDTRONIC, INC. ,  PUDIL, Bryant, J. ,  GERBER, Martin, T. ,  LURA, David, B ,  MEYER, Thomas, E.

Inventor： PUDIL, Bryant, J. ,  GERBER, Martin, T. ,  LURA, David, B ,  MEYER, Thomas, E.

IPC: A61M1/14

CPC classification number: A61M1/1696 ,  A61M1/16 ,  A61M1/1605 ,  A61M1/165 ,  A61M1/287 ,  A61M1/34 ,  A61M1/3406 ,  A61M1/3413 ,  A61M1/3437 ,  A61M2205/33 ,  A61M2205/3324 ,  A61M2205/50

Abstract: Systems and methods for managing the pH of a dialysate fluid during hemodialysis therapy. The systems and methods adjust dialysate pH and buffer concentration to generate a predetermined total bicarbonate buffer concentration in a dialysate entering a dialyzer.

Abstract translation: 用于在血液透析治疗期间管理透析液的pH的系统和方法。 系统和方法调节透析液pH和缓冲液浓度，以在进入透析器的透析液中产生预定的总碳酸氢盐缓冲液浓度。

公开(公告)号：WO2014121166A1

公开(公告)日：2014-08-07

申请号：PCT/US2014/014352

申请日：2014-02-01

Applicant: MEDTRONIC, INC. ,  MEYER, Thomas, E. ,  LURA, David, B. ,  PUDIL, Bryant, J. ,  GERBER, Martin, T. ,  DANIELS, Mark, F.

Inventor： MEYER, Thomas, E. ,  LURA, David, B. ,  PUDIL, Bryant, J. ,  GERBER, Martin, T. ,  DANIELS, Mark, F.

IPC: A61M1/14 ,  A61M5/168

CPC classification number: A61M1/16 ,  A61M1/1605 ,  A61M1/165 ,  A61M1/169 ,  A61M1/1696 ,  A61M1/3413 ,  A61M1/3437 ,  A61M1/3609 ,  A61M1/3626 ,  A61M1/3627 ,  A61M1/3643 ,  A61M1/3644 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3368 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2209/06

Abstract: Systems and methods for cleaning and disinfecting a medical therapy device that delivers any one of hemodialysis, hemodiafiltration, and hemofiltration. The system has a base module that has at least one segment of a controlled compliant flow path and at least one pair of jumpered ports configured on the base module. One or more components have connections connectable to the jumpered ports of the base module to provide for fluid communication between the segment of the controlled compliant flow path in the base module and a flow path defined by the one or more components. The base module is connected to the one or more components that define a flow path configurable for carrying out in part at least one function performed during any one of hemodialysis, hemodiafiltration or hemofiltration.

Abstract translation: 用于清洁和消毒输送血液透析，血液透析滤过和血液滤过中的任何一种的医疗治疗装置的系统和方法。 该系统具有基本模块，该基本模块具有被控制的兼容流动路径的至少一个段和配置在基本模块上的至少一对跳接端口。 一个或多个组件具有可连接到基本模块的跨接端口的连接，以提供在基本模块中受控制的兼容流动路径的段与由一个或多个组件限定的流动路径之间的流体连通。 基座模块连接到一个或多个部件，其限定可以部分地执行血液透析，血液透析过滤或血液滤过中的任何一个期间执行的至少一个功能的流路。

公开(公告)号：WO2014121164A1

公开(公告)日：2014-08-07

申请号：PCT/US2014/014350

申请日：2014-02-01

Applicant: MEDTRONIC, INC. ,  MEYER, Thomas, E. ,  LURA, David, B. ,  PUDIL, Bryant, J. ,  GERBER, Martin, T.

Inventor： MEYER, Thomas, E. ,  LURA, David, B. ,  PUDIL, Bryant, J. ,  GERBER, Martin, T.

IPC: A61M1/14 ,  A61M1/16

CPC classification number: A61M1/1621 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1605 ,  A61M1/165 ,  A61M1/1652 ,  A61M1/1656 ,  A61M1/1658 ,  A61M1/1664 ,  A61M1/1666 ,  A61M1/1668 ,  A61M1/1672 ,  A61M1/1676 ,  A61M1/169 ,  A61M1/1696 ,  A61M1/3413 ,  A61M1/3437 ,  A61M1/3609 ,  A61M1/3626 ,  A61M1/3627 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3649 ,  A61M1/365 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3368 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2209/06 ,  A61M2230/65

Abstract: Systems and methods for controlling fluid movement and volumes of fluid between a subject and a controlled compliant flow path. The controlled compliant flow path has a means for selectively metering in and metering out fluid from the controlled compliant flow path. An extracorporeal flow path is in fluid communication with the controlled compliant flow path across a semi-permeable membrane where the extracorporeal flow path has a first terminal end and a second terminal end.

