公开(公告)号：WO2009112488A2

公开(公告)日：2009-09-17

申请号：PCT/EP2009/052786

申请日：2009-03-10

Applicant: MIVENION GMBH ,  LICHA, Kai ,  SCHIRNER, Michael ,  BAHNER, Malte ,  HAAG, Rainer ,  HEEK, Timm ,  WYSZOGRODZKA, Monika

Inventor： LICHA, Kai ,  SCHIRNER, Michael ,  BAHNER, Malte ,  HAAG, Rainer ,  HEEK, Timm ,  WYSZOGRODZKA, Monika

IPC: A61K49/00 ,  A61K51/00

CPC classification number: A61K49/0036 ,  A61K41/0057 ,  A61K41/0071 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0054 ,  A61K49/0056 ,  C08G83/004

Abstract: Subject of the present invention are polyether polyol dendron conjugates comprising a specific polyether polyol dendron moiety, at least one certain fluorescent effector molecule (E). Such polyether polyol dendron conjugates may be used for diagnostic and therapeutic purposes, whereby the optical properties of the at least one certain fluorescent effector molecule are enhanced due to the attachment to the polyether polyol dendron conjugate.

Abstract translation: 本发明的主题是包含特定的聚醚多元醇树枝状部分，至少一种特定的荧光效应分子（E）的聚醚多元醇树枝状缀合物。 这种聚醚多元醇树突缀合物可以用于诊断和治疗目的，由此由于与聚醚多元醇树突缀合物的连接，至少一种某种荧光效应分子的光学性质得到增强。

公开(公告)号：WO2011095311A1

公开(公告)日：2011-08-11

申请号：PCT/EP2011/000425

申请日：2011-01-31

Applicant: MIVENION GMBH ,  LICHA, Kai ,  SCHIRNER, Michael ,  WELKER, Pia ,  HAAG, Rainer ,  WEINHART, Marie ,  PAULUS, Florian

Inventor： LICHA, Kai ,  SCHIRNER, Michael ,  WELKER, Pia ,  HAAG, Rainer ,  WEINHART, Marie ,  PAULUS, Florian

IPC: A61K47/48 ,  A61K49/00 ,  A61K49/12 ,  C08G83/00

CPC classification number: C07D487/22 ,  A61K41/0071 ,  A61K47/59 ,  A61K49/0032 ,  A61K49/0041 ,  A61K49/0054 ,  A61K49/085 ,  A61K49/124 ,  A61K51/065 ,  C07C237/14 ,  C07D403/10 ,  C07D403/14 ,  C07D405/12 ,  C07H21/02 ,  C08G83/003

Abstract: The present invention relates generally to methods and compositions for targeting of intracellular molecules involved in proliferation and protein synthesis of activated cells using polyanionic multivalent macromolecules. In particular aspect, multiple sulfate groups linked to polyol are specifically targeted to the cytoplasm and nucleus of proliferating and activated cells. The invention further comprises novel polyanionic macromolecular compounds and formulations.

Abstract translation: 本发明一般涉及使用聚阴离子多价大分子靶向参与活化细胞的增殖和蛋白质合成的细胞内分子的方法和组合物。 特别地，与多元醇连接的多个硫酸酯基特异性靶向增殖和激活细胞的细胞质和细胞核。 本发明还包括新颖的聚阴离子大分子化合物和制剂。

公开(公告)号：WO2009112488A3

公开(公告)日：2009-12-10

申请号：PCT/EP2009052786

申请日：2009-03-10

Applicant: MIVENION GMBH ,  LICHA KAI ,  SCHIRNER MICHAEL ,  BAHNER MALTE ,  HAAG RAINER ,  HEEK TIMM ,  WYSZOGRODZKA MONIKA

Inventor： LICHA KAI ,  SCHIRNER MICHAEL ,  BAHNER MALTE ,  HAAG RAINER ,  HEEK TIMM ,  WYSZOGRODZKA MONIKA

IPC: A61K49/00 ,  A61K51/00 ,  A61P29/00 ,  A61P35/00

CPC classification number: A61K49/0036 ,  A61K41/0057 ,  A61K41/0071 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0054 ,  A61K49/0056 ,  C08G83/004

Abstract: Subject of the present invention are polyether polyol dendron conjugates comprising a specific polyether polyol dendron moiety, at least one certain fluorescent effector molecule (E). Such polyether polyol dendron conjugates may be used for diagnostic and therapeutic purposes, whereby the optical properties of the at least one certain fluorescent effector molecule are enhanced due to the attachment to the polyether polyol dendron conjugate.

Abstract translation: 本发明的主题是包含特定聚醚多元醇树枝状大分子部分的聚醚多元醇树枝状大分子结合物，至少一种特定的荧光效应分子（E）。 此类聚醚多元醇树枝状分子偶联物可用于诊断和治疗目的，由此至少一种某些荧光效应分子的光学性质由于与聚醚多元醇树枝状分子偶联物的连接而增强。

公开(公告)号：WO2009034177A2

公开(公告)日：2009-03-19

申请号：PCT/EP2008062193

申请日：2008-09-12

Applicant: MIVENION GMBH ,  BAHNER MALTE

Inventor： BAHNER MALTE

IPC: A61K49/00

CPC classification number: A61K49/0034 ,  A61K49/0032 ,  A61K49/0082

Abstract: The present invention relates to the provision of nanoparticular formulations comprising a PEG-alkyl block copolymer and a near infrared fluorescent dye, the preparation of these nanoparticular formulations, pharmaceutical compositions comprising the nanoparticular formulations of the present invention, as well as their use as contrast medium.

Abstract translation: 本发明涉及提供包含PEG-烷基嵌段共聚物和近红外荧光染料的纳米颗粒制剂，这些纳米颗粒制剂的制备，包含本发明的纳米颗粒制剂的药物组合物以及它们作为造影剂的用途 。

公开(公告)号：WO2009112488A4

公开(公告)日：2010-02-18

申请号：PCT/EP2009052786

申请日：2009-03-10

Applicant: MIVENION GMBH ,  LICHA KAI ,  SCHIRNER MICHAEL ,  BAHNER MALTE ,  HAAG RAINER ,  HEEK TIMM ,  WYSZOGRODZKA MONIKA

Inventor： LICHA KAI ,  SCHIRNER MICHAEL ,  BAHNER MALTE ,  HAAG RAINER ,  HEEK TIMM ,  WYSZOGRODZKA MONIKA

IPC: A61K49/00 ,  A61K51/00 ,  A61P29/00 ,  A61P35/00

CPC classification number: A61K49/0036 ,  A61K41/0057 ,  A61K41/0071 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0054 ,  A61K49/0056 ,  C08G83/004

Abstract: Subject of the present invention are polyether polyol dendron conjugates comprising a specific polyether polyol dendron moiety, at least one certain fluorescent effector molecule (E). Such polyether polyol dendron conjugates may be used for diagnostic and therapeutic purposes, whereby the optical properties of the at least one certain fluorescent effector molecule are enhanced due to the attachment to the polyether polyol dendron conjugate.

Abstract translation: 本发明的主题是包含特定聚醚多元醇树枝状部分，至少一种某种荧光效应分子（E）的聚醚多元醇树枝状缀合物。 这种聚醚多元醇树突缀合物可用于诊断和治疗目的，由此由于与聚醚多元醇树枝状结合物的连接，至少一种某些荧光效应分子的光学性质得到增强。

公开(公告)号：WO2009034177A3

公开(公告)日：2009-03-19

申请号：PCT/EP2008/062193

申请日：2008-09-12

Applicant: MIVENION GMBH ,  BAHNER, Malte

Inventor： BAHNER, Malte

IPC: A61K49/00

Abstract: The present invention relates to the provision of nanoparticular formulations comprising a PEG-alkyl block copolymer and a near infrared fluorescent dye, the preparation of these nanoparticular formulations, pharmaceutical compositions comprising the nanoparticular formulations of the present invention, as well as their use as contrast medium.

公开(公告)号：WO2009022003A1

公开(公告)日：2009-02-19

申请号：PCT/EP2008/060726

申请日：2008-08-14

Applicant: MIVENION GMBH ,  BAHNER, Malte

Inventor： BAHNER, Malte

IPC: A61B5/00 ,  A61K49/00

CPC classification number: A61B5/0059 ,  A61B5/4528

Abstract: A first aspect of the invention relates to a device for a diagnosis and/or therapy monitoring of inflammatory diseases, such as rheumatoid arthritis. It comprises at least a rest or support device (1) for holding at least one extremity (11) of a person. Thereby, the support device has the task of facilitating the at least one extremity, preferably two extremities, for instance the two hands to be comfortably and immovably placed as long as possible. This support device can be provided with a rest with several accessories, such as indentations, bowl-like recesses, ridges, elastic or non-elastic straps and/or loops, etc.. Furthermore, at least an excitation source (2) for at least partially illuminating one extremity at least with a radiation of defined excitation wavelength. Furthermore, at least an image sensor (3) is incorporated for capturing at least a reference signal from the extremity as well as several signals from the regions of medical interest (ROI) of the extremity (11). Moreover, a device according to the invention comprises a comparator for comparing the reference signal with the signals from the regions of medical interest (ROI).

Abstract translation: 本发明的第一方面涉及用于诊断和/或治疗炎症性疾病如类风湿性关节炎的装置。 它至少包括用于保持人的至少一个肢体（11）的休息或支撑装置（1）。 因此，支撑装置具有促进至少一个肢体，优选两个末端的任务，例如两只手可以尽可能地舒适地和不可移动地放置。 该支撑装置可以设置有诸如凹痕，碗状凹部，脊，弹性或非弹性带和/或环等的多个附件的休息。此外，至少一个用于在 至少部分地用定义的激发波长的辐射照明一个末端。 此外，还包括至少一个图像传感器（3），用于至少捕获来自末端的参考信号以及来自末端（11）的医疗感兴趣区域（ROI）的几个信号。 此外，根据本发明的装置包括用于将参考信号与来自医疗感兴趣区域（ROI）的信号进行比较的比较器。