Abstract translation: 用于控制受试者和受控顺应流动路径之间的流体运动和流体体积的系统和方法。 受控制的柔性流动路径具有用于选择性地计量来自受控制的顺应流动路径的流体的计量装置。 体外流路与跨过半透膜的受控顺应性流动路径流体连通，其中体外流路具有第一末端和第二末端。

公开(公告)号：WO2014121169A1

公开(公告)日：2014-08-07

申请号：PCT/US2014/014357

申请日：2014-02-02

Applicant: MEDTRONIC, INC. ,  PUDIL, Bryant, J. ,  MEYER, Thomas, E. ,  LURA, David, B. ,  GERBER, Martin, T.

Inventor： PUDIL, Bryant, J. ,  MEYER, Thomas, E. ,  LURA, David, B. ,  GERBER, Martin, T.

IPC: G01N7/00 ,  G01N27/02 ,  G01N25/18

CPC classification number: A61M1/1656 ,  A61M1/1605 ,  A61M1/1658 ,  A61M1/1668 ,  A61M1/1696 ,  A61M1/287 ,  A61M2205/3317 ,  A61M2205/7518 ,  G01N33/84

Abstract: A pH-buffer measurement system that has at least one source for modifying the pH of a fluid entering the system, the source selected from an acid source and a base source. The acid source adds an acid equivalent to provide an acid reacted fluid and the base source adds a base equivalent to provide a base reacted fluid. The source is in fluid communication with a flow path and a component for determining a fluid characteristic of the acid reacted fluid or the base reacted fluid. The fluid characteristic that is measured is any one of a gas phase pressure, an electrical conductivity, or thermal conductivity.

Abstract translation: pH缓冲测量系统，其具有至少一个来源，用于改变进入系统的流体的pH，源选自酸源和碱源。 酸源添加酸当量以提供酸反应的流体，并且碱源添加碱当量以提供碱反应的流体。 源与流路和用于确定酸反应流体或基底反应流体的流体特性的部件流体连通。 测量的流体特性是气相压力，导电性或热导率中的任一种。

公开(公告)号：WO2014121168A1

公开(公告)日：2014-08-07

申请号：PCT/US2014/014356

申请日：2014-02-02

Applicant: MEDTRONIC, INC. ,  PUDIL, Bryant, J. ,  GERBER, Martin, T. ,  LURA, David, B. ,  MEYER, Thomas, E.

Inventor： PUDIL, Bryant, J. ,  GERBER, Martin, T. ,  LURA, David, B. ,  MEYER, Thomas, E.

IPC: A61M1/14

CPC classification number: A61M1/287 ,  A61M1/1656 ,  A61M1/1666 ,  A61M1/1668 ,  A61M1/1696 ,  A61M1/3406 ,  A61M1/3472

Abstract: Systems and methods for managing the sodium concentration of a dialysate fluid during hemodialysis therapy and adjusting sodium concentration using a sodium management system to generate a sodium-modified fluid. The systems and methods also provide a mechanism for controlled addition of sodium ions to the dialysate to generate a predetermined total sodium concentration in a dialysate.

Abstract translation: 用于在血液透析治疗期间管理透析液的钠浓度并使用钠管理系统调节钠浓度以产生钠改性流体的系统和方法。 所述系统和方法还提供了将钠离子控制加入到透析液中以在透析液中产生预定的总钠浓度的机制。

公开(公告)号：WO2014121163A1

公开(公告)日：2014-08-07

申请号：PCT/US2014/014349

申请日：2014-02-01

Applicant: MECTRONIC, INC. ,  MEYER, Thomas E. ,  LURA, David B. ,  PUDIL, Bryant J. ,  GERBER, Martin T.

Inventor： MEYER, Thomas E. ,  LURA, David B. ,  PUDIL, Bryant J. ,  GERBER, Martin T.

IPC: A61M1/14

CPC classification number: A61M1/3621 ,  A61M1/16 ,  A61M1/1605 ,  A61M1/165 ,  A61M1/1658 ,  A61M1/1666 ,  A61M1/3609 ,  A61M1/3627 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3334 ,  A61M2205/3368 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2230/65

Abstract: Systems and methods for using a sodium chloride source and a buffer source such as sodium bicarbonate in a controlled compliant flow path to generate from water a physiologically compatible fluid having a suitable level of a sodium ion and/or a buffer for use in hemodialysis, hemodiafiltration and hemofiltration. The system has a conditioning flow path that has at least a salination valve or salination pump, and at least one container has at least one solute in excess of the solubility of that solute. At least one of the solutes is a buffer source or sodium chloride. The conditioning flow path is in fluid communication with a controlled compliant flow path. The conditioning flow path can selectively meter fluid into and out of the controlled compliant flow path.

Abstract translation: 在受控的顺应性流动路径中使用氯化钠源和缓冲源（例如碳酸氢钠）的系统和方法，以从水中产生具有适合水平的钠离子和/或缓冲液的生理学相容的液体，用于血液透析，血液透析 和血液滤过。 该系统具有至少具有盐化阀或盐化泵的调节流动路径，并且至少一个容器具有超过该溶质的溶解度的至少一个溶质。 至少一种溶质是缓冲液或氯化钠。 调节流动路径与受控制的顺应流动路径流体连通。 调节流动路径可以选择性地将流体进入和流出被控制的顺应流动路径